Keywords: Affinity tag; Tag-removing protease; Salt tolerance; P1' promiscuity; SUMO; NEDD8;
مقالات ISI (ترجمه نشده)
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Ubiquitination and SUMOylation in the chronic inflammatory tumor microenvironment
Keywords: Inflammation-associated cancer; Ubiquitin-proteasome system (UPS); Small ubiquitin-like modifier (SUMO); Tumor microenvironment; Cytokine profile; Transcription factors; 15d-PGJ2; 15-Deoxy-Delta-12,14-prostaglandin J2; AR; androgen receptor; Ala; alanine;
Comparative transcriptomic analyses of male and female adult Toxocara canis
Keywords: ALG; apoptosis-linked gene; BTB; broad/complex/tramtrack/bric a brac; CCR4; C-C chemokine receptor type 4; CEH; carboxylesterase 1; CRN; cell death related nuclease; CSR; chromosome segregation protein; DPY; dumpy; EH; eclosion hormone; Elk-1; ets-like pr
Cullin 5-RING E3 ubiquitin ligases, new therapeutic targets?
Keywords: E3 ubiquitin ligase; Cullin RING ligase; Ubiquitin-proteasome system; Therapeutic targets; ASB; ankyrin repeat-containing proteins with a SOCS box; β-Trcp; β-transducin repeat-containing protein; BTB; bric-a-brac; CIS1; cytokine-inducible Src homology
The ubiquitin family meets the Fanconi anemia proteins
Keywords: Fanconi anemia; DNA repair; Ubiquitin; NEDD8;
Nedd8 targets ubiquitin ligase Smurf2 for neddylation and promote its degradation
Keywords: Protein neddylation; Protein ubiquitination; Nedd8; Ubiquitin ligase; Smurf2;
Skp1: Implications in cancer and SCF-oriented anti-cancer drug discovery
Keywords: Arf6; ADP-ribosylation factor 6; BIMEL; extra-long isoform of BIM; β-TRCP; β-transducin repeat-containing protein; CDCA3; cell division cycle associated 3; CDK; cyclin-dependent kinase; CENP-E; centrosome-associated protein E; Cks1; cyclin-dependent pro
A lysine-to-arginine mutation on NEDD8 markedly reduces the activity of cullin RING E3 ligase through the impairment of neddylation cascades
Keywords: NEDD8; Neddylation; Cullins; Cullin-RING E3 ligases; Ubiquitination
Synaptic structure and function are altered by the neddylation inhibitor MLN4924
Keywords: NEDD8; neural precursor cell expressed, developmentally down-regulated 8; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; Ubc12; ubiquitin carrier protein 12; RING; really interesting new gene; HECT; homologous to the E6-AP carboxyl
Discovery of deoxyvasicinone derivatives as inhibitors of NEDD8-activating enzyme
Keywords: Drug discovery; Ubiquitin-like; NEDD8; Deoxyvasicinone; Pharmacophore
Mechanisms of p53 degradation
Keywords: ATM; ataxia telangiectasia mutated; CHIP; C-terminus of HSP70-interacting protein; CBP; CREB binding protein; COP1; constitutively photo-morphogenic 1; DDB1; DNA damage binding protein 1; DHFR; dihydrofolate reductase; DUB; de-ubiquitinating enzyme; E1; u
pVHL interacts with Ceramide kinase like (CERKL) protein and ubiquitinates it for oxygen dependent proteasomal degradation
Keywords: pVHL; the Von Hippel-Lindau tumor suppressor protein; ECV complex; elongin B/C-Cul2-VHL protein complex; PHD1-3; prolyl hydroxylase domain proteins 1-3; UPS; ubiquitin proteasome system; HIFs; hypoxia inducible factors; ROS; reactive oxygen species;
The β-catenin E3 ubiquitin ligase SIAH-1 is regulated by CSN5/JAB1 in CRC cells
Keywords: AP-1; activator protein-1; APC; adenomatous polyposis coli; CK1; casein kinase 1; CoIP; co-immunoprecipitation; CRC; colorectal cancer; CRL; cullin RING E3 ubiquitin ligase; CSN; COP9 signalosome; CSN5; fifth subunit of the CSN; Cul1; cullin-1; GSK-3β; g
Cullin 3 as a novel target in diverse pathologies
Keywords: Cullin 3; Proteasome; Nedd8; Nrf2; Oxidative stress; Cell cycle
NEDD8 conjugation in Schistosoma mansoni: Genome analysis and expression profiles
Keywords: NEDD8; NEDDylation; Schistosomula development; Differential expression
Constitutively active Cullin-RING-Ligases fail to rescue loss of NEDD8 conjugation in Schizosaccharomyces pombe
Keywords: NEDD8; Cullin-RING-Ligase; Uba3; Pcu1; Schizosaccharomyces pombe
Inhibition of NEDD8-conjugation pathway by novel molecules: Potential approaches to anticancer therapy
Keywords: Ubiquitination; SCF complex; NEDD8; MLN4924; Ubc12; NUB1
Alteration of protein folding and degradation in motor neuron diseases: Implications and protective functions of small heat shock proteins
Keywords: ALS; amyotrophic lateral sclerosis; AR; androgen receptor; ATG5; autophagy-related gene 5; Bag; Bcl-2 associated athanogene; CBP; CREB-binding protein; CMA; chaperone-mediated autophagy; CMT; Charcot-Marie-Tooth; DAO; d-amino acid oxidase; DCTN1; dynactin
Toward understanding Machado-Joseph disease
Keywords: ATXN3; ataxin-3; bZIP; basic leucine zipper motif; CBPC; REB binding protein; cDNA; complementary DNA; CHIP; C-terminus of Hsc70 interacting protein; CK2; casein kinase 2; CMV; cytomegalovirus; CNS; central nervous system; CREB; cAMP-response element bind
COP9 signalosome function in the DDR
Keywords: COP9 signalosome; Nedd8; Cullin-RING ubiquitin ligase; Nucleotide excision repair; Checkpoint control;
The COP9 signalosome and its role in plant development
Keywords: Arabidopsis; Auxin response; Cell cycle; COP9 signalosome; CSN5; DNA damage; E3 ubiquitin ligases; NEDD8; Ubiquitin
Biochemical and cellular effects of inhibiting Nedd8 conjugation
Keywords: Nedd8; Ubc12; Cullin RING E3 ligases; Ubiquitin; RhoA; Neddylation; Actin cytoskeleton; Protein degradation
The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1
Keywords: Bacterial infection; Effector; Cell-cycle; NEDD8; UbiquitinGST, glutathione S-transferase; FACS, fluorescence-activated cell sorter; mKO, monomeric Kusabira Orange; mAG, monomeric Azami-Green; AMC, C-terminal 7-amido-4-methylcoumarin; IPTG, isopropyl thio
C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues
Keywords: CAND1; CRL; Cullin; Nedd8; Neddylation; Ubiquitin ligase; Seam cells
The mechanism of poly-NEDD8 chain formation in vitro
Keywords: Cullin; NEDD8; Ubc12; ROC1; Ubiquitin ligase
Role of NEDD8 in HIV-associated lipodystrophy
Keywords: HAART; HIV infection; Lipodystrophy; NEDD8
60th residues of ubiquitin and Nedd8 are located out of E2-binding surfaces, but are important for K48 ubiquitin-linkage
Keywords: Ubiquitin; Nedd8; K48-linkage; E2; Cross-saturation;
The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription
Keywords: COP9 signalosome; Cullin; Nedd8; Proteasome; Transcription;
TRIP12 functions as an E3 ubiquitin ligase of APP-BP1
Keywords: APP-BP1; TRIP12; NEDD8; E3 ubiquitin ligase; Protein degradation
Glutamine attenuates inflammation and NF-κB activation via Cullin-1 deneddylation
Keywords: Lung injury; NEDD8; IκBα; Cecal ligation and puncture; Sepsis
Inhibition of APP intracellular domain (AICD) transcriptional activity via covalent conjugation with Nedd8
Keywords: APP; AICD; Nedd8; Ubiquitin-like protein; Protein modification; Transcriptional regulation
Ubiquitin and ubiquitin-like specific proteases targeted by infectious pathogens: Emerging patterns and molecular principles
Keywords: OTU; ovarian tumor domain; UBP; ubiquitin processing protease; UCH; ubiquitin C-terminal hydrolase; ULP; ubiquitin-like specific protease; USP; ubiquitin specific protease; Ubl; ubiquitin-like protein; Bacteria; Hydrolase; ISG15; Nedd8; Protease; SUMO; Ub
Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotype
Keywords: egr-1; Nedd8; Cellular proliferation; Actin;
A sensitive fluorescence intensity assay for deubiquitinating proteases using ubiquitin-rhodamine110-glycine as substrate
Keywords: Nedd8; Protease assay; Rhodamine; SUMO; Ubiquitin-specific proteases
Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells - Evidence for cullin dimerization
Keywords: Cullin; E3 ubiquitin ligase; Nedd8; Neddylation; Ubiquitination; Protein degradation;
Detection of modification by ubiquitin-like proteins
Keywords: Ubiquitin; SUMO; NEDD8; Ubiquitin-like protein
A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers
Keywords: Ubiquitin-like modifiers; SUMO; NEDD8; Mass spec; Proteomics
Evolutionally Conserved Intermediates Between Ubiquitin and NEDD8
Keywords: NOE, nuclear Overhauser effect; HSQC, heteronuclear single quantum coherence; UBL, ubiquitin-likeubiquitin; NEDD8; NMR; pressure; high energy conformer
Interaction of NUB1 with the proteasome subunit S5a
Keywords: NUB1; NUB1L; AIPL1; NEDD8; Ubiquitin; Proteasome; S5a; UBL; UBA;
Regulation of the p73 protein stability and degradation
Keywords: p53; p73; Nedd8; Itch; Apoptosis; Cell death; DNA damage; Cell cycle; Protein stability; Ubiquitination;
CAND1 enhances deneddylation of CUL1 by COP9 signalosome
Keywords: CAND1; COP9 signalosome; Deneddylation; Ubiquitin; CUL1; SCF E3 ubiquitin ligase; Cullin-RING ligase; Cullin; Nedd8; Ubiquitination;
Binding of JAB1/CSN5 to MIF is mediated by the MPN domain but is independent of the JAMM motif
Keywords: C60SMIF; MIF mutant with Cys60 exchanged for Ser; CALC; Cys-Ala-Leu-Cys motif; CSN; COP9 signalosome; CSN5; subunit 5 of COP9 signalosome; IVT; in vitro transcription/translation; FCS; fetal calf serum; JAB1; c-Jun activation domain binding protein-