The role of Litopenaeus vannamei p38 in white spot syndrome virus infection
Keywords: p38; Litopenaeus vannamei; WSSV; Gene silencing; Host defense
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Chondroprotective effects and multi-target mechanisms of Icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model
Keywords: Icariin; Osteoarthritis; Matrix metalloproteinase-13; p38; JNK; β-catenin;
Hypericum caprifoliatum and Hypericum connatum affect human trophoblast-like cells differentiation and Ca2+ influx
Keywords: BeWo; JEG-3; Hypericaceae; ERK1/2; p38; Ca2+ influx
Role of p38, ERK1/2, focal adhesion kinase, RhoA/ROCK and cytoskeleton in the adipogenesis of human mesenchymal stem cells
Keywords: p38; ERK1/2; Focal adhesion kinase; RhoA/ROCK; Cytoskeleton; Adipogenesis
Urokinase-type plasminogen activator (uPA) stimulates triglyceride synthesis in Huh7 hepatoma cells via p38-dependent upregulation of DGAT2
Keywords: Urokinase; Triglycerides; DGAT2; p38; PPARα; Fatty acids;
Er-Miao-San, a traditional herbal formula containing Rhizoma Atractylodis and Cortex Phellodendri inhibits inflammatory mediators in LPS-stimulated RAW264.7 macrophages through inhibition of NF-κB pathway and MAPKs activation
Keywords: Er-Miao-San; Nitric oxide; Inducible nitric oxide synthase; P38; Nuclear factor-κB; Traditional Chinese medicine;
PPM1B depletion induces premature senescence in human IMR-90 fibroblasts
Keywords: Cellular senescence; PP2C; PPM1B; p53; p38; MAPKHDF, human diploid fibroblast; SA, senescence-associated; GUSB, β-glucuronidase; PAI, plasminogen activator inhibitor type 1; X-Gal, 5-bromo-4-chloro-3-indolyl β-d-galactoside; RT-qPCR, reverse transcriptase
Molecular characterization and immunomodulatory activity of sulfated fucans from Agarum cribrosum
Keywords: NO; nitric oxide; iNOS; inducible NO synthase; TNF-α; tumor necrosis factor-α; COX-2; cyclooxygenase-2; IL; interleukin; NF-κB; nuclear factor-kappa B; MAPKs; mitogen-activated protein kinases; ERK; including extracellular signal-regulated kinases; JNK
p38α regulates SERCA2a function
Keywords: Phospholamban; SERCA2a; p38; Cardiac contractilityAMVM, adult mouse ventricular myocyte; ARVM, adult rat ventricular myocyte; dn, dominant negative; ET-1, endothelin-1; GRK, G protein coupled receptor kinase; I-1, inhibitor-1; MAPK, mitogen-activated prot
Role of extracellular signal-regulated kinases 1 and 2 and p38 mitogen-activated protein kinase pathways in regulating replication of Penicillium marneffei in human macrophages
Keywords: Penicillium marneffei; Macrophages; Tumor necrosis factor-α; ERK 1/2; p38
Abrus precatorius agglutinin-derived peptides induce ROS-dependent mitochondrial apoptosis through JNK and Akt/P38/P53 pathways in HeLa cells
Keywords: Abrus agglutinin derived peptides; ROS; p38; JNK; Apoptosis and autophagy; Hollow fiber assay
Genistein induces morphology change and G2/M cell cycle arrest by inducing p38 MAPK activation in macrophages
Keywords: Genistein; Macrophage; Morphology; Cell cycle; p38; Phagocytosis;
Adipocyte-derived factors impair insulin signaling in differentiated human vascular smooth muscle cells via the upregulation of miR-143
Keywords: Vascular smooth muscle cells; Insulin signaling; p38; Adipokines; miRNA;
Tiliroside, a dietary glycosidic flavonoid, inhibits TRAF-6/NF-κB/p38-mediated neuroinflammation in activated BV2 microglia
Keywords: Tiliroside; NF-κB; p38; TRAF-6; Neuroinflammation; Antioxidant;
Activation of p38 and changes in mitochondria accompany autophagy to premature senescence-like phenotype switch upon chronic exposure to selenite in colon fibroblasts
Keywords: Sodium selenite; Colonic fibroblasts; p38; Premature senescence; Mitochondria; Autophagy
Involvement of MAPK signaling pathway in the osteogenic gene expressions of Cervi Pantotrichum Cornu in MG-63 human osteoblast-like cells
Keywords: Cervi Pantotrichum Cornu; Osteoblast; MG-63; MAPK; ERK1/2; JNK1/2; p38; ELK1; cJUN; COL1A1; ALPL; BGLAP; SPP1
Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence
Keywords: oncogene-induced senescence; p38; phosphoinositide 3-kinase; AKT
TEGDMA-induced oxidative DNA damage and activation of ATM and MAP kinases
Keywords: Dental resin; TEGDMA; DNA oxidation; ATM; p38; ERK1/2
Surface layer proteins isolated from Clostridium difficile induce clearance responses in macrophages
Keywords: Clostridium difficile; Surface layer proteins; Macrophage; Cytokine; Phagocytosis; p38
Hepatitis C virus core protein enhances HIV-1 replication in human macrophages through TLR2, JNK, and MEK1/2-dependent upregulation of TNF-α and IL-6
Keywords: APCs; antigen-presenting cells; ERK; extracellular signal-regulated protein kinase 1/2; HKLM; heat killed Listeria monocytogenes; IL-6; interleukin 6; JNK; c-Jun amino-terminal kinase; MDMs; primary monocyte derived macrophages; p38; p38 MAP kinase; PD980
Map2k4δ - Identification and functional characterization of a novel Map2k4 splice variant
Keywords: AKT; protein kinase B; ATF-2; activating transcription factor 2; BrdU; 5-bromo-2-deoxyuridine; DVD; domain of versatile docking; E; embryonic day; ERK; extracellular signal-regulated kinase; Fas-L; Fas ligand; ID; immunodepletion; IP; immunoprecipitation;
Chronic blockade of extrasynaptic NMDA receptors ameliorates synaptic dysfunction and pro-death signaling in Huntington disease transgenic mice
Keywords: Huntington disease; NMDA receptor; GluN2B; Extrasynaptic; p38; pCREB; Calpain; Calcium signaling; Striatum; Memantine;
Essential role of IL-10/STAT3 in chronic stress-induced immune suppression
Keywords: TLR4, toll-like receptor 4; WT, wild-type; KO, knockout; DC, dendritic cell; IHC, immunohistochemistry; Th1, T helper-1; Th2, T helper-2TLR4; STAT3; p38; Chronic stress; Apoptosis; Immune suppression
A novel compound RY10-4 induces apoptosis and inhibits invasion via inhibiting STAT3 through ERK-, p38-dependent pathways in human lung adenocarcinoma A549 cells
Keywords: RY10-4; ERK; p38; STAT3; Lung cancer;
Human cord blood stem cell paracrine factors activate the survival protein kinase Akt and inhibit death protein kinases JNK and p38 in injured cardiomyocytes
Keywords: Akt; apoptosis; JNK; myocytes; p38; umbilical cord stem cells;
Identification and analysis of CD133+ melanoma stem-like cells conferring resistance to taxol: An insight into the mechanisms of their resistance and response
Keywords: Cancer stem cells; CD133; Apoptosis; Taxol; JNK; P38
Synthesis and anticancer activities of 4-(4-substituted piperazin)-5,6,7-trialkoxy quinazoline derivatives
Keywords: Quinazoline; Anticancer; ERK1/2; P38; Antiphosphorylation; Cell cycleAO/EB, acridine orange/ethidium bromide; 13C NMR, 13C Nuclear Magnetic Resonance; DMSO, dimethyl sulfoxide; LDH, lactate dehydrogenase; EGF, epidermal growth factor; EGFR, epidermal grow
Age-related activation of MKK/p38/NF-κB signaling pathway in lung: From mouse to human
Keywords: ALI; acute lung injury; ANOVA; analysis of variance; BALF; bronchoalveolar lavage fluid; COPD; chronic obstructive pulmonary disease; DAB; 3, 3â²-diaminobenzidine tetrahydrochloride; DAPI; 4â², 6-diamidino-2-phenylindole; DMSO; dimethyl sulphoxide; ERKs
Chronic tooth pulp inflammation induces persistent expression of phosphorylated ERK (pERK) and phosphorylated p38 (pp38) in trigeminal subnucleus caudalis
Keywords: ANOVA; analysis of variance; AOI; area of interest; CFA; complete Freund's adjuvant; Cy3; indocarbocyanine; EMG; electromyogram; ERK; extracellular signal-regulated kinase; FITC; fluorescein isothiocyanate; GFAP; glial fibrillary acidic protein; JOR; Ja
Neuroprotection elicited by P2Y13 receptors against genotoxic stress by inducing DUSP2 expression and MAPK signaling recovery
Keywords: CaMKII; calcium/calmodulin kinase II; CREB; (cAMP-response-element-binding protein)-binding protein; DAPI; 2-(4-amidinophenyl)-1H-indole-6-carboxamidine; DUSP; dual-specificity phosphatase; ERK; extracellular-signal-regulated kinase; JNK; c-Jun Kinase; 2M
Thermogenic adipocytes: From cells to physiology and medicine
Keywords: ATP; adenosine triphosphate; BAT; brown adipose tissue; BMI; body mass index; Bmp; bone morphogenetic protein; cPGI2; carbaprostacyclin; cAMP; cyclic adenosine monophosphate; C/EBPβ; CCAAT/enhancer binding protein β; cGMP; cyclic guanosine monophosphate
p38 MAP kinase enhances EGF-induced apoptosis in A431 carcinoma cells by promoting tyrosine phosphorylation of STAT1
Keywords: A431 cells; Epidermal growth factor; MAP kinase; p38; STAT1; Tyrosine phosphorylation;
Baicalin plays an anti-inflammatory role through reducing nuclear factor-κB and p38 phosphorylation in S. aureus-induced mastitis
Keywords: Baicalin; S. aureus mastitis; Anti-inflammation; Nuclear factor-kappaB (NF-κB); p38;
Insulin-like growth factor-1 induces MUC8 and MUC5B expression via ERK1 and p38 MAPK in human airway epithelial cells
Keywords: Insulin-like growth factor-1; MUC8; MUC5B; ERK1; p38; Airway epithelial cell;
The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode
Keywords: p38; Kinase; Inhibitors;
Attenuated expression of the tight junction proteins is involved in clopidogrel-induced gastric injury through p38 MAPK activation
Keywords: DAPI; 4â²,6-diamidino-2-phenylindole; DMSO; dimethyl sulfoxide; ERK; extracellular signal-regulated kinase; FITC; fluorescein isothiocyanate; GES-1; immortalized human gastric epithelial cells line; GI; gastrointestinal; HBSS; Hank's Balanced Salt Soluti
CD34+ cells from patients with myelodysplastic syndrome present different p21 dependent premature senescence
Keywords: Myelodysplastic syndromes; CD34+ cells; Senescence; Reactive oxygen species; DNA damage; p21; p38;
Targeting hyaluronic acid production for the treatment of leukemia: Treatment with 4-methylumbelliferone leads to induction of MAPK-mediated apoptosis in K562 leukemia
Keywords: CML; Hyaluronic acid; Apoptosis; p38;
Activation of TAK1 by Sef-S induces apoptosis in 293T cells
Keywords: Ub; ubiquitin; Ub; nubiquitination; wt; wild type; FBS; fetal bovine serum; IgG; immunoglobulin G; SPRED; Sprouty-related EVH1-domain containing; FGF; fibroblast growth factor; Sef; Erk1/2; JNK; p38; MAPK; Apoptosis;
TRAIL/MEKK4/p38/HSP27/Akt survival network is biphasically modulated by the Src/CIN85/c-Cbl complex
Keywords: TRAIL; tumor necrosis factor-related apoptosis-inducing ligand; CIN85; c-Cbl interacting protein of 85Â kDa; DR4/5; death receptor 4/5; TRAF4; TNF receptor-associated factor 4; GADD45; growth arrest and DNA damage induced gene-45; HSP27; heat shock protei
Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic à cell exhaustion
Keywords: Ins2; Insulin 2 protein; ER; endoplasmic reticulum; ASK1; apoptosis signal-regulating kinase 1; UPR; unfolded protein response; PERK; protein kinase RNA-like ER kinase; ATF6; activating transcription factor 6; IRE1; inositol-requiring enzyme 1; ERAD; ER-a
The role of p38 in irinotecan-induced DNA damage and apoptosis of colon cancer cells
Keywords: Colon cancer; Irinotecan; p38; Apoptosis; DNA damage;
Anti-inflammatory effect and selectivity profile of AS1940477, a novel and potent p38 mitogen-activated protein kinase inhibitor
Keywords: p38; Mitogen-activated protein kinase; Inhibitor; Lipopolysaccharide; Tumor necrosis factor α; Interleukin-6;
Neuroprotective effects of Polygonum multiflorum extract against glutamate-induced oxidative toxicity in HT22 hippocampal cells
Keywords: Polygonum multiflorum; Oxidative neurotoxicity; HT22 cell; ERK; p38;
Down-regulation of LRRK2 in control and DAT transfected HEK cells increases manganese-induced oxidative stress and cell toxicity
Keywords: LRRK2; leucine-rich repeat kinase 2; DAT; dopamine transporter; DA; dopamine; Mn; manganese; HEK; human embryonic kidney; ROS; reactive oxygen species; JNK; c-Jun N-terminal kinases; p38; 38 mitogen-activated protein kinase; AP13A2; probable cation-transp
Artemisia leaf extract induces apoptosis in human endometriotic cells through regulation of the p38 and NFκB pathways
Keywords: Endometriosis; Traditional medicine in Asia and Oceania; Artemisia princeps; Apoptosis; p38; NFκB;
Cytokine regulation by MAPK activated kinase 2 in keratinocytes exposed to sulfur mustard
Keywords: SM; sulfur mustard; NHEK; normal human epidermal keratinocytes; MAPK; mitogen activated protein kinase; siRNA; small interfering RNA; MK2/MAPKAPK2; MAPK activated kinase 2; MK3/MAPKAPK3; MAPK activated kinase 3; MK5/MAPKAPK5; MAPK activated kinase 5; TNF-
The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo
Keywords: Sorafenib; Ruthenium; Drug accumulation; P38; STAT3; Cell cycle arrest; Synergism;
Molecular mechanisms involved in interleukin 1-beta (IL-1β)-induced memory impairment. Modulation by alpha-melanocyte-stimulating hormone (α-MSH)
Keywords: IL-1β; Memory consolidation; α-MSH; Glutamate release; p38; ERK; BDNF;
Effect of oxymatrine, the active component from Radix Sophorae flavescentis (Kushen), on ventricular remodeling in spontaneously hypertensive rats
Keywords: Oxymatrine; Radix Sophorae flavescentis (Kushen); SHR; Ventricular remodeling; Gene overexpression; Signaling pathway; ACE; angiotensin converting enzyme; Ang II; angiotensin II; BSA; bovine serum albumin; BW; body weight; CHF; congestive heart failure; E