Nrf2 participates in depressive disorders through an anti-inflammatory mechanism
Keywords: Nrf2; Depression; Inflammation; Rofecoxib; Trophic factors; Sulforaphane;
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A systems biology perspective on Nrf2-mediated antioxidant response
Keywords: ROS; Keap1; Nrf2; Oxidative stress; Antioxidant; Redox homeostasis; Feedback; Feedforward; Ultrasensitive motif; Loop gain
Coffee Induces Expression of Glucuronosyltransferases by the Aryl Hydrocarbon Receptor and Nrf2 in Liver and Stomach
Keywords: Liver Cancer; Glucuronidation; Coffee; ARE; antioxidant response element; HCC; hepatocellular carcinoma; Nrf2; nuclear factor erythroid-related factor 2; PCR; polymerase chain reaction; siRNA; short interfering RNA; tBHQ; tert-butylhydroquinone; TCDD; 2,3
The development of RAD51C, Cystatin A, p53 and Nrf2 luciferase-reporter assays in metabolically competent HepG2 cells for the assessment of mechanism-based genotoxicity and of oxidative stress in the early research phase of drug development
Keywords: HepG2 cells; Compound screening; High-throughput; Luminescence; RAD51C; Cystatin A; p53; Nrf2; Genotoxicity; Clastogenicity; ECVAM genotoxicity list
Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver
Keywords: Nrf2; Transgenic; Liver; Protein expression; iTRAQ; Lipid metabolism;
Protective effect of bromocriptine against BH4-induced Cath.a cell death involving up-regulation of antioxidant enzymes
Keywords: Antioxidant enzyme; Bromocriptine; Cath.a; Nrf2; Parkinson's disease; Tetrahydrobiopterin (BH4)
tBHQ inhibits LPS-induced microglial activation via Nrf2-mediated suppression of p38 phosphorylation
Keywords: tBHQ; Nrf2; Microglia; Inflammation; p38 MAPK
Sulforaphane improves cognitive function administered following traumatic brain injury
Keywords: TBI; Nrf2; Prefrontal cortex; Hippocampus; Spatial memory
El polimorfismo â1131 T>C del promotor del gen de la apolipoproteÃna A5 altera la unión de NRF2 (nuclear respiratory factor-2) y disminuye la actividad del promotor
Keywords: ApoA5; NRF2; rSNPs; Expresión genética; APOA5; NRF2; rSNPs; Transcription levels;
Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems
Keywords: Nrf2; Transcription factor; Keap1 gene-knockdown mouse; Oxidative stress; Cytoprotection; Obstructive cholestasis
Essential role of Nrf2 in keratinocyte protection from UVA by quercetin
Keywords: Nrf2; UVA; Oxidative stress; Quercetin; Polyphenol
Resveratrol and 4-hydroxynonenal act in concert to increase glutamate cysteine ligase expression and glutathione in human bronchial epithelial cells
Keywords: Resveratrol; Glutathione; Glutamate cysteine ligase; Combination effect; EpRE; Nrf2; Signal transduction; 4-Hydroxynonenal; Antioxidant; Detoxifying enzyme
Ethanol-induced expression of glutamate–cysteine ligase catalytic subunit gene is mediated by NF-κB
Keywords: Ethanol; Glutamate–cysteine ligase; γ-Glutamylcysteine synthetase; NF-κB; Nrf2
Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide
Keywords: Nrf2; Diet-induced obesity; Fatty acid synthase; Triterpenoid
Heat Stress Activates Interleukin-8 and the Antioxidant System via Nrf2 Pathways in Human Dental Pulp Cells
Keywords: Antioxidants; defense system; heat stress; Nrf2; pulp cells
Nrf2 protects against As(III)-induced damage in mouse liver and bladder
Keywords: Arsenic; Oxidative Stress; As(III); Nrf2; ROS
PKCδ mediates Nrf2-dependent protection of neuronal cells from NO-induced apoptosis
Keywords: PKCδ; Nitric oxide; Apoptosis; Neuron; Nrf2; ARE;
Cell stiffness, contractile stress and the role of extracellular matrix
Keywords: Oxidative stress; Nrf2; ECM; Airway smooth muscle; Airway hyperreactivity; Asthma
Induction of antioxidant and phase 2 drug-metabolizing enzymes by falcarindiol isolated from Notopterygium incisum extract, which activates the Nrf2/ARE pathway, leads to cytoprotection against oxidative and electrophilic stress
Keywords: Falcarindiol; Nrf2; ARE; Drug-metabolizing enzyme; Menadione; Cytotoxicity
5,6-Dihydrocyclopenta[c][1,2]-dithiole-3(4H)-thione is a promising cancer chemopreventive agent in the urinary bladder
Keywords: Dithiolethione; Phase 2 enzyme; Nrf2; Chemoprevention; Bladder cancer
Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells
Keywords: Nrf2; 5-Fluorouracil; Chemoresistance; Colon cancer cells; Antioxidant enzymes; Glutathione transferase
Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice
Keywords: ROS; reactive oxygen species; SOD; superoxide dismutase; FALS; familial amyotrophic lateral sclerosis; GST; glutathione S-transferase; 4-HNE; 4-hydroxynonenal; CDNB; 1-chloro-2,4-dinitrobenzene; MDA; malondialdehyde; Fe-NTA; ferric nitrilotriacetate; HE
Methylmercury disruption of embryonic neural development in Drosophila
Keywords: Methylmercury; Drosophila; Embryo; Alternative model; Nrf2; Neurogenesis; Neuron migration
Down-regulation of the detoxifying enzyme NAD(P)H:quinone oxidoreductase 1 by vanadium in Hepa 1c1c7 cells
Keywords: Act-D; actinomycin D; AhR; aryl hydrocarbon receptor; ARE; antioxidant responsive element; c12; AhR-deficient Hepa 1c1c7 cells; CHX; cycloheximide; DMSO; dimethylsulfoxide; EMSA; Electrophoretic mobility shift assay; Hepa 1c1c7; murine hepatoma Hepa 1c1c7
Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages
Keywords: Nrf2; AP-1; NF-κB; Hypochlorous acid; Antioxidant response element; Oxidative stress; Genomic profiling
Anti-NF-κB and anti-inflammatory activities of synthetic isothiocyanates: Effect of chemical structures and cellular signaling
Keywords: Cancer chemopreventive compounds; Isothiocyanates; NF-κB; Anti-inflammatory response; Nrf2;
Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice
Keywords: Pten KO; Pten-deficient; EPA; eicosapentaenoic acid; ROS; reactive oxygen species; HCC; hepatocellular carcinoma; NASH; non-alcoholic steatohepatitis; NAFLD; non-alcoholic fatty liver disease; TG; triglyceride; PUFA; polyunsaturated fatty acid; SREBP-1; s
Attenuation of oxidative stress, inflammation and apoptosis by minocycline prevents retrovirus-induced neurodegeneration in mice
Keywords: Moloney murine leukemia virus-ts1; Minocycline; Oxidative stress; Inflammation; Apoptosis; Nrf2;
Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress
Keywords: Nrf2; Oxidative stress; Glutathione; Glutathione reductase; Cigarette smoke; COPD; Emphysema; Free radicals
Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim
Keywords: Oxidative stress; Heme oxygenase-1; Synergy; Curcumin; Protandim; Antioxidant supplement; Nrf2; Phytochemicals; Free radicals
Activation of transcription factors and gene expression by oxidized low-density lipoprotein
Keywords: OxLDL; oxidized LDL; AP1; activator protein 1; NF-κB; nuclear factor κ of B cells; STAT; signal transducer and activator of transcription; NFAT; nuclear factor of activated T cells; HIF; hypoxia-inducible factor; Sp1; specific protein 1; PPAR; peroxisom
Phase I to II cross-induction of xenobiotic metabolizing enzymes: A feedforward control mechanism for potential hormetic responses
Keywords: Hormesis; Bioactivation; Feedforward; Feedback; Overcompensation; Reactive metabolite; Xenobiotics; Nrf2
The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cells
Keywords: Cytochromes P450; AhR; PAHs; Aldo–keto reductases; NQO1; NRF2
An in vitro screening cascade to identify neuroprotective antioxidants in ALS
Keywords: 5-LOX; 5-lipoxygenase; AAPH; 2,2â²-azobis(2-methylpropionamidine) dihydrochloride; ALS; amyotrophic lateral sclerosis; ARE; antioxidant response element; BBB; blood-brain barrier; CAPE; caffeic acid phenethyl ester; CNS; central nervous system; DCF; di
Ebselen attenuates cisplatin-induced ROS generation through Nrf2 activation in auditory cells
Keywords: Cisplatin; Ebselen; Heme-oxygenase 1; HEI-OC1 auditory cell; Nrf2; NAD(P)H:quinine oxidoreductase; γ-Glutamylcysteine synthetase; Lipid peroxidation; Organotypic culture; Auditory brainstem response (ABR)ARE, antioxidant response element; Cisplatin, cis-d
Nrf2 promotes neuronal cell differentiation
Keywords: Nrf2; Keap1; Oxidative stress; Neuronal differentiation; SH-SY5Y; NQO1; Free radicals;
Convergence of nitric oxide and lipid signaling: Anti-inflammatory nitro-fatty acids
Keywords: âNO; nitric oxide; sGC; soluble guanylate cyclase; cGMP; cyclic guanosine monophosphate; COX; cyclooxygenase; LOX; lipoxygenase; NO2-FA; nitrated fatty acids; NOS; nitric oxide synthase; ONOO-; peroxynitrite; RSNO; nitrosothiols; PUFAs; polyunsaturated
Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2–Keap1 signaling
Keywords: EGCG; Bleomycin; Pulmonary fibrosis; Nrf2; Keap1; Inflammation
Prohibitin Is a Novel Regulator of Antioxidant Response That Attenuates Colonic Inflammation in Mice
Keywords: ARE; antioxidant response element; DSS; dextran sodium sulfate; FITC; fluorescein isothiocyanate; GSH; glutathione; GSSG; glutathione disulfide; MPO; myeloperoxidase; Nrf2; nuclear factor erythroid 2-related factor 2; PCR; polymerase chain reaction; PHB
Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
Keywords: Keap1; Methylation; Nrf2; Lung cancer; Bisulfite sequencing (BSG)
Nordihydroguaiaretic acid activates the antioxidant pathway Nrf2/HO-1 and protects cerebellar granule neurons against oxidative stress
Keywords: Heme oxygenase-1; Nrf2; Neuroprotection; NDGA; 3-Nitropropionic acid; Antioxidant response elements;
Epigallocatechin activates haem oxygenase-1 expression via protein kinase Cδ and Nrf2
Keywords: Epigallocatechin; Haem oxygenase-1; Monocytic cells; Nrf2; Protein kinase C; Green tea polyphenols;
Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis
Keywords: Nrf2; NFκB; DSS; AOM; Apoptosis
Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1–Cul3 interaction
Keywords: Keap1; Nrf2; Arsenic; Cul3; E3 ubiquitin ligase
Bromocriptine activates NQO1 via Nrf2-PI3K/Akt signaling: Novel cytoprotective mechanism against oxidative damage
Keywords: Bromocriptine; NQO1; Nrf2; Oxidative damage; Parkinson's disease; PI3K/Akt
(−)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells
Keywords: Antioxidant enzymes; EGCG; Nrf2; Manganese superoxide dismutase; Glutamate–cysteine ligase; Heme oxygenase; MCF10A cells
Nrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements
Keywords: Nrf2; Antioxidant response element (ARE); Mouse CD36; Alternative first exons; Macrophage; Scavenger receptors; 15-deoxy-Δ12,14-prostaglandin J2
Keap1 modification and nuclear accumulation in response to S-nitrosocysteine
Keywords: Nitric oxide; S-nitrosocysteine; S-nitrosylation; Oxidation; Keap1; Nrf2; Nuclear localization; Free radicals
Effect of mercury(II) on Nrf2, thioredoxin reductase-1 and thioredoxin-1 in human monocytes
Keywords: Thioredoxin-1; Trx1; Nrf2; Thioredoxin reductase-1; TrxR1; Cytotoxicity; Mercury; Hg(II); Dental amalgam; Redox balance; Biocompatibility
Nrf2-mediated haeme oxygenase-1 up-regulation induced by cobalt protoporphyrin has antinociceptive effects against inflammatory pain in the formalin test in mice
Keywords: Nrf2; HO-1; Mice; Knockout mice; Nociception; Cobalt protoporphyrin; Formalin test; Haeme oxygenase-1