The see-saw of Keap1-Nrf2 pathway in cancer
Keywords: Cancer; Keap1; Nrf2; Oxidative stress; Tumor suppressor; Tumor promoter;
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Paeonol alleviates epirubicin-induced renal injury in mice by regulating Nrf2 and NF-κB pathways
Keywords: Epirubicin; Paeonol; Nephrotoxicity; Nrf2; NF-κB;
Butein induction of HO-1 by p38 MAPK/Nrf2 pathway in adipocytes attenuates high-fat diet induced adipose hypertrophy in mice
Keywords: Butein; HO-1; Nrf2; P38 MAPK; Adipose hypertrophy; Glucose intolerance;
Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress
Keywords: Coptisine (PubChem CID: 72322); L-ascorbic acid (PubChem CID: 54670067); Coptisine; Antioxidation; Akt; JNK; Nrf2; NQO1;
Possible involvement of Nrf2 and PPARγ up-regulation in the protective effect of umbelliferone against cyclophosphamide-induced hepatotoxicity
Keywords: UMB; umbelliferone; PPARγ; peroxisome proliferator activated receptor gamma; CP; cyclophosphamide; Nrf2; nuclear factor erythroid 2-related factor 2; iNOS; inducible nitric oxide synthase; NF-κB; nuclear factor-kappa B; HO-1; heme oxygenase 1; ROS; Reac
DJ-1 regulating PI3K-Nrf2 signaling plays a significant role in bibenzyl compound 20C-mediated neuroprotection against rotenone-induced oxidative insult
Keywords: 8-OHdG; 8-hydroxygluanine; ARE; antioxidant response element; GSK3β; glycogen synthase kinase 3β; HO-1; hemeoxygenase-1; LDH; lactate dehydrogenase; MDA; malondialdehyde; NQO1; NADPH quinone oxidoreductase 1; Nrf2; nuclear factor erythroid 2-related fac
Hesperetin protects against H2O2-triggered oxidative damage via upregulation of the Keap1-Nrf2/HO-1 signal pathway in ARPE-19 cells
Keywords: AMD; Hesperetin; Oxidative stress; Nrf2; HO-1;
Protective effect of Rumenic acid rich cow's milk against colitis is associated with the activation of Nrf2 pathway in a murine model
Keywords: ALA; α-Linolenic Acid; CLA; Conjugated Linoleic Acid; DAI; Disease Activity Index; DSS; Dextran Sodium Sulfate; En; naturally-enriched RA milk; En+; En+DSS challenge; GCL; γ-Glutamate Cysteine Ligase; GCs; Goblet Cells; GSR; Glutathione-S-reductase; GST
Protective effects of phenolics rich extract of ginger against Aflatoxin B1-induced oxidative stress and hepatotoxicity
Keywords: Aflatoxin B1; Hepatotoxicity; Ginger phenolics; Oxidative stress; Nrf2;
Central administration of tert-butylhydroquinone attenuates hypertension via regulating Nrf2 signaling in the hypothalamic paraventricular nucleus of hypertensive rats
Keywords: Paraventricular nucleus; Hypertension; Nrf2; Tert-butylhydroquinone; Oxidative stress;
The protective effects of compatibility of Aconiti Lateralis Radix Praeparata and Zingiberis Rhizoma on rats with heart failure by enhancing mitochondrial biogenesis via Sirt1/PGC-1α pathway
Keywords: Sirt1; Sirtuin 1; PGC-1α; peroxisome proliferator-activated receptor gamma coactivator 1α; NRF1; nuclear respiratory factor 1; NRF2; nuclear respiratory factor 2; CK; creatine kinase; LDH; lactate dehydrogenase; BNP; brain natriuretic peptide; cTnT; car
MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells
Keywords: Arsenite; miR-155; Nrf2; Oxidative damage; Carcinogenesis;
The protective effect of hyperoside on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2
Keywords: Hyperoside; Chronic liver fibrosis; Oxidative stress; Nrf2;
Regulation mechanism of oxidative stress induced by high glucose through PI3K/Akt/Nrf2 pathway in juvenile blunt snout bream (Megalobrama amblycephala)
Keywords: Megalobrama amblycephala; Oral glucose administration; Oxidative stress; PI3K/Akt pathway; Nrf2;
Capillarisin augments anti-oxidative and anti-inflammatory responses by activating Nrf2/HO-1 signaling
Keywords: Anti-inflammatory; Antioxidant; Capillarisin; HO-1; JNK; Nrf2; 6-OHDA; 6-hydroxydopamine; ARE; antioxidant response element; COX2; cyclooxygenase2; DCF-DA; 2â²,7â²-dihydrofluorescein-diacetate; DMEM; Dulbecco's modified Eagle's medium; ERK; extracellula
Apocynin protects against neurological damage induced by quinolinic acid by an increase in glutathione synthesis and Nrf2 levels
Keywords: APO; Apocynin; ATP; adenosine triphosphate; CDNB; 1-choloro-2,4-dinitrobenzene; EDTA; ethylenediamine tetraacetic acid; GPx; glutathione peroxidase; GSH; glutathione; GST; glutathione-S-transferase; NDA; 2,3-naphthalenedicarboxaldehyde; NOX; NADPH oxidase
Lycopene relieves AFB1-induced liver injury through enhancing hepatic antioxidation and detoxification potential with Nrf2 activation
Keywords: Lycopene; Aflatoxin B1; Liver injury; Oxidative stress; Glutathione transferase; Nrf2;
EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage
Keywords: Oxidative stress; Exendin-4; Nrf2; Beta cell; INS-1 cell; Type 2 diabetes; ARE; antioxidant response element; CHX; cycloheximide; DCFDA; dihydrodichlorofluorescein diacetate; DHE; dihydroethidium; EX4; Exendin-4; GCLC; glutamate-cysteine ligase catalytic
Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants
Keywords: Keap1; Nrf2; Oxidants; Electrophiles; Cysteine sensor;
Rosmarinic acid counteracts activation of hepatic stellate cells via inhibiting the ROS-dependent MMP-2 activity: Involvement of Nrf2 antioxidant system
Keywords: Rosmarinic acid; Liver fibrosis; HSC; Nrf2; MMP-2;
Oxidized 5-aminosalicylic acid activates Nrf2-HO-1 pathway by covalently binding to Keap1: Implication in anti-inflammatory actions of 5-aminosalicylic acid
Keywords: IBD; inflammatory bowel disease; ROS; reactive oxygen species; PLD; phospholipase d; Nrf2; Nuclear factor-erythroid 2 (NF-E2) p45-related factor 2; Keap1; Kelch-like ECH-associated protein 1; NFκB; nuclear factor-kappa B; 5-ASA; 5-aminosalicylic acid; NR
The NRF2 activator DH404 attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling
Keywords: AngII; angiotensin II; ANOVA; analysis of variance; ANP; atrial natriuretic peptide; DH404; dihydro-CDDO-trifluoroethyl amide; eNOS; endothelial nitric oxide synthase; Grx1; glutaredoxin 1; GSS; glutathionylation; Keap1; Kelch-like erythroid cell-derived
Hydrogen sulfide-producing cystathionine γ-lyase is critical in the progression of kidney fibrosis
Keywords: CSE; Cystathionine γ-lyase; H2S; Hydrogen sulfide; GSH; Glutathione; CKD; Chronic kidney disease; UUO; Unilateral ureteral obstruction; P5P; Pyridoxal-5â²-phosphate; CBS; Cystathionine β-synthase; 3-MST; 3-mercaptopyruvate sulfurtransferase; Nrf2; NFâ
Commiphora molmol resin attenuates diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis by modulating oxidative stress, inflammation, angiogenesis and Nrf2/ARE/HO-1 signaling
Keywords: Myrrh; Carcinogenesis; Nrf2; Oxidative stress; Inflammation;
Acrylamide-induced neurotoxicity in primary astrocytes and microglia: Roles of the Nrf2-ARE and NF-κB pathways
Keywords: Acrylamide; Neurotoxicity; Astrocytes; Microglia; Nrf2; NF-κB;
Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases
Keywords: ALP; alkaline phosphatase; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; BER; base excision repair; cAMP; cyclic adenosine monophosphate; CDK; cyclin-dependent kinase; CHIP; carboxyl terminus of Hsp70-interacting protein; CLL; chronic lympho
Silver nanoparticles induce hormesis in A549 human epithelial cells
Keywords: Silver nanoparticles; Acrolein; GSH; Hormesis; Nrf2;
Saffron (Crocus sativus) intake provides nutritional preconditioning against myocardial ischemia-reperfusion injury in Wild Type and ApoE(â/â) mice: Involvement of Nrf2 activation
Keywords: Saffron; Myocardial infarct size; ApoE(â/â) mice; Molecular signaling; Nrf2;
Research PaperNrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease
Keywords: GPx; glutathione peroxidase; HO-1; heme oxygenase-1; MPP+; Â 1-methyl-4-phenylpyridinium; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Nrf2; nuclear factor erythroid 2 related factor 2; PD; Parkinson's disease; SNpc; substantia nigra pars compacta;
Pomegranate (Punica granatum L.) wine polyphenols affect Nrf2 activation and antioxidant enzyme expression in human neuroblastoma cells (SH-SY5Y)
Keywords: Nrf2; nuclear factor erythroid 2-related factor 2; HO-1; heme oxygenase-1; GPx; glutathione peroxidase; SOD; superoxide dismutase; NF-κB; nuclear factor κB; AJ; pomegranate aril juice; PJ; pomegranate whole fruit juice; AW; pomegranate aril wine; PW; po
Respiratory syncytial virus induces NRF2 degradation through a promyelocytic leukemia protein â ring finger protein 4 dependent pathway
Keywords: AEC; Airway epithelial cell; AOE; Antioxidant enzyme; ARE; Antioxidant response element; CBP; CREB-binding protein; HDAC; Histone deacetylase; IFN; Interferon; IP; Immunoprecipitation; KEAP1; Kelch like-ECH-associated protein 1; MEF; Mouse embryonic fibro
Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration
Keywords: AMD; Age Related Macular Degeneration; ANOVA; Analysis of Variance; ARBP; 60S Acidic Ribosomal Protein P0; BEST1; Bestrophin; CAT; Catalase; cDNA; Complementary DNA; CMST; Cell Mito Stress Test; CRABP; Cellular Retinoic Acid Binding Protein; CRALBP; Cellu
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
Keywords: α-SYN; alpha synuclein; β-TrCP; β-transducin repeat containing E3 ubiquitin protein ligase; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ASK1; apo
Anthraquinone derivative exerted hormetic effect on the apoptosis in oxygen-glucose deprivation-induced PC12 cells via ERK and Akt activated Nrf2/HO-1 signaling pathway
Keywords: BME; Oxygen-glucose deprivation; PC12Â cells; Hormetic effect; Nrf2;
Benznidazole, the trypanocidal drug used for Chagas disease, induces hepatic NRF2 activation and attenuates the inflammatory response in a murine model of sepsis
Keywords: Benznidazole; Sepsis; CLP; Liver; NRF2;
Ursolic acid attenuates cigarette smoke-induced emphysema in rats by regulating PERK and Nrf2 pathways
Keywords: Ursolic acid; Cigarette smoke; Emphysema; Unfolded protein response; Apoptosis; PERK; Nrf2;
Ethanol extract and its dichloromethane fraction of Alpinia oxyphylla Miquel exhibited hepatoprotective effects against CCl4-induced oxidative damage in vitro and in vivo with the involvement of Nrf2
Keywords: Chrysin (PubChem CID: 5281607); Kaempferide (PubChem CID: 5281666); Nootkatone (PubChem CID: 1268142); Tectochrysin (PubChem CID: 5281954); Alpinia oxyplylla; Carbon tetrachloride; Hepatoprotection; Antioxidants; Nrf2;
Inhibition of Nrf2 enhances the anticancer effect of 6-O-angeloylenolin in lung adenocarcinoma
Keywords: 6-O-Angeloylenolin; SILAC proteomics; Apoptosis; ROS; Nrf2;
Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats
Keywords: Oleuropein; Mitochondria; Nrf2; Oxidative stress; Hypertension;
Suppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activation
Keywords: Nrf2; p47phox; NADPH oxidase; Keap1; Ubiquitination; Lung inflammation;
Research ArticleRole of pterostilbene in attenuating immune mediated devastation of pancreatic beta cells via Nrf2 signaling cascade
Keywords: Cytokine cocktail; Diabetes; MIN6; Nrf2; Streptozotocin;
Upregulating Nrf2-dependent antioxidant defenses in Pacific oysters Crassostrea gigas: Investigating the Nrf2/Keap1 pathway in bivalves
Keywords: Nrf2; Keap1; Oyster; Bivalves; Glutathione; Antioxidant response element; Curcumin;
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1)
Keywords: NRF2; Antioxidant; Biochemical methods; KEAP1; Neurodegeneration; Drug discovery; Protein-protein interaction;
Resveratrol mitigates trophoblast and endothelial dysfunction partly via activation of nuclear factor erythroid 2-related factor-2
Keywords: Activin A; Fms-like tyrosine kinase 1; Heme oxygenase-1; Nuclear factor erythroid 2-related factor-2 (Nrf2); Preeclampsia; Resveratrol; Nrf2; Nuclear factor erythroid 2-related factor-2;
Propolis reversed cigarette smoke-induced emphysema through macrophage alternative activation independent of Nrf2
Keywords: COPD; chronic obstructive pulmonary disease; CS; cigarette smoke; ROS; reactive oxygen species; Nrf2; NF-E2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; ARE; antioxidant response element; HO-1; heme-oxygenase-1; NQ-O1; (NAD(P)H:quinone ox
Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity
Keywords: ARE; Anti-oxidant response element; BBB; Blood-brain barrier; COPD; Chronic obstructive pulmonary disease; CS; Cigarette smoke; CSE; Cigarette smoke extract; 2DM; Type 2 diabetes mellitus; FITC; Fluorescein isothiocyanate; FTC; Federal trade control; Glut
Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver
Keywords: ACC; acetyl CoA carboxylase; ApoB; apolipoprotein B; COX-1; cytochrome c oxidase subunit 1; CPT1-l; carnitine palmitoyltrasnferase; FAS; fatty acid synthase; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GCLC; glutamate-cysteine ligase catalytic; GCL
Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPARγ, and suppressing oxidative stress and apoptosis in rats
Keywords: Methotrexate; Berberine; Oxidative stress; Apoptosis; Nrf2; PPAR;
High-sucrose diet induces diabetic-like phenotypes and oxidative stress in Drosophila melanogaster: Protective role of Syzygium cumini and Bauhinia forficata
Keywords: D. melanogaster; Drosophila melanogaster; HSD; high sucrose diet; DM; diabetes mellitus; SC; syzygium cumini; BF; Bauhinia forficata; IPC; insulin-producing cells; dILP; insulin-like peptides; InR; insulin receptor; AGEs; glycation end products; HPLC; hig
Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation
Keywords: Dox; doxorubicin; FXR; the farnesoid X receptor; AMPKα; AMP- activated protein kinase α; HO-1; hemeoxygenase-1; GST; glutathione-s-transferase; Nrf2; NF-E2-related factor 2; BUN; blood urea nitrogen; Cr; creatinine; HMGB1; high mobility group box 1; NF-