Keywords: عامل فاکتور هسته ای E2 عامل 2; SC; subcutaneous; OA-NO2; nitro oleic acid; ACD; allergic contact dermatitis; CHS; contact hypersensitivity; LNO2; nitro linoleic acid; CLA-NO2; conjugated nitro linoleic acid; PPAR-γ; peroxisome proliferator-activated receptor-γ; Nrf2; nuclear factor E
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Keywords: عامل فاکتور هسته ای E2 عامل 2; Strawberry; LPS; Human Dermal Fibroblast; Inflammation; Oxidative stress; Antioxidant response; Prevention; 2-DG; 2-deoxyglucose; 2,4 DNP; 2,4-Dinitrophenol; ABB; annexin binding buffer; ABTS; 2,20-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) diammo
Keywords: عامل فاکتور هسته ای E2 عامل 2; SCE; sugar cane extract; DSS; dextran sulfate sodium; Nrf2; nuclear factor E2-related factor 2; CAT; catalase; SOD1; superoxide dismutase 1; Gpx1; glutathione peroxidase 1; Gpx4; glutathione peroxidase 4; TNF-α; tumor necrosis factor-alpha; GSH-PX; gluta
Keywords: عامل فاکتور هسته ای E2 عامل 2; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; ARE; antioxidant response element; COX; cyclooxygenase; DAMP; damage-associated molecular pattern; DC; dendritic cell; EC; epoxycyclopentenone; EI; epoxyisoprostane; ICAM; intercellular adhesion molecule; IFN-Î
Keywords: عامل فاکتور هسته ای E2 عامل 2; Sulforaphane; Mitochondrial biogenesis; Mitochondrial dynamics; Cell death; Cancer; Nuclear factor E2-related factor 2;
Keywords: عامل فاکتور هسته ای E2 عامل 2; ACC; acetyl-CoA carboxylase; ApoB; apolipoprotein B; ApoCII; apolipoprotein C-II; APPL-1; adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and a leucine zipper motif; CD36; fatty acid translocase; CETP; cholesteryl est
Keywords: عامل فاکتور هسته ای E2 عامل 2; ARE; antioxidant response elements; CMN; curcumin; DAMP; damage-associated molecular patterns; DAG; diacyloglycerol; fMLF; formylated chemotactic peptide - f-MetLeuPhe; FPR; formyl peptide receptor; FPRL; FPR-like protein; GSH; glutathione; HMGB1; high
Keywords: عامل فاکتور هسته ای E2 عامل 2; Acat2; cholesterolacyl transferase 2; ALT; alanine aminotransferase; AST; aspartate aminotransferase; Bax; Bcl-2-associated x protein; BUN; blood urea nitrogen; CREA; creatinine; DBIL; direct bilirubin; DMEM; Dulbecco's modified eagle medium; Gclc; glut
Keywords: عامل فاکتور هسته ای E2 عامل 2; Quercetin; Antioxidant enzymes; Nuclear factor E2-related factor 2; Malondialdehyde; Oxidative stressNrf2, nuclear factor E2-related factor 2; TBARS, thiobarbituric acid-reactive substances; MDA, malondialdehyde; GSH, reduced glutathione; GSSH, oxidized g
Keywords: عامل فاکتور هسته ای E2 عامل 2; ARE; antioxidant response element; ATP; adenosine triphosphate; BDNF; brain-derived neurotrophic factor; CAT; catalase; COX; cyclooxygenase; CREB; cAMP-response element-binding-protein (CREB); DNA; deoxyribonucleic acid; EFE; ethyl ferulate (ethyl 4-hydro
Nrf2 activation protects against intratracheal LPS induced mouse/murine acute respiratory distress syndrome by regulating macrophage polarization
Keywords: عامل فاکتور هسته ای E2 عامل 2; Acute respiratory distress syndrome; Nuclear factor E2-related factor 2; Macrophage polarization; Lipopolysaccharide; Inflammatory response;
Possible use of Punica granatum (Pomegranate) in cancer therapy
Keywords: عامل فاکتور هسته ای E2 عامل 2; 27HC; 27-hydroxycholesterol; 8-OHdG; 8-hydroxy-2â² -deoxyguanosine; 8-oxodG; 8-oxo-7,8-dihydro-2â²-deoxyguanosine; APC; adenomatous polyposis coli; AR; androgen receptors; AOM; azoxymethane; ATP; adenosine triphosphate; B(a)P; benzo(a)pyrene; Bad; Bcl-2
Rubus idaeus L. (red raspberry) blocks UVB-induced MMP production and promotes type I procollagen synthesis via inhibition of MAPK/AP-1, NF-κβ and stimulation of TGF-β/Smad, Nrf2 in normal human dermal fibroblasts
Keywords: عامل فاکتور هسته ای E2 عامل 2; Normal human dermal fibroblasts; Ultraviolet B; Rubus idaeus L; Matrix metalloproteinase; Type I procollagen; UV; Ultraviolet; NHDFs; normal human dermal fibroblasts; RI; Rubus idaeus L.; MMP-1; matrix metalloproteinase-1; MMP-3; matrix metalloproteinase-
Curcumin enhances LXRα in an AMP-activated protein kinase-dependent manner in human macrophages
Keywords: عامل فاکتور هسته ای E2 عامل 2; LXR; liver X receptor; ABCA1; ATP-binding cassette transporter A1; ABCG1; ATP-binding cassette transporter G1; SREBP1c; sterol response element binding protein 1c; AMPK; AMP-activated protein kinase; PMA; phorbol myristate acetate; fMLP; formyl-Met-Leu-Ph
Anti-inflammatory activity of Khayandirobilide A from Khaya senegalensis via NF-κB, AP-1 and p38 MAPK/Nrf2/HO-1 signaling pathways in lipopolysaccharide-stimulated RAW 264.7 and BV-2 cells
Keywords: عامل فاکتور هسته ای E2 عامل 2; Limonoids; Anti-inflammatory; NF-κB; AP-1; Nrf2/HO-1; KLA; Khayandirobilide A; LPS; lipopolysaccharide; NO; nitric oxide; PGE2; prostaglandin E2; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase-2; TNF-α; tumor necrosis factor-α; IL-6; inte
Treatment of Parkinson's disease in rats by Nrf2 transfection using MRI-guided focused ultrasound delivery of nanomicrobubbles
Keywords: عامل فاکتور هسته ای E2 عامل 2; Parkinson's disease (PD); Blood-brain-barrier (BBB); MRI-Guided focused ultrasound nanomicrobubble; Nuclear factor E2-related factor 2 (Nrf2); Reactive oxygen species (ROS); PD; Parkinson's disease; DBS; deep brain stimulation; BBB; blood-brain-barrier; M
Dietary lipids differentially modulate the initiation of experimental breast carcinogenesis through their influence on hepatic xenobiotic metabolism and DNA damage in the mammary gland
Keywords: عامل فاکتور هسته ای E2 عامل 2; AA; arachidonic acid; AhR; aryl-hydrocarbon receptor; c; control; CYP1; Cytochrome P450 family 1; DMBA; 7,12-dimethylbenz(a)anthracene; d.o.; days old; EROD; ethoxyresorufin-O-deethylase; GC/MS; gas chromatography/mass spectrometry; GSTs; glutathione S-tr
Connexin43 regulates high glucose-induced expression of fibronectin, ICAM-1 and TGF-β1 via Nrf2/ARE pathway in glomerular mesangial cells
Keywords: عامل فاکتور هسته ای E2 عامل 2; AGEs; advanced glycation end products; ARE; anti-oxidant response element; Cx43; connexin43; DN; diabetic nephropathy; ECM; extracellular matrix; EMSA; electrophoretic mobility shift assay; FN; fibronectin; GMCs; glomerular messangial cells; GJIC; Gap jun
Nrf2 deficiency exacerbates ochratoxin A-induced toxicity in vitro and in vivo
Keywords: عامل فاکتور هسته ای E2 عامل 2; AP; alkaline phosphatase; BEN; Balkan endemic nephropathy; EMT; epithelial to mesenchymal cell transition; γ-GTP; γ-glutamyltranspeptidase; HO-1; heme oxygenase-1; IARC; The International Agency for Research on Cancer; LDH; lactate dehydrogenase; LLC-PK
Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys
Keywords: عامل فاکتور هسته ای E2 عامل 2; PD; Polydatin; HO-1; heme oxygenase 1; SOD1; superoxide dismutase 1; DN; diabetic nephropathy; CKIP-1; Casein kinase 2 interacting protein-1; Nrf2; nuclear factor E2-related factor 2; ARE; antioxidant response element; FN; fibronectin; ICAM-1; intercellul
Anti-inflammatory effect of strawberry extract against LPS-induced stress in RAW 264.7 macrophages
Keywords: عامل فاکتور هسته ای E2 عامل 2; Strawberry; Phenolic compounds; LPS; Inflammation; ROS; Prevention; 2,4 DNP; 2,4-Dinitrophenol; ACYs; anthocyanins; ARE; antioxidant responsive element; CDNB; 1-chloro-2,4-dinitro benzene; DMEM; Dulbecco's Modified Eagle Medium; DPPH; 2,2-DiPhenyl-1-Picry
Chebulic acid prevents hepatic fibrosis induced by advanced glycation end-products in LX-2 cell by modulating Nrf2 translocation via ERK pathway
Keywords: عامل فاکتور هسته ای E2 عامل 2; T. chebula; Terminalia chebula Retz.; Glycer-AGEs; glyceraldehyde-derived advanced glycation end-products; NASH; nonalcoholic steatohepatitis; ROS; reactive oxygen species; ARE; antioxidant response element; Nrf2; nuclear factor E2-related factor 2; MAP k
Induction of Nrf2/ARE-mediated cytoprotective genes by red ginseng oil through ASK1-MKK4/7-JNK and p38 MAPK signaling pathways in HepG2 cells
Keywords: عامل فاکتور هسته ای E2 عامل 2; antioxidant response element; cytoprotection; nuclear factor E2-related factor 2; phase II enzyme; red ginseng oil;
Sophoraflavanone G from Sophora alopecuroides inhibits lipopolysaccharide-induced inflammation in RAW264.7 cells by targeting PI3K/Akt, JAK/STAT and Nrf2/HO-1 pathways
Keywords: عامل فاکتور هسته ای E2 عامل 2; SG; Sophoraflavanone G; LPS; lipopolysaccharide; NO; nitric oxide; PGE2; prostaglandin E2; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase-2; TNF-α; tumor necrosis factor-α; IL-6; interleukin-6; IL-1β; interleukin-1β; PI3K; phosphoinositi
Combination of chlorogenic acid and salvianolic acid B protects against polychlorinated biphenyls-induced oxidative stress through Nrf2
Keywords: عامل فاکتور هسته ای E2 عامل 2; Chlorogenic acid; Salvianolic acid B; Oxidative stress; Synergetic effect; Nuclear factor E2-related factor 2
Photoprotection by dietary phenolics against melanogenesis induced by UVA through Nrf2-dependent antioxidant responses
Keywords: عامل فاکتور هسته ای E2 عامل 2; ARE; antioxidant response element; AV; avobenzone; CA; caffeic acid; CDNB; 1-chloro-2,4-dinitrobenzene; DCPIP; 2,6-dichloroindophenol; DMEM; dulbecco's modified Eagle medium; DPBS; dulbecco's phosphate buffered saline; DTNB; (5,5â²-dithio-bis-2-(nitr
Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases
Keywords: عامل فاکتور هسته ای E2 عامل 2; Neurodegenerative diseases; Oxidative stress; Neuroinflammation; Nuclear factor E2-related factor 2; Nrf2; Electrophile response elements; Phase II antioxidant response; Nrf2-inducers
Magnolia officinalis (Hou Po) bark extract stimulates the Nrf2-pathway in hepatocytes and protects against oxidative stress
Keywords: عامل فاکتور هسته ای E2 عامل 2; ARE; antioxidant response element; GCLC; glutamate-cysteine ligase catalytic subunit; Hepa1c1c7; murine hepatoma cells; HepG2; human hepatoma cells; HMOX1; heme oxygenase-1; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; Keap1; Kelch-like ECH-associated
Antioxidant tert-butylhydroquinone ameliorates arsenic-induced intracellular damages and apoptosis through induction of Nrf2-dependent antioxidant responses as well as stabilization of anti-apoptotic factor Bcl-2 in human keratinocytes
Keywords: عامل فاکتور هسته ای E2 عامل 2; tBHQ; tert-butylhydroquinone; MDA; malondialdehyde; SOD; superoxide dismutase; CAT; catalase; NRF2; nuclear factor E2-related factor 2; HO-1; heme oxygenase-1; NQO1; NAD(P)H: quinine oxidoreductase 1; r-GCL; glutamate-cysteine ligase; Bcl-2; B-cell lympho
Activated AMPK boosts the Nrf2/HO-1 signaling axis-A role for the unfolded protein response
Keywords: عامل فاکتور هسته ای E2 عامل 2; ACC; acetyl-CoA carboxylase; AMPK; AMP-activated kinase; ARE; antioxidant response element; βTrcP1; β-transducin-repeat containing protein 1; CaMKK; calcium calmodulin-dependent kinase kinase; CHO; Chinese hamster ovary; DCF; dichlorofluorescein; DMSO;
Research ReportDiallyl trisufide protects against oxygen glucose deprivation -induced apoptosis by scavenging free radicals via the PI3K/Akt -mediated Nrf2/HO-1 signaling pathway in B35 neural cells
Keywords: عامل فاکتور هسته ای E2 عامل 2; DATS; diallyl trisulfide; OGD; oxygen glucose deprivation; Nrf2; nuclear factor E2-related factor 2; HO-1; Heme oxygenase-1; PI3K; phosphatidylinositol 3 kinase; Akt; protein kinase B; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide; DC
Keap1-Nrf2 regulated redox signaling in utero: Priming of disease susceptibility in offspring
Keywords: عامل فاکتور هسته ای E2 عامل 2; CE; Cornified envelope; GCL; Glutamyl cysteine ligase; GDM; Gestational diabetes mellitus; IUGR; Intrauterine growth retardation; NADPH; Nicotinamide adenine dinucleotide phosphate; NQO1; NADPH:quinone oxidoreductase 1; Nrf2; Nuclear factor E2-related fac
Hypermethylation of the Keap1 gene inactivates its function, promotes Nrf2 nuclear accumulation, and is involved in arsenite-induced human keratinocyte transformation
Keywords: عامل فاکتور هسته ای E2 عامل 2; ROS; reactive oxygen species; Nrf2; nuclear factor E2-related factor 2; ARE; antioxidant response element; HO-1; heme oxygenase 1; SOD; superoxide dismutase; CAT; catalase; Keap1; Kelch-like ECH-associated protein 1; Bach1; BTB and CNC homolog 1; FBS; fet
Sulforaphane induces autophagy through ERK activation in neuronal cells
Keywords: عامل فاکتور هسته ای E2 عامل 2; SFN; sulforaphane; Nrf2; nuclear factor E2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; ARE; antioxidant response element; LC-3; microtubule-associated protein 1 light chain 3; AV; autophagic vesicle; ERK; extracellular signal-regulated k
Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model
Keywords: عامل فاکتور هسته ای E2 عامل 2; AMPK; AMP-activated protein kinase; Cr; creatinine; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HO-1; heme oxygenase 1; IL; interleukin; iNOS; inducible nitric oxide synthase; MAPK; mitogen-activated protein kinase; NF-κB; nuclear factor κB; Nrf2;
Osthole improves an accelerated focal segmental glomerulosclerosis model in the early stage by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-κB-mediated COX-2 expression and apoptosis
Keywords: عامل فاکتور هسته ای E2 عامل 2; acFSGS; accelerated focal segmental glomerulosclerosis; BUN; urea nitrogen; Col-IV; collagen IV; COX-2; cyclooxygenase-2; Cr; creatinine; Ccr; creatinine clearance; DHE; dihydroethidium; EPHL; glomerular epithelial cell hyperplasia lesion; FSGS; focal seg
Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line
Keywords: عامل فاکتور هسته ای E2 عامل 2; AOX1; aldehyde oxidase 1; ARE; antioxidant response element; B2M; β-2-micoglobulin; BDE-47; 2,2â²,4,4â²-tetra-BDE; BSO; buthionine sulfoximine; CMV; cytomegalovirus; COX-2; cyclooxygenase-2; DHCR24; 24-dehydrocholesterol reductase; DMSO; dimethyl sulfo
The involvement of Nrf2 in the protective effects of diallyl disulfide on carbon tetrachloride-induced hepatic oxidative damage and inflammatory response in rats
Keywords: عامل فاکتور هسته ای E2 عامل 2; ALT; alanine aminotransferase; ANOVA; analysis of variance; ARE; antioxidant response element; AST; aspartate aminotransferase; Bax; Bcl-2-associated X; CCl4; carbon tetrachloride; Cox-2; cyclooxygenase-2; CYPs; cytochrome P450 isoenzymes; DADS; diallyl d
H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis
Keywords: عامل فاکتور هسته ای E2 عامل 2; GSH; glutathione; HH; hemochromatosis; HO-1; hemeoxygenase-1; NFH; heavy-chain neurofilament protein; Nrf2; nuclear factor E2-related factor 2; SOD; superoxide dismutase; TDP-43; TAR DNA-binding protein 43; TfR; transferrin receptor; H63D HFE; SOD1(G93A);
Carotenoid derivatives inhibit nuclear factor kappa B activity in bone and cancer cells by targeting key thiol groups
Keywords: عامل فاکتور هسته ای E2 عامل 2; BCO1; 15,15â²-β-carotene oxygenase 1; BCO2; β,β-carotene-9,10-oxygenase 2; DMSO; dimethyl sulfoxide; DTT; dithiotreitol; EMSA; electrophoretic mobility shift assay; EpRE/ARE; electrophile/antioxidant response element; IkB; NF-kB inhibitory protein; IK
Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the nuclear factor E2-related factor 2 pathway
Keywords: عامل فاکتور هسته ای E2 عامل 2; Nuclear factor E2-related factor 2; Antioxidant response element; Sage; Neuroprotection; Phenolic diterpenes; Carnosic acid; Carnosol;
Carvedilol, a third-generation β-blocker prevents oxidative stress-induced neuronal death and activates Nrf2/ARE pathway in HT22 cells
Keywords: عامل فاکتور هسته ای E2 عامل 2; Carvedilol; Oxidative stress; Nuclear factor E2-related factor 2; Heme oxygenase-1; Cell death;
Suppressive effects of Indigofera suffruticosa Mill extracts on lipopolysaccharide-induced inflammatory responses in murine RAW 264.7 macrophages
Keywords: عامل فاکتور هسته ای E2 عامل 2; ARE; antioxidant response element; CO; carbon monoxide; DMSO; dimethyl sulfoxide; EE-IDS; ethanol extracts of Indigofera suffruticosa Mill; EMSA; electrophoretic mobility shift assay; ERK1/2; extracellular signal-regulated kinase 1/2; FE; formononetin equ
Developmental role of nuclear factor E2-related factor 2 in mitigating methamphetamine fetal toxicity and postnatal neurodevelopmental deficits
Keywords: عامل فاکتور هسته ای E2 عامل 2; Nuclear factor E2-related factor 2; Nrf2; Methamphetamine; DNA oxidation; Fetal toxicity; Neurodevelopmental deficits; Free radicals;
Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway
Keywords: عامل فاکتور هسته ای E2 عامل 2; ARE; antioxidant-response element; AP-1; activator protein-1; DEM; diethyl maleate; GCLC; glutamate-cysteine ligase, catalytic subunit; GCLM; glutamate-cysteine ligase, modifier subunit; GSH; glutathione; GSTA4; glutathione S-transferase Alpha 4; HMOX
Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity
Keywords: عامل فاکتور هسته ای E2 عامل 2; ARE; antioxidant response element; HO-1; heme oxygenase-1; Keap1; kelch-like ECH-associated protein 1; NQO1; NAD(P)H quinone oxidoreductase-1; Nrf2; nuclear factor E2-related factor 2; ROS; reactive oxygen species; Eriodictyol-7-O-glucoside; Nrf2; Activat
Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage
Keywords: عامل فاکتور هسته ای E2 عامل 2; 18S; 18S ribosomal RNA; ARE; antioxidant response element; DMA3 +; dimethylarsinous acid; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; GCLC; γ-glutamate cysteine ligase catalytic subunit; GSIS; glucose-stimulated insulin secretion;
NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes
Keywords: عامل فاکتور هسته ای E2 عامل 2; Nrf2; nuclear factor E2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; NQO1; NAD(P)H:quinine oxidoreductase 1; GSK-3β; glycogen synthase kinase-3β; GST; glutathione S-transferase, HO-1, heme oxygenase-1; ARE; antioxidant response element,
Protective potential of IL-6 against trimethyltin-induced neurotoxicity in vivo
Keywords: عامل فاکتور هسته ای E2 عامل 2; γ-GCL; γ-glutamylcysteine ligase; GSH; reduced glutathione; GSSG; oxidized glutathione; HO-1; heme oxygenase-1; TNF-α; tumor necrosis factor-α; IFN-γ; interferon-γ; IL-6; interleukin-6; rIL-6; recombinant IL-6 protein; Nrf2; NF-E2-related factor 2;
Inflammation-related gene expression by lipid oxidation-derived products in the progression of atherosclerosis
Keywords: عامل فاکتور هسته ای E2 عامل 2; 7α-OH; 7α-hydroxycholesterol; 7-K; 7-ketocholesterol; 9-ONC; 9-oxononanoyl cholesterol; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; α-EPOX; 5α,6α-epoxycholesterol; AP-1; activator protein-1; ARE; antioxidant-responsive element; ATF; activating trans