Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor
Keywords: PI3K; mTOR; Kinase inhibitors
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Discovery of 2-ureidophenyltriazines bearing bridged morpholines as potent and selective ATP-competitive mTOR inhibitors
Keywords: mTOR; PI3K; Kinase; Inhibitor; Cancer; Oncology; Antiproliferative
Triazines incorporating (R)-3-methylmorpholine are potent inhibitors of the mammalian target of rapamycin (mTOR) with selectivity over PI3Kα
Keywords: mTOR; PI3K; Kinase inhibitors; Cancer; Oncology
Skeletal muscle: Increasing the size of the locomotor cell
Keywords: Ageing; AKT; Amino acids; Atrophy; Hypertrophy; Skeletal muscle; mTOR; MyoD; Protein synthesis
Phospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathway
Keywords: Phospholipase D; mTOR; HDM2; Serum- and glucocorticoid-induced kinase 1
N-Formyl-3,4-methylenedioxy-benzylidene-γ-butyrolaetam, KNK437 induces caspase-3 activation through inhibition of mTORC1 activity in Cos-1 cells
Keywords: TSC2, tuberous sclerosis complex 2; KNK437, N-formyl-3,4-methylenedioxy-benzylidene-γ-butyrolaetamKNK437 (N-formyl-3,4-methylenedioxy-benzylidene-γ-butyrolaetam); mTOR; Raptor; Apoptosis; Mitochondria
Prolidase-dependent regulation of TGF c and TGF β receptor expressions in human skin fibroblasts
Keywords: Prolidase; mTOR; TGF β; AKT; Rapamycin
Tumor growth in patients with tuberous sclerosis complex on the ketogenic diet
Keywords: Tuberous sclerosis complex; TSC; Ketogenic diet; mTOR; Subependymal giant cell tumor; Angiomyolipoma; Nutrition;
Mammalian target of rapamycin: A new target in prostate cancer
Keywords: Rapamycin; mTOR; Prostate cancer
Structure-activity relationship of tocopherol derivatives suggesting a novel non-antioxidant mechanism in antiprion potency
Keywords: Vitamin E; Tocopherol; Prion; Protein kinase C; Rapamycin; mTOR;
Allosteric and ATP-competitive kinase inhibitors of mTOR for cancer treatment
Keywords: Kinase inhibitors; mTOR; Anticancer agents;
AMP-activated kinase (AMPK)-generated signals in malignant melanoma cell growth and survival
Keywords: AICAR; 5-aminoimidazole-4-carboxamide riboside; AMPK; AMP-activated kinase; mTOR; mammalian target of rapamycin; PI3-K; phosphatidylinositol 3-kinase; AMP-activated kinase (AMPK); Malignant melanoma; 5-Aminoimidazole-4-carboxamide riboside (AICAR); Metfor
Fasting-related autophagic response in slow- and fast-twitch skeletal muscle
Keywords: Autophagy; Skeletal muscle; LC3; p62; mTOR;
Testosterone-induced hypertrophy of L6 myoblasts is dependent upon Erk and mTOR
Keywords: Muscle; Hypertrophy; Testosterone; mTOR; Erk
High-frequency electrically stimulated skeletal muscle contractions increase p70s6k phosphorylation independent of known IGF-I sensitive signaling pathways
Keywords: Akt; phosphatidylinosoltol regulated protein kinase; IGF-I; insulin-like growth factor-I; IOD; integrated optical densities; IRS-1; insulin related substrate-1; MKR; IGF-I receptor mutant mouse; mTOR; mammalian target of rapamycin; PI3K; phosphatidylinoso
Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)
Keywords: mTOR; Kinase inhibitors; Anticancer agent; Phosphoinositide-3-kinase; Serine/threonine kinase
4-Substituted-7-azaindoles bearing a ureidobenzofuranone moiety as potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)
Keywords: mTOR; PI3K; Cancer; Serine/threonine kinase
Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K
Keywords: mTOR; PI3K; Cancer; Oncology; Kinase
Macroautophagy modulates cellular response to proteasome inhibitors in cancer therapy
Keywords: HDAC6; IRE1-JNK; ATF4; mTOR; LC3; Aggresome; Bortezomib
Mechanisms involved in the enhancement of mammalian target of rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice
Keywords: PKB; protein kinase B; mTOR; mammalian target of rapamycin; GDF-8; growth differentiation factor-8; TGF-β; transforming growth factor-β; 4E-BP1; eukaryotic translation initiation factor 4E-binding protein-1; rpS6; ribosomal protein S6; COX IV; cytochrom
PTEN/mTOR and axon regeneration
Keywords: Pten; mTOR; axon; regeneration; PNS; CNS;
Regulation of neural stem/progenitor cell maintenance by PI3K and mTOR
Keywords: Neural stem cells; PI3K; mTOR
Overexpression of the Mammalian Target of Rapamycin: A Novel Biomarker for Poor Survival in Resected Early Stage Non-small Cell Lung Cancer
Keywords: Non-small cell lung cancer; Prognosis; Biomarker; mTOR
Activation of mTOR signaling pathway contributes to survival of cervical cancer cells
Keywords: mTOR; P70S6K; Cervical cancer; Rapamycin; siRNA
Mammalian target of rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma of the head and neck
Keywords: mTOR; CCR7; PI3K; Squamous cell carcinoma of head and neck; Survival;
2-Arylureidophenyl-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)triazines as highly potent and selective ATP competitive mTOR inhibitors: Optimization of human microsomal stability
Keywords: mTOR; PI3K; Kinase inhibitors; Cancer; Oncology; Microsomes
Role of the Akt/mTOR survival pathway in cisplatin resistance in ovarian cancer cells
Keywords: Cisplatin resistance; Ovarian cancer cells; Akt; mTOR; Apoptosis
Novel treatment strategies for patients with relapsed classical Hodgkin lymphoma
Keywords: Reed Sternberg; Brentuximab vedotin; SGN-35; Panobinostat; HADC; Everolimus; mTOR; Rituximab
Opposing and uncoupling effects of mTOR and S6K1 in the regulation of endothelial tissue factor expression
Keywords: mTOR, mammalian target of rapamycin; TF, tissue factor; HUVEC, human umbilical vein endothelial cell; rAd, recombinant adenovirus; shRNA, short hairpin RNAEndothelial cell; mTOR; S6K1; Thrombin; Tissue factor; TNFα
Glucose-dependent insulinotropic polypeptide stimulates the proliferation of colorectal cancer cells
Keywords: Glucose-dependent insulinotropic polypeptide; GIP; Obesity; Colorectal cancer; Akt; mTOR;
mTOR inhibitor rapamycin alone or combined with cisplatin inhibits growth of esophageal squamous cell carcinoma in nude mice
Keywords: Apoptosis; Esophageal squamous cell carcinoma (ESCC); mTOR; Rapamycin; Signaling pathway
Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy
Keywords: mTOR; Rapamycin; Chronic seizure; Acquired epilepsy; Mossy fiber sprouting
Autophagic cell death induced by 5-FU in Bax or PUMA deficient human colon cancer cell
Keywords: WT, wild type; PCD, programmed cell death; 5-FU, 5-fluorouracil; LC3, microtubule associated protein 1 light chain 3; DAPI, 4′,6′-diamidino-2-phenylindole dihydrochloride; 3-MA, 3-methyladenineAutophagic cell death; Apoptosis; Bax; PUMA; mTOR
Metformin is a potent inhibitor of endometrial cancer cell proliferation—implications for a novel treatment strategy
Keywords: Endometrial cancer; Metformin; mTOR; Telomerase
Inhibition of glycogen biosynthesis via mTORC1 suppression as an adjunct therapy for Pompe disease
Keywords: mTOR; Pompe disease; Glycogen storage disease; Glycogen synthase; Rapamycin; Enzyme replacement therapy
RAD001 shows activity against gastric cancer cells and overcomes 5-FU resistance by downregulating thymidylate synthase
Keywords: Gastric cancer; RAD001; mTOR; Thymidylate synthase
PEComes abdomino-pelviens : à propos d'une série de cinq cas
Keywords: PECome abdomino-pelvien; Angiomyolipome; Cellule périvasculaire épithélioide; Pigmenté; HMB45; MTOR; Abdomino-pelvic PEComa; Angiomyolipoma; Perivascular epithelioid cell; Pigmented; HMB45; MTOR;
CommentaryModulation of cell sensitivity to antitumor agents by targeting survival pathways
Keywords: AMPK; AMP-dependent protein kinase; ER; endoplasmic reticulum; ERK; extracellular signal-regulated kinases; GRP78; glucose-regulated protein 78; HDAC; histone deacetylase; mTOR; mammalian target of rapamycin; MAPK; mitogen-activated protein kinase; PI3K;
Depletion of mammalian target of rapamycin (mTOR) via siRNA mediated knockdown leads to stabilization of β-catenin and elicits distinct features of cardiomyocyte hypertrophy
Keywords: siRNA; mTOR; Wnt signaling; Cardiac hypertrophy
Regulation of gastric hormones by systemic rapamycin
Keywords: GI; gastrointestinal tract; mTOR; mammalian target of rapamycin; Rapa; rapamycin; S6; ribosomal protein S6; Gastric mTOR; Gastric endocrine cells; Gastric hormones;
Physiological role of autophagy as an intracellular recycling system: With an emphasis on nutrient metabolism
Keywords: AMP; adenosine monophosphate; AMPK; AMP-activated protein kinase; Atg; autophagy-related; ATP; adenosine triphosphate; Bak; Bcl-2 homologous antagonist/killer; Bax; Bcl-2 associated X protein; Bcl-2; B-cell leukemia/lymphoma 2; Cvt; cytoplasm-to-vacuole t
Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function
Keywords: Cardiac function; LKB1; AMP-activated protein kinase; mTOR
mTOR inhibitor RAD001 (Everolimus) enhances the effects of imatinib in chronic myeloid leukemia by raising the nuclear expression of c-ABL protein
Keywords: Chronic myeloid leukemia; p210 BCR-ABL; p145 c-ABL; Imatinib mesylate; mTOR; RAD001
Deregulated signalling networks in human brain tumours
Keywords: GBM; glioblastoma multiforme; RTK; receptor tyrosine kinase; EGF(R); epidermal growth factor (receptor); PDGF(R); platelet-derived growth factor (receptor); VEGF(R); vascular endothelial growth factor (receptor); ERBB2; v-erb-b2 erythroblastic leukemia vi
Traitements ciblés des sarcomes et des tumeurs conjonctives rares
Keywords: sarcome; facteur de croissance tyrosine-kinase; PDGF; MCSF; RANKL; mTOR; KIT; sarcoma; tyrosine-kinase growth factor; PDGF; MCSF; RANKL; mTOR; KIT;
mTOR inhibition by everolimus counteracts VEGF induction by sunitinib and improves anti-tumor activity against gastric cancer in vivo
Keywords: Angiogenesis; Gastric cancer; mTOR; Sunitinib; VEGF
Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins: Roles in skeletal muscle growth and differentiation
Keywords: IGF; IGFBP; Myoblast; Proliferation; Hypoxia; HIF-1; MAPK; Akt; mTOR
Antiproliferation of cardamonin is involved in mTOR on aortic smooth muscle cells in high fructose-induced insulin resistance rats
Keywords: Cardamonin; Rapamycin; Fructose; mTOR; Insulin resistance; Vascular smooth muscle cell; (Rat)
Targeted Treatments for Cognitive and Neurodevelopmental Disorders in Tuberous Sclerosis Complex
Keywords: TSC; mTOR; rapamycin; neurocognition; memory; autism; autism spectrum disorders;