کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10895531 | 1083076 | 2016 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulation of connexins by the ubiquitin system: Implications for intercellular communication and cancer
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کلمات کلیدی
IP3epidermal growth factor receptor substrate 15TGF-βTSG101SMURF2Nedd4HECTESCRTEPS15ZO-1SCFPKCIGF-1Inositol trisphosphate12-O-tetradecanoylphorbol-13-acetateHRSSUMOERADEGFtPAcAMP - cAMPLC-MS/MS - LC-MS / MSMAPK - MAPKSmall interfering RNA - RNA تداخل کوچکsiRNA - siRNAAdenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPCyclic adenosine monophosphate - آدنوزین مونوفسفات CyclicIntercellular communication - ارتباط بین سلولیsmall ubiquitin-related modifier - اصلاح کننده کوچک کوچک ubiquitinSDS-PAGE - الکتروفورز ژل پلی آکریل آمیدSodium dodecyl sulfate polyacrylamide gel electrophoresis - الکتروفورز ژل پلی اتیل آمید سدیم دودسیل سولفاتAMsh - امشinsulin-like growth factor-1 - انسولین مانند عامل رشد 1transforming growth factor-β - تبدیل فاکتور رشد βendoplasmic reticulum-associated degradation - تداخل وابسته به شبکیه آندوپلاسمیEMT - تکنسین فوریتهای پزشکیRing - حلقهCancer - سرطانHepatocyte growth factor-regulated tyrosine kinase substrate - سوسپانیت تیروزین کیناز تنظیم شده توسط عامل رشد هپاتوسیتepidermal growth factor - عامل رشد اپیدرمیgap junction - فاصله ی شکافphosphatase and tensin homolog - فسفاتاز و تنسین همولوگendosomal sorting complex required for transport - مجتمع مرتب سازی آندوسومی مورد نیاز برای حمل و نقلZonula occludens-1 - نوار ابزار بسته 1Protein kinase C - پروتئین کیناز سیmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenPten - ژن PTENreally interesting new gene - ژن جدید واقعا جالبliquid chromatography tandem mass spectrometry - کروماتوگرافی مایع اسپکترومتری دو طرفهconnexin - کنسکسینEpithelial-mesenchymal transition - گذار اپیتلیال-مزانشیمیUbiquitin - یوبیکویتین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The connexins constitute a family of integral membrane proteins that form intercellular channels, enabling adjacent cells to directly exchange ions and small molecules. The connexin channels assemble into distinct plasma membrane domains known as gap junctions. Intercellular communication via gap junctions has an important role in regulating cell growth and differentiation, as well as in maintaining tissue homeostasis. Connexin43 (Cx43), the most ubiquitously expressed connexin isoform in human tissues, has been shown to act as a tumor suppressor and is frequently downregulated during cancer development. Cx43 has a short half-life, and modulation of the Cx43 turnover rate represents an important mechanism by which the level of gap junctional intercellular communication is regulated under basal conditions. Moreover, many growth factors, oncogenes, and tumor promoters are potent inducers of Cx43 endocytosis and endolysosomal degradation, resulting in loss of gap junctions. Emerging evidence indicates that the ubiquitin system has a major role in these processes. Recent studies have shown that ubiquitination is also involved in the autophagy-mediated degradation of Cx43 in a process mediated by the proto-oncogenic E3 ubiquitin ligase NEDD4. Moreover, ubiquitination of connexins has been implicated in modulating the level of intercellular communication via gap junctions in response to oxidative stress. This review article provides an overview of our current understanding of the role of the ubiquitin system in the regulation of connexins and discusses how the malfunction of these processes may contribute to the loss of intercellular communication via gap junctions during carcinogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer - Volume 1865, Issue 2, April 2016, Pages 133-146
Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer - Volume 1865, Issue 2, April 2016, Pages 133-146
نویسندگان
Edward Leithe,