Keywords: سمیاتید تیمیدیلات; Presbycusis; Susceptibility; Methylene tetrahydrofolate reductase; Methionine synthase; Thymidylate synthase;
مقالات ISI سمیاتید تیمیدیلات (ترجمه نشده)
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Keywords: سمیاتید تیمیدیلات; Neural tube defects; Thymidylate synthase; 5-fluorouracil; DNA synthesis; Proliferation;
Keywords: سمیاتید تیمیدیلات; 5-FU; 5-fluorouracil; BNP; brain natriuretic peptide; CK; creatinine phosphokinases; CK-MB; creatinine phosphokinases-myocardial band; CV; cardiovascular; DYPD; dihydropyrimidine dehydrogenase; ECG; electrocardiography; EF; ejection fraction; FAC; fluoroa
Keywords: سمیاتید تیمیدیلات; Nuclear thymidylate synthesis; Antifolate; Folate-mediated one-carbon metabolism; Sumoylation; Thymidylate synthase;
Keywords: سمیاتید تیمیدیلات; Predictive biomarkers; Pathology response; Esophageal cancer; Chemo(radio)therapy; Meta-analysis; ESCC; Esophageal squamous cell carcinoma; AC; Adenocarcinoma; TS; Thymidylate synthase; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; CYFRA21-1;
Keywords: سمیاتید تیمیدیلات; Folate pathway; Trypanosomatids; Structure-based drug design; Selective inhibition; Enzyme inhibitor; Anti-parasitic drug; PTR1; Pteridine reductase 1; DHFR; Dihydrofolate reductase; dUMP; Deoxyuridine monophosphate; dTMP; Deoxythymidine monophosphate; hD
Keywords: سمیاتید تیمیدیلات; FdUMP; 5-Fluorouracil; Gemcitabine; Nanodelivery; dFdCMP; CPSNP; calcium phosphosilicate nanoparticle; mPEG; methoxy-polyethylene glycol; cPEG; carboxy-polyethylene glycol; malPEG; maleimide-polyethylene glycol; Cit; citrate; NT; no treatment; TS; thymidy
Keywords: سمیاتید تیمیدیلات; CH2THF; 5,10-methylene tetrahydrofolate; DCD; dCTP deaminase; DCD-DUT; bifunctional dCTP deaminase-dUTPase; DUT; dUTPase; DHF; dihydrofolate; DHFR; dihydrofolate reductase; DHFR-TS; bifunctional dihydrofolate reductase - thymidylate synthase; FAD; f
Keywords: سمیاتید تیمیدیلات; Enterococcus faecalis; Enzyme inhibition; Thymidylate synthase; X-ray crystallography screening; Phthalimide scaffold; Antibacterial;
Keywords: سمیاتید تیمیدیلات; 5-FU; 5-fluorouracil; 5-FC; 5-fluorocytosine; YPD; yeast extract-peptone-dextrose; EMM; Edinburgh minimal medium; YES; yeast extract with supplements; GFP; green fluorescent protein; TS; thymidylate synthase; 5-Fluorouracil; Membrane trafficking; Fission
Keywords: سمیاتید تیمیدیلات; Quartz crystal microbalance; Microscale thermophoresis; Protein complex; Thymidylate synthase; Dihydrofolate reductase; Thymidylate biosynthesis;
Keywords: سمیاتید تیمیدیلات; 3-AP; 3-aminopyridine-2-carboxaldehyde thiosemicarbazone; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related protein; AMP/ADP/ATP; adenosine mono-, di-, and tri-phosphate; BLM; Bloom syndrome RecQ helicase-like; BRAF; V-raf mu
Keywords: سمیاتید تیمیدیلات; AdoMet; S-adenosylmethionine; DHF; dihydrofolate; DHFR; DHF reductase; ENU; ethylnitrosourea; ESTR; Expanded Simple Tandem Repeat; FA; folic acid; MTHFR; 5,10-methylenetetrahydrofolate reductase; MN; micronucleus; CD24-; Pig-a mutant phenotype; NCE; normo
Keywords: سمیاتید تیمیدیلات; Rheumatoid arthritis; Thymidylate synthase; Homocystein; Polymorphism; MethotrexateArtrite reumatoide; Timidilato sintase; Homocisteína; Polimorfismo; Metotrexato
Keywords: سمیاتید تیمیدیلات; MSI-H; microsatellite instability high; MSS; microsatellite stable; PAM; prediction analysis for microarrays; IL 1B; interleukin 1B; TYMS; thymidylate synthase; MDX 1100; monoclonal antibody MDX 1100; CIMP; CpG island methylator phenotype; BAT25; mononucl
Keywords: سمیاتید تیمیدیلات; Chemoresistance; Thymidylate synthase; Anticancer drugs; Folate metabolism; Folate dependent enzymes; Pathways perturbations; Proteomic; Personalized Medicine; Clinical trials; Holistic/reductionistic approach
Keywords: سمیاتید تیمیدیلات; AcN; acetonitrile; FdUrd; 5-fluoro-dUrd; FdUMP; 5-fluoro-dUMP; TFA; trifluoroacetic acid; TS; thymidylate synthase; meTHF; N5,10-methylenetetrahydrofolate; KPA; potassium phosphoramidate; MOAC; metal oxide/hydroxide affinity chromatography; m-pTS, h-pTS,
Keywords: سمیاتید تیمیدیلات; Thymidylate synthase; Cryptosporidium; Inhibitor; Dihydrofolate reductase; Crystal structure;
Keywords: سمیاتید تیمیدیلات; Virtual screening; Thymidylate synthase; Dihydrofolate reductase; Toxoplasma gondii;
Keywords: سمیاتید تیمیدیلات; X-ray crystallography; Fragment screening; HIV; Influenza; BpGCDH; B. pseudomallei glutaryl-CoA dehydrogenase; DHNA; 7,8-dihydroneopterin aldolase; DMSO; dimethylsulfoxide; FBDD; fragment-based drug discovery; HCV; hepatitis C virus; HIV; human immunodef
Design, synthesis and biological evaluation of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido)benzoyl hydrazide derivatives as thymidylate synthase (TS) inhibitors and as potential antitumor drugs
Keywords: سمیاتید تیمیدیلات; Thymidylate synthase; Anti-proliferative activity; Apoptosis;
Oncogenic long noncoding RNA MALAT1 and HCV-related hepatocellular carcinoma
Keywords: سمیاتید تیمیدیلات; AFP; alpha fetoprotein; AUC; area under the ROC curve; cDNA; complementary DNA; DRAIC; Down-regulated RNA In Cancer; EMT; epithelial-mesenchymal transition; eRNAs; enhancer RNAs; EZH2; Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit; GAS5; growt
Computational elucidation of novel antagonists and binding insights by structural and functional analyses of serine hydroxymethyltransferase and interaction with inhibitors
Keywords: سمیاتید تیمیدیلات; SHMT; Serine hydroxymethyltransferase; Ld; Leishmania donovani; PLP; Pyridoxal phosphate; THF; Tetrahydrofolate; TS; Thymidylate synthase; PDB; Protein Data Bank; NCBI; National Center for Biotechnology Information; DOPE; Discrete optimized protein energy
Thymidylate synthase prompts metastatic progression through the dTMP associated EMT process in pancreatic ductal adenocarcinoma
Keywords: سمیاتید تیمیدیلات; Thymidylate synthase; Deoxyribonucleotide triphosphate nucleoside pools balance; Metastasis; Epithelial to mesenchymal transition; Pancreatic ductal adenocarcinoma; PDA; pancreatic ductal adenocarcinoma; TS; thymidylate synthase; dUMP; deoxyuridine monoph
Astaxanthin: A mechanistic review on its biological activities and health benefits
Keywords: سمیاتید تیمیدیلات; Astaxanthin (PubChem CID: 5368397); Beta-Carotene (PubChem CID: 5280489); Beta-Cryptoxanthin (PubChem CID: 5281235); Canthaxanthin (PubChem CID: 5281227); Lutein (PubChem CID: 5281243); Zeaxanthin (PubChem CID: 5280899); Alpha-Tocopherol (PubChem CID: 149
Associative role of TYMS6bpdel polymorphism and resulting hyperhomocysteinemia in the pathogenesis of preterm delivery and associated complications: A study from Northeast India
Keywords: سمیاتید تیمیدیلات; PTD; preterm delivery; LBW; low birth weight; MTHFR; Methylene Tetrahydrofolate Reductase; TYMS; Thymidylate Synthase; IUD; intra uterine death; Del; deletion; Ins; insertion; MTHF; methylene tetrahydrofolate; UTI; urinary tract infection; UTR; untranslat
Salinomycin acts through reducing AKT-dependent thymidylate synthase expression to enhance erlotinib-induced cytotoxicity in human lung cancer cells
Keywords: سمیاتید تیمیدیلات; Salinomycin; Erlotinib; Thymidylate synthase; AKT; Non-small cell lung cancer;
Original ArticleAG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization
Keywords: سمیاتید تیمیدیلات; Anticancer compound; Mitochondrial metabolism; Electron transport chain; Hypoxia; NADH-ubiquinone oxidoreductase; NADH; nicotinamide adenine dinucleotide; RTK; receptor tyrosine kinase; TS; thymidylate synthase; CCS; cosmic calf serum; DMSO; dimethyl sulf
Flavin-dependent thymidylate synthase: N5 of flavin as a Methylene carrier
Keywords: سمیاتید تیمیدیلات; Thymidylate; Flavin; Thymidylate synthase; Enzyme; Mechanisms; N5-flavin adduct;
Metronomic S-1 dosing and thymidylate synthase silencing have synergistic antitumor efficacy in a colorectal cancer xenograft model
Keywords: سمیاتید تیمیدیلات; Colorectal cancer; PEG-coated shRNA-lipoplex; RNAi; S-1; Short hairpin RNA; Thymidylate synthase;
Spectroscopic and calorimetric assays reveal dependence on dCTP and two metals (Zn2 + + Mg2 +) for enzymatic activity of Schistosoma mansoni deoxycytidylate (dCMP) deaminase
Keywords: سمیاتید تیمیدیلات; SmdCMP deaminase; deoxycytidylate deaminase from Schistosoma mansoni; dCTP; deoxycytidine triphosphate; TS; thymidylate synthase; dUMP; deoxyuridine monophosphate; ITC; isothermal titration calorimetry; dCMP; deoxycytidine monophosphate; dTTP; deoxythymid
Design, synthesis and biological evaluation of novel 6-substituted pyrrolo [3,2-d] pyrimidine analogues as antifolate antitumor agents
Keywords: سمیاتید تیمیدیلات; 6-substituted pyrrolo[3,2-d]pyrimidines; Anti-proliferation; Structure-activity relationship; Dihydrofolate reductase; Thymidylate synthase; G2/M-phase increased; Colony formation inhibition;
Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS
Keywords: سمیاتید تیمیدیلات; TS; thymidylate synthase; Ce; Caenorhabditis elegans; Ec; Escherichia coli; Lc; Lactobacillus casei; Ts; Trichinella spiralis; DHFR; dihydrofolate reductase; Thymidylate synthase (TS); Crystal structures; Molecular docking; Inhibitors of Trichinella spira
A folylpoly-γ-glutamate synthase single nucleotide polymorphism associated with response to pemetrexed treatment combined with platinum for non-small cell lung cancer
Keywords: سمیاتید تیمیدیلات; SNP; single nucleotide polymorphism; FPGS; folylpoly-γ-glutamate synthase; PEM; pemetrexed; MTX; methotrexate; NSCLC; non-small cell lung cancer; Bev; bevacizumab; TS; thymidylate synthase; DHFR; dihydrofolate reductase; GARFT; glycinamide ribonucleotide
Administration of adjuvant oral tegafur/uracil chemotherapy post hepatocellular carcinoma resection: A randomized controlled trial
Keywords: سمیاتید تیمیدیلات; dihydropyrimidine dehydrogenase; hepatocellular carcinoma; thymidylate synthase
Molecular Biomarker Study in a Randomised Phase III Trial of Irinotecan Plus S-1 versus S-1 for Advanced Gastric Cancer (GC0301/TOP-002)
Keywords: سمیاتید تیمیدیلات; Excision repair cross-complementing gene 1; gastric cancer; irinotecan; predictive factor; thymidine phosphorylase; thymidylate synthase;
Thermal stability and binding energetics of thymidylate synthase ThyX
Keywords: سمیاتید تیمیدیلات; Thymidylate synthase; FAD; dUMP; Differential scanning calorimetry; Isothermal titration calorimetry;
Astaxanthin enhances pemetrexed-induced cytotoxicity by downregulation of thymidylate synthase expression in human lung cancer cells
Keywords: سمیاتید تیمیدیلات; Astaxanthin; Pemetrexed; Thymidylate synthase; ERK1/2; Non-small cell lung cancer;
MTHFD1 regulates nuclear de novo thymidylate biosynthesis and genome stability
Keywords: سمیاتید تیمیدیلات; MTHFD1; SHMT; TYMS; DHFR; Thymidylate; Folate; Lamin; DNA replication; Multi-enzyme complex; FOCM; folate-mediated one-carbon metabolism; MTHFD1; methylenetetrahydrofolate dehydrogenase 1; SHMT1; cytoplasmic serine hydroxymethyltransferase; TYMS; thymidyl
ReviewFlavin-Dependent Methylation of RNAs: Complex Chemistry for a Simple Modification
Keywords: سمیاتید تیمیدیلات; SAM; S-adenosyl-L-methionine; m5U; 5-methyluridine; tmRNA; transfer-mRNA; CH2Â =Â THF; N5,N10-methylenetetrahydrofolate; FAD; flavin adenine dinucleotide; ThyA; thymidylate synthase; dUMP; desoxyuridine monophosphate; THF; tetrahydrofolate; ThyX; thymidyl
Pathways controlling dNTP pools to maintain genome stability
Keywords: سمیاتید تیمیدیلات; BER; base excision repair; CDA; cytidine deaminase; MMR; mis-match repair; MTH; MutT homologue; MUTYH; MutY homologue; Nudix; nucleoside diphosphate linked to some other moiety, X; NUDT; Nudix-type; OGG1; 8-oxoguanine glycosylase; ROS; reactive oxygen spe
Intratumoral gene expression of 5-fluorouracil pharmacokinetics-related enzymes in stage I and II non-small cell lung cancer patients treated with uracil-tegafur after surgery: A prospective multi-institutional study in Japan
Keywords: سمیاتید تیمیدیلات; Uracil-tegafur; Non-small cell lung cancer; Adjuvant chemotherapy; Biomarker; Thymidylate synthase; Dihydropyrimidine dehydrogenase; Orotate phosphoribosyltransferase; Thymidine phosphorylase
Synthesis and evaluation of C-5 modified 2â²-deoxyuridine monophosphates as inhibitors of M. tuberculosis thymidylate synthase
Keywords: سمیاتید تیمیدیلات; Thymidylate synthase; Nucleoside 5â²-monophosphates; 2â²-Deoxyuridine analogs; Mycobacterium tuberculosis; Inhibition;
Polimorfismo do gene timidilato sintase e nível plasmático total de homocisteína em um grupo de pacientes turcos com artrite reumatoide: relação com a atividade da doença e toxicidade ao metotrexato
Keywords: سمیاتید تیمیدیلات; Artrite reumatoide; Timidilato sintase; Homocisteína; Polimorfismo; MetotrexatoRheumatoid arthritis; Thymidylate synthase; Homocystein; Polymorphism; Methotrexate
Inhibition of thymidylate synthase by 2â²,2â²-difluoro-2â²-deoxycytidine (Gemcitabine) and its metabolite 2â²,2â²-difluoro-2â²-deoxyuridine
Keywords: سمیاتید تیمیدیلات; 2â²,2â²-Difluoro-2â²-deoxyuridine; Thymidylate synthase; 2â²,2â²-Difluoro-2â²-deoxycytidine; Cytidine analogues;
dNTP deficiency induced by HU via inhibiting ribonucleotide reductase affects neural tube development
Keywords: سمیاتید تیمیدیلات; NTDs; neural tube defects; HU; hydroxyurea; RNR; ribonucleotide reductase; GD; gestation day; dNTP; deoxynucleoside triphosphate; HE; hematoxylin and eosin; SAM; S-adenosyl methionine; MTX; methotrexate; TS; thymidylate synthase; TUNEL; terminal deoxynucl
TAS-102, a novel antitumor agent: A review of the mechanism of action
Keywords: سمیاتید تیمیدیلات; 5-Fluorouracil; Fluoropyrimidines; Mechanism of action; Metastatic colorectal cancer; TAS-102; Thymidylate synthase;
MYC and metabolism on the path to cancer
Keywords: سمیاتید تیمیدیلات; 2-DG; 2-deoxyglucose; 4E-BP; eIF4E-binding protein; 5,10-methylene THF; 5,10-methylenetetrahydrofolate; ACC; acetyl-CoA carboxylase; ACLY; ATP-citrate lyase; AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; ChIP-seq; chromatin immunoprecip
Ubiquitin-independent proteasomal degradation
Keywords: سمیاتید تیمیدیلات; Ubiquitin; Proteasome; Degron; Degradation; Rpn4; Thymidylate synthase; Ornithine decarboxylase; Protein disorder; Intrinsically disordered proteins;
Synergistic effects of pemetrexed and amrubicin in non-small cell lung cancer cell lines: Potential for combination therapy
Keywords: سمیاتید تیمیدیلات; Non-small cell lung cancer; Thymidylate synthase; Pemetrexed; Amrubicin