Keywords: MD; Mediterranean diet; HT; hydroxytyrosol; IUPAC; International Union of Pure and Applied Chemistry; ADME; absorption, distribution, metabolism and excretion processes; EVOO; extra virgin olive oil; HTA; HT acetate; Tyr; tyrosol; EFSA; European Food Safe
مقالات ISI (ترجمه نشده)
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Keywords: ARE; Anti-Oxidant Response Element; BBB; Blood-Brain Barrier; CS; Cigarette Smoke; CSE; Cigarette Smoke Extract; 2DM; Type 2 Diabetes Mellitus; FJC; Fluoro-Jade C; FTC; Federal Trade Control; ISO; International Organization for Standardization; MF; Metfor
Keywords: Polyphenols; Antibiotics; Antioxidants; PACAP; Aβ; β-amyloid; AD; Alzheimer's disease; AMPK; AMP-activated protein kinase; BBB; blood-brain barrier; BDNF; brain-derived neurotrophic factor; CAT; catalase; CNS; central nervous system; COX-2; cyclooxyge
Keywords: Oxysterols; Survival; Nrf2; Autophagy; 5,6-S; 5,6-secosterol; 24OH; 24-hydroxycholesterol; 25OH; 25-hydroxycholesterol; 27OH; 27-hydroxycholesterol; 7K; 7-ketocholesterol; 7βOH; 7β-hydroxycholesterol; AGE; advanced glycation end products; AMPK; AMP-acti
Keywords: AA; arachidonic acid; ADP; adenosine diphosphate; AIF; apoptosis-inducing factor; AMPK; AMP-activated protein kinase; ANT; adenine nucleotide translocase; Apaf-1; apoptotic protease activating factor-1; ATP; adenosine triphosphate; ATP-ase; ATP synthase;
Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation
Keywords: RSV; resveratrol; STZ; streptozotocin; ROS; reactive oxygen species; RNS; reactive nitrogen species; SOD; superoxide dismutase; Nrf2; nuclear factor erythroid 2-related factor 2; Keap1; kelch-like ECH-associated protein 1; NQO-1; NAD(P)H:quinone oxidoredu
Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces hepatic steatosis and endoplasmic reticulum stress by inducing nuclear factor erythroid-derived 2-related factor 2 nuclear translocation
Keywords: Glucagon-like peptide-1; Exendin-4; Nuclear factor erythroid-derived 2-related factor 2; Endoplasmic reticulum stress; Nonalcoholic fatty liver disease; ATF6; Activation transcription factor-6; Bip; Binding immunoglobulin protein; CHOP; C/EBP homologous p
Neochlorogenic acid inhibits against LPS-activated inflammatory responses through up-regulation of Nrf2/HO-1 and involving AMPK pathway
Keywords: ARE; antioxidant-responsive element; CM-H2DCFDA; chloromethyl 2â²,7â²-dichlorodihydrofluorescein diacetate; COX-2; cyclooxygenase-2; HO-1; heme oxygenase-1; iNOS; inducible nitric oxide synthase; IRAK; interleukin-1 receptor-associated kinase; LPS; lipo
Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: Involvement of the crosstalk between Nrf2 and NF-κB pathways regulated by MAPKs
Keywords: ACR; acrylamide; NAC; N acetylcysteine; MAPKs; mitogen activated protein kinases; ERK; extracellular signal regulated protein kinase; JNK; c-Jun N-terminal kinase; Nrf2; NF-E2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; HO-1; hemeoxygena
Camptosorus sibiricus rupr aqueous extract prevents lung tumorigenesis via dual effects against ROS and DNA damage
Keywords: CSR; Camptosorus sibiricus Rupr; B[a]P; benzo(a)pyrene; ROS; reactive oxygen species; UPLC-DAD-QTOF; Ultra performance liquid chromatography-Diode array detector-QTOF; HPLC DMEM; High Performance Liquid Chromatography Dulbecco's modified Eagle's medium; M
Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis
Keywords: ROS; reactive oxygen species; NQO-1; NADPH:quinone oxidoreductase 1; HO-1; heme oxygenase-1; ARE; antioxidant response element; Nrf2; nuclear factor erythroid 2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; DMF; dimethyl fumarate; CDDO-Me;
Response of intestinal HT-29 cells to the trichothecene mycotoxin deoxynivalenol and its sulfated conjugates
Keywords: DON; deoxynivalenol; DON-3-Sulf; deoxynivalenol-3-sulfate; DON-15-Sulf; deoxynivalenol-15-sulfate; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; Keap-1; kelch-like ECH-associated protein 1; Nrf-2; nuclear factor (erythroid-derived 2)-like 2; γ-GCL; ga
Astaxanthin: A mechanistic review on its biological activities and health benefits
Keywords: Astaxanthin (PubChem CID: 5368397); Beta-Carotene (PubChem CID: 5280489); Beta-Cryptoxanthin (PubChem CID: 5281235); Canthaxanthin (PubChem CID: 5281227); Lutein (PubChem CID: 5281243); Zeaxanthin (PubChem CID: 5280899); Alpha-Tocopherol (PubChem CID: 149
Cerebroprotection by salvianolic acid B after experimental subarachnoid hemorrhage occurs via Nrf2- and SIRT1-dependent pathways
Keywords: 8-OHdG; 8-hydroxyguanosine; AMPK; adenosine monophosphate-activated protein kinase; ARE; antioxidant response element; DCFH-DA; 2,7-dichlorodihdrofluorescein diacetate; DMSO; dimethylsulfoxide; EBI; early brain injury; GSH; glutathione; GSH-Px; glutathion
Redox regulation of proteasome function
Keywords: Abcd1; ATP binding cassette subfamily D member 1; AD; Alzheimer's disease; ALD; adrenoleukodystrophy; ALS; amyotrophic lateral sclerosis; AP-1; activator protein-1; APP; amyloid precursor protein; CNS; central nervous system; DDI; DNA-damage inducible 1;
Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration
Keywords: AMD; Age Related Macular Degeneration; ANOVA; Analysis of Variance; ARBP; 60S Acidic Ribosomal Protein P0; BEST1; Bestrophin; CAT; Catalase; cDNA; Complementary DNA; CMST; Cell Mito Stress Test; CRABP; Cellular Retinoic Acid Binding Protein; CRALBP; Cellu
Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity
Keywords: ARE; Anti-oxidant response element; BBB; Blood-brain barrier; COPD; Chronic obstructive pulmonary disease; CS; Cigarette smoke; CSE; Cigarette smoke extract; 2DM; Type 2 diabetes mellitus; FITC; Fluorescein isothiocyanate; FTC; Federal trade control; Glut
Oxadiazole-substituted naphtho[2,3-b]thiophene-4,9-diones as potent inhibitors of keratinocyte hyperproliferation. Structureâactivity relationships of the tricyclic quinone skeleton and the oxadiazole substituent
Keywords: Antiproliferative activity; HaCaT cells; Quinone; Redox activation; Superoxide radical; 7-AAD; 7-aminoactinomycin D; CPR; NADPH-cytochrome P450 oxidoreductase; DCC; N,N'-dicyclohexylcarbodiimide; DHE; dihydroethidium; DMAP; 4-(dimethylamino)pyridine; DTPA
Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells
Keywords: ABC; ATP-binding cassette; ABCC; The ABC subfamily C; ABCC1; ATP-binding cassette subfamily C member 1; AHR; aryl hydrocarbon receptor; AKR1C1; aldo-keto reductase family 1 member C1; AREs; antioxidant-responsive elements; B-Raf; B-Raf proto-oncogene, ser
Effects of diclofenac on the expression of Nrf2 and its downstream target genes in mosquito fish (Gambusia affinis)
Keywords: PPCPs; pharmaceuticals and personal care products; DCF; diclofenac; tBHQ; tert-butylhydroquinone; Nrf2; NF-E2-related factor 2; NQO-1; NADPH quinine oxidoreductase 1; GCLC; r-glutamylcysteine ligase catalytic subunit; GSTA; alpha-glutathione S-transferase
Keap1 knockdown in melanocytes induces cell proliferation and survival via HO-1-associated β-catenin signaling
Keywords: CoPP; cobalt (III) protoporphyrin IX chloride; GCLC; gamma-glutamyl-cysteine-ligase catalytic subunit; GCLM; gamma-glutamyl-cysteine ligase modifying subunit; GO; gene ontology; GSK-3β; glycogen synthase kinase 3 beta; HO-1; heme oxygenase-1; KEAP1; kelc
A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice
Keywords: ANOVA; analysis of variance; AREs; antioxidant-response elements; BARD; bardoxolone methyl; CCA; common carotid artery; HO-1; heme oxygenase-1; IRI; ischemia-reperfusion injury; Keap-1; Kelch-like ECH-associated protein 1; MCAO; middle cerebral artery o
8-Halo-substituted naphtho[2,3-b]thiophene-4,9-diones as redox-active inhibitors of keratinocyte hyperproliferation with reduced membrane-damaging properties
Keywords: Antiproliferative activity; HaCaT cells; Naphtho[2,3-b]thiophene-4,9-diones; Quinone; Redox activation; Superoxide radical; CPR; NADPH-cytochrome P450 oxidoreductase; DCC; N,Nâ²-dicyclohexylcarbodiimide; DHE; dihydroethidium; DMAP; 4-dimethylaminopyridin
Nrf2 antioxidant defense is involved in survival signaling elicited by 27-hydroxycholesterol in human promonocytic cells
Keywords: ARE; antioxidant response element; CYP27A1; 27-hydroxylase; DAPI; 4,6-diamidino-2-phenylindole; DPI; diphenyleneiodonium chloride; ERK; extracellular signal-regulated kinase; GPx; glutathione peroxidase; GSR; glutathione reductase; HO-1; heme oxygenase-1;
Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of LPS-induced inflammation and redox imbalance: Evidence from in vitro and in vivo studies
Keywords: AP-1; activator protein-1; ARE; antioxidant response element; ATF2; activating transcription factor 2; CoQ0; coenzyme Q0; COX-2; cyclooxygenase-2; ERK; extracellular signal-regulated kinase; GSH; glutathione; HO-1; heme oxygenase-1; I-κB; inhibitor-κB;
Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer
Keywords: ACC; acetyl-CoA carboxylase; CC; coral calcium; CCH; coral calcium hydride; FAS; fatty acid synthase; FCCP; carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone; FFA; free fatty acid; HDL-C; high-density lipoprotein cholesterol; γ-GCL; γ-glutamyl cystei
Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis
Keywords: NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; Nrf2; nuclear factor erythroid 2-related factor 2; Keap1; Kelch-like ECH associated protein 1; TUNEL; terminal deoxynucleotidyl transferase dUTP nick end labeling; MTT; 3-(4,5-di
Gleditsia species: An ethnomedical, phytochemical and pharmacological review
Keywords: AFGS; the ethanol extract from the anomalous fruits of Gleditsia sinensis Lam.; ALI; acute lung injury; AML; acute myelogenous leukemia; AP-1; activator protein-1; ARDS; acute respiratory distress syndrome; bFGF; basic fibroblast growth factor; CDK; cycli
PF-4708671, a specific inhibitor of p70 ribosomal S6 kinase 1, activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1
Keywords: PF-4708671; p70 ribosomal S6 kinase 1 (S6K1); p62; Autophagy; Nuclear factor erythroid 2-related factor 2 (Nrf2); Kelch-like ECH-associated protein 1 (Keap1); GSTA1; glutathione S-transferase A1; Keap1; Kelch-like ECH-associated protein 1; MEF; mouse embr
Curcumin inhibits PhIP induced cytotoxicity in breast epithelial cells through multiple molecular targets
Keywords: Phytochemicals; Cancer prevention; Reactive oxygen species; DNA damage; DNA adduct; Heterocyclic amines; AOPI; acridine orange/propidium iodide; BRCA-1; breast cancer 1 early onset; CAT; catalase; DCFDA; 2â²,7â²-dichlorodihydrofluorescein diacetate; DEP
Blockage of ROS and NF-κB-mediated inflammation by a new chalcone L6H9 protects cardiomyocytes from hyperglycemia-induced injuries
Keywords: DCM; diabetic cardiomyopathy; L6H9; (E)-2,6-difluoro-4â²-methoxychalcone; Cur; curcumin; DHE; dihydroethidium; HG; high glucose; ARE; antioxidant-responsive element; NQO-1; NADPH quinine oxidoreductase-1; ROS; reactive oxygen species; HO-1; heme oxygenas
Tanshinone IIA protects dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity through miR-153/NF-E2-related factor 2/antioxidant response element signaling pathway
Keywords: 6-OHDA; 6-hydroxydopamine; ARE; antioxidant response element; BSA; bovine serum albumin; Cyt C; cytochrome c; DA; dopamine; DAPI; 4â²,6-diamidino-2-phenylindole; DCFH-DA; 2â²,7â²-dichlorodihydrofluorescein diacetate; DMSO; dimethylsulfoxide; DOPAC; dih
Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity
Keywords: 6-OHDA; 6-hydroxydopamine; AD; Alzheimer's disease; ARE; antioxidant response elements; DA; dopamine; DMF; dimethyl fumarate; DOPAC; dihydroxyphenylacetic acid; GCLC; glutathione cysteine ligase regulatory subunit; GCLM; glutathione cysteine ligase modu
Oleanolic acid attenuates obstructive cholestasis in bile duct-ligated mice, possibly via activation of NRF2-MRPs and FXR antagonism
Keywords: OA; oleanolic acid; LCA; lithocholic acid; UDCA; ursodeoxycholic acid; PBC; primary biliary cirrhosis; PSC; primary sclerosing cholangitis; MRP; multidrug resistance-associated protein; NRF2; nuclear factor-E2-related factor; siRNA; small interfering RNA;
Dermato-protective properties of ergothioneine through induction of Nrf2/ARE-mediated antioxidant genes in UVA-irradiated Human keratinocytes
Keywords: γ-GCLC; γ-glutamate-cysteine ligage; â³Î¨m; mitochondrial membrane potential; ARE; antioxidant response element; DAPI; 4â²,6-diamidino-2-phenylindole dihydrochloride; DCFH2-DA; 2â²,7â²-dichlorofluorescin-diacetate; EGT; ergothioneine; FBS; fetal bov
Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model
Keywords: AMPK; AMP-activated protein kinase; Cr; creatinine; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HO-1; heme oxygenase 1; IL; interleukin; iNOS; inducible nitric oxide synthase; MAPK; mitogen-activated protein kinase; NF-κB; nuclear factor κB; Nrf2;
Cyanidin-3-O-glucoside modulates intracellular redox status and prevents HIF-1 stabilization in endothelial cells in vitro exposed to chronic hypoxia
Keywords: ARE; antioxidant responsive element; C3G; cyanidin-3-O-glucoside; HIF-1; hypoxia inducible factor-1; HO-1; heme oxygenase-1; HUVECs; human umbilical vein endothelial cells; MMP; matrix metalloproteinase; NQO-1; NAD(P)H:quinone oxidoreductase; Nrf2; NF-E2-
AMPK activation prevents prenatal stress-induced cognitive impairment: Modulation of mitochondrial content and oxidative stress
Keywords: AMPK; AMP-activated protein kinase; Arc; activity-regulated cytoskeleton-associated protein; BDNF; brain-derived neurontrophic factor; EMX2; empty spiracles homeobox 2; GAP43; growth-associated protein-43; GCL; glutamate-cysteine ligase; HO-1; heme oxygen
Eriodictyol-7-O-glucoside activates Nrf2 and protects against cerebral ischemic injury
Keywords: AEBSF; benzamidine; ARE; antioxidant response element; DCFH-DA; 2â²,7â²-dichlorodihydrofluorescein diacetate; EAAT3; excitatory amino acid transporter 3; E7G; eriodictyol-7-O-glucoside; GSH; glutathione; γ-GCS; gamma glutamate cysteine ligase; HE; hema
Research ReportPuerarin attenuates neuronal degeneration and blocks oxidative stress to elicit a neuroprotective effect on substantia nigra injury in 6-OHDA-lesioned rats
Keywords: SN; substantia nigra; 6-OHDA; 6-hydroxydopamine; AM; amantadine; PR; puerarin; TH; Tyrosine hydroxylase; GSH-Px; glutathione peroxidase; SOD; superoxide dismutase; MDA; malonaldehyde; HO-1; heme oxygenase-1; NQO-1; NAD(P)H: quinone oxidoreductase-1; SOD2;
Ethanol extract of Alismatis Rhizoma reduces acute lung inflammation by suppressing NF-κB and activating Nrf2
Keywords: Ethanol extract of Alisma orientale; EEAO; Nuclear factor (NF)-erythroid (E) 2 related factor 2; Nrf2; Glutamate-cysteine ligase catalytic subunit; GCLC; NAD(P)H:quinine oxidoreductase-1; NQO-1; Heme oxygenase-1; HO-1; Nuclear factor-kappaB; NF-κB; Cyclo
Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: The role of IL-6 signaling and Nrf2/AKR1C axis identification
Keywords: AKR1Cs; aldo-keto reductase family members (e.g. AKR1C1, AKR1C2, or AKR1C3); ARE; antioxidant response element; cisplatin; cis-diamminedichloroplatinum(II) (CDDP); ERCC-1; excision repair cross-complementing-1; ERK; extracellular signal-related kinase; FF
Role of α-lipoic acid in dextran sulfate sodium-induced ulcerative colitis in mice: Studies on inflammation, oxidative stress, DNA damage and fibrosis
Keywords: UC; ulcerative colitis; MPO; myeloperoxidase; IL; interleukin; TNF-α; tumor necrosis factor-alpha; NF-κB; nuclear factor-kappa B; COX-2; cyclooxygenase-2; STAT3; signal transducer and activator of transcription 3; Nrf2; nuclear erythroid 2-related facto
A novel di terpene para-hydroquinone compound derived from cryptoquinone protects neuronal cells against oxidative stress and activates the Nrf2/ARE pathway
Keywords: ARE; antioxidant-responsive element; CA; carnosic acid; DMSO; dimethyl sulfoxide; FDA; fluorescein diacetate; GSH; reduced glutathione; GSSG; oxidized glutathione; GST; glutathione S-transferase; HO-1; heme oxygenase-1; MTT; 3-(4,5-dimethylthiazol-2-yl)-2
Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC α/βII by Gymnasterkoreayne B
Keywords: Nrf2; Gymnasterkoreayne B; PKC; ERK; NQO-1
Ankaflavin, a novel Nrf-2 activator for attenuating allergic airway inflammation
Keywords: AK; ankaflavin; AREs; antioxidant response elements; BALF; bronchoalveolar lavage fluid; CAT; catalase; DMSO; dimethyl sulfoxide; ECL; enhanced chemiluminescent; ESI-MS; electrospray ionization-mass spectrometry; FBS; fetal bovine serum; GABA; γ-aminob
Ginsenoside Rg3 enhances the chemosensitivity of tumors to cisplatin by reducing the basal level of nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1/NAD(P)H quinone oxidoreductase-1 and prevents normal tissue damage by scavenging cisp
Keywords: Ginsenoside Rg3; Cisplatin; ROS scavenging; Nrf2; HO-1; NQO-1;
Protective action of nipradilol mediated through S-nitrosylation of Keap1 and HO-1 induction in retinal ganglion cells
Keywords: ARE; antioxidant response element; ChIP; chromatin immunoprecipitation; c-PTIO; 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide; GCLC; glutamate cysteine ligase catalytic subunit; DeNip; denitro-nipradilol; 4HNE; 4-hydroxy-2-nonenal; HO-
Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
Keywords: ARE; Antioxidant-responsive element; BHA; Butylated hydroxyanisole; BTB; Broad complex-tramtrack-bric-a-brac; bZip; Basic leucine zipper; CBP; CREB binding protein; C/EBPβ; CCAAT/enhancer binding protein β; CNC; Cap' n' collar; Cox2; Cyclooxygenase