کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9015868 | 1127578 | 2005 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacogenetics for individualized cancer chemotherapy
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کلمات کلیدی
Bcrpmultidrug resistance 1 geneTNFTSERO6-methylguanine-DNA methyltransferaseNQODPYDXRCC1TPMTMDR1MTHFRRFCMRPMGMTCyPCDAG6PDUGTGST5,10-methylenetetrahydrofolate reductase - 5،10-methylenetetrahydrofolate reduktazeABC transporter - ABC حمل کنندهUDP-glucuronosyltransferase - UDP-گلوکورونوسیل ترانسفرازinterleukin - اینترلوکینThiopurine S-methyltransferase - تیوپورین S-متیل ترانسفرازATP-binding cassette transporter - حمل کننده کاسه اتصال ATPdihydropyrimidine dehydrogenase - دی هیدروپیریمیدین دهیدروژنازToxicity - سمی بودنthymidylate synthase - سمیاتید تیمیدیلاتcytidine deaminase - سیتیدین دامینازtumor necrosis factor - فاکتور نکروز تومورCancer drug resistance - مقاومت در برابر سرطانMultidrug resistance-related protein - پروتئین مرتبط با مقاومت چند داروییSingle nucleotide polymorphisms - پلیمورفیسم تک نوکلئوتیدیSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتیدReduced folate carrier - کاهش دهنده فولاتglutathione S-transferase - گلوتاتیون S-ترانسفرازglucose-6-phosphate dehydrogenase - گلوکز 6-فسفات دهیدروژنازEstrogen receptor - گیرنده استروژن
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The same doses of medication cause considerable heterogeneity in efficacy and toxicity across human populations. Genetic factors are thought to represent important determinants of drug efficacy and toxicity. Pharmacogenetics focuses on the prediction of the response of tumor and normal tissue to standard therapy by genetic profiling and, thereby, to select the most appropriate medication at optimal doses for each individual patient. In the present review, we discuss the relevance of single nucleotide polymorphisms (SNP) in genes, whose gene products act upstream of the actual drug target sites, that is, drug transporters and drug metabolizing phase I and II enzymes, or downstream of them, that is, apoptosis-regulating genes and chemokines. SNPs in relevant genes, which encode for proteins that interact with anticancer drugs, were also considered, that is, enzymes of DNA biosynthesis and metabolism, DNA repair enzymes, and proteins of the mitotic spindle. A significant body of evidence supports the concept of predicting drug efficacy and toxicity by SNP genotyping. As the efficacy of cancer chemotherapy, as well as the drug-related toxicity in normal tissues is multifactorial in nature, sophisticated approaches such as genome-wide linkage analyses and integrate drug pathway profiling may improve the predictive power compared with genotyping of single genes. The implementation of pharmacogenetics into clinical routine diagnostics including genotype-based recommendations for treatment decisions and risk assessment for practitioners represents a challenge for the future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 107, Issue 2, August 2005, Pages 155-176
Journal: Pharmacology & Therapeutics - Volume 107, Issue 2, August 2005, Pages 155-176
نویسندگان
Thomas Efferth, Manfred Volm,