Draft genome sequence of a sponge-derived Brevibacillus sp. TP-B0800, a producer of ulbactins with tumor cell migration inhibitory activity

A sponge-derived Brevibacillus sp. TP-B0800 produces new polycyclic thiazoline derivatives designated ulbactins F and G which possess inhibitory activity against tumor cell migration. To elucidate the biosynthetic pathway of ulbactins, we read the genome sequence of this strain. The genome harbors six gene clusters related to nonribosomal peptides, one of which was identified to be responsible for ulbactin biosynthesis. We propose the putative ulbactin-biosynthetic pathway based on bioinformatics analysis. The genome information reported here also suggested potential of this strain to produce edeine, tyrocidin, and unidentified secondary metabolites.