Keywords: FTM-C; fumitremordin C; BCRP; breast cancer resistance protein; PKS; polyketide synthase; NRPS; nonribosomal peptide synthetase; α-KG; α-ketoglutarate; SAR; structure-activity relationship; KSP; kinesin spindle protein; TAS1; tenuazonic acid synthetase
مقالات ISI (ترجمه نشده)
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Keywords: Antibiotics; Biosynthesis; Bioinformatics; NRPS; PKS; Natural productA, adenylation domain; BGC, biosynthetic gene cluster; C, condensation domain; GPR, gene-protein-reaction; HMM, hidden Markov model; LC, liquid chromatography; MS, mass spectrometry; NMR
Keywords: BGC; biosynthetic gene cluster; HGT; horizontal gene transfer; PKS; polyketide synthase; NRPS; nonribosomal peptide synthetase; TC; terpene cyclase; DMAT; dimethylallyl-tryptophan synthase; Natural products; Biosynthetic gene clusters; Secondary metabolis
Keywords: ACE; abundance-based coverage estimators; BGC; biosynthetic gene cluster; CI; confidence interval; CID; Compound Identifiers; FAS; fatty acid synthase; InChI; International Chemical Identifier; KS; ketosynthase; MIBiG; Minimum Information about Biosynthet
Keywords: 1H-NMR; proton nuclear magnetic resonance spectroscopy; 3D; three-dimensional; ANOVA; analysis of variance; APCI; atmospheric pressure chemical ionization; DA; discriminant analysis; DESI; desorption electrospray ionization; DI-MS; desorption ionization
Keywords: BBB; Basso, Beattie and Bresnahan; BDA; biotinylated dextran amine; ChABC; chondroitinase ABC; CSPGs; chondroitin sulphate proteoglycans; CST; corticospinal tract; CTB; cholera toxin B; ECM; extracellular matrix; GAG; glycosaminoglycan; GFAP; glial fibril
Keywords: Fungal secondary metabolism; Natural products; Genetic engineering; PKS; polyketide synthase; NRPS; non-ribosomal peptide synthetase;
Preparation of new halogenated diphenyl pyrazine analogs in Escherichia coli by a mono-module fungal nonribosomal peptide synthetase from Penicillium herquei
Keywords: Diphenyl pyrazine; Biosynthesis; NRPS; Tyrosine recognition; Enzyme promiscuity;
Description of an orthologous cluster of ochratoxin A biosynthetic genes in Aspergillus and Penicillium species. A comparative analysis
Keywords: Cluster; Halogenase; P450; PKS; NRPS; bZIP;
Unusual features of the large linear plasmid pSA3239 from Streptomyces aureofaciens CCM 3239
Keywords: DIG; digoxigenin; ORF; open reading frames; PFGE; pulse-field gel electrophoresis; PKS; polyketide synthase; NRPS; non-ribosomal peptide synthase; Tap; telomere-associated protein; TIR; terminal inverted repeat; TP; terminal proteins; Streptomyces; Plasmi
Dysregulated gliotoxin biosynthesis attenuates the production of unrelated biosynthetic gene cluster-encoded metabolites in Aspergillus fumigatus
Keywords: BGC; Fungal proteomics; LC-MS; Metabolomics; Methyltransferase; NRPS;
Old and new glycopeptide antibiotics: From product to gene and back in the post-genomic era
Keywords: Glycopeptide antibiotics; Vancomycin; Teicoplanin; A40926; Dalbavancin; Natural product screening; Strain improvement; Fermentation; Genetic engineering; Combinatorial biochemistry; Dahp; 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase; Atf; acyltran
Both a PKS and a PPTase are involved in melanin biosynthesis and regulation of Aureobasidium melanogenum XJ5-1 isolated from the Taklimakan desert
Keywords: PKS; polyketide synthase; PPTase; phosphopantetheinyl transferases; NRPS; nonribosomal peptide synthetase; NPG1; the gene encoding a PPTase; UV; ultraviolet; DHN; dihydroxynaphthalene; l-DOPA; l-3,4-dihydroxyphenylalanine; THN; tetrahydroxynaphthalene; KS
The rhizoferrin biosynthetic gene in the fungal pathogen Rhizopus delemar is a novel member of the NIS gene family
Keywords: CAS; chrome azurol S; DKA; diabetic ketoacidosis; NIS; NRPS-independent siderophore; NRPS; non-ribosomal peptide synthetase; Mucormycosis; Rhizopus delemar; Siderophore biosynthesis; NRPS-independent siderophore (NIS);
Draft genome sequence of a sponge-derived Brevibacillus sp. TP-B0800, a producer of ulbactins with tumor cell migration inhibitory activity
Keywords: A; adenylation; ACP; acyl carrier protein; AMT; aminotransferase; AT; acyltransferase; C; condensation; CoL; CoA ligase; Cy; cyclization; E; epimerization; KS; ketosynthase; KR; ketoreductase; MT; methyltransferase; NBRC; Biological Resource Center, Natio
Intracellular co-localization of the Escherichia coli enterobactin biosynthetic enzymes EntA, EntB, and EntE
Keywords: Siderophore; Enterobactin; Protein-protein interactions; Bacterial two-hybrid; CAS assay; ArCP; aryl carrier protein domain; BACTH; bacterial adenylate cyclase two-hybrid; CAS; chrome azurol S; DHB; 2,3-dihydroxybenzoic acid; DTT; dithiothreitol; Fur; fer
Subunit orientation in the Escherichia coli enterobactin biosynthetic EntA-EntE complex revealed by a two-hybrid approach
Keywords: Siderophore; Enterobactin; Protein-protein interactions; Bacterial two-hybrid; CAS assay; BACTH; bacterial adenylate cyclase two-hybrid; CAS; chrome azurol S; DHB; 2,3-dihydroxybenzoic acid; DTT; dithiothreitol; Fur; Ferric Uptake Regulator; HRP; horserad
Structural insights into the regulation of NADPH binding to reductase domains of nonribosomal peptide synthetases: A concerted loop movement model
Keywords: SDR; short-chain dehydrogenase/reductase; R-domain; reductase domain; NADP(H); nicotinamide adenine dinucleotide phosphate(reduced); Short-chain dehydrogenase/reductase (SDR); Reductase domain; NRPS; Gating loop; Catalytic loop;
A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis
Keywords: Biosynthesis; Decalin; Diels-Alder cycloaddition; Fusarium PKS-NRPS hybrid; Secondary metabolite; ATMT; Agrobacterium tumefaciens-mediated transformation; C6; Zn(II)2Cys6-type; ER; enoyl reductase; EtOAc; ethyl acetate; LC/ESI-MS; liquid chromatography/el
Bioprospecting Portuguese Atlantic coast cyanobacteria for bioactive secondary metabolites reveals untapped chemodiversity
Keywords: Atlantic Ocean; Bioactive compounds; Marine cyanobacteria; Molecular networking; NRPS; PKS;
Antimicrobial peptides and proteins in the face of extremes: Lessons from archaeocins
Keywords: Antimicrobial compounds; Bacteriocin; Archaeocin; Halocin; Sulfolobicin; AMP; antimicrobial peptide/protein; Da; dalton; Hal; halocin; HLH; helix-loop-helix; ORF; open reading frame; NHE; Na+/H+ exchanger; NRPS; nonribosomal peptide synthetase; PKS; polyk
Delineating the reaction mechanism of reductase domains of Nonribosomal Peptide Synthetases from mycobacteria
Keywords: Short-chain Dehydrogenase/Reductase (SDR); Sequential order bi-bi reaction mechanism; Reductase domain; NRPS; Cation-Ï interaction;
Characterization of the biosynthetic gene cluster for the ribosomally synthesized cyclic peptide ustiloxin B in Aspergillus flavus
Keywords: Ustiloxin B; Fungal secondary metabolite biosynthesis; Aspergillus flavus; Gene cluster; Ribosomal peptide synthesis; EIC; extracted ion chromatogram; ER; endoplasmic reticulum; LC-MS; liquid chromatography-mass spectrometry; NRPS; non-ribosomal pepti
Identification and biochemical characteristics of lipopeptides from Bacillus mojavensis A21
Keywords: NRPS; PCR; MALDI-TOF-MS; Fengycin; Surfactin; Pumilacidin
Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites
Keywords: ACP; acyl carrier protein; AT; acyltransferase; COBRA; constraint-based reconstruction and analysis; DoBISCUIT; Database Of BIoSynthesis clusters CUrated and InTegrated; MRSA; methicillin-resistant Staphylococcus aureus; NRPS; nonribosomal peptide synthet
Subcellular localization of the pyoverdine biogenesis machinery of Pseudomonas aeruginosa: A membrane-associated “siderosome”
Keywords: MALDI-TOF; Matrix-Assisted Laser Desorption/Ionization Time-of-Flight; NRPS; nonribosomal peptide synthetase; Bacteria; Iron; Nonribosomal peptide synthesis; Protein interaction; Siderophore;
Identification of a novel tetrapeptide structure of the Mycobacterium avium glycopeptidolipid that functions as a specific target for the host antibody response
Keywords: CID; collision-induced dissociation; dTal; 6-deoxytalose; ELISA; enzyme-linked immunosorbent assay; GC; gas chromatography; GPL; glycopeptidolipid; MAC; Mycobacterium avium complex; MS; mass spectrometry; NRPS; non-ribosomal peptide synthetase; nsGPL; ser
Motifs in the C-terminal region of the Penicillium chrysogenum ACV synthetase are essential for valine epimerization and processivity of tripeptide formation
Keywords: Non-ribosomal peptide synthetases; Penicillin biosynthesis; l-Valine epimerase; ACV syntethase; Penicillin; ACV; α-aminoadipyl-cysteinyl-valine; ACVS; ACV synthetase; NRPS; non-ribosomal peptide synthetase;
A novel reporter system for bacterial and mammalian cells based on the non-ribosomal peptide indigoidine
Keywords: Blue pigment; BpsA; Indigoidine; Non-ribosomal peptide synthase; NRPS; PPTase; Svp; Synthetic biology; Reporter gene;
Gliotoxin effects on fungal growth: Mechanisms and exploitation
Keywords: Aspergillus fumigatus; Proteomics; Natural products; Aspergillus; Yeast; NRPS;
Aminoacyl-coenzyme A synthesis catalyzed by a CoA ligase from Penicillium chrysogenum
Keywords: AMP; adenosine 5â²-monophosphate; ATP; adenosine 5â²-triphosphate; CoA; coenzyme A; HPLC; high-performance liquid chromatography; NRPS; non-ribosomal peptide synthetase; PPi; inorganic pyrophosphate; Coenzyme A ligase; Aminoacyl-coenzyme A; β-Phenylala
Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced by Streptomyces clavuligerus
Keywords: Dithiolopyrrolone; Holomycin; NRPS; Heterologous expression; Biosynthesis;
SMURF: Genomic mapping of fungal secondary metabolite clusters
Keywords: NRPS; PKS; Prenyltransferases; Polyketides; Antibiotics; Secondary metabolism; Filamentous fungi; Aspergillus; Genome annotation
Improved tryprostatin B production by heterologous gene expression in Aspergillus nidulans
Keywords: Aspergillus; Secondary metabolism; NRPS; Tryprostatin; Fumitremorgin; Heterologous expression
Top-down mass spectrometry on low-resolution instruments: Characterization of phosphopantetheinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways
Keywords: Mass spectrometry; Linear ion trap; Tandem mass spectrometry; Top-down mass spectrometry; Phosphopantetheine; Phosphopantetheinlylation; Acyl carrier protein; AcpC; Streptococcus agalactiae; Group B Streptococcus; GBS; NRPS; PKS; Polyketide synthase; Non-
Creating and screening Cochliobolus heterostrophus non-ribosomal peptide synthetase mutants
Keywords: Ascomycete; Development; NRPS; Secondary metabolism
Identification and functional analysis of the fusaricidin biosynthetic gene of Paenibacillus polymyxa E681
Keywords: Paenibacillus polymyxa; Fusaricidin; Fusaricidin synthetase gene; NRPS
Production of the non-ribosomal peptide plipastatin in Bacillus subtilis regulated by three relevant gene blocks assembled in a single movable DNA segment
Keywords: Gene assembly; OGAB; Bacillus subtilis; NRPS; Plasmid
Relationship between activating and editing functions of the adenylation domain of apo-tyrocidin synthetase 1 (apo-TY1)
Keywords: Non-ribosomal peptide synthetases (NRPS); Adenylation domain; Aminoacyl adenylate stability; Editing; aaRS; aminoacyl-tRNA synthetase; AMMP; 2-amino-6-mercapto-7-methylpurine; AMMPR; 2-amino-6-mercapto-7-methylpurine ribonucleoside; Apo-TY1; TY1 devoid of
Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56
Keywords: Myxobacteria; Sorangium cellulosum; Secondary metabolism; Chivosazol; PKS; NRPS; Biosynthetic gene cluster
The biosynthetic genes for disorazoles, potent cytotoxic compounds that disrupt microtubule formation
Keywords: A; NRPS adenylation domain; ACP; acyl carrier protein; AT; acyltransferase; C; NRPS condensation domain; CP; carrier protein; DEBS; 6-deoxyerythronolide B synthase; DH; dehydratase; ER; enoyl reductase; KR; ketoreductase; KS; β-ketoacyl-ACP synthase; MT;
The expression of selected non-ribosomal peptide synthetases in Aspergillus fumigatus is controlled by the availability of free iron
Keywords: NRPS; Iron; Siderophore; MALDI ToF; Secondary metabolites; Proteomics; 4â²-PPTase;