Glutamate-dependent phosphorylation of the mammalian target of rapamycin (mTOR) in Bergmann glial cells
Keywords: Bergmann glia; Glutamate receptors; mTOR; Translation;
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Phase II trial of temsirolimus in patients with relapsed or refractory multiple myeloma
Keywords: Multiple myeloma; mTOR; Temsirolimus; Pharmacokinetics;
Posttransplant anemia: the role of sirolimus
Keywords: anemia; mTOR; posttransplant; renal; sirolimus
Phosphatidic acid signaling to mTOR: Signals for the survival of human cancer cells
Keywords: Phospholipase D; Phosphatidic acid; mTOR; Rapamycin; Survival signal; Cancer
Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model
Keywords: TSC; mTOR; ERK/MAPK; rapamycin; PD98059
The variation of AkT/TSC1–TSC1/mTOR signal pathway in hepatocytes after partial hepatectomy in rats
Keywords: TSC; mTOR; Signal pathway; Partial hepatectomy; Liver regeneration
The role of protein synthesis in cell cycling and cancer
Keywords: Cell cycle; Elongation factor 2; Elongation factor 2 kinase; Apoptosis; Cancer; AMPK; AMP-activated Kinase; cAMP; cyclic AMP; PKA; Protein Kinase A; FLIP; FLICE-Like Inhibitor Protein; XIAP; X-linked Inhibitor of Apoptosis; EF2; Elongation Factor 2; cdc2/
New agents for AML and MDS
Keywords: acute myeloid leukaemia (AML); myelodysplastic syndromes (MDS); FMS-like tyrosine kinase receptors (FLT3 inhibitors); farnesyl transferase inhibitor (FTI); clofarabine; histone deacetylase (HDAC); DNMT; mTOR; parthenolide; PIM kinase;
Rapamycin reduces high-amplitude, mechanical stretch-induced apoptosis in pulmonary microvascular endothelial cells
Keywords: ALI; acute lung injury; ARDS; acute respiratory distress syndrome; ATII cell; alveolar type II cell; FCS; fetal calf serum; HMVEC-L; human microvascular endothelial cells of the lung; LDH; lactic acid dehydrogenase; mTOR; mammalian target of rapamycin; PB
Effects of dopamine on LC3-II activation as a marker of autophagy in a neuroblastoma cell model
Keywords: Dopamine; Autophagy; LC3; HIF-1α; mTOR; Ubiquitine
IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes
Keywords: Anergy; Interleukin 2; mTOR; T cell; NFAT
Differentiation-Induced Post-Transcriptional Control of B7-H1 in Human Trophoblast Cells
Keywords: Placenta; Trophoblast; Syncytiotrophoblast; Epidermal growth factor; Interferon-gamma; mTOR; Polysomal RNA; Phosphatidylinositol 3-kinase; B7-H1; PD-L1; PD-1
Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells
Keywords: Honokiol; MDA-MB-231; Apoptosis; Src; mTOR
Inhibition of PKHD1 may cause S-phase entry via mTOR signaling pathway
Keywords: PKHD1; Rapamycin; mTOR; HIF-1α; VEGF;
Activation of microglia/macrophages expressing phosphorylated S6 ribosomal protein in a case of hemimegalencephaly with progressive calcification and atrophy
Keywords: Hemimegalencephaly; Microglia; Macrophage; mTOR; Tuberous sclerosis; Balloon cell; α-B-crystallin
Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM
Keywords: PAM; mTOR; Sphingosine-1-phosphate; Rheb; TSC2; Ubiquitin ligase; Guanosine exchange factor; Insulin
Concomitant supplementation of lycopene and eicosapentaenoic acid inhibits the proliferation of human colon cancer cells
Keywords: Lycopene; Eicosapentaenoic acid; Akt; mTOR; Proliferation; Colon cancer cells
Systematic gene expression profile of hypothalamus in calorie-restricted mice implicates the involvement of mTOR signaling in neuroprotective activity
Keywords: Calorie restriction; Hypothalamus; mTOR; Aging; Microarray; Mice
Rethinking phosphatidylinositol 3-monophosphate
Keywords: Autophagy; Myotubularin; mTOR; Phosphoinositide; Phosphoinositide 3-kinase; Rab5;
Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo
Keywords: HCC; Hep atocellular carcinoma; HCV; Hepatitis C virus; HBV; Hepatitis B virus; LGDN; low-grade dysplastic nodules; HGDN; high-grade dysplastic nodules; Liver cancer; HCV; Signaling pathway; Molecular therapies; Ras; mTOR;
Expression and mechanism of mammalian target of rapamycin in age-related renal cell senescence and organ aging
Keywords: Cellular senescence; mTOR; HDFs
Phosphatidylinositol-3-Kinase/Akt Signaling Pathway and Kidney Cancer, and the Therapeutic Potential of Phosphatidylinositol-3-Kinase/Akt Inhibitors
Keywords: kidney; carcinoma; renal cell; D 21266; 1-phosphatidylinositol 3-kinase; mTOR protein; 17-HWT; 17-hydroxy-wortmannin; APC; alkylphosphocholine; ERK; extracellular regulated kinase; GSK3; glycogen synthase kinase-3; HIF; hypoxia-inducible factor; IC50; hal
Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms
Keywords: mTOR; Rheb; TSC; HIF; YY1; SGK1; PRAS40; FKBP38; 4E-BP1; S6K1
Akt-dependent and -independent mechanisms of mTOR regulation in cancer
Keywords: mTOR; Cancer; Akt; AMPK
TIS21/BTG2/PC3 and cyclin D1 are key determinants of nuclear diacylglycerol kinase-ζ-dependent cell cycle arrest
Keywords: cdk; cyclin dependent kinase; DG; diacylglycerol; DGK; diacylglycerol kinase; ECL; enhanced chemiluminescence; GSK; glycogen synthase kinase; mTOR; mammalian Target Of Rapamycin; NLS; nuclear localization signal; p70S6K; p70S6 kinase; PA; phosphatidic aci
Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1
Keywords: Mammalian target of rapamycin; mTOR; Raptor; Hydrogen peroxide; Tuberous sclerosis complex; PRAS40; Proline-rich Akt substrate; 4E-BP1; Insulin; Free radicals
Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN
Keywords: FFA; free fatty acid; UFA; unsaturated fatty acid; NAFLD; non-alcoholic fatty liver diseases; HCC; hepatocellular carcinoma; HCA; hepatocellular adenoma; OA; oleic acid; PoA; palmitoleic acid; PA; palmitic acid; LA; linoleic acid; SA; stearic acid; EMT; e
Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation
Keywords: Microglia; Astrocytes; mTOR; NOS2; COX; Cytokines
Activating transcription factor 4 and CCAAT/enhancer-binding protein-β negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress
Keywords: ATF4; C/EBP-β; ER stress; mTOR; Oxidative stress; Redd1/RTP801;
Recent advances in neurobiology of Tuberous Sclerosis Complex
Keywords: Tuberous sclerosis; Epilepsy; Mental retardation; TSC1; TSC2; mTOR; Rapamycin; Autism
Murine Glut-1 transporter haploinsufficiency: Postnatal deceleration of brain weight and reactive astrocytosis
Keywords: Glut-1 deficiency mouse model; Brain development; Microcephaly; Apoptosis; Proliferation; Astrogliosis; mTOR; GSK3-β; Fasting; Lithium
Evidence of molecular links between PKR and mTOR signalling pathways in Aβ neurotoxicity: Role of p53, Redd1 and TSC2
Keywords: Alzheimer's disease; PKR; p53; Redd1; TSC2; mTOR
Glutamine Increases Autophagy Under Basal and Stressed Conditions in Intestinal Epithelial Cells
Keywords: BBE; brush border expression; DMEM; Dulbecco's modified Eagle medium; Hsp; heat shock protein; IEC; intestinal epithelial cell; LC3; microtubule-associated protein light chain 3; MAP; mitogen-activated protein; mTOR; mammalian target of rapamycin; PARP; p
Dysregulated molecular networks in head and neck carcinogenesis
Keywords: Oral cancer; Signal transduction; Targeted therapies; Oncogenes; Tumor suppressor genes; mTOR
Rosiglitazone-induced heart remodelling is associated with enhanced turnover of myofibrillar protein and mTOR activation
Keywords: Protein synthesis; Calpain/calpastatin; Proteasome; mTOR; AMPK; Peroxisome proliferator-activated receptor γ agonist; Glycogen; Rapamycin; MAPK;
Molecular Mechanisms of Pancreatic Dysfunction Induced by Protein Malnutrition
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; CCK; cholecystokinin; IP; intraperitoneal; mTOR; mammalian target of rapamycin; S6; ribosomal protein S6;
A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to p38MAPK-dependent activation of mTOR and cyclinD1 expression in prostate and lung cancer cells
Keywords: AR; EGFR; mTOR; Prostate cancer; Lung cancer;
Prevention of steatohepatitis by pioglitazone: Implication of adiponectin-dependent inhibition of SREBP-1c and inflammation
Keywords: Adipo; adiponectin; AdipoR; adiponectin receptor; AMPK; AMP-activated protein kinase; ACC; acetyl-CoA carboxylase; ACO; acyl CoA oxidase; cDNA; complementary deoxyribonucleic acid; FA; fatty acid; FAS; fatty acid synthase; HSP-90; heat shock protein 90; I
The novel orally bioavailable inhibitor of phosphoinositol-3-kinase and mammalian target of rapamycin, NVP-BEZ235, inhibits growth and proliferation in multiple myeloma
Keywords: Multiple myeloma; NVP-BEZ235; PI3 kinase; Akt; mTOR
IGF-I, EGF, and sex steroids regulate autophagy in bovine mammary epithelial cells via the mTOR pathway
Keywords: Autophagy; Apoptosis; Mammary gland; mTOR; Growth factors; Sex steroids
Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) regulates growth and patterning of the postnatal mouse cerebellum
Keywords: COUP-TFII; IGF-1; Akt1; mTOR; Cerebellum; Foliation; GSK-3β;
Molecular target therapy for gastroenteropancreatic endocrine tumours: Biological rationale and clinical perspectives
Keywords: Pancreatic endocrine tumours; Carcinoids; Targeted therapy; Angiogenesis; Tyrosine kinase; mTOR
An update on preventive and regenerative therapies in diabetes mellitus
Keywords: Autoimmune disease; Beta-cell mass; Diabetes; Prevention; Regeneration; Regulatory T-cell; CD; cluster of differentiation; CTLA; cytotoxic T lymphocyte antigen; DPP-4; dipeptidyl peptidase-4; GAD; glutamic acid decarboxylase; GLP-1; glucagon-like peptide-
Diacylglycerol kinase alpha, from negative modulation of T cell activation to control of cancer progression
Keywords: Diacylglycerol kinase; DGK; Sphingosine kinase; SPK; Ceramide kinase; CERK; Vascular endothelial growth factor; VEGF; Hepatocyte growth factor; HGF; Epidermal growth factor; EGF; Protein kinase C; PKC; Protein kinase D; PKD; Peroxisome proliferator-activa
Akt regulates skeletal development through GSK3, mTOR, and FoxOs
Keywords: myrAkt, myristoylated Akt; EGFP, enhanced green fluorescence protein; tg(L), transgenic mice with low expression; tg(H), transgenic mice with high expression; FoxO3a-TM, FoxO3a triple mutant; dn, dominant negativeAkt; GSK3; mTOR; FoxO; Chondrocyte maturat
Novel therapeutics in breast cancer—Looking to the future
Keywords: Breast cancer; HER-2; Trastuzumab-DM1; HSP-90; Epothilones; mTOR; IGF-1R; PKC inhibitors and PARP1 inhibitors
Positioning mitochondrial plasticity within cellular signaling cascades
Keywords: Mitochondrial dynamics; Fusion; Fission; Signaling; Motility; Cristae; Cell cycle; Apoptosis; Metabolism; Immunity; mTOR; Disease
Cell death in the injured brain: Roles of metallothioneins
Keywords: ADP; adenosine diphosphate; AIF; apoptosis-inducing factor; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolyl-propionic acid; Apaf-1; apoptotic protease-activating factor 1; Atg; autophagy gene; Bak; Bcl-2-homologous antagonist/killer; Bax; Bcl-2-associated
Role of TSC–mTOR pathway in diabetic nephropathy
Keywords: Diabetes; mTOR; TSC; Rapamycin; Diabetic nephropathy
Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins
Keywords: Lung cancer; Cisplatin resistance; mTOR; BCL2; BCLxL