کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1910527 | 1046775 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice
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کلمات کلیدی
gsta44-HNE4-hydroxynonenalMDAHEK293Nrf2GSTCDNB1-chloro-2,4-dinitrobenzene - 1-کلرو-2،4-دینیتروبنزنROS - ROSIron - آهنfamilial amyotrophic lateral sclerosis - اسکلروز جانبی جانبی آمیوتروفی فامیلیOxidative stress - تنش اکسیداتیوfALS - جعل اسنادFree radicals - رادیکال آزادSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازnuclear factor E2-related factor 2 - عامل فاکتور هسته ای E2 عامل 2antioxidant-responsive element - عنصر پاسخ دهنده آنتی اکسیدانferric nitrilotriacetate - فریت نیتریلتری اسیدmalondialdehyde - مالون دی آلدهیدARE - هستندhuman embryonic kidney 293 - کلیه جنینی انسان 293glutathione S-transferase - گلوتاتیون S-ترانسفرازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Copper/zinc-superoxide dismutase (SOD1) plays a protective role in cells by catalyzing the conversion of the superoxide anion into molecular oxygen and hydrogen peroxide. Although SOD1 knockout (KO) mice exhibit a reduced life span and an elevated incidence of dysfunctions in old age, young SOD1 KO mice grow normally and exhibit no abnormalities. This fact leads to the hypothesis that other antioxidative proteins prevent oxidative stress, compensating for SOD1. Differently expressed genes in 3-week-old SOD1 KO and littermate wild-type mice were explored. A gene remarkably elevated in SOD1 KO mouse kidneys was identified as the glutathione S-transferase Alpha 4 gene (Gsta4), which encodes the GSTA4 subunit. The GSTA4 protein level and activity were also significantly increased in SOD1 KO mouse kidneys. The administration of an iron complex, a free radical generator, induced GSTA4 expression in wild-type mouse kidneys. Iron deposition detected in SOD1 KO mouse kidney is thought to be an inducer of GSTA4. In addition, overexpression of mouse GSTA4 cDNA in human embryonic kidney cells decreased cell death caused by both 4-hydroxynonenal and hydrogen peroxide. These findings suggest that compensatory induced GSTA4 plays a protective role against oxidative stress in young SOD1 KO mouse kidneys.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 47, Issue 5, 1 September 2009, Pages 559-567
Journal: Free Radical Biology and Medicine - Volume 47, Issue 5, 1 September 2009, Pages 559-567
نویسندگان
Daisaku Yoshihara, Noriko Fujiwara, Tomomi Ookawara, Shinsuke Kato, Haruhiko Sakiyama, Shunichi Yokoe, Hironobu Eguchi, Keiichiro Suzuki,