کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10738027 | 1046678 | 2011 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation
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کلمات کلیدی
NLRIL-1βEpigallocatechin-3-gallateTregGPXEGCGNrf2IL-18RLUTconvEpigallocatechin-3-gallate (EGCG)Nuclear factor E2-related factor 2 (Nrf2)TNFNF-κBROS - ROSNLRP3 inflammasome - التهاب NLRP3inflammation - التهاب( توروم) Immunohistochemistry - ایمونوهیستوشیمیIHC - ایمونوهیستوشیمیinterleukin - اینترلوکینELISA - تست الیزاEnzyme-linked immunosorbent assay - تست الیزاOxidative stress - تنش اکسیداتیوBUN - خوبdihydroethidium - دی هیدروتیدیمnuclear factor E2-related factor 2 - عامل فاکتور هسته ای E2 عامل 2tumor necrosis factor - فاکتور نکروز تومورNuclear factor-kappa B - فاکتور هسته ای-کاپا BSystemic lupus erythematosus - لوپوس اریتماتوی سیستمیکSLE - لوپوس منتشر یا لوپوس اریتماتوس سیستمیکRegulatory T - مقررات Tlupus nephritis - نفریت لوپوسیblood urea nitrogen - نیتروژن اوره خونDHE - وcreatinine - کراتینینglutathione peroxidase - گلوتاتیون پراکسیدازReactive oxygen species - گونههای فعال اکسیژنNod-like receptor - گیرنده Nod مانند
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Patients with lupus nephritis show an impaired oxidative status and increased levels of interleukin (IL)-1β and IL-18, which are closely linked to inflammation and correlated with disease activity. Although epigallocatechin-3-gallate (EGCG), the major bioactive polyphenol present in green tea with antioxidant and free radical scavenging activities, has been reported to have anti-inflammatory effects by inhibiting nuclear factor-kappa B (NF-κB)-mediated inflammatory responses in vivo, its effectiveness for the treatment of lupus nephritis is still unknown. In the present study, 12-week-old New Zealand black/white (NZB/W) F1 lupus-prone mice were treated daily with EGCG by gavage until sacrificed at 34 weeks old for clinical, pathological, and mechanistic evaluation. We found that the administration (1) prevented proteinuria, renal function impairment, and severe renal lesions; (2) increased renal nuclear factor E2-related factor 2 (Nrf2) and glutathione peroxidase activity; (3) reduced renal oxidative stress, NF-κB activation, and NLRP3 mRNA/protein expression and protein levels of mature caspase-1, IL-1β, and IL-18; and (4) enhanced splenic regulatory T (Treg) cell activity. Our data clearly demonstrate that EGCG has prophylactic effects on lupus nephritis in these mice that are highly associated with its effects of enhancing the Nrf2 antioxidant signaling pathway, decreasing renal NLRP3 inflammasome activation, and increasing systemic Treg cell activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 51, Issue 3, 1 August 2011, Pages 744-754
Journal: Free Radical Biology and Medicine - Volume 51, Issue 3, 1 August 2011, Pages 744-754
نویسندگان
Pei-Yi Tsai, Shuk-Man Ka, Jia-Ming Chang, Hsiang-Cheng Chen, Hao-Ai Shui, Chen-Yun Li, Kuo-Feng Hua, Wen-Liang Chang, Jiann-Jyh Huang, Sung-Sen Yang, Ann Chen,