C. elegans multi-dendritic sensory neurons: Morphology and function
Keywords: مسکن; C. elegans; Somatosensory system; Nociceptor; Proprioceptor; Behavior; Movement;
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Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch
Keywords: مسکن; capsaicin; nerve growth factor; neuropathic pain; nociceptor; TRPV1;
A search for activation of C nociceptors by sympathetic fibers in complex regional pain syndrome
Keywords: مسکن; CRPS; Sympathetically maintained pain; Nociceptor; Sympathetic efferent; Sympathetic–sensory interaction
Thermoreceptors and thermosensitive afferents
Keywords: مسکن; Noxious; Innocuous; TRP; Nociceptor; Skin; Transduction; Monkey
Peptide-mediated transdermal delivery of botulinum neurotoxin type A reduces neurogenic inflammation in the skin
Keywords: مسکن; Neurogenic inflammation; Plasma extravasation; Vasodilation; Substance P; CGRP; Botulinum neurotoxin; Nociceptor; Transdermal drug delivery;
Modeling skin thermal pain sensation: Role of non-Fourier thermal behavior in transduction process of nociceptor
Keywords: مسکن; Skin tissue; Non-Fourier thermal behavior; Neural response; Thermal pain; Modeling; Nociceptor
Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites
Keywords: مسکن; Na+ channel; Tetrodotoxin; Sensory neuron; Nociceptor; Pain; Local anesthetic
Patterns of activity-dependent conduction velocity changes differentiate classes of unmyelinated mechano-insensitive afferents including cold nociceptors, in pig and in human
Keywords: مسکن; Nociceptor; Skin; Axonal conduction; Electrophysiology; Microneurography; Activity-dependent conduction slowing;
Persistent inflammation alters the density and distribution of voltage-activated calcium channels in subpopulations of rat cutaneous DRG neurons
Keywords: مسکن; Pain; Nociceptor; Primary afferent; Retrograde tracer; Protein trafficking; Sensitization;
NMDA receptors in primary afferents require phosphorylation by Src family kinases to induce substance P release in the rat spinal cord
Keywords: مسکن; C-fiber; dorsal horn; internalization; nociceptor; neurokinin-1 receptor; protein tyrosine phosphataseaCSF, artificial cerebrospinal fluid; ANOVA, analysis of variance; Ca(V), voltage-dependent calcium channel; CGRP, calcitonin gene-related peptide; DMSO,
Ultraviolet-B-induced mechanical hyperalgesia: A role for peripheral sensitisation
Keywords: مسکن; Hyperalgesia; Nociceptor; Pain; Inflammation;
Conditioning lesions enhance growth state only in sensory neurons lacking calcitonin gene-related peptide and isolectin B4-binding
Keywords: مسکن; axonal regeneration; nociceptor; axotomy; neurotrophic factor; mouseATF-3, activating transcription factor-3; CCI, chronic constriction injury; CGRP, calcitonin gene-related peptide; DRG, dorsal root ganglion; Erk, extracellular signal-related protein kin
TRPA1: A potential target for anti-tussive therapy
Keywords: مسکن; Cough; Airway sensory nerve; C-fiber; Nociceptor; TRPA1; TRPV1; Irritant; Electrophilic; Reactive; Oxidative stress; COPD; Asthma
Endothelin-1 raises excitability and reduces potassium currents in sensory neurons
Keywords: مسکن; Pain; Nociceptor; Potassium channel; Endothelin-1; Excitability;
Thermoreceptors and thermosensitive afferents
Keywords: مسکن; Noxious; Innocuous; TRP; Nociceptor; Skin; Transduction; Monkey
C-nociceptors sensitized to cold in a patient with small-fiber neuropathy and cold allodynia
Keywords: مسکن; Cold hyperalgesia; Microneurography; C fiber; Nociceptor; Neuropathic pain;
The TRPV1 ion channel: Implications for respiratory sensation and dyspnea
Keywords: مسکن; Pain; Nociceptor; Airway innervation; Vagus n.; C-fibres; Visceral nociception; Hyperalgesia; COPD; Asthma
The analgesic action of topical diclofenac may be mediated through peripheral NMDA receptor antagonism
Keywords: مسکن; Jaw muscle; Nociceptor; Trigeminal; Non-steroidal anti-inflammatory drug; N-Methyl-d-aspartate; Craniofacial pain;
Roles of transient receptor potential channels in pain
Keywords: مسکن; TRPA1; TRPV1; TRPM8; Cold; Mechanotransduction; Nociceptor; Sensory neuron; Cutaneous; Inflammation; Prostaglandin; NGF; Artemin; Bradykinin; Kinase; Scaffold protein
Quantification of Neural Protein in Extirpated Tooth Pulp
Keywords: مسکن; NaV1.8; nociceptor; pain; primary afferent
Peripheral cannabinoid CB1 receptors inhibit evoked responses of nociceptive neurones in vivo
Keywords: مسکن; Cannabinoid CB1 receptor; Nociceptor; Antinociception
Les récepteurs P2X de l'ATP dans les neurones du système nociceptif spinal : rôle dans les douleurs neuropathiques
Keywords: مسکن; Neurone sensoriel; Nocicepteur; Corne dorsale de la moelle épinière; Allodynie; Hyperalgésie; Sensory neurons; Nociceptor; Dorsal horn of the spinal cord; Allodynia; Hyperalgesia;
Release of calcitonin gene-related peptide from the jugular-nodose ganglion complex in rats - A new model to examine the role of cardiac peptidergic and nitrergic innervation
Keywords: مسکن; CGRP; Neuronal NO synthase; Nitric oxide; Neuropeptide release; Nociceptor; Immunohistochemistry; Vagal afferents;
Spinal subarachnoid adrenal medullary transplants reduce hind paw swelling and peripheral nerve transport following formalin injection in rats
Keywords: مسکن; DRG, dorsal root ganglia; GAP43, growth-associated protein 43; IR, immunoreactivity; NGF, nerve growth factor; SP, substance PAxonal transport; Chromaffin cell; Dorsal root reflex; Growth-associated protein 43; Nociceptor; Spinal cord; Substance P
Activation of the 5-HT1B/D receptor reduces hindlimb neurogenic inflammation caused by sensory nerve stimulation and capsaicin
Keywords: مسکن; Neurogenic inflammation; Plasma extravasation; Vasodilation; Substance P; CGRP; Sumatriptan; 5-HT1B/D receptor agonists; Nociceptor;
Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors
Keywords: مسکن; TRPV1; TRPA1; Nociceptor; Capsaicin; Mustard oil; Trigeminal; Pain
Sensitization of primary afferents to mechanical and heat stimuli after incision in a novel in vitro mouse glabrous skin-nerve preparation
Keywords: مسکن; Mouse; Glabrous skin; Nociceptor; In vitro preparation;
Neurotrophin-3 significantly reduces sodium channel expression linked to neuropathic pain states
Keywords: مسکن; Nav1.8; Nav1.9; DRG; Sciatic nerve; CCI; Nociceptor; Nerve growth factor;
Early loss of peptidergic intraepidermal nerve fibers in an STZ-induced mouse model of insensate diabetic neuropathy
Keywords: مسکن; Diabetes; Neuropathy; Pain; Nociceptor; Behavior; MrgD;
Identification of capsaicin-sensitive rectal mechanoreceptors activated by rectal distension in mice
Keywords: مسکن; nociceptor; sensory nerve; afferent; rectum; mechanoreceptor; rectal nerveCt, threshold cycle; DRG, dorsal root ganglia; IMA, i.m. array; PBS, phosphate-buffered saline; rIGLE, rectal intraganglionic laminar ending; TRPV1, transient receptor potential van
Sensitisation of TRPV1 in rat sensory neurones by activation of SNSRs
Keywords: مسکن; Pain; Primary sensory neurone; Nociceptor; TRPV1; GPCR; SNSR;
Nociception in fish: stimulus–response properties of receptors on the head of trout Oncorhynchus mykiss
Keywords: مسکن; Fish; Trout; Trigeminal ganglion; Nociceptor; Somatosensory receptor
Mechanisms of adrenosensitivity in capsaicin induced hyperalgesia
Keywords: مسکن; Capsaicin; Nociceptor; Sympathetic-afferent coupling; Prostaglandins;
Electrophysiological properties and chemosensitivity of acutely dissociated trigeminal somata innervating the cornea
Keywords: مسکن; nociceptor; pain; primary sensory neuron; autacoids; patch clampAP, action potential; BAPTA, 1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid; CNT, corneal nerve terminal; cTGN, corneal trigeminal ganglion neuron; EGTA, ethylene glycol-bis(β-amino
Critical Evaluation of the Colocalization Between Calcitonin Gene-Related Peptide, Substance P, Transient Receptor Potential Vanilloid Subfamily Type 1 Immunoreactivities, and Isolectin B4 Binding in Primary Afferent Neurons of the Rat and Mouse
Keywords: مسکن; Calcitonin gene-related peptide; transient receptor potential vanilloid subfamily type 1; dorsal root ganglia; trigeminal ganglia; isolectin B4; nociceptor; immunohistochemistry
Two types of neurotransmitter release patterns in isolectin B4-positive and negative trigeminal ganglion neurons
Keywords: مسکن; exocytosis; endocytosis; sensory neurons; fluorescent dye; nociceptor; pain signaling; CGRP; calcitonin gene-related peptide; Cm; cell membrane capacitance; FBS; fetal bovine serum; FM4-64; N-(3-triethylammoniumpropyl)-4-(6-(4-(diethylamino)phenyl)hexatri
Peripheral and central components of habituation of heat pain perception and evoked potentials in humans
Keywords: مسکن; Nociceptor; Primary sensory neuron; Suppression; Fatigue; Contact-heat evoked potentials; Laser-evoked potentials
ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation
Keywords: مسکن; Pain; Acid; Proton; Ion; Nociceptor; Carrageenan
Nociceptors of dorsal root ganglion express proton-sensing G-protein-coupled receptors
Keywords: مسکن; Dorsal root ganglion; Proton-sensing receptor; G-protein-coupled receptor; Nociceptor; Pain; Nociception
Participation of TRPV1 and TRPV2 in the rat laryngeal sensory innervation
Keywords: مسکن; TRPV1; TRPV2; Nociceptor; Nodose ganglion; Laryngeal defense system
Analgesic treatment of ciguatoxin-induced cold allodynia
Keywords: مسکن; Allodynia; Ciguatoxin; Cold pain; Nociceptor; Peripheral; Sensory neuropathy;
Inflammation increases the excitability of masseter muscle afferents
Keywords: مسکن; myositis; nociceptor; sensitization; retrograde tracer; sensory neuron; pain; AHP; afterhyperpolarization; ANOVA; analysis of variance; AP; action potential; CFA; complete Freund's adjuvant; DiI; 1,1â²-dioctadecyl-3,3,3â²,3â²-tetramethylindocarbocyan
The role of the capsaicin receptor TRPV1 and acid-sensing ion channels (ASICS) in proton sensitivity of subpopulations of primary nociceptive neurons in rats and mice
Keywords: مسکن; sensory neuron; pain; nociceptor; capsaicin-receptor; knockout; ASIC; acid-sensing ion channel; D-MEM; Dulbecco's modified eagle medium; DRG; dorsal root ganglion; ECS; extracellular solution; IB4; isolectin B4; MES; 2-[N-morpholino]ethanesulfonic acid;
Differential expression of synaptoporin and synaptophysin in primary sensory neurons and up-regulation of synaptoporin after peripheral nerve injury
Keywords: مسکن; synaptic vesicle protein; nociceptor; dorsal root ganglion; dorsal spinal cord; sciatic nerve transection; gene expression regulationCGRP, calcitonin gene-related peptide; DRG, dorsal root ganglion; ECL, enhanced chemiluminescence; GAPDH, glyceraldehyde-3
Co-expression of the voltage-gated potassium channel Kv1.4 with transient receptor potential channels (TRPV1 and TRPV2) and the cannabinoid receptor CB1 in rat dorsal root ganglion neurons
Keywords: مسکن; nociceptor; primary sensory neuron; vanilloid receptors; immunohistochemistryCB1, cannabinoid receptor 1; cRNA, complementary RNA; DRG, dorsal root ganglion; HEK, human embryonic kidney; IB4, isolectin B4; Kv1.4, voltage-gated potassium channel subtype 1.
Analysis of the variation in use-dependent inactivation of high-threshold tetrodotoxin-resistant sodium currents recorded from rat sensory neurons
Keywords: مسکن; dorsal root ganglia; nociceptor; NaV1.8; TTX-resistant Na+ current; firing rate adaptation; sodium current inactivationANOVA, analysis of variance; DRG, dorsal root ganglia; EGTA, ethylene glycol-bis (β-aminoethylether)-N,N,N′,N′-tetraacetic acid; f, fitt
Anatomy, physiology and pharmacology of pain
Keywords: مسکن; pain; nociceptor; nociception; pathways; descending inhibition; gate control; wide dynamic range; neurons; neurotransmitters; physiology;
Inflammation alters sodium currents and excitability of temporomandibular joint afferents
Keywords: مسکن; Nociceptor; Primary afferent; Trigeminal ganglion; Sensitization; Patch-clamp; Oral-facial pain;
Analysis of human Nav1.8 expressed in SH-SY5Y neuroblastoma cells
Keywords: مسکن; Pain; Dorsal root ganglion; Nociceptor; Sodium channel; Deltamethrin;
Dorsal root ganglion neurones in culture: A model system for identifying novel analgesic targets?
Keywords: مسکن; Dorsal root ganglia (DRG); Ion channel; KCNQ; Nociceptor; Patch clamp; Pain; Methods;