Propofol inhibits NF-κB activation to ameliorate airway inflammation in ovalbumin (OVA)-induced allergic asthma mice
Keywords: Propofol; OVA; Asthma; NF-kB;
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Transcutaneous immunization with a novel imiquimod nanoemulsion induces superior T cell responses and virus protection
Keywords: APC; antigen presenting cell; CCR; CC chemokine receptor; CTL; cytotoxic T lymphocyte; HLPC; high performance liquid chromatography; IFN; interferon; IL-1R; interleukin 1 receptor; IMI-Sol; imiquimod solid nanoemulsions; LCMV; lymphocytic choriomeningitis
Self-micellizing solid dispersion of cyclosporine A for pulmonary delivery: Physicochemical, pharmacokinetic and safety assessments
Keywords: AUC; area under the curve of blood concentration versus time curve; BALF; bronchoalveolar lavage fluid; BUN; blood urea nitrogen; Cmax; maximum concentration; CsA; cyclosporine A; CsA-RP; amorphous cyclosporine A-based respirable powder; FPD; fine particl
Novel interferon-γ enzyme-linked immunoSpot assay using activated cells for identifying hypersensitivity-inducing drug culprits
Keywords: DLST; drug-induced lymphocyte stimulation test; LTT; lymphocyte transformation test; cADR; cutaneous adverse drug reactions; PBMCs; peripheral blood mononuclear cells; ELISpot; enzyme-linked immunospot; OVA; ovalbumin; SJS; Stevens-Johnson syndrome; TEN;
Pulvis Fellis Suis extract attenuates ovalbumin-induced airway inflammation in murine model of asthma
Keywords: AHR; airway hyperresponsiveness; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BALF; bronchoalveolar lavage fluid; DEX; dexamethasone; ELISA; enzyme-linked immunosorbent assay; IgE; immunoglobulin E; IL; interleukin; OVA; ovalbumin; PBS;
Oral administration with diosgenin enhances the induction of intestinal T helper 1-like regulatory T cells in a murine model of food allergy
Keywords: CCL; chemokine (C-C motif) ligand; CCR; C-C chemokine receptor; CXCL; chemokine (C-X-C motif) ligand; CXCR; C-X-C chemokine receptor; Foxp3; forkhead box P3; IFN; interferon; Ig; immunoglobulin; IHC; immunohistochemical; IL; interleukin; OVA; ovalbumin; R
Tissue resident macrophages are sufficient for demyelination during peripheral nerve myelin induced experimental autoimmune neuritis?
Keywords: EAN; Tissue macrophage; Monocyte; Demyelination; Peripheral nerve; Antibodies; AIDP; Acute Inflammatory Demyelinating Neuropathy; BNB; blood-nerve-barrier; CFA; complete freunds adjuvant; CMAP; compound muscle action potentials; EAN; experimental autoimmu
Topical ocular treatment with monoclonal antibody Fab fragments targeting Japanese cedar pollen Cry j 1 inhibits Japanese cedar pollen-induced allergic conjunctivitis in mice
Keywords: H&E; hematoxylin and eosin; OVA; ovalbumin; JCP; Japanese cedar pollen; mAb; monoclonal antibody; P1-3 and P1-8; Cry j 1-specific IgG1 mAb; Fabs; Allergic conjunctivitis; Japanese cedar pollen; Cry j 1; Eosinophils;
A suicidal strain of Listeria monocytogenes is effective as a DNA vaccine delivery system for oral administration
Keywords: BHIC; charcoal-treated brain heart infusion broth; FACS; fluorescence-activated cell sorting; FCS; fetal calf serum; FBC; fetal bovine serum; CSFC; carboxyfluorescein diacetate succinimidyl ester; Luc; luciferase; MHC; major histocompatibility complex; OV
Th2 related markers in milk allergic inflammatory mice model, versus OVA
Keywords: Allergen; Allergy; Intranasal challenge; Low fat milk; OVA; Th2;
Research paperComprehensive analysis of epigenetically regulated genes in anergic T cells
Keywords: APC; antigen-presenting cells; GO; gene ontology; GRAIL; gene related to anergy in lymphocytes; DGK; diacylglycerol kinase; OVA; ovalbumin; Treg cell; regulatory T cell; T cell anergy; DNA methylation; GO analysis; Next-generation sequencing technology; T
Research paperRole of heterogeneous cell population on modulation of dendritic cell phenotype and activation of CD8 T cells for use in cell-based immunotherapies
Keywords: DC; dendritic cell; GM-CSF; granulocyte macrophage colony stimulating factor; TLR; toll-like receptor; MPLA; monophosphoryl lipid A; LPS; lipopolysaccharide; TH1; T-helper 1; TH2; T-helper 2; OVA; ovalbumin; CFSE; carboxyfluorescein succinimidyl ester; MF
Suppressive effect of ethanol extract from passion fruit seeds on IgE production
Keywords: DNFB; dinitrofluorobenzene; ELISA; enzyme-linked immunosorbent assay; FBS; fetal bovine serum; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HRP; horseradish peroxidase; ITES; insulin, transferrin, ethanolamine, and sodium selenite; OVA; ovalbumin; PBS
Immunomodulatory activity of exopolysaccharide producing Leuconostoc citreum strain isolated from Pico cheese
Keywords: Leuconostoc citreum; Lactic acid bacteria; OVA; IgE; Probiotic;
Activation and exhaustion of antigen-specific CD8+ T cells occur in different splenic compartments during infection with Plasmodium berghei
Keywords: CFSE; 5-(and 6)-carboxyfluorescein diacetate succinimidyl ester; DCs; dendritic cells; LAG-3; lymphocyte activated gene 3; LCMV; lymphocytic choriomeningitis virus; LM-OVA; Listeria monocytogenes expressing OVA; mAb; monoclonal antibody; MFI; mean fluores
Non-redundant role of the chemokine receptor CX3CR1 in the anti-inflammatory function of gut macrophages
Keywords: CNS; central nervous system; DC; dendritic cells; D.A.I.; disease activity index; DSS; dextran sulphate sodium; GFP; green fluorescent protein; IL-10R; IL-10 receptor; KO; knock out; MLN; mesenteric lymph nodes; MÏ; macrophages; OVA; ovalbumin; Macrophag
Airways antiallergic effect and pharmacokinetics of alkaloids from Alstonia scholaris
Keywords: Scholaricine; 19-Epischolaricine; Vallesamine; Picrinine; Pharmacokinetic; Asthma; TA; total alkaloids; Sch; scholaricine; Epi; 19-epischolaricine; Val; vallesamine; Pic; picrinine; DXM; dexamethasone; OVA; ovalbumin; BALF; broncho-alveolar lavage fluid;
MyD88 Contributes to Staphylococcal Enterotoxin B-Triggered Atopic Dermatitis-Like Skin Inflammation in Mice
Keywords: AD; atopic dermatitis; LN; lymph node; MyD88; myeloid differentiation primary response gene 88; OVA; ovalbumin; SEB; staphylococcal enterotoxin B; Th; T helper cell; WT; wild-type;
Enhanced expression of PD-L1 and IFN-γ on dendritic cells is associated with BCG-induced Th2 inhibition
Keywords: BCG; Mycobacterium bovis bacillus Calmette-Guérin; DC; dendritic cells; HE; hematoxylin and eosin; OVA; ovalbumin; PD; programmed death; PD-L; programmed death ligand; SR; sirius red; TLRs; tool-like receptors; TSLP; thymic stromal lymphopoietin; Treg; r
The environment, epigenome, and asthma
Keywords: Asthma; DNA methylation; epigenetics; nasal epithelium; microbiome; air pollution; allergens; DMR; Differentially methylated region; GF; Germ-free; GWAS; Genome-wide association study; OVA; Ovalbumin; PAH; Polyaromatic hydrocarbon; PM; Particulate matter;
A multi-view OVA model based on decision tree for multi-classification tasks
Keywords: Decision tree; Multi-class classification; OVA; Membership vector;
Bcl-2 inhibitors reduce steroid-insensitive airway inflammation
Keywords: Airway inflammation; eosinophil; neutrophil; apoptosis; Bcl-2; steroid insensitive; AHR; Airway hyperresponsiveness; BAL; Bronchoalveolar lavage; CFA; Complete Freund adjuvant; FACS; Fluorescence-activated cell sorting; OVA; Ovalbumin; PE; Phycoerythrin;
MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2
Keywords: Severe asthma; corticosteroids; airway hyperresponsiveness; miR-21; PI3 kinase; histone deacetylase 2; Chlamydia species; Haemophilus influenzae; influenza; respiratory syncytial virus; AAD; Allergic airway disease; AHR; Airway hyperresponsiveness; Ant-21
Exosomes: Therapy delivery tools and biomarkers of diseases
Keywords: AAV; adeno-associated virus; APC; antigen-presenting cell; CNS; central nervous system; CSF; cerebrospinal fluid; DC; dendritic cell; EBV; Epstein-Barr virus; EGFR; epidermal growth factor receptor; EEF; eukaryotic elongation factors; ESCRT; endosomal-sor
Staphylococcal serine protease-like proteins are pacemakers of allergic airway reactions to Staphylococcus aureus
Keywords: Asthma; IgE; Staphylococcus aureus; serine protease-like proteins; type 2 inflammation; APC; Allophycocyanin; BALF; Bronchoalveolar lavage fluid; FITC; Fluorescein isothiocyanate; Hla; Staphylococcus aureus α-hemolysin; OVA; Ovalbumin; PE; Phycoerythrin;
MicroRNA-155 is a critical regulator of type 2 innate lymphoid cells and IL-33 signaling in experimental models of allergic airway inflammation
Keywords: miR-155; ILC2; IL-33; IL-13; allergy; asthma; eosinophils; ILC2; Type 2 innate lymphoid cell; miR; MicroRNA; OVA; Ovalbumin; WT; Wild-type;
Allergen endotoxins induce T-cell-dependent and non-IgE-mediated nasal hypersensitivity in mice
Keywords: Allergic rhinitis; CD4+ TÂ cell; endotoxin; histamine; hypersensitivity; IgE; monocyte/macrophage; nonallergic rhinitis; LPS; AR; Allergic rhinitis; DT; Diphtheria toxin; Ec-OVA; Endotoxin-containing OVA; Ef-OVA; Endotoxin-free OVA; ILC2; Group 2 innate l
Combining Type I Interferons and 5-Aza-2â²-Deoxycitidine to Improve Anti-Tumor Response against Melanoma
Keywords: DAC; decitabine; ISG; interferon-stimulated gene; MDSC; myeloid-derived suppressor cell; MTS; 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium; OVA; ovalbumin; PBMC; peripheral blood mononuclear cell; Treg; regulato
Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects
Keywords: Allergy protection; dendritic cells; endosomal acidification; Lactococcus lactis G121; pattern recognition receptor; Toll-like receptor 13; Toll-like receptor 8; bacterial RNA; Baf A1; Bafilomycin A1; BMDC; Bone marrow-derived dendritic cell; cfu; Colon
Piper nigrum extract ameliorated allergic inflammation through inhibiting Th2/Th17 responses and mast cells activation
Keywords: Piper nigrum; Allergic asthma; Mast cells; Th1/Treg; Th2/Th17; Anti-OVA specific IgE; PNE; Piper nigrum extract; Dex; Dexamethasone; OVA; ovalbumin; DMSO; dimethylsulfoxide; PBS; phosphate-buffered saline; BALF; bronchoalveolar lavage fluid; Ig; immunoglo
Lifelong memory responses perpetuate humoral TH2 immunity and anaphylaxis in food allergy
Keywords: IgE; mast cells; memory B cells; plasma cells; TH2; food allergy; anaphylaxis; IgG1; peanut allergy; germinal centers; APC; Allophycocyanin; BM; Bone marrow; BZ; Bortezomib; CD40L; CD40 ligand; CFSE; Carboxyfluorescein succinimidyl ester; CYC; Cyclophosph
TIPS pentacene loaded PEO-PDLLA core-shell nanoparticles have similar cellular uptake dynamics in M1 and M2 macrophages and in corresponding in vivo microenvironments
Keywords: Asthma; LPS; Nanoparticle; Pulmonary drug delivery; Inflammation; PEG; polyethylene glycol; Th1; T helper cell type 1; Th2; T helper cell type 2; AAMs; alternatively activated macrophage; PLGA; poly(lactide-co-glycolide); LiLa; lipid-latex hybrid; PtdSer;
IL-33 dysregulates regulatory T cells and impairs established immunologic tolerance in the lungs
Keywords: Regulatory T cells; TH2 cells; IL-33; allergy; asthma; lung; APC; Antigen-presenting cell; BAL; Bronchoalveolar lavage; DC; Dendritic cell; eGFP; Enhanced green fluorescent protein; FACS; Fluorescence-activated cell sorting; Foxp3; Forkhead box P3; HDM; H
Follicular helper T cells mediate IgE antibody response to airborne allergens
Keywords: Follicular T cells; IL-4; IgE; allergy; allergens; TH2 cells; APC; Antigen-presenting cell; BAL; Bronchoalveolar lavage; eGFP; Enhanced green fluorescent protein; FACS; Fluorescence-activated cell sorting; GC; Germinal center; HDM; House dust mite; ICOS;
Protein kinase Cθ controls type 2 innate lymphoid cell and TH2 responses to house dust mite allergen
Keywords: House dust mite; allergic asthma; eosinophils; protein kinase Cθ; innate lymphoid cells; nuclear factor of activated T cells; interferon regulatory factor 4; BAL; Bronchoalveolar lavage; BALF; Bronchoalveolar lavage fluid; BMDC; Bone marrow-derived den
Ethnopharmacological communicationGlabretal-type triterpenoid from the root bark of Dictamnus dasycarpus ameliorates collagen-induced arthritis by inhibiting Erk-dependent lymphocyte proliferation
Keywords: CFSE; carboxyfluorescein succinimidyl ester; ChIP; chromatin immunoprecipitation; CIA; collagen induced arthritis; IRE; internal regulatory element; OVA; ovalbumin peptide; PI; propidium iodide; URE; upstream regulatory element; Cell cycle; Collagen induc
IL-13 Signals Independent of IL-4 Receptor-Alpha Chain to Drive Ovalbumin-Induced Dermatitis
Keywords: AD; atopic dermatitis; ERK; extracellular signal-regulated kinase; MAPK; mitogen-activated protein kinase; OVA; ovalbumin; PBS; phosphate buffered saline; Rα; receptor-alpha; Th2; T helper 2; TGF; transforming growth factor;
Abietic acid attenuates allergic airway inflammation in a mouse allergic asthma model
Keywords: Abietic acid; OVA; Asthma; NF-κB;
Purification of recombinant ovalbumin from inclusion bodies of Escherichia coli
Keywords: E. coli; Escherichia coli; ova; ovalbumin; SDS; sodium dodecyl sulfate; PAGE; polyacrylamide gel electrophoresis; CD; circular dichroism; LB; Luria Bertani; IPTG; isopropyl β-d-thio galactopyranoside; HPLC; high performance liquid chromatography; IBs; in
Stratified analysis of lectin-like chaperones in the folding disease-related metabolic syndrome rat model
Keywords: Endoplasmic reticulum; Chaperone; Diabetes mellitus; Obesity; Protein interaction; Aggregation; CRT; calreticulin; CNX; calnexin; d-OVA; denatured ovalbumin; ER; endoplasmic reticulum; MDH; malate dehydrogenase; OVA; ovalbumin; TBS; Tris-buffered saline;
Production of a soluble single-chain variable fragment antibody against okadaic acid and exploration of its specific binding
Keywords: Okadaic acid; CLEIA; Single-chain variable fragment; Binding complex; OA; okadaic acid; DSP; diarrhetic shellfish poisoning; ELISA; enzyme-linked immunosorbent assay; scFv; single-chain variable fragment; CDR; complementarity-determining region; PDB; Prot
TIM-3 is not essential for development of airway inflammation induced by house dust mite antigens
Keywords: Allergy; Asthma; House dust mite; Mouse; TIM-3; BALF; Bronchoalveolar lavage fluid; HDM; House dust mite; OVA; Ovalbumin; TIM-3; T cell immunoglobulin domain and mucin domain-containing molecule 3;
Research paperMyD88 modulates eosinophil and neutrophil recruitment as well as IL-17A production during allergic inflammation
Keywords: AHR; airway hyperreactivity; BALF; bronchoalveolar lavage fluid; mDC; myeloid dendritic cell; MyD88; myeloid differentiation factor 88; NOD; non-obese diabetic; OVA; ovalbumin; PBS; phosphate-buffered saline; Penh; enhanced pause; TLR; Toll-like receptor;
Epicutaneous (EC) immunization with type II collagen (COLL II) induces CD4+ CD8+ T suppressor cells that protect from collagen-induced arthritis (CIA)
Keywords: Ab; antibody; ALNC; axillary and inguinal lymph node cells; anti-CPP; Anti-cyclic citrullinated peptide; CFA; complete Freund's adjuvants; CHS; contact hypersensitivity reactions; CIA; collagen-induced arthritis; COLL II; type II collagen; EAE; experiment
Klf10 deficiency in mice exacerbates pulmonary inflammation by increasing expression of the proinflammatory molecule NPRA
Keywords: ANP; Atrial natriuretic peptide; BAL; Bronchoalveolar lavage fluid; cGMP; Cyclic guanosine monophosphate; ChIP-PCR; Chromatin immunoprecipitation-polymerase chain reaction; COPD; Chronic obstructive pulmonary disease; EMSA; Electrophoretic mobility shift
Kinin B1 receptor antagonist BI113823 reduces allergen-induced airway inflammation and mucus secretion in mice
Keywords: OVA; ovalbumin; BAL; bronchoalveolar lavage; COX; cyclooxygenase; MMP; matrix metalloproteinase; iNOS; inducible nitric oxide synthase; PAS; periodic acid of schiff; LPS; lipopolysaccharides; TNF-α; tumor necrosis factor alpha; IL-1β; interleukin 1-beta
EpCAM Expressed by Murine Epidermal Langerhans Cells Modulates Immunization to an Epicutaneously Applied Protein Antigen
Keywords: Ab; antibody; Ag; antigen; DC; dendritic cell; EpCAM; epithelial cell adhesion molecule; ETA; exotoxin; KO; knockout; LC; Langerhans cell; LN; lymph node; MHCII; MHC class II antigen; Ova; ovalbumin; PKC; protein kinase C; SG; stratum granulosum; TJ; tigh
Pheretima aspergillum decoction suppresses inflammation and relieves asthma in a mouse model of bronchial asthma by NF-κB inhibition
Keywords: Respiratory system; Hypoxanthine (PubChem CID: 790); Choline (PubChem CID: 305); l-alanine (PubChem CID: 5950); l-lysine (PubChem CID: 5962); l-leucine (PubChem CID: 6106); l-valine (PubChem CID: 6287); OVA; Asthma; Traditional Chinese medicine; Airway; E
Staphylococcus aureus PSM peptides induce tolerogenic dendritic cells upon treatment with ligands of extracellular and intracellular TLRs
Keywords: DC; dendritic cell; PSM; phenol-soluble modulin; TLR; Toll-like receptor; Treg; regulatory T cell; CA; community-associated; MRSA; methicillin-resistant Staphylococcus aureus; FPR2; formyl peptide receptor 2; BMDC; bone marrow-derived DC; OVA; ovalbumin;
Anti-inflammatory properties of an isoxazole derivative - MZO-2
Keywords: AFC; antibody forming cells; cFa; complete Freund's adjuvant; COX; cyclooxygenase; CsA; cyclosporine; Dex; dexamethasone; DMSO; dimethylsulfoxide; FCS; fetal calf serum; iFa; incomplete Freund's adjuvant; LPS; lipopolysaccharide; MTT; (3-[4,5-dimethylthia