دانلود مقالات ISI درباره O6-Methylguanine-Dna Methyltransferase + ترجمه فارسی

مقاومت به مواد مخدر در گلوبلاستوم و سیتوتوکسی سمیت ترکیبات جلبک دریایی به تنهایی و در ترکیب با داروهای ضد سرطان: یک مینی بررسی

Drug resistance in glioblastoma and cytotoxicity of seaweed compounds, alone and in combination with anticancer drugs: A mini review

Keywords: Anticancer activity; Apoptosis; DNA repair; Glioblastoma; Seaweed compounds; Temozolomide; AIC; 5-aminoimidazole-4-carboxamide; Akt; Protein kinase B (PKB); AP site; apurinic/apyrimidinic site; AP-1; activator protein-1; APE-1; AP endonuclease; Bax; Bcl-2

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

ویژگی های بالینی مرتبط با انتشار داخل جمعی از گلیوم

Clinical characteristics associated with the intracranial dissemination of gliomas

Keywords: A; astrocytoma; AA; anaplastic astrocytoma; AO; anaplastic oligodendroglioma; AOA; anaplastic oligoastrocytoma; EGFR; epidermal growth factor receptor; FISH; fluorescence in situ hybridization; MGMT; O6-methylguanine-DNA methyltransferase; MMP9; matrix me

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

نقص تعمیر ناپذیر و سندرم لینچ: نقش دانشمند اساسی در مبارزه با سرطان

Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancer

Keywords: LS; Lynch syndrome; CRC; colorectal cancer; HNPCC; hereditary non-polyposis colon cancer; MMR; mismatch repair; FAP; familial adenomatous polyposis; CFS; cancer family syndrome; MSI; microsatellite instability; IDL; insertion/deletion loop; MSH2; human mu

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

مجدد کرانیوتومی برای درجه چهارم گلیوبلاستوما: اثرات و نتایج از موسسه ملی علوم اعصاب سنگاپور

Re-do Craniotomy for Recurrent Grade IV Glioblastomas: Impact and Outcomes from the National Neuroscience Institute Singapore

Keywords: High-grade glioma; Overall Survival; Recurrent; Re-do Craniotomy; ADLs; Activities of daily living; EOR; Extent of resection; GBM; World Health Organization grade IV glioblastoma; GTR; Gross total resection; IRB; Institutional Review Board; MGMT; O6-methy

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2016 سفارش ترجمه

گلیوبلاستوما چندفرم: پاتوژنز و درمان

Glioblastoma multiforme: Pathogenesis and treatment

Keywords: Glioblastoma; Treatment; Review; Pharmacology; Targeted therapy; Stem cell; AKT; protein kinase B; BBB; blood-brain barrier; BCNU; carmustin; CCNU; lomustin; c-MET; hepatocyte growth factor receptor; EGF(R); epidermal growth factor (receptor); EGFRvIII; e

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2015 سفارش ترجمه

بررسی اثرات متابولیسم فرمالدئید

Investigations on potential co-mutagenic effects of formaldehyde

Keywords: Comet assay; Micronucleus test; Gene expression; O6-methylguanine-DNA methyltransferase; DNA repair;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

اثرات راننده و مسافرتی جهش های ایزوسیترات دهیدروژناز 1 و 2 در انکوزیسیون و افزایش طول عمر

The driver and passenger effects of isocitrate dehydrogenase 1 and 2 mutations in oncogenesis and survival prolongation

Keywords: ΑKG; α-ketoglutarate; AML; acute myeloid leukemia; BCAT1; branched-chain amino acid transporter 1; BRD4; bromodomain-containing protein 4; D-2HG; D-2-hydroxyglutarate or R-2-hydroxyglutarate; D-2HGA; D-2-hydroxyglutarate aciduria; D2HGDH; D-2-hydroxyglu

دانلود رایگان متن کامل مقاله ISI 58 صفحه سال انتشار : 2014 سفارش ترجمه

Up-regulation of MSH6 is associated with temozolomide resistance in human glioblastoma

Keywords: Glioblastoma; Temozolomide resistance; MSH6; DNA mismatch repair; O6-methylguanine-DNA methyltransferase;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2

Keywords: ABC; ATP-binding cassette; AUC; area under the curve; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; GBM; glioblastoma; MGMT; O6-methylguanine-DNA methyltransferase; MRI; magnetic resonance imaging; P-gp; P-glycoprotein; WT; wild-type;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Preparation of PEGylated liposomes incorporating lipophilic lomeguatrib derivatives for the sensitization of chemo-resistant gliomas

Keywords: BBB; blood-brain barrier; Br-Cn; bromoalkane; Br-C12; 1-bromododecane; Br-C14; 1-bromotetradecane; Br-C16; 1-bromohexadecane; Br-C18; 1-bromooctadecane; CHOL; cholesterol; DCM; dichloromethane; DLS; dynamic light scattering; DMEM; Dulbecco's modified Ea

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

Changes of DNA repair gene methylation in blood of chronic fluorosis patients and rats

Keywords: Fluorosis; O6-methylguanine-DNA methyltransferase; Mismatch repair gene; Methylation;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

Synthesis of PET probe O6-[(3-[11C]methyl)benzyl]guanine by Pd0-mediated rapid C-[11C]methylation toward imaging DNA repair protein O6-methylguanine-DNA methyltransferase in glioblastoma

Keywords: MGMT; O6-methylguanine-DNA methyltransferase; TMZ; temozolomide; O6-BG; O6-benzylguanine; PET; positron emission tomography; AGT; O6-alkylguanine-DNA alkyltransferase; TFA; trifluoroacetyl; [11C]mMeBG; 11C-labeled O6-[(3-methyl)benzyl]guanine; BOC; tert-b

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O6-methylguanine-DNA methyltransferase

Keywords: Specificity protein 1; Superoxide dismutase 2; Reactive oxygen species; Temozolomide; O6-methylguanine-DNA methyltransferase;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Immunohistochemical analysis of O6-methylguanine-DNA methyltransferase (MGMT) protein expression as prognostic marker in glioblastoma patients treated with radiation therapy with concomitant and adjuvant Temozolomide

Keywords: O6-methylguanine-DNA methyltransferase; Glioblastoma; Temozolomide; Immunohistochemistry

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

The role of temozolomide in the treatment of aggressive pituitary tumors

Keywords: O6-methylguanine-DNA methyltransferase; Pituitary adenoma; Pituitary carcinoma; Temozolomide

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo

Keywords: CFA; colony formation assay; MGMT; O6-methylguanine-DNA methyltransferase; O6-BG; O6-benzylguanine; POH; perillyl alcohol; TMZ; temozolomide; NEO212; perillyl alcohol covalently linked to temozolomide (TMZ-POH); O6-methylguanine-DNA methyltransferase; MGM

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

MGMT enrichment and second gene co-expression in hematopoietic progenitor cells using separate or dual-gene lentiviral vectors

Keywords: O6-methylguanine-DNA methyltransferase; MGMT; P140K; IRES; F2A; Lentivirus; Gene therapy;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Tamoxifen in combination with temozolomide induce a synergistic inhibition of PKC-pan in GBM cell lines

Keywords: GBM; glioblastoma; MGMT; O6-methylguanine-DNA methyltransferase; TMX; tamoxifen; TMZ; temozolomide; PKC; protein kinase C; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; PGP; (P-glycoprotein ); SERM; non-steroidal selective estrogen r

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

The role of Myc and let-7a in glioblastoma, glucose metabolism and response to therapy

Keywords: GBM; glioblastoma multiforme; let-7a; lethal-7a; miRNA; microRNA; TCGA; The Cancer Genome Atlas; GLUT; glucose transporter; PKM2; pyruvate kinase M2; PDK; pyruvate dehydrogenase kinase; MGMT; O6-methylguanine-DNA methyltransferase; GSK3β; glycogen syntha

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2015 سفارش ترجمه

Impact of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and MGMT expression on dacarbazine resistance of Hodgkin's lymphoma cells

Keywords: Hodgkin's lymphoma; Dacarbazine; O6-methylguanine-DNA methyltransferase; Promoter methylation;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Methylation and expression profiles of MGMT gene in thymic epithelial tumors

Keywords: MGMT; O6-methylguanine-DNA methyltransferase; TET; thymic epithelial tumors; MSP; methylation-specific PCR; MG; myasthenia gravis; M; methylated; NI; non-informative case; U; unmethylated; WHO; World Health Organization; MI; methylation index; O6-methylgu

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

DNA repair mechanisms in dividing and non-dividing cells

Keywords: DNA repair; Neural cells; Neurological disorder; Dividing and non-dividing; Endogenous DNA damage; AOA1; ataxia with ocular motor apraxia 1; AP; apurinic/apyrimidinic; APE1; AP endonuclease 1; APTX; aprataxin; ATM; ataxia telangiectasia mutated; CPDs; cyc

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2013 سفارش ترجمه

Development of a new application of the comet assay to assess levels of O6-methylguanine in genomic DNA (CoMeth)

Keywords: BER; base excision repair; BG; O6-benzylguanine; Mx; methoxyamine; MMS; methyl methanesulfonate; MMR; mismatch repair; MNU; N-methyl-N-nitrosourea; MPG; N-methylpurine-DNA glycosylase; O6meG; O6-methylguanine; MGMT; O6-methylguanine-DNA methyltransferase;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2013 سفارش ترجمه

Genetics and pharmacogenomics of diffuse gliomas

Keywords: Companion diagnostics; Glioma; 1p/19q co-deletion; IDH1; Pharmacogenomics; EGFRvIII; CGH; comparative genomic hybridization; CNA; copy number aberrations; CRC; colorectal carcinoma; CML; chronic myeloid leukemia; EGFR; epidermal growth factor receptor; FF

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

MGMT Gene Promoter Methylation as a Potent Prognostic Factor in Glioblastoma Treated With Temozolomide-Based Chemoradiotherapy: A Single-Institution Study

Keywords: Glioblastoma; O6-methylguanine-DNA methyltransferase; Methylation; Prognostic factor; Radiotherapy;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

DNA methylation-based biomarkers in serum of patients with breast cancer

Keywords: 5-Aza-CdR; 5-aza-2′-deoxycytidine; 5-Aza-CR; 5-azacytidine; 5mC; 5-methylcytidine; AIMS; amplification of inter-methylated sites; APC; adenomatous polyposis coli; BiMP; bisulfite methylation profiling; BRCA1; breast cancer gene 1; BsPP; bisulfite padloc

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2012 سفارش ترجمه

O6-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: Enzyme activity, promoter methylation and immunohistochemistry

Keywords: MGMT; O6-methylguanine-DNA methyltransferase; Alkyltransferase; Promoter methylation; DNA repair; Drug resistance;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Selection of genetically modified hematopoietic cells in vitro and in vivo using alkylating agent lysomustine

Keywords: Hematopoiesis; Gene therapy; O6-Methylguanine-DNA methyltransferase; O6-Benzylguanine; BCNU; Lysomustine;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Chemoradiotherapy of Newly Diagnosed Glioblastoma With Intensified Temozolomide

Keywords: Glioblastoma; indomethacin; O6-methylguanine-DNA methyltransferase; MGMT; radiotherapy; temozolomide;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

O6-Methylguanine-DNA methyltransferase expression and prognostic value in brain metastases of lung cancers

Keywords: Brain metastasis; O6-Methylguanine-DNA methyltransferase; MGMT; Immunohistochemistry

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Aberrant methylation of tumour-related genes in thymic epithelial tumours

Keywords: DNA methylation; Cancer-related genes; O6-methylguanine-DNA methyltransferase; Thymoma; Thymic carcinoma

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Diet Synergistically Affects Helicobacter pylori-Induced Gastric Carcinogenesis in Nonhuman Primates

Keywords: ANOVA; analysis of variance; ENNG; ethyl-nitro-nitrosoguanidine; C; controls; H; H pylori-infected; E; receiving ENNG; EH; H pylori-infected receiving ENNG; IL; interleukin; MGMT; O6-methylguanine-DNA methyltransferase; rRNA; ribosomal RNA; RT-PCR; re

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2009 سفارش ترجمه

MGMT inhibitors—The Trinity College–Paterson Institute experience, a chemist's perception

Keywords: O6-Alkylguanine-DNA alkyltransferase; O6-Methylguanine-DNA methyltransferase; AGT; MGMT; Inhibitors; Inactivators; PaTrin-2; Lomeguatrib; Patrin™

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy

Keywords: O6-Alkylguanine-DNA alkyltransferase; AGT; O6-Methylguanine-DNA methyltransferase; MGMT; DNA repair; Protein crystal structure

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2007 سفارش ترجمه

Significance of the O6-methylguanine-DNA methyltransferase and glutathione S-transferase activity in the sera of patients with malignant and benign ovarian tumors

Keywords: O6-Methylguanine-DNA methyltransferase; Glutathione S-transferase; Sera; Ovarian tumors;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Unfolding mechanism of a hyperthermophilic protein O6-methylguanine-DNA methyltransferase

Keywords: CD; circular dichroism; GdnHCl; guanidine hydrochloride; MGMT; O6-methylguanine-DNA methyltransferase; Tk; Thermococcus kodakaraensis; Proteins and enzymes; MGMT; EC 2.1.1.63; 1MGT.PDB; Archaea; Hyperthermostable protein; O6-methylguanine-DNA methyltransf

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Pharmacogenetics for individualized cancer chemotherapy

Keywords: Cancer drug resistance; Single nucleotide polymorphisms; Toxicity; ABC transporter; ATP-binding cassette transporter; BCRP; breast cancer-related protein; CDA; cytidine deaminase; CYP; cytochrome P450 monoxigenase; DPYD; dihydropyrimidine dehydrogenase; E

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2005 سفارش ترجمه