کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5560279 1561745 2017 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sulforaphane induces differential modulation of mitochondrial biogenesis and dynamics in normal cells and tumor cells
ترجمه فارسی عنوان
سولفورفان موجب دیالوگی مدولاسیون بیوگرافی میتوکندری و پویایی سلول های طبیعی و سلول های توموری می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی


- Sulforaphane (SFN) induces mitochondrial biogenesis in normal and cancer cells.
- SFN-induced mitochondrial biogenesis decreases cell viability in cancer cells.
- SFN modulates differentially mitochondrial dynamics in normal and cancer cells.
- Sulforaphane could be inducing a metabolic shifting in prostate cancer cells.

Antioxidant-based chemotherapy has been intensely debated. Herein, we show that sulforaphane (SFN) induced mitochondrial biogenesis followed by mitochondrial fusion in a kidney cell line commonly used in nephroprotective models. At the same concentration and exposure time, SFN induced cell death in prostate cancer cells accompanied by mitochondrial biogenesis and fragmentation. Stabilization of the nuclear factor E2-related factor-2 (Nrf2) could be associated with these effects in the tumor cell line. An increase in the peroxisome proliferator-activated receptor-γ co-activator-1α (PGC1α) level and a decrease in the hypoxia-inducible factor-1α (HIF1α) level would suggest a possible metabolic shift. The knockdown in the nuclear respiratory factor-1 (NRF1) attenuated the SFN-induced effect on prostate cancer cells demonstrating that mitochondrial biogenesis plays an important role in cell death for this kind of tumor cells. This evidence supports SFN as a potential antineoplastic agent that could inhibit tumor development and could protect normal tissues by modulating common processes.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 100, February 2017, Pages 90-102
نویسندگان
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