PPARγ regulates the mitochondrial dysfunction in human neural stem cells with tumor necrosis factor alpha

► Rosiglitazone rescued the effects of TNFα on cell survivability in hNSCs. ► Activation of PPARγ enhanced the AMPK and SIRT1 levels in the hNSCs with TNFα. ► Rosiglitazone improved the expression of PGC1α in the hNSCs with TNFα. ► Rosiglitazone normalized mitochondrial function in the hNSCs with TNFα.