Keywords: α-SMA; α-smooth muscle actin; Ad; adamantane; BMP-7; bone morphogenetic protein 7; CD; β-cyclodextrine; CKD; chronic kidney disease; CPP; cell penetrating peptide; COX-2; cyclooxygenase 2; CTGF; connective tissue growth factor; DAMPs; danger associated
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Keywords: Marburg virus; Nucleoprotein; Inclusions; Late domain; ESCRT; Alix; Nedd4; Lamp-1
Keywords: 4E-BP1; 4E-binding protein-1; AA; amino acid; ALS; autophagy-lysosomal system; AMPK; adenosine monophosphate-activated protein kinase; COPD; chronic obstructive pulmonary disease; CRP; C-reactive protein; ERK; extracellular signal regulated kinase; FFM; f
E3-ubiquitin ligase NEDD4 enhances bone formation by removing TGFβ1-induced pSMAD1 in immature osteoblast
Keywords: NEDD4; neural precursor cell-expressed, developmentally down-regulated protein 4; TGFβ1; transforming growth factor β1; BMP2; bone morphogenetic protein 2; PI3K; phosphatidylinositol-4,5-bisphosphate 3-kinase; AKT (PKB); protein kinase B; ERK; extracell
The connexin 43 C-terminus: A tail of many tales
Keywords: Akt; protein kinase B; CCN; CYR61/connective tissue growth factor/nephroblastoma overexpressed; CDK1; cyclin-dependent kinase 1; CIP75; Cx43-interacting protein of 75Â kDa; CIP85; Cx43-interacting protein of 85-kDa; CK1; casein kinase 1; Csk; C-terminal c
USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination
Keywords: Insulin-like growth factor (IGF); Insulin receptor substrate (IRS)-2; Ubiquitin-specific protease 15 (USP15); Nedd4; Ubiquitination; IGF; insulin-like growth factor; IRS; insulin receptor substrate; PI3K; phosphatidylinositol 3-kinase; USP; ubiquitin-spec
The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer
Keywords: Curcumin; Pancreatic cancer; NEDD4; Cell growth; Invasion;
Low density lipoprotein receptor class A domain containing 4 (LDLRAD4) promotes tumorigenesis of hepatic cancer cells
Keywords: LDLRAD4; Nedd4; Tumorigenesis; TGF-β signaling; Cancer cell;
Calcium dependent regulation of protein ubiquitination - Interplay between E3 ligases and calcium binding proteins
Keywords: ACK; activated Cdc42-associated tyrosine kinase; CaM; calmodulin; CAMKII; CaM dependent kinase II; DUBs; deubiquitinases; Herp; homocysteine inducible ER protein; MGRN1; Mahogunin Ring Finger 1; NEDD4; neural precursor cell-expressed developmentally downr
Learning, memory and long-term potentiation are altered in Nedd4 heterozygous mice
Keywords: Nedd4, neural precursor cell expressed developmentally down-regulated 4Ubiquitination; Memory; Nedd4; Long term potentiation; AMPA receptor; GluA1
Quinoxaline-based inhibitors of Ebola and Marburg VP40 egress
Keywords: Ebola virus; Marburg virus; RNA viruses; Virus egress; PPxY; Nedd4; L-domain; Budding; Antiviral therapeutic
Cell autonomous roles of Nedd4 in craniofacial bone formation
Keywords: Craniofacial development; Neural crest cell; Osteoblast; Ossification; Nedd4;
Cardiac ubiquitin ligases: Their role in cardiac metabolism, autophagy, cardioprotection and therapeutic potential
Keywords: ATG; autophagy-related gene; AMPK; AMP activated protein kinase; BECN1; beclin1; b-TrCP; beta-transducin repeat-containing protein; Cbl; Casitas B-lineage lymphoma; CHIP; Carboxyl terminus of Hsc70 interacting protein; CHMP2B; charged multivesicular body
Upregulation of MuRF1 and MAFbx participates to muscle wasting upon gentamicin-induced acute kidney injury
Keywords: UPS; ubiquitin proteasome system; AKI; acute kidney injury; ATN; acute tubular necrosis; CKD; chronic kidney disease; MuRF1; muscle ring finger protein-1; MAFbx; muscle atrophy F-box protein; MUSA1; muscle ubiquitin ligase of the SCF complex in atrophy-1;
Regulation of connexins by the ubiquitin system: Implications for intercellular communication and cancer
Keywords: AMSH; associated molecule with the SH3 domain of STAM (signal transducing adaptor molecule); ATP; adenosine triphosphate; cAMP; cyclic adenosine monophosphate; CIP75; Cx43-interacting protein of 75 kD; CIP85; Cx43-interacting protein of 85 kDa; Cx; connex
NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt signaling
Keywords: Nedd4; IGF-1R; Endometrial cancer; PI3K
Study of PTEN subcellular localization
Keywords: AKAP; A kinase anchoring protein; ArA; arachidonic acid; Ca2+; calcium; CLS; cytoplasmic localization signal; Co-IP; co-immunoprecipitation; COX; cytochrome c oxidase; ER; endoplasmic reticulum; ER-RFP; endoplasmic reticulum-targeted red fluorescent prote
Copy Number Variable MicroRNAs in Schizophrenia and Their Neurodevelopmental Gene Targets
Keywords: CAPRIN1; Copy number variation; MicroRNA; NEDD4; NTRK2; PAK2; RHOA; Schizophrenia; SYNGAP1; 16p13.11;
Nuclear trafficking of Pten after brain injury leads to neuron survival not death
Keywords: Ndfip1; Neuroprotection; Nedd4; Pten; Traumatic brain injury; Ubiquitination
TMEPAI inhibits TGF-β signaling by promoting lysosome degradation of TGF-β receptor and contributes to lung cancer development
Keywords: TMEPAI; Transmembrane prostate androgen-induced protein; Nedd4; Neural precursor cell-expressed developmentally down-regulated 4; TβRI; TGF-β type I receptor; TβRII; TGF-β type II receptor; TMEPAI; Lysosome; TGF-β signaling; TGF-β receptor; Lung can
The links between AKT and two intracellular proteolytic cascades: Ubiquitination and autophagy
Keywords: BRCA1; breast cancer susceptibility gene 1; BRCT; Brca1 C-terminal; CHIP; chaperone-associated ubiquitin ligase; CYLD; cylindromatosis; DAPK; death-associated protein kinase; DUB; deubiquitinating enzyme); EGF; epidermal growth factor; FADD; fas-associate
Brucella infection inhibits macrophages apoptosis via Nedd4-dependent degradation of calpain2
Keywords: Brucella abortus; Apoptosis; Nedd4; Calpain2; Intracellular calcium;
Mahogunin ring finger 1 suppresses misfolded polyglutamine aggregation and cytotoxicity
Keywords: AIP4; atrophin-interacting protein 4; Baf; bafilomycin; BMP; bis(monoacylglycero)phosphate; CMA; chaperone-mediated autophagy; CQ; chloroquine; HD; Huntington disease; HECT; homologous to E6-AP C-terminus; IB; inclusion bodies; Lamp2a; lysosome associated
Role of the ubiquitin-proteasome system in brain ischemia: Friend or foe?
Keywords: 3-MA; 3-methyladenine; 15d-PHJ2; 15-deoxy-Î12,14-prostaglandin J2; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid; AMPAR; AMPA receptors; APC/C; anaphase-promoting complex/cyclosome; APV; D-aminophosphonovalerate; ATF4; activating transcri
Identification of ubiquitin-modified lysine residues and novel phosphorylation sites on eukaryotic initiation factor 2B epsilon
Keywords: DMEM; Dulbecco's modified Eagle's medium; eIF; eukaryotic initiation factor; HECT; homologous to E5-AP carboxyl terminus; LC; liquid chromatography; MS/MS; tandem mass spectrometry; NEDD4; neural precursor cell expressed, developmentally down-regulate
NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway
Keywords: AKT; v-akt murine thymoma viral oncogene; CRC; colorectal cancer; FDR; false discovery rate; HECT; homologous to E6AP C terminus; KEGG; Kyoto Encyclopedia of Genes and Genomes; mut; mutated; NCBI; National Center for Biotechnology Information; PBS; phosph
Ubiquitylation and degradation of elongating RNA polymerase II: The last resort
Keywords: RNA polymerase II; Ubiquitin; Elongin; Rsp5; NEDD4; Transcript elongation;
Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D
Keywords: NMDA receptors; GluN2D subunit; Glutamate; Nedd4; Ubiquitin ligase; Ubiquitination; Excitotoxicity; Proteomics; Mass spectrometry;
Nedd4 and Nedd4-2: Ubiquitin ligases at work in the neuron
Keywords: Nedd4; Nedd4-2; Neurons; Ubiquitination; Trafficking
Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical development
Keywords: Ndfip1, Nedd4 family-interacting protein 1; Nedd4, neural precursor cell-expressed developmentally down-regulated gene 4; Robo, roundabout; Comm, commissureless; PTEN, phosphatase and tensin homolog deleted chromosome 10Ndfip1; Nedd4; Cerebral cortex; Pro
The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties
Keywords: Neural crest cell; Nedd4; Ubiquitin ligase; Ectomesenchyme; Neuroglial; Stem-cell maintenance
Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression
Keywords: Beclin 1; Phosphatidylinositol 3-kinase (PI3K); VPS34; VPS15; Ubiquitination; Ubiquitin-protein ligase (E3); Cancer; NEDD4; TRAF6; BCL-2;
Differential regulation of Nedd4 ubiquitin ligases and their adaptor protein Ndfip1 in a rat model of ischemic stroke
Keywords: Nedd4; Itch; Ndfip1; E3 ubiquitin ligase; Ubiquitination; Cerebral ischemia; Stroke; Neuroprotection;
Endocytosis and post-endocytic sorting of connexins
Keywords: CHO; Chinese hamster ovary; CIP75; connexin43-interacting protein of 75-kDa; CIP85; connexin43-interacting protein of 85-kDa; Dab2; disabled-2; EEA1; early endosomal autoantigen 1; EGF; epidermal growth factor; ENaC; amiloride-sensitive epithelial sodium
Disruption of E3 ligase NEDD4 in peripheral neurons interrupts axon outgrowth: Linkage to PTEN
Keywords: Nedd4; PTEN; Phosphoinositide 3-kinase [PI3-K]; Peripheral nerve; Injury; Axotomy; Dorsal root ganglion [DRG]
Molecular regulation of Nogo-A in neural cells: Novel insights into structure and function
Keywords: Nogo-A; Nedd4; Nedd4-2; WWP1; Ubiquitinylation
NEDD4-2 associates with γc and regulates its degradation rate
Keywords: Cytokine; Receptor; Ubiquitin ligase; Signaling; Degradation; Lymphocyte; NEDD4; IL-2;
Ubiquitin ligase adaptors: Regulators of ubiquitylation and endocytosis of plasma membrane proteins
Keywords: Ubiquitin; Substrate specificity; Ubiquitin ligase; Adaptor; Endocytosis; Nedd4; Rsp5; Cbl; Arrestin
Eps15 interacts with ubiquitinated Cx43 and mediates its internalization
Keywords: Cx, connexin; GJIC, gap junction intercellular communication; CME, Clathrin-mediated endocytosis; UIM, ubiquitin-interacting motifCx43; Eps15; Ubiquitin; Endocytosis; Nedd4
Tsg101 can replace Nedd4 function in ASV Gag release but not membrane targeting
Keywords: Tsg101; Nedd4; ASV; HIV-1; Gag; L domain