Loss of NRF2 impairs gastric nitrergic stimulation and function
Keywords: Mice; NRF2; nNOSα; Nitric oxide; Gastric motility; GCLC; GCLM; Gastroparesis; Free radicals;
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Genipin up-regulates heme oxygenase-1 via PI3-kinase-JNK1/2-Nrf2 signaling pathway to enhance the anti-inflammatory capacity in RAW264.7 macrophages
Keywords: Genipin; HO-1; Nrf2; PI3-kinase; JNK1/2; Anti-inflammatory;
Extract of the mushroom Mycoleptodonoides aitchisonii induces a series of anti-oxidative and phase II detoxifying enzymes through activation of the transcription factor Nrf2
Keywords: Mycoleptodonoides aitchisonii; Nrf2; Antioxidant response element; Phase II enzymes
Transcription factor Nrf2 suppresses LPS-induced hyperactivation of BV-2 microglial cells
Keywords: Nrf2; Microglia; p38; NF-κB; NQO1; Glutathione;
ent-kaur-16-en-19-oic acid, isolated from the roots of Aralia continentalis, induces activation of Nrf2
Keywords: Inflammation; Kaurenoic acid; Herbal treatment; Anti-inflammation; Nrf2;
Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole
Keywords: tert-Butylbenzoquinone; tert-Butylhydroquinone; Electrophile; Keap1; Nrf2
Resveratrol protects human keratinocytes HaCaT cells from UVA-induced oxidative stress damage by downregulating Keap1 expression
Keywords: Resveratrol; HaCaT cell; Oxidative stress; Nrf2; Keap1
Role of sulforaphane in the anti-initiating mechanism of lung carcinogenesis in vivo by modulating the metabolic activation and detoxification of benzo(a)pyrene
Keywords: Benzo(a)pyrene; Sulforaphane; Xenobiotic enzymes; Aryl hydrocarbon receptor; Nrf2
Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells
Keywords: Anti-inflammation; BV2; Heme oxigenase-1; Microglia; Nrf2; Xanthohumol
Activity-dependent neuroprotective protein (ADNP)-derived peptide (NAP) ameliorates hypobaric hypoxia induced oxidative stress in rat brain
Keywords: NAP peptide; Hypobaric hypoxia; Brain; Antioxidant status; Nrf2
Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells
Keywords: Nrf2; Keap1; Nitric oxide; Nitrosative stress; Nitrosylation; PC12 cells
The protective effect of magnesium lithospermate B against glucose-induced intracellular oxidative damage
Keywords: LAB; magnesium lithospermate B; ROS; reactive oxygen species; HO-1; heme oxygenase-1; Nrf2; nuclear factor E2-related factor2; GSTs; glutathione S-transferases; CAT; hydrogen peroxidase; H2O2; hydrogen peroxide; SOD; superoxide dismutase; O2â; superoxid
Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages
Keywords: Polyphenols; Protocatechuic acid; Nrf2; GSH peroxidase; Glutathione reductase; JNK;
Nuclear factor erythroid 2-related factor-2 activity controls 4-hydroxynonenal metabolism and activity in prostate cancer cells
Keywords: Prostate cancer; 4-Hydroxynonenal; Nrf2; KEAP1; Oxidative stress; Aldehyde metabolism; Glutathione; GS-HNE adduct; GST A4; DNA damage; Apoptosis; Free radicals;
Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury
Keywords: CDDO-Me; 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid-methyl ester; COX-2; cyclooxygenase-2; DHE; dihydroethidium; GCLC; glutamate-cysteine ligase, catalytic subunit; GCLM; glutamate-cysteine ligase, modifier subunit; HO-1; heme oxygenase-1; ICAM-1
Transcription factor Nrf2 maintains the basal expression of Mdm2: An implication of the regulation of p53 signaling by Nrf2
Keywords: Nrf2; Mdm2; p53; Oxidative stress; MEFs;
NRF2 deficiency reduces life span of mice administered thoracic irradiation
Keywords: Radiation-induced fibrosis; Late normal tissue injury; NRF2; TGF-β; Nrf2 null mice; PAI-1; FSP-1; Free radicals
Research ReportMG132 enhances neurite outgrowth in neurons overexpressing mutant TAR DNA-binding protein-43 via increase of HO-1
Keywords: TDP-43; TAR DNA-binding protein-43; ALS; amyotrophic lateral sclerosis; HO-1; heme oxygenase-1; Nrf2; nuclear factor E2-related factor 2; SOD1; superoxide dismutase 1; ARE; antioxidant response element; TBARS; thiobarbituric acid-reactive substance; FTLD-
Essential role of Nrf2 in protection against hydroquinone- and benzoquinone-induced cytotoxicity
Keywords: Hydroquinone; Benzoquinone; Nrf2; ARE-driven; Apoptosis; Glutathione; ARE; antioxidant response element; BQ; benzoquinone; CO; carbon monoxide; ED50; effective dose 50; GCLM; glutamate cysteine ligase modifier subunit; GSH; glutathione; GSS; glutathione s
Protective mechanisms of anthocyanins from purple sweet potato against tert-butyl hydroperoxide-induced hepatotoxicity
Keywords: Purple sweet potato; Anthocyanins; tert-butyl hydroperoxide; Nrf2; Hepatoprotection;
Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells
Keywords: PEGylated curcumin; Nrf2; Novozym 435; chemo-Enzymatic synthesis
An IκBα phosphorylation inhibitor induces heme oxygenase-1(HO-1) expression through the activation of reactive oxygen species (ROS)–Nrf2–ARE signaling and ROS–PI3K/Akt signaling in an NF-κB-independent mechanism
Keywords: Bay 11-7082; Heme oxygenase-1; NF-κB; Reactive oxygen species; Nrf2; PI3K
Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages
Keywords: Nrf2; Macrophage; Ferroportin 1; Iron metabolism; Inflammation
Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway
Keywords: ARE; antioxidant responsive element; DEM; diethylmaleate; IL-1β; interleukin-1 beta; Keap1; Kelch-like ECH-associated protein 1; LMB; leptomycin B; Nrf2; NF-E2-related factor 2; PMA; phorbol 12-myristate 13-acetate; tBHQ; tert-butyl hydroxyquinone; TNFα
Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells
Keywords: Nrf2; Influenza; Nasal epithelial cells; Viral entry;
PPARγ stabilizes HO-1 mRNA in monocytes/macrophages which affects IFN-β expression
Keywords: 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; CRE; causes recombination; CO; carbon monoxide; CHX; cycloheximide; d/n; dominant negative; DPI; diphenyliodonium; HE; hydroethidine; HO-1; heme oxygenase-1; LPS; lipopolysaccharide; LysM; lysozyme M; mac; macr
Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis
Keywords: NRF2; KEAP1; Oxidative stress; PGAM5; FAC1(BPTF); Prothymosin α; NF-κB; p62; Apoptosis; Autophagy; Free radicals;
Hypochlorite-modified high-density lipoprotein promotes induction of HO-1 in endothelial cells via activation of p42/44 MAPK and zinc finger transcription factor Egr-1
Keywords: Chlorinated HDL; Hypochlorous acid; Inflammation; Myeloperoxidase; MPO-H2O2-chloride system; Nrf2;
Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicity
Keywords: Nrf2; NQO1; HO-1; Proximal tubule; Nephrotoxicity; Cadmium; Cyclosporine A; Diquat dibromide; DNA microarray;
Manganese potentiates LPS-induced heme-oxygenase 1 in microglia but not dopaminergic cells: Role in controlling microglial hydrogen peroxide and inflammatory cytokine output
Keywords: Manganese; Microglia; N27 cells; Heme oxygenase-1; Cytokines; H2O2; Nitric oxide; Small Maf; Nrf2;
The effect of Nrf2 knockout on the constitutive expression of drug metabolizing enzymes and transporters in C57Bl/6 mice livers
Keywords: Nrf2; Phase I metabolizing enzymes; Phase II metabolizing enzymes; Cytochrome P450
Transcription Factor Nrf2 Protects the Spinal Cord from Inflammation Produced by Spinal Cord Injury
Keywords: sulforaphane; Nrf2; spinal cord injury; inflammation; neuroprotection
Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPARγ) in K562 cancer cells
Keywords: Carotenoids; K562 cancer cells; PPARγ; p21; Cyclin D1; Nrf2;
Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo
Keywords: NADPH; nicotinamide adenine dinucleotide phosphate; Nrf2; NF-E2-related factor 2; Q-PCR; quantitative polymerase chain reaction; ER; endoplasmic reticulum; EB; embryoid body; αMHC; α myosin heavy chain; βMHC; β myosin heavy chain; MLC2v; myosin regula
Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation
Keywords: BUN; blood urea nitrogen; Cr; creatinine; DHE; dihydroethidium; EGCG; epigallocatechin-3-gallate; ELISA; enzyme-linked immunosorbent assay; GPx; glutathione peroxidase; IHC; immunohistochemistry; IL; interleukin; NF-κB; nuclear factor-kappa B; NLR; NOD-l
Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage
Keywords: Nrf2; Nqo1; Hmox1; Oxidative damage; Sulforaphane; Astrocytes; Neuroprotection;
The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: Results of a ring-study in five laboratories
Keywords: LLNA; local lymph node assay; Nrf2; nuclear factor-erythroid 2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; ARE; antioxidant response element; SOP; standard operating procedure; WLR; within laboratory reproducibility; BLR; between laborat
(â)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68
Keywords: CBB; Coomassie Brilliant Blue G-250; Chaps; 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate; CHX; cycloheximide; DAPI; 4â²,6-diamino-2-phenylindole; DTT; dithiothreitol; ECL; enhanced chemiluminescence; EC; (â)-epicatechin; ECG; (â)-epicate
Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression
Keywords: Bilirubin; Carlinoside; Liver damage; Nrf2; UGT1A1;
Animal models relevant to human prostate carcinogenesis underlining the critical implication of prostatic stem/progenitor cells
Keywords: ADT; androgen deprivation therapy; AI; androgen-independent; ALDH; aldehyde dehydrogenase; AR; androgen receptor; ARR2; two androgen-responsive regions; BM; bone marrow; CXCR4; CXC chemokine receptor 4; CK; cytokeratin; ECM; extracellular matrix; EGFR; ep
ROS-activated p38 MAPK/ERK-Akt cascade plays a central role in palmitic acid-stimulated hepatocyte proliferation
Keywords: Akt; protein kinase B; CAT; catalase; CDKs; cyclin-dependent kinases; ER; endoplasmic reticulum; ERK; extracellular signal-regulated kinase; FASN; fatty acid synthase; FFAs; free fatty acids; H2DCFDA; 2â²,7â²-dichlorofluorescin diacetate; JNK; c-Jun NH2
Chemical modifications of resveratrol for improved protein kinase C alpha activity
Keywords: PKC; protein kinase C; DAG; diacylglycerol; TPA; 12-O-tetradecanoylphorbol-13-acetate; PDB; protein data bank; NMR; nuclear magnetic resonance; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; HEK; human embryonic kidney; PDS; 4,4â²-dip
Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation
Keywords: Nrf2; Protandim; CDDO-Me; BG-12; Sulforaphane; Gene expression;
Curcumin prevents Cr(VI)-induced renal oxidant damage by a mitochondrial pathway
Keywords: BHT; butylated hydroxytoluene; BUN; blood urea nitrogen; CAT; catalase; CCCP; m-chlorophenylhydrazone; CDNB; 1-chloro-2,4-dinitrobenzene; CUR; curcumin; DNPH; 2,4-dinitrophenylhydrazine; DPPH; 2,2-diphenyl-1-picrylhydrazyl radical; EDTA; ethylenediaminete
PGD2 and PGE2 regulate gene expression of Prx 6 in primary macrophages via Nrf2
Keywords: AACOCF3; arachidonyl trifluoromethyl ketone; AC; adenylate cyclase; AGC; cAMP-dependent protein kinase A/protein kinase G/protein kinase C; BMM; bone marrow-derived macrophages; CAPE; caffeic acid phenethyl ester; COX; cyclooxygenase; cPLA2; cytosolic pho
Cysteine/cystine redox signaling in cardiovascular disease
Keywords: AMS; 4-acetamido-4â²-maleimidylstilbene-2,2â²-disulfonic acid; BMI; body mass index; CVD; cardiovascular disease; Cys; cysteine; CySS; cystine; EhCySS; redox state of cysteine/cystine; EhGSSG; redox state of GSH/GSSG; DCF; dichlorofluorescin; Trx; thior
Adaptive response to oxidative stress: Bacteria, fungi, plants and animals
Keywords: AHP1; alkylhydroperoxide reductase; AHR; aryl hydrocarbon receptor; ARE; antioxidant response element; 2CPA; 2-Cys peroxiredoxin-A; CRD; cysteine rich domain; Cul3; Cullin 3; DPH; diphenylhexatriene; EpRE; electrophile response element; ERK; extracellular
Arsenic-induced oxidative stress and its reversibility
Keywords: GSH; glutathione; GSSG; glutathione disulfide; NAC; N-acetylcysteine; ROS; reactive oxygen species; RNS; reactive nitrogen species; O2â¢â; superoxide anion; â¢OH; hydroxyl radical; 1O2; singlet oxygen; MMAV; monomethyl arsonate; MMAIII; monomethyl ars
Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction
Keywords: Cigarette smoke; Oxidant; Antioxidants; Nrf2; Inflammation
Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane
Keywords: Chemoprevention; Glutathione (GSH); Selenium; Sulforaphane (SFN); SFN-isoSe; Antioxidant response element (ARE); Nrf2; γ-GCL; HepG2-ARE reporter cells; Wildtype and Nrf2 deficient mouse embryonic fibroblasts (MEF)