Inhibition of 12/15-LO ameliorates CVB3-induced myocarditis by activating Nrf2
Keywords: 12/15-Lipoxygenase; Nrf2; Heme oxygenase-1; Coxsackievirus B3; Viral myocarditis;
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Diesel exhaust particles (DEP) pre-exposure contributes to the anti-oxidant response impairment in hCMEC/D3 during post-oxygen and glucose deprivation damage
Keywords: DEP; diesel exhaust particles; UFPs; ultrafine particles; PAHs; polycyclic aromatic hydrocarbons; BBB; brain blood barrier; ROS; reactive oxygen species; AhR; aryl hydrocarbon receptor; Nrf2; Nuclear factor (erythroid-derived 2)-like 2; HIF-1α; hypoxia-i
Tenuigenin inhibits LPS-induced inflammatory responses in microglia via activating the Nrf2-mediated HO-1 signaling pathway
Keywords: Tenuigenin; LPS; Inflammatory response; Nrf2;
Biological function and mechanism of lncRNA-MEG3 in Tenon's capsule fibroblasts proliferation: By MEG3-Nrf2 protein interaction
Keywords: Glaucoma; MEG3; Nrf2; Proliferation; Transforming growth factor-β2; Tenon's capsule fibroblasts;
Astrocyte heme oxygenase-1 reduces mortality and improves outcome after collagenase-induced intracerebral hemorrhage
Keywords: GFAP; glial fibrillary acidic protein; HO; heme oxygenase; ICH; intracerebral hemorrhage; MTT; Methylthiazolyldiphenyl-tetrazolium; Nrf2; nuclear factor erythroid 2-related factor 2; Tg; transgenic; Glia; Intracerebral hemorrhage; Nrf2; Stroke; Subarachno
Frailty Is Associated With Lower Expression of Genes Involved in Cellular Response to Stress: Results From the Toledo Study for Healthy Aging
Keywords: Frailty; oxidative stress; hypoxia; gene expression; Nrf2;
Salinomycin overcomes radioresistance in nasopharyngeal carcinoma cells by inhibiting Nrf2 level and promoting ROS generation
Keywords: Salinomycin; Radioresistance; Nrf2; ROS; Nasopharyngeal carcinoma;
Lansoprazole halts contrast induced nephropathy through activation of Nrf2 pathway in rats
Keywords: Contrast induced nephropathy; Lansoprazole; Nrf2; Oxidative stress;
Regeneration of glutathione by α-lipoic acid via Nrf2/ARE signaling pathway alleviates cadmium-induced HepG2 cell toxicity
Keywords: α-Lipoic acid; Nrf2; Cadmium; Glutathione; Regeneration;
Protective effects of morin on lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting TLR4/NF-κB and activating Nrf2/HO-1 signaling pathways
Keywords: LPS/D-GalN; Morin; Nrf2; NF-κB;
Microcystin-LR exposure induces oxidative damage in Caenorhabditis elegans: Protective effect of lutein extracted from marigold flowers
Keywords: Survival rate; Dichlorofluorescein diacetate assay; Reactive oxygen species; Cyanotoxins; ANOVA; analysis of variance; CAT; catalase; C. elegans; Caenorhabditis elegans; DCFH-DA; 2â²-7â²-dichlorofluorescin diacetate; DMSO; dimethyl sulphoxide; Nrf2; E2-
Tussilagonone-induced Nrf2 pathway activation protects HepG2 cells from oxidative injury
Keywords: Tussilagonone; Hepatoprotective effect; Oxidative injury; Nrf2; ERK1/2; AMPK; 5â²AMP-activated protein kinase; ARE; antioxidant response element; DTT; dithiothreitol; ERK1/2; extracellular signal-regulated kinase; HO-1; heme oxygenase 1; JNK; c-Jun N-ter
Asiatic acid enhances Nrf2 signaling to protect HepG2 cells from oxidative damage through Akt and ERK activation
Keywords: Asiatic acid; Nrf2; Oxidative stress; HepG2 cells;
Curcumin attenuates lipopolysaccharide/d-galactosamine-induced acute liver injury by activating Nrf2 nuclear translocation and inhibiting NF-kB activation
Keywords: Curcumin; Oxidative stress; Liver injury; Nrf2; NF-kB;
NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology
Keywords: NRF2; Alzheimer's disease; Transcriptomics; Proteotoxicity; Neuroinflammation; Oxidative stress;
Mulberry crude extracts induce Nrf2 activation and expression of detoxifying enzymes in rat liver: Implication for its protection against NP-induced toxic effects
Keywords: Nonylphenol; Mulberry; Nrf2; GST; UGT2b1;
Ginsenoside Rg18 suppresses lipopolysaccharide-induced neuroinflammation in BV2 microglia and amyloid-β-induced oxidative stress in SH-SY5Y neurons via nuclear factor erythroid 2-related factor 2/heme oxygenase-1 induction
Keywords: COX-2; cyclooxygenase-2; HO-1; heme oxygenase-1; iNOS; inducible nitric oxide synthase; LPS; lipopolysaccharide; MAPK; mitogen-activated protein kinase; NGA; ginsensoside Rg18; Nrf2; nuclear factor erythroid 2-related factor 2; TNF-α; tumour necrosis fac
Peptide IPPKKNQDKTE ameliorates insulin resistance in HepG2 cells via blocking ROS-mediated MAPK signaling
Keywords: Insulin resistance; HepG2 cells; Reactive oxygen species; Nrf2; HO-1;
Chinese herbal medicine compound Yi-Zhi-Hao pellet inhibits replication of influenza virus infection through activation of heme oxygenase-1
Keywords: TMC; Influenza A virus; Heme oxygenase 1; Hemagglutinin; Nrf2; NF-κB;
Nrf2 activator corosolic acid meliorates alloxan induced diabetic nephropathy in mice
Keywords: Corosolic acid; Nrf2; Diabetic nephropathy; Oxidative stress; Inflammation; Pentacyclic triterpenoid;
Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission
Keywords: Sulforaphane; Nrf2; Drp1; Mitochondria; Fission; Fusion; Apoptosis;
Alpinumisoflavone radiosensitizes esophageal squamous cell carcinoma through inducing apoptosis and cell cycle arrest
Keywords: ESCC; esophageal squamous cell carcinoma; EC; esophageal cancer; AIF; alpinumisoflavone; ESCC; Alpinumisoflavone; Radiosensitivity; ROS; Nrf2;
NRF2 overexpression in mesenchymal stem cells induces stem-cell marker expression and enhances osteoblastic differentiation
Keywords: NRF2; CoCl2; Hypoxia; MSC; Stemness; Osteoblastic differentiation;
Original articleOmega-3 polyunsaturated fatty acids improve the antioxidative defense in rat astrocytes via an Nrf2-dependent mechanism
Keywords: Astrocytes; Ï-3PUFA; Glutathione; Nrf2; p38MAPK;
Upregulation of NRF2 through autophagy/ERK 1/2 ameliorates ionizing radiation induced cell death of human osteosarcoma U-2 OS
Keywords: Ionizing radiation; Autophagy; NRF2; ERK1/2; Radio-sensitization;
Selenium antagonizes cadmium-induced apoptosis in chicken spleen but not involving Nrf2-regulated antioxidant response
Keywords: Nrf2; nuclear factor erythroid 2-related factor 2; HO-1; heme oxygenase-1; NQO1; NAD(P)H: quinine oxidoreductase 1; H2O2; hydrogen peroxide; Keap1; Kelch-like ECH-associated protein; MDA; malondialdehyde; T-AOC; total antioxidative capacity; SOD; superoxi
RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems
Keywords: 3-MA; 3-methyladenine; ARE; antioxidant response elements; ATG5; autophagy related 5; CI; combination index; DCF-DA; 2â²,7â²-dichlorofluorescein diacetate; GSH; glutathione; HNC; head and neck cancer; IHC; immunohistochemistry; LC3; microtubule-associat
Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells
Keywords: Silymarin; Acrylamide; Nrf2; Antioxidant; Oxidative stress;
Benzyl isothiocyanate ameliorates acetaldehyde-induced cytotoxicity by enhancing aldehyde dehydrogenase activity in murine hepatoma Hepa1c1c7 cells
Keywords: Benzyl isothiocyanate; Aldehyde dehydrogenase; Acetaldehyde; Nrf2; Hepa1c1c7 cells; ALDH; aldehyde dehydrogenase; ARE; antioxidant response element; BITC; benzyl isothiocyanate; HO-1; heme oxygenase-1; GST; glutathione S-transferases; GCLC; glutamate-cyst
JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2
Keywords: Nrf2; nuclear factor erythroid 2-related factor 2; PQ; paraquat; PD; Parkinson's disease; SA; saline; ROS; reactive oxygen species; JWA-nKO; neuron-specific JWA knockout mice; JWA-nWT; neuron-specific JWA knockout age-matched wild-type mice; SNpc; subst
N-Me-trichodermamide B isolated from Penicillium janthinellum, with antioxidant properties through Nrf2-mediated signaling pathway
Keywords: N-Me-trichodermamide B; Oxidative stress; HO-1; Nrf2; p38; CWKYOAJKOQIXNM-NYGSYELISA-N;
Methyleugenol protects against t-BHP-triggered oxidative injury by induction of Nrf2 dependent on AMPK/GSK3β and ERK activation
Keywords: Methyleugenol; Oxidative stress; Reactive oxygen species; Nrf2;
Nutritionally relevant concentrations of resveratrol and hydroxytyrosol mitigate oxidative burst of human granulocytes and monocytes and the production of pro-inflammatory mediators in LPS-stimulated RAW 264.7 macrophages
Keywords: Inflammation; Oxidative burst; Resveratrol; Hydroxytyrosol; miR-146a; Nrf2;
β-Patchoulene from patchouli oil protects against LPS-induced acute lung injury via suppressing NF-κB and activating Nrf2 pathways
Keywords: β-Patchoulene; Acute lung injury; NF-κB; Nrf2; miR-146a;
Quercetin and baicalein suppress monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats
Keywords: Sinusoidal obstruction syndrome; TLRs/NFκB; Egr1; Nrf2; MAPKs; PI3K;
Protective effect of 3H-1, 2-dithiole-3-thione on cellular model of Alzheimer's disease involves Nrf2/ARE signaling pathway
Keywords: Alzheimer's disease; 3H-1, 2-dithiole-3-thione; N2a/APPswe; Nrf2;
The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice
Keywords: Dimethyl fumarate (PubChem CID: 637568); FTY720 (PubChem CID: 107969); Nrf2; EAE; IL-17; IL-6;
Green tea epigallocatechin 3-gallate alleviates hyperglycemia and reduces advanced glycation end products via nrf2 pathway in mice with high fat diet-induced obesity
Keywords: Diabetes; Advance glycation end-products; Epigallocatechin gallate; Nrf2; Dicarbonyl stress; RAGE;
Dehydrobruceine B enhances the cisplatin-induced cytotoxicity through regulation of the mitochondrial apoptotic pathway in lung cancer A549 cells
Keywords: Lung cancer; Chemotherapy resistance; Dehydrobruceine B; Cisplatin; Nrf2;
Protection from Cr(VI)-induced malignant cell transformation and tumorigenesis of Cr(VI)-transformed cells by luteolin through Nrf2 signaling
Keywords: Hexavalent chromium; Luteolin; Nrf2; Apoptosis resistance; Carcinogenesis;
Novel antioxidants' synthesis and their anti-oxidative activity through activating Nrf2 signaling pathway
Keywords: Antioxidant; Nrf2; GCLC; PC12;
Sodium butyrate regulates Th17/Treg cell balance to ameliorate uveitis via the Nrf2/HO-1 pathway
Keywords: NaB; sodium butyrate; EAU; experimental autoimmune uveitis; Nrf2; nuclear factor erythroid 2 -related factor 2; HO-1; heme oxygenase-1; DLN; draining lymphoid nodes; Treg cells; CD4Â +Â T regulatory cells; Foxp3; Forkhead box protein 3; STAT-3; signal tra
Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis by down-regulating iNOS, inducing antioxidative enzymes and arresting cell cycle progression
Keywords: NOB; nobiletin; PMF; polymethoxyflavone; AOM; azoxymethane; DSS; dextran sulfate sodium; LPS; lipopolysaccharide; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase-2; Nrf2; nuclear factor erythroid 2-related factor 2; HO-1; heme oxygenase-1; NQ
ReviewContradictory roles of Nrf2/Keap1 signaling pathway in cancer prevention/promotion and chemoresistance
Keywords: Keap1; Nrf2; Oxidative stress; Detoxification; Cancer; Chemoresistance;
Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma
Keywords: Malignant mesothelioma; CD44; Glutathione; Nrf2; Oxidative stress;
Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells
Keywords: CBS; cystathionine β-synthase; CSE; cystathionine γ-lyase; Drp1; dynamin-related protein 1; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; ERK; extracellular signal-regulated kinase; G protein; GTP-binding protein; GC; guanylate cyclase; GDP; guanosine 5'
Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway
Keywords: Advance glycation end-products; Phloretin; [6]-Gingerol; Nrf2; CML; RAGE; GSH;
Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants
Keywords: Keap1; Nrf2; Oxidants; Electrophiles; Cysteine sensor;
Apocynin protects against neurological damage induced by quinolinic acid by an increase in glutathione synthesis and Nrf2 levels
Keywords: APO; Apocynin; ATP; adenosine triphosphate; CDNB; 1-choloro-2,4-dinitrobenzene; EDTA; ethylenediamine tetraacetic acid; GPx; glutathione peroxidase; GSH; glutathione; GST; glutathione-S-transferase; NDA; 2,3-naphthalenedicarboxaldehyde; NOX; NADPH oxidase
Hesperetin protects against H2O2-triggered oxidative damage via upregulation of the Keap1-Nrf2/HO-1 signal pathway in ARPE-19 cells
Keywords: AMD; Hesperetin; Oxidative stress; Nrf2; HO-1;