Sindbis virus replication, is insensitive to rapamycin and torin1, and suppresses Akt/mTOR pathway late during infection in HEK cells

►Sindbis, an oncolytic virus, causes translational shut-off, and inactivates eIF2α. ► Rapamycin, torin1 do not affect replication. ► PI3K/Akt/mTOR is not required, and suppressed by infection. ► Time dependent virus and drug effects on Akt/mTOR. ► mTOR suppression by virus, may counteract drug resistance.