Heteroactivator effects on the coupling and spin state equilibrium of CYP2C9
Keywords: Cytochrome P450; P450; CYP; Heteroactivation; Coupling; Shunting; Atypical kinetics;
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Spook and Spookier code for stage-specific components of the ecdysone biosynthetic pathway in Diptera
Keywords: Ecdysone; Molting; CYP; p450;
The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome
Keywords: Defense; Toxicity; P450; Nuclear receptor; MRP; PGP; AHR; Coregulation; Oxidative stress; Detoxification;
The haloperoxidase of the agaric fungus Agrocybe aegerita hydroxylates toluene and naphthalene
Keywords: AaP, Agrocybe aegerita peroxidase; CPO, chloroperoxidase; P450, cytochrome P450 enzymeHaloperoxidase; P450; Peroxygenase; Toluene; Naphthalene; Agrocybe
Early years of oxygenase research in Bethesda, Osaka, Urbana, and Kanazawa
Keywords: CYP101; Flavoprotein; Hydroxylation; Oxygenase; P450; P450cam; P450scc; P45011β; Pyrocatechase; Salicylate hydroxylase;
P450 aromatase inhibition assay using a competitive ELISA
Keywords: Aromatase; P450; Inhibition; ELISA; Endocrine disruptors; Drug discovery; High throughput screening;
Reactivity of a new class of P450 enzyme models
Keywords: Enzyme models; P450; Heme-thiolate proteins; Iron porphyrins; Catalysis; Epoxidation; Hydroxylation; N-Dealkylation; Diol cleavage;
Molecular identity and gene expression of aldosterone synthase cytochrome P450
Keywords: Aldosterone synthase; 11β-Hydroxylase; Salt-inducible kinase; CYP11B1; CYP11B2; P450;
Mutagenic activation of betel quid-specific N-nitrosamines catalyzed by human cytochrome P450 coexpressed with NADPH-cytochrome P450 reductase in Salmonella typhimurium YG7108
Keywords: Areca nut; Betel leaf; 3-(N-Nitrosomethylamino)propionitrile; 3-(N-Nitrosomethylamino)propionaldehyde; N-Nitrosoguvacoline; Metabolic activation; Genetically engineered S. typhimurium; CPR; NADPH-cytochrome P450 reductase (EC 1.6.2.4, NADPH:ferrihemoprote
The last step in the biosynthesis of aryl carotenoids in the cheese ripening bacteria Brevibacterium linens ATCC 9175 (Brevibacterium aurantiacum sp. nov.) involves a cytochrome P450-dependent monooxygenase
Keywords: Carotenoid; Brevibacterium linens; Brevibacterium aurantiacum; P450; Hydroxylation; Isorenieratene; Tetcyclacis;
CYP1A1 genotype-selective inhibition of benzo[a]pyrene activation by quercetin
Keywords: P450; Cytochrome P450; CYP1A1; Human cytochrome P450 1A1; P450 reductase; Human NADPH-cytochrome P450 reductase; B[a]P; Benzo[a]pyrene; 7,8-diol-B[a]P; (±)-trans -7,8-dihydro-7,8-dihydroxy-B[a]P; Diolepoxide 1; (±)-B[a]P-r-7,t-8-dihydrodiol-c-9,10-epoxi
Engineering the substrate specificity of cytochrome P450 CYP102A2 by directed evolution: production of an efficient enzyme for bioconversion of fine chemicals
Keywords: BMP; the heme domain of P450 BM3; CPR; NADPH: cytochrome P450 reductase; CYP; cytochrome P450; CYP102 or P450 BM3; cytochrome P450 monooxygenase from Bacillus megaterium; CYP102A2; cytochrome P450 monooxygenase from Bacillus subtilis; FAD; flavin adenine
Structural biology of heme monooxygenases
Keywords: P450; Peroxidase; Heme oxygenase; Nitric oxide synthase; Crystallography; Oxygen activation;
Use of directed evolution of mammalian cytochromes P450 for investigating the molecular basis of enzyme function and generating novel biocatalysts
Keywords: Cytochrome P450; P450; Directed evolution; Random mutagenesis; Biocatalysts;
Chloroperoxidase-catalyzed oxidation of 4,6-dimethyldibenzothiophene as dimer complexes: Evidence for kinetic cooperativity
Keywords: Chloroperoxidase; P450; Dibenzothiophene; Ligand interaction; Enzyme kinetics; Ï-Ï Dimer; Fluorescence;
Effects of nonylphenol on hepatic testosterone metabolism and the expression of acute phase proteins in winter flounder (Pleuronectes americanus): Comparison to the effects of Saint John's Wort
Keywords: Nonylphenol; PXR; P450; CYP3A; Testosterone metabolism; Acute phase proteins; Flounder; Gene expression;
Thermal inactivation of the reductase domain of cytochrome P450 BM3
Keywords: Cytochrome; P450; BM3; BMR; Reductase; Thermal stability; Inactivation; Domain;
Essential Role of Singlet Oxygen Species in Cytochrome P450-dependent Substrate Oxygenation by Rat Liver Microsomes
Keywords: cytochrome P450; CYP2E1; p-nitrophenol hydroxylation; singlet oxygen (1O2); electron spin resonance-spin trapping; rate constant; P450; Cytochrome P450; NADPH; nicotinamide adenine dinucleotide phosphate reduced form; NADH; nicotinamide adenine dinucleoti
Propiconazole-induced cytochrome P450 gene expression and enzymatic activities in rat and mouse liver
Keywords: Propiconazole; PCR; P450; Alkoxyresorufin O-dealkylation; Gene expression quantitative real-time RT-PCR;
Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4
Keywords: Trazodone; Metabolite; Bioactivation; P450; Hepatotoxicity; Oxidation;
Differences between the structural requirements for ABA 8′-hydroxylase inhibition and for ABA activity
Keywords: ABA; Abscisic acid; P450
The basis for the safening of clomazone by phorate insecticide in cotton and inhibitors of cytochrome P450s
Keywords: Clomazone; Safening; Phorate; Cotton; Corn; P450; Microsomes; 5-OH clomazone; P450 inhibitors;
Molecular and biochemical mechanisms in teratogenesis involving reactive oxygen species
Keywords: ASA; acetylsalicylic acid; ATM; ataxia telangiectasia mutated; COX; cyclooxygenase (PHS component); CYP; cytochromes P450; ETYA; eicosatetraynoic acid; G6PD; glucose-6-phosphate dehydrogenase; GSH; glutathione; iNOS; inducible nitric oxide synthase; IR; i
Possible Involvement of Singlet Oxygen Species as Multiple Oxidants in P450 Catalytic Reactions
Keywords: cytochrome P450; P450 catalytic cycle; substrate oxygenation; multiple activated oxygen species; singlet oxygen (1O2); electron spin resonance (ESR); ESR-spin trapping; P450; Cytochrome P450; NADPH; nicotinamide adenine dinucleotide phosphate reduced form
CAR and PXR: Xenosensors of endocrine disrupters?
Keywords: PXR; CAR; Endocrine disruption; Metabolism; P450; Detoxification;
Herbivore-induced, indirect plant defences
Keywords: ACC; 1-aminocyclopropane-1-carboxylic acid; ALA; alamethicin; CAM; calmodulin; CDPK; calcium-dependent protein kinase; DMNT; (E)-4,8-dimethyl-1,3,7-nonatriene; EAG; electroantennogram; EF; extrafloral; EFN; extrafloral nectar; ERF; ethylene-responsive tra