Survivin: A novel player in insulin cardioprotection against myocardial ischemia/reperfusion injury
Keywords: Insulin; Survivin; mTOR; Ischemia/reperfusion; Apoptosis;
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High glucose upregulation of early-onset Parkinson's disease protein DJ-1 integrates the PRAS40/TORC1 axis to mesangial cell hypertrophy
Keywords: Akt kinase; Kidney; Diabetes; mTOR
Mammalian target of rapamycin (mTOR) phosphorylates inositol 1,4,5-trisphosphate receptor type 2 and increases its Ca2+ release activity
Keywords: Inositol 1,4,5-trisphosphate receptor; mTOR; Phosphorylation; Calcium
Lithium induces c-Ret expression in mouse inner medullary collecting duct cells
Keywords: Li+; lithium; mIMCD; murine inner medullary collecting duct; GSK-3β; glycogen synthase kinase 3β; BIO; 6-bromoindirubin-3â²-oxime; TCF/LEF; T cell factor/lymphoid enhancer factor; mTOR; mammalian target of rapamycin; Ret; REarranged during Transfection
Visfatin exerts angiogenic effects on human umbilical vein endothelial cells through the mTOR signaling pathway
Keywords: Visfatin; Angiogenesis; Adipocytokine; mTOR; GSK3β;
Development of sulfonamide AKT PH domain inhibitors
Keywords: AKT; protein kinase B; β-ARK; β-adrenergic receptor kinase; CREB; cAMP response element-binding; DMEM; Dulbecco's modified Eagle medium; DPIEL; deoxyphosphatidylinositol ether lipid; ELISA; enzyme-linked immunosorbent assay; ESI; electrospray ionizati
Inhibitors of mTOR overcome drug resistance from topoisomerase II inhibitors in solid tumors
Keywords: mTOR; DNA damage; Chemotherapeutic drugs; G2/M arrest; Topoisomerase II; γH2AX
Thérapies ciblées et radiothérapie dans les cancers bronchiques non à petites cellules
Keywords: Non small cell lung carcinoma; Antiangiogenic agents; Concomitant radiochemotherapy; EGFR; MTOR; Histone deacetylase; Aurora kinase; Cancer stem cellsCarcinome bronchique non à petites cellules; Antiangiogéniques; Chimioradiothérapie concomitante; EGFR; M
Identifying Inhibitors of Epithelial-Mesenchymal Transition by Connectivity Map–Based Systems Approach
Keywords: TGF-beta; Epithelial-mesenchymal transition; Connectivity map; Lung cancer; mTOR; PI3K; HSP90
Signaling through EAAT-1/GLAST in cultured Bergmann glia cells
Keywords: Glutamate transporters; Bergmann glia; mTOR; Transcription regulation; Translational control
Intracellular GTP level determines cell's fate toward differentiation and apoptosis
Keywords: GTP; Guanosine-5â²-triphosphate; ATP; Adenosine-5â²-triphosphate; Ado; Adenosine; Guo; Guanosine; GPIIb; Glycoprotein IIb; MPA; Mycophenolic acid; 3-HK; 3-Hydrogenkwadaphnine; DMSO; Dimethyl sulfoxide; HPLC; High performance liquid chromatography; mTOR;
mTOR and rapamycin in the kidney: signaling and therapeutic implications beyond immunosuppression
Keywords: autophagy; cilia; mTOR; PKD; podocyte; VHL
Circadian regulation of mammalian target of rapamycin signaling in the mouse suprachiasmatic nucleus
Keywords: circadian; SCN; S6; per1; mTOR; ERKAVP, arginine vasopressin; CTs, circadian times; MAPK, mitogen-activated protein kinase; mTOR, mammalian target of rapamycin; pS6, phosphorylated S6 ribosomal protein; SCN, suprachiasmatic nuclei
The role of the phosphatidylinositol 3-kinase (PI3K) pathway in the development and treatment of uterine cancer
Keywords: Endometrial cancer; Uterine cancer; PI3K; mTOR; PTEN; AKT
Autophagy is induced by 3β-O-succinyl-lupeol (LD9-4) in A549 cells via up-regulation of Beclin 1 and down-regulation mTOR pathway
Keywords: LD9-4; Apoptosis; Autophagy; Beclin 1; mTOR; A549;
Identification of Cancer Stem Cells in Human Gastrointestinal Carcinoid and Neuroendocrine Tumors
Keywords: Carcinoid Tumors; Cancer Stem Cells; Src Family Kinase Inhibitor PP2; Neuroendocrine Tumors; ALDH; aldehyde-dehydrogenase; CSC; cancer stem cell; DMEM; Dulbecco's modified Eagle medium; DMSO; dimethyl sulfoxide; DOPC; 1,2-dioleoyl-sn-glycero-3-phosphatidy
Moving to tolerance: Clinical application of T regulatory cells
Keywords: APC; antigen presenting cell; ATG; anti thymocyte globulin; aTreg; adaptive T regulatory cell; AZT; 3â²-azido-3â²-deoxythymidine; CNI; calcineurin inhibitor; CyA; cyclosporin A; DC; dendiric cell; DST; donor specific transfusion; GVHD; graft versus host
Modulation of human embryonic stem cell-derived cardiomyocyte growth: A testbed for studying human cardiac hypertrophy?
Keywords: ANF; atrial natriuretic factor; bFGF; basic human fibroblast growth factor; CaMK II; Ca2+/calmodulin-dependent kinase II; EB; embryoid body; ERK; extracellular signal-regulated kinases; GSK3; glycogen synthase kinase 3; HDACII; histone deacetylase; FKBP;
Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model
Keywords: 3-MA; 3-methyl adenine; LC3; microtubule-associated protein light chain-3; mTOR; mammalian target of rapamycin; PD; Parkinson's disease; PI3K-III; phosphoinositide 3-kinase III; PINK1; PTEN-induced kinase 1; PP2A; protein phosphatase 2A; PINK1; PP2A; Au
Inhibition by rapamycin of the lipoteichoic acid-induced granulocyte-colony stimulating factor expression in mouse macrophages
Keywords: G-CSF; LTA; Macrophage; mTOR; Oct-2; Rapamycin
A phospho-proteomic screen identifies novel S6K1 and mTORC1 substrates revealing additional complexity in the signaling network regulating cell growth
Keywords: S6K1 signaling; mTOR; Phospho-proteomics; Chaperonin
Crosstalk between VEGFR2 and muscarinic receptors regulates the mTOR pathway in serum starved SK-N-SH human neuroblastoma cells
Keywords: VEGF; Muscarinic; VEGFR2; mTOR; Crosstalk; PKC; Phosphatase
Autophagy as a therapeutic target in cardiovascular disease
Keywords: Heart failure; Cardiac hypertrophy; Remodeling; Autophagy; Plasticity; HDAC inhibitors; Hypertrophy; AMPK; IP3; mTOR; PKA; p53
Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass
Keywords: 4E-BP1; 4E binding protein 1; 5â²UTR; 5â² untranslated region; AICAR; 5-aminoimidazole-4-carboxamide riboside; AMP; adenosine monophosphate; AMPK; 5â²-AMP-activated protein kinase; AMPK α1â/â; AMPK α1 subunit knockout; AMPKα1â/âα2â/â; A
Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain
Keywords: reeler; synapse; hippocampus; NMDA receptor; PTEN; ApoER2; apolipoprotein E receptor 2; CA1; cornu ammonis area 1; CoIP; co-immunoprecipitation; ECL; enhanced chemiluminescence; HEPES; 4-(2-hydroxyethyl)-piperazine-1-ethanesulphonic acid; IgG; immunoglobu
Activation of STAT1 is required for interferon-alpha-mediated cell death
Keywords: Interferon; Apoptosis; STAT; Deguelin; PI3K; Rapamycin; mTOR
Making sense of regulatory T cell suppressive function
Keywords: APC; antigen presenting cells; BM; bone marrow; BMT; bone-marrow transplantation; cAMP; cyclic AMP; CTL; cytotoxic T lymphocytes; CTLA-4; cytotoxic T-lymphocyte antigen 4; DC; dendritic cells; DN; double negative Treg cells; EAE; experimental autoimmune e
Tissue and serum biomarkers as prognostic variables in endometrioid-type endometrial cancer
Keywords: Endometriod endometrial carcinoma; p53; PTEN; mTOR; Microsatellite instability; β-Catenin; K-ras; Vascular endothelial growth factor; DNA aneuploidy; CA 125
Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction
Keywords: Apoptosis; TLR4; mTOR; Fibrosis; Ischemia/reperfusion; Inflammation;
Uncovering the role of hypoxia inducible factor-1α in skin carcinogenesis
Keywords: Bax; Bcl-2-associated X protein; BCC; Basal cell carcinoma; Bcl-2; B cell lymphoma; Bcl-xL; B-cell lymphoma-extra large; BNIP3; BCL2/adenovirus E1B 19Â kDa protein-interacting protein 3; CMM; Cutaneous malignant melanoma; CBP; cyclic-AMP response element
Caveolin-1 overexpression enhances androgen-dependent growth and proliferation in the mouse prostate
Keywords: Caveolin-1; Androgen receptor; Testosterone; Prostate; mTOR; RB
A novel cardioprotective p38-MAPK/mTOR pathway
Keywords: I/R, ischemia/ reperfusion injury; MI, myocardial infarction; H/R, hypoxia/reoxigenation; ROS, reactive oxygen species; AAR, area at risk; IA, infarct area; NRVM, neonatal rat ventricular myocytesIschemia/reperfusion; oxidant stress; mTOR; p38 MAPK; cell
Neuroprotective effects of MAPK/ERK1/2 and calpain inhibitors on lactacystin-induced cell damage in primary cortical neurons
Keywords: AIF; apoptosis inducing factor; DIV; day in vitro; ERK1/2; extracellular signal-regulated kinase 1/2; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GDNF; glia-derived neurotrophic factor; JNK; c-Jun N-terminal kinase; LC; lactacystin; LDH; lactate dehy
Autophagy, Microbial Sensing, Endoplasmic Reticulum Stress, and Epithelial Function in Inflammatory Bowel Disease
Keywords: Inflammatory Bowel Disease; Crohn's Disease; Ulcerative Colitis; Pathogenesis; Autophagy; Endoplasmic Reticulum Stress; Unfolded Protein Response; Innate Immunity; Genetics; Agr2; anterior gradient gene 2; AIEC; enteroadherent-invasive Escherichia coli; A
Temsirolimus Inhibits Malignant Pleural Mesothelioma Growth In Vitro and In Vivo: Synergism with Chemotherapy
Keywords: Mesothelioma; mTOR; Temsirolimus; Chemotherapy; Cisplatin resistance
Targeting PI3K Signaling as a Therapeutic Approach for Colorectal Cancer
Keywords: Colon Cancer; Neoplasm; Signal Transduction; Genetics; Tumor; CRC; colorectal cancer; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; GPCR; G-protein-coupled receptor; IRS1; insulin receptor substrate 1; MEF; murine embryonic fibro
Targeting autophagy during cancer therapy to improve clinical outcomes
Keywords: AMPK; AMP activated protein kinase; ATG; autophagy-related genes; Bif-1; endophilin B1; BNIP3; Bcl-2/adenovirus E1B 19Â kDa-interacting protein; CML; chronic myeloid leukemia; CQ; chloroquine; DAP1; death-associated protein 1; HCQ; hydroxychloroquine; HDA
Paradigm of kinase-driven pathway downstream of epidermal growth factor receptor/Akt in human lung carcinomas
Keywords: Lung carcinoma; EGFR; Akt; mTOR; p70S6-kinase
Bfl-1/A1 acts as a negative regulator of autophagy in mycobacteria infected macrophages
Keywords: TACO, tryptophan–aspartate containing coat protein; mTOR, mammalian target of rapamycin; PI3K, phosphatidylinositol 3-kinase; LC3, microtubule-associated protein 1 light chain 3Autophagy; Mycobacteria; Bfl-1/A1; mTOR; Rapamycin
The multiple roles of amphiregulin in human cancer
Keywords: AREG; amphiregulin; TACE; tumor-necrosis factor-alpha converting enzyme; ADAM; a disintegrin and metalloproteinase; CTF; carboxy-terminal fragment; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EGFR-TKI; epidermal growth factor rec
Lack of compensatory pAKT activation and eIF4E phosphorylation of lymphoma cells towards mTOR inhibitor, RAD001
Keywords: RAD001; mTOR; AKT; eIF4E; Cyclin D3; c-Myc; IRS-1;
Systemic inhibition of the mammalian target of rapamycin (mTOR) pathway reduces neuropathic pain in mice
Keywords: Inflammatory pain; Local translation; mTOR; Neuropathic pain; Temsirolimus (CCI-779); Torin1;
Lipolysis - A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores
Keywords: 2-AG; 2-arachidonoyl glycerol; ABHD1-15; α/β hydrolase domain containing protein 1-15; ARF1; ADP-ribosylation factor 1; ATGL; adipose triglyceride lipase; BAT; brown adipose tissue; BiFC; bimolecular fluorescence complementation; CDS; Chanarin-Dorfman
Resolvins: Natural agonists for resolution of pulmonary inflammation
Keywords: Catabasis; Lipid mediators; Lung; Neutrophils; Omega-3; Polyunsaturated fatty acids; AA; arachidonic acid; ALI; acid lung injury; ALX/FPR2; lipoxin A4 receptor/formyl peptide receptor 2; ARDS; acute respiratory distress syndrome; ATL; aspirin-triggered li
Functions of Autophagy in Hepatic and Pancreatic Physiology and Disease
Keywords: Steatosis; Cell Death; Pancreatitis; Hepatitis Virus; AT; α1-antitrypsin; Atg; autophagy-related gene; ATP; adenosine triphosphate; CMA; chaperone-mediated autophagy; ER; endoplasmic reticulum; HBx; hepatitis B virus protein X; LAMP-2; lysosome-associate
PI3K/mTOR signaling regulates prostatic branching morphogenesis
Keywords: Prostate; Branching morphogenesis; PI3K; mTOR; Migration
Role of Notch and its oncogenic signaling crosstalk in breast cancer
Keywords: 4T1 cells; mouse mammary cancer cell line; ADAM; a disintegrin and metalloprotease; Akt; protein kinase B; ALDH; aldehyde dehydrogenase; ANK; ankyrin; Axin2; the Axin-related protein; BALB/c; an albino, laboratory-bred strain of the house mouse; Bcl-2; B-
mTOR Inhibitors in Advanced Renal Cell Carcinoma
Keywords: Kidney neoplasms; mTOR; Targeted therapy; Renal cell carcinoma; Treatment resistance;
Energy metabolism in adult neural stem cell fate
Keywords: ACC; adenylate cyclase complex; AICAR; aminoimidazole carboxamide ribonucleotide; AMPK; AMP-activated protein kinase; Aspm; abnormal spindle-like microcephaly-associated; BDNF; brain-derived neurotrophic factor; bFGF; basic fibroblast growth factor; bHLH;
4-Methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors
Keywords: PI3K; mTOR; Kinase inhibitor; Cancer