Keywords: Mitochondrial dysfunction; Testosterone; Mitophagy; Hypogonadism; BNIP3; BCL2/adenovirus E1B 19â¯kDa protein-interacting protein 3; TA; tibialis anterior; ERK 1/2; extracellular signal-regulated kinase 1/2; AMPK; 5â² AMP-activated protein kinase; LC3;
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Keywords: AA; Antimycin A; ADFI; average daily feed intake; ADG; average daily gain; AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; CAT; catalase; CR; caloric restriction; CS; citrate synthase; cyt b; cytochrome b; ESRRA; estrogen-related receptor
Keywords: Adipocytes; Anti-obesity; Browning; Molecular docking; Trans-anethole; ACC; acyl-CoA carboxylase; ACO; acyl-coenzyme A oxidase 1; AMPK; AMP-activated protein kinase; AR; adrenergic receptor; ATGL; adipose triglyceride lipase; BAT; brown adipose tissue; Be
Keywords: 3-MC; 3-methylcholanthrene; Ah; aryl hydrocarbon; AhE; aryl hydrocarbon receptor; AP-1; activator protein-1; ARE; antioxidant response element; ATF4; activating transcription factor 4; β-NF; β-naphthoflavone; β-NF-RE; β-NF-responsive element; β-TRCP;
Keywords: AP-1; activating protein 1; ATM; ataxia telangiectasia mutated kinase; BFU-E; erythroid burst-forming unit; CKD; chronic kidney disease; COPD; chronic obstructive pulmonary disease; DUOXs; dual oxidases; eGFR; estimated glomerular filtration rate; ESRD; e
Keywords: AIPC; Androgen-independent prostate cancer; AKAP1; cAMP signaling; AML; acute myeloid leukemia; BAK; Bcl-2 homologous antagonist killer; BAX; Bcl-2-associated X protein; BCL-2; B-cell lymphoma 2; BMRP; BCL-2 interacting mitochondrial ribosomal protein; C7
Keywords: Drp1; Dynamin-related protein1; GSK3β; Glucose synthase kinase 3 beta; CDK5; Cyclin dependent kinase 5; miRNA; micro ribonucleic acid; NMDAR; N-methyl-D-aspartate receptor; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; AD; Alzhei
Keywords: Blood-brain barrier; Neurovascular unit; Glycolysis; Lactate; Brain development; AGEs; advanced glycation end products; ADP; ribose-adenosine diphosphate ribose; ATP; adenosine triphosphate; BBB; blood-brain barrier; BDNF; brain-derived growth factor; C
Keywords: GSIS; glucose-stimulated insulin secretion; T; testosterone; DHT; 5α-dihydrotestosterone; AR; androgen receptor; Tfam; mitochondrial transcription factor A; PGC-1α; peroxisome proliferator-activated receptor γ coactivator 1α; NRF1; nuclear respiratory
Keywords: ALAS1; 5-aminolevulinate synthase 1; ANT; anthracycline; BVR A; biliverdin reductase A; COX1, COX4; mitochondrial and nuclear genome-encoded complex IV subunits, respectively; DAU; daunorubicin; DEX; dexrazoxane; FU; post-treatment follow up; GSH; reduced
Activation of cyclin D1 affects mitochondrial mass following traumatic brain injury
Keywords: TBI; Mitochondria; Cyclin D1; NRF1;
BDNF mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle
Keywords: 7,8-DHF; 7,8-Dihydroxyflavone; ACC; accetyl CoA carboxylase; AdipoQ; adiponectin; AMPK; AMP-activated protein kinase; ANGPT-L3; angiopoietin-like 3; BAT; brown adipose tissue; BDNF; brain derived neurotrophic factor; CREB; cAMP responsive element binding
The multifaceted role of glutathione S-transferases in cancer
Keywords: Glutathione-S transferase; Carcinogenesis; Biomarkers; Drug resistance; Tumor suppressor; AD; Aricaidine; AP-1; Activator protein 1; ASK1; Apoptosis signal-regulating kinase; CSC; cancer stem cells; EGFR; Epidermal growth factor receptor; GSH; glutathione
Triptolide-induced hepatotoxicity can be alleviated when combined with Panax notoginseng saponins and Catapol
Keywords: Triptolide (PubChem CID:107985); Catapol (PubChem CID:24721265); Panax notoginseng saponins (PubChem CID:441934); Triptolide; Catapol; Panax notoginseng saponins; Nrf1; Hepatotoxicity; Mitochondria;
Coordinate regulation by transcription factors and DNA methylation in the core promoter region of SIRT6 in bovine adipocytes
Keywords: SIRT6; Promoter; Transcriptional regulation; DNA methylation; Bovine; Adipocyte; qPCR; real-time quantitative; CEBPβ; CCAAT enhancer binding protein beta; PAX6; paired box 6; KLF2; Kruppel-like factor 2; CMYB; myb proto-oncogene protein; NRF1; nuclear re
Inhibitory effect of Ligustrum vulgare leaf extract on the development of neuropathic pain in a streptozotocin-induced rat model of diabetes
Keywords: Ligustrum vulgare; Diabetic neuropathy; Hyperalgesia; Allodynia; Oleacein; 5-LOX; 5 - lipoxygenase; ACE; angiotensin converting enzyme; CCI; chronic constriction injury; COX-2; cyclooxygenase - 2; DPN; painful diabetic neuropathy; ICAM-1; intercellular ad
Nrf1 is paved as a new strategic avenue to prevent and treat cancer, neurodegenerative and other diseases
Keywords: Nrf1; Drug; Cancer; Neurodegenerative; Proteasome; Chemoprevention; Therapy;
A negative feedback loop between microRNA-378 and Nrf1 promotes the development of hepatosteatosis in mice treated with a high fat diet
Keywords: 3â²UTRs; 3â² untranslated regions; Acad1; Acyl-coenzyme A dehydrogenase 1; Acox1; Acyl-coenzyme A oxidase 1; ASO; anti-sense oligonucleotide; ChIP; chromatin immunoprecipitation; Cpt1a; Carnitine palmitoyltransferase 1A; FAO; fatty acid oxidation; Fasn;
Loss of DJ-1 promotes browning of white adipose tissue in diet-induced obese mice
Keywords: ACC; acyl-CoA carboxylase; Actb; beta-actin encoding gene; AMPK; AMP-activated protein kinase; ATG; autophagy-related protein; ATGL; adipose triglyceride lipase; ATP5B; ATP synthase subunit beta; β3-AR; beta 3 adrenergic receptor; C/EBPα; CCAAT/enhancer
Topovectorial mechanisms control the juxtamembrane proteolytic processing of Nrf1 to remove its N-terminal polypeptides during maturation of the CNC-bZIP factor
Keywords: Nrf1; Topovectorial regulation; Regulated juxtamembrane proteolysis; Ubiquitination; Topobiology; Ubiquitin-like (UBL) domain; Membrane cholesterol-recognized sensor; AD1; acidic domain 1; CRAC; cholesterol-recognition amino acid consensus motif; ER; endo
Mechanisms controlling the multistage post-translational processing of endogenous Nrf1α/TCF11 proteins to yield distinct isoforms within the coupled positive and negative feedback circuits
Keywords: Nrf1; DDI-1/2; p97; Proteoform; Proteasome; Post-Translational Modification; Proteolysis; ER Stress; Hrd1; BTZ; bortezomib; CNC; cap 'n' collar; CHX; cycloheximide; DDI-1; DNA-damage inducible protein homolog 1; Epox; expoxomicin; ER; endoplasmic reticulu
The protective effects of compatibility of Aconiti Lateralis Radix Praeparata and Zingiberis Rhizoma on rats with heart failure by enhancing mitochondrial biogenesis via Sirt1/PGC-1α pathway
Keywords: Sirt1; Sirtuin 1; PGC-1α; peroxisome proliferator-activated receptor gamma coactivator 1α; NRF1; nuclear respiratory factor 1; NRF2; nuclear respiratory factor 2; CK; creatine kinase; LDH; lactate dehydrogenase; BNP; brain natriuretic peptide; cTnT; car
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
Keywords: α-SYN; alpha synuclein; β-TrCP; β-transducin repeat containing E3 ubiquitin protein ligase; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ASK1; apo
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases
Keywords: ALP; alkaline phosphatase; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; BER; base excision repair; cAMP; cyclic adenosine monophosphate; CDK; cyclin-dependent kinase; CHIP; carboxyl terminus of Hsp70-interacting protein; CLL; chronic lympho
Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes
Keywords: Proteostasis; Ubiquitination; Deubiquitination; Neurodegeneration; Gene regulation; ARE; antioxidant response element; CNC; Cap'n'Collar; DUB; deubiquitinating enzyme; Nrf1; NF-E2-related factor 1; NFE2L1; NF-E2-like 1; qRT-PCR; quantitative real time- PC
The plasticizer BBP selectively inhibits epigenetic regulator sirtuin during differentiation of C3H10T1/2 stem cell line
Keywords: BBP; Benzyl butyl phthalate; PGC1α; Peroxisome proliferator-activated receptor gamma coactivator 1 alpha; NRF1; Nuclear respiratory factor 1; NRF2; Nuclear respiratory factor 2; Tfam; Mitochondrial transcription factor A; FOXO1; Forkhead box protein O1;
Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1α signaling pathway
Keywords: NaF; Sodium; ROS; Reactive oxygen species; O2â¢â; superoxide; GSH; Glutathione; MDA; Malondialdehyde; Bax; Bcl2-associated X protein; Bcl-2; B-cell CLL/lymphoma 2; GAPDH; Glyceraldehyde-3-Phosphate Dehydrogenase; COXIV; Cytochrome C Oxidase Subunit IV;
USP15 stabilizes the transcription factor Nrf1 in the nucleus, promoting the proteasome gene expression
Keywords: Ubiquitination; Deubiquitination; Proteasomal degradation; Transcription factor; Gene regulation; ARE; antioxidant response element; CNC; Cap'n'Collar; DUB; deubiquitinating enzyme; ER; endoplasmic reticulum; NHB1; N-terminal homology box 1; Nrf1; NF-
Dietary lipid concentration affects liver mitochondrial DNA copy number, gene expression and DNA methylation in large yellow croaker (Larimichthys crocea)
Keywords: ATPase 6; ATP synthase 6; COX; Cytochrome c oxidase; CS; Citrate synthase; CYTB; Cytochrome b; D-loop; Displacement loop; HIF1α; Hypoxia-inducible factor 1α; mtDNA; Mitochondrial DNA; MDA; Malondialdehyde; ND6; NADH dehydrogenase subunit 6; ND2; NADH de
Peroxisome proliferator-activated receptor-γ (PPARγ) agonist is neuroprotective and stimulates PGC-1α expression and CREB phosphorylation in human dopaminergic neurons
Keywords: PPARγ; PGC-1α; SIRT1; CREB; Dopaminergic neurons; Mitochondria; AC6; adenylyl cyclase 6; CRE; cAMP responsive element; CREB; cAMP responsive element-binding protein; FCCP; carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone; GW1929; N-(2-benzoylphenyl)
Research reportProtective effects of PGC-1α via the mitochondrial pathway in rat brains after intracerebral hemorrhage
Keywords: ICH; intracerebral hemorrhage; PGC-1α; Peroxisome proliferator activated receptor co-activator-1α; NRF1; Nuclear respiratory factor 1; Tfam; Mitochondrial transcription factor A; mtDNA; Mitochondrial DNA; UCP2; uncoupling protein 2; SOD2; superoxide dis
The transcription factor, Nuclear factor, erythroid 2 (Nfe2), is a regulator of the oxidative stress response during Danio rerio development
Keywords: ARE; antioxidant response element; bp; base pair; bZIP; basic leucine zipper; ChIP; chromatin immunoprecipitation; CNC; Cap'n'Collar (CNC); hpe; hours post exposure; hpf; hours post fertilization; KO; knockout; NFE2; Nuclear Factor (Erythroid-Derived
An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy
Keywords: AA; Ascorbic acid; AEM1; ARE expression modulator 1; AEG1; Astrocyte elevated gene-1; Akt; Protein kinase B; AMPK; AMP-activated protein kinase; APL; Acute promyelocytic leukemia; ARE; Antioxidant response element; ATO; Arsenic trioxide; Bach; BTB and CNC
Induction of Herpud1 expression by ER stress is regulated by Nrf1
Keywords: ARE; antioxidant response element; CNC; Cap and Collar; ER; endoplasmic reticulum; Nrf1; Nuclear factor erythroid-derived 2-related factor 1; ERAD; ER-associated protein degradation; Nuclear factor erythroid-derived 2-related factor 1; ER stress; Transcri
α-Lipoic acid treatment increases mitochondrial biogenesis and promotes beige adipose features in subcutaneous adipocytes from overweight/obese subjects
Keywords: α-Lip; α-Lipoic acid; LDH; lactate dehydrogenase; mtDNA; mitochondrial DNA; Sirt1; Sirtuin 1; PGC-1α; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; Nrf1; nuclear respiratory factor 1; Tfam; mitochondrial transcription factor; C
Loss of MED1 triggers mitochondrial biogenesis in C2C12 cells
Keywords: MED1; Mitochondrial biogenesis; Nrf1; Oxygen consumption;
Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation
Keywords: 12S; mitochondrial rRNA; AICAR; aminoimidazole-4-carboxamide riboside, an adenosine analogue stimulating AMPK; AMPK; catalytic α1/2-subunit of AMP dependent protein kinase; pAMPK; AMPK phosphorylated at serine 172 of the α-subunit; AU; arbitrary units;
Regulation of the biogenesis of OXPHOS complexes in cell transition from replicating to quiescent state
Keywords: AKAP; A-kinase anchor proteins; Akt; protein kinase B; CREB; cAMP response element-binding protein; HT; hydroxytyrosol; NHDF-neo; neonatal normal human dermal fibroblasts; NRF1; nuclear respiratory factor 1; OXPHOS; oxidative phosphorylation system; PGC-1
Metabolic and transcriptional responses of gilthead sea bream (Sparus aurata L.) to environmental stress: New insights in fish mitochondrial phenotyping
Keywords: ACAA2; 3-ketoacyl-CoA thiolase, mitochondrial; AIFM1; apoptosis-related protein 1; AIFM3; apoptosis-related protein 3; ANOVA; analysis of variance; BAX; apoptosis regulator BAX; BCL2; apoptosis regulator Bcl-2; BCLX; Bcl-2-like protein 1; CAT; catalase; C
The role of Nrf1 and Nrf2 in the regulation of copper-responsive transcription
Keywords: Nrf1; Nrf2; ARE; Transcription; Copper; Metallothionein-1;
Mitochondrial dysfunction as a central actor in intellectual disability-related diseases: An overview of Down syndrome, autism, Fragile X and Rett syndrome
Keywords: Intellectual disability; Mitochondria; Mitochondrial dysfunction; Oxidative phosphorylation; Neurogenesis; Neuroplasticity; Down syndrome; Rett syndrome; Autism; Fragile X; Oxidative stress; Drug development; Epigallocatechine-3-gallate; ANT; adenine nucl
Effects of post-exercise recovery in a cold environment on muscle glycogen, PGC-1α, and downstream transcription factors
Keywords: ERRa; NRF1; NRF2; TFAM; mRNA; Mitochondria;
Maternal high-fat intake during pregnancy programs metabolic-syndrome-related phenotypes through liver mitochondrial DNA copy number and transcriptional activity of liver PPARGC1A
Keywords: Actb; beta-actin; Gapdh; glyceraldehyde 3-phosphate dehydrogenase; HOMA-IR; homeostasis model assessment of insulin resistance; mtDNA; mitochondrial DNA; MS; metabolic syndrome; nDNA; nuclear DNA; Hnf4a; hepatocyte nuclear factor 4, alpha gene; Nrf1; nucl
Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1
Keywords: ARE; antioxidant response element; CNC-BZIP; Cap 'n' Collar-type basic leucine zipper; CPD; Cdc4 phosphodegron domain; ER; endoplasmic reticulum; GSK3; glycogen synthase kinase 3; Nrf1; nuclear factor E2-related factor-1; SCF; Skp1-Cul1-F-box; UPS
Wild bitter gourd increased metabolic rate and up-regulated genes related to mitochondria biogenesis and UCP-1 in mice
Keywords: ACADL1; acyl-Coenzyme A dehydrogenase, long-chain; ACSL3; acyl-CoA synthetase long-chain family member 3; AMPK; AMP activated protein kinase; BAT; brown adipose tissue; BG; bitter gourd; BGP; bitter gourd powder; CLN; 9c, 11t, 13t-conjugated linolenic aci
Punctum on two different transcription factors regulated by PGC-1α: Nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2
Keywords: γGCS; gamma-glutamylcysteine synthetase; ARE; antioxidant responsive element; BAT; brown adipose tissue; CNC; Cap 'n' collar; COX; cytochrome c oxidase; CR; calorie restriction; CREB; cAMP response element-binding protein; ERRs; Estrogen-related rece
Human PSENEN and U2AF1L4 genes are concertedly regulated by a genuine bidirectional promoter
Keywords: TSS; transcription start site; ChIP; chromatin immunoprecipitation; Transcription regulation; Promoter architecture; Mutagenesis; 5â²-RACE; NRF1;
PPARγ regulates the mitochondrial dysfunction in human neural stem cells with tumor necrosis factor alpha
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; adenosine monophosphate-activated protein kinase; Aβ; beta-amyloid; DHE; dihydroethidium; hNSCs; human neural stem cells; NRF1; nuclear respiratory factor1; PCR; polymerase chain reacti
Sulfur dioxide inhalation stimulated mitochondrial biogenesis in rat brains
Keywords: Sulfur dioxide; Mitochondria; mtDNA; NRF1; TFAM
Human AP endonuclease/redox factor APE1/ref-1modulates mitochondrial function after oxidative stress by regulating the transcriptional activity of NRF1
Keywords: APE1; apurinic/apyrimidinic endonuclease; ChIP; chromatin immunoprecipitation; COX; cytochrome c oxidase; DOX; doxycycline; EMSA; electrophoretic mobility-shift assay; ETC; electron transport chain; MMP; mitochondrial membrane potential; MT-CO1; mitochond