Site dependent intestinal absorption of darunavir and its interaction with ketoconazole
Keywords: Darunavir; P-gp; P450; Ketoconazole; Site dependent absorption; In situ perfusion
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Multiple P450 genes: Identification, tissue-specific expression and their responses to insecticide treatments in the oriental fruit fly, Bactrocera dorsalis (Hendel) (Diptera: Tephritidea)
Keywords: Oriental fruit fly; P450; Transcriptional profiles; Insecticide metabolismCYP, cytochrome P450; FB, fat body; GSPs, gene specific primers; M, midgut; MT, Malpighian tubule; RT-qPCR, real-time quantitative PCR; UTR, untranslated region
Peroxidase activity stabilization of cytochrome P450BM3 by rational analysis of intramolecular electron transfer
Keywords: Electron-transfer; Molecular mechanics; Peroxidase; P450; QM/MM; Stabilization
Studies on the in vivo contribution of human cytochrome P450s to the hepatic metabolism of glaucine, a new drug of abuse
Keywords: Glaucine; Isomers; HLM; P450; Metabolism; Kinetics
Monkey liver cytochrome P450 2C19 is involved in R- and S-warfarin 7-hydroxylation
Keywords: P450; general term for cytochrome P450 (EC 1.14.14.1); Cynomolgus monkey; Human; CYP2C19; CYP2C9; Stereoselectivity;
Cytochrome P450BM-3 reduces aldehydes to alcohols through a direct hydride transfer
Keywords: P450; cytochrome P450; BM-3; Bacillus megaterium cytochrome P450 102A1; CPR; cytochrome P450 reductase; BMR; P450BM-3 reductase domain; BMP; heme domain of P450BM-3; MBA; p-methoxy-benzaldehyde; WT; wild type enzyme;
Cytochrome P450 in fluke Opisthorchis felineus: Identification and characterization
Keywords: Opisthorchis felineus; Fluke; P450; Biotransformation enzymes;
Influence of insecticide Bacillus thuringiensis subsp. israelensis treatments on resistance and enzyme activities in Aedes rusticus larvae (Diptera: Culicidae)
Keywords: Bacillus thuringiensisisraelensis; Detoxifying enzymes; Mosquito resistance; Aedes rusticus; Glutathione S-transferase; Bti; GST; P450; Esterase
Lead exposure improves the tolerance of Spodoptera litura (Lepidoptera: Noctuidae) to cypermethrin
Keywords: Lead (Pb); Insecticide tolerance; Spodoptera litura; Cypermethrin; P450
Crystal structure of cytochrome P450 CYP105N1 from Streptomyces coelicolor, an oxidase in the coelibactin siderophore biosynthetic pathway
Keywords: P450; CYP105N1; Streptomyces coelicolor; Coelibactin; Estradiol;
Construction and characterization of a Yarrowia lipolytica mutant lacking genes encoding cytochromes P450 subfamily 52
Keywords: Yarrowia lipolytica; cytochrome P450ALK; n-alkane; ACS; acyl-CoA synthetase; ARE1; alkane responsive element 1; bHLH; basic helix-loop-helix; ER; endoplasmic reticulum; FADH; fatty alcohol dehydrogenase; FALDH; fatty aldehyde dehydrogenase; FAOD; fatty al
Basal and 3-methylcholanthrene-induced expression of cytochrome P450 1A, 1B and 1C genes in the Brazilian guppy, Poecilia vivipara
Keywords: P450; CYP1A; Fish; Poecilia vivipara; PAH; Pollution;
Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs
Keywords: DIC; diclofenac; IBU; ibuprofen; IND; indomethacin; ETC; electron transport chain; KEP; ketoprofen; KER; ketorolac; MDR; multidrug resistance; NAP; naproxen; NSAID; non-steroidal anti-inflammatory drug; P450; cytochrome P450; ROS; reactive oxygen species;
Induction of cytochrome P450 3A by Shexiang Baoxin Pill and its main components
Keywords: P450; cytochrome P450; CYP3A; cytochrome P450 3A; DDI; drug-drug interaction; TCM; traditional Chinese medicine; SBP; Shexiang Baoxin Pill; MDZ; midazolam; CHD; coronary heart diseases; MUS; muscone; TES; testosterone; GRf; ginsenoside Rf; GRg1; ginseno
Brassinosteroids induce plant tolerance against phenanthrene by enhancing degradation and detoxification in Solanum lycopersicum L.
Keywords: Antioxidant; Brassinosteroid; Glutathione S-transferase; P450; Phenanthrene
Design, synthesis and evaluation of the inhibitory selectivity of novel trans-resveratrol analogues on human recombinant CYP1A1, CYP1A2 and CYP1B1
Keywords: P450; CYP1A1; CYP1A2; CYP1B1; trans-Stilbene derivatives; Molecular docking
The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: Quantification of steroid intermediates and end products in H295R cells
Keywords: P450; cytochrome P450; 3βHSD; 3β-hydroxysteroid dehydrogenase II; CYP11A1; cytochrome P450 side-chain cleavage; PREG; pregnenolone; CYP17A1; P450 17α-hydroxylase/1720 lyase; 17OH-PREG; 17-hydroxypregnenolone; DHEA; dehydroepiandrosterone; DHEA-S; dehyd
High-throughput enzyme evolution in Saccharomyces cerevisiae using a synthetic RNA switch
Keywords: Synthetic biology; High-throughput screen; RNA switch; P450;
Difficulties in dopamine transporter radioligand PET analysis: the example of LBT-999 using [18F] and [11C] labelling
Keywords: [18F]LBT-999; PET radiotracer; DAT; Radiometabolites; Tissue kinetics; P450;
Conformational dynamics of CYP3A4 demonstrate the important role of Arg212 coupled with the opening of ingress, egress and solvent channels to dehydrogenation of 4-hydroxy-tamoxifen
Keywords: P450; cytochrome P450 enzymes; 4OHT; 4-hydroxy-tamoxifen; SOM; sites of metabolism; RALX; raloxifene; P450; 4-Hydroxyâtamoxifen; Dehydrogenation; Molecular dynamics; Docking; Conformational dynamics;
NADPH-cytochrome P450 oxidoreductase: Prototypic member of the diflavin reductase family
Keywords: CYPOR; NADPH-cytochrome P450 oxidoreductase; CYPOR/POR; CYPOR gene; P450; cytochrome P450; cyt c; cytochrome c; cyt b5; cytochrome b5; NOS; nitric oxide synthase; iNOS; inducible NOS; nNOS; neuronal NOS; eNOS; endotherial NOS; NOSred; the reductase doma
Word frequency modulates the processing of emotional words: Convergent behavioral and electrophysiological data
Keywords: Word frequency; Emotion; Event-related potentials (ERPs); P450
The CYP701B1 of Physcomitrella patens is an ent-kaurene oxidase that resists inhibition by uniconazole-P
Keywords: GA; gibberellin; KO; ent-kaurene oxidase; P450; cytochrome P450 monooxygenase; UNI; uniconazole-P; Cytochrome P450; Diterpene; ent-Kaurene oxidase; ent-Kaurenoic acid; Gibberellin; Physcomitrella patens;
Reverse type I inhibitor of Mycobacteriumtuberculosis CYP125A1
Keywords: P450; CYP125; Mycobacterium tuberculosis; Cholesterol degradation; CYP125-inhibitor complex; X-ray structure;
ABA 9â²-hydroxylation is catalyzed by CYP707A in Arabidopsis
Keywords: Arabidopsis; Cruciferae; Abscisic acid; Catabolism; P450; CYP707A; Neophaseic acid; Phaseic acid;
Simultaneous determination of alfentanil and midazolam in human plasma using liquid chromatography and tandem mass spectrometry
Keywords: LC–MS/MS; P450; Alfentanil; Midazolam; Solid phase extraction; CYP3A
Reactive oxygen species alter autocrine and paracrine signaling
Keywords: Ad3A4; CYP3A4-expressing adenovirus; AdRSV; control adenovirus vector; AmR; amphiregulin; CD14; monocyte differentiation antigen; CYP2E1; cytochrome P450 2E1; CYP3A4; cytochrome P450 3A4; CYPH; cyclophilin A; ER; endoplasmic reticulum; ICAM1; intracellula
Heterologous expression and characterization of the sterol 14α-demethylase CYP51F1 from Candida albicans
Keywords: P450; CYP51; Lanosterol; Azole; Candida albicans;
The effects of nitrogen-heme-iron coordination on substrate affinities for cytochrome P450 2E1
Keywords: P450; CYP; 2E1; Type II binding; Nitrogen-iron coordination; QSAR;
MicroRNAs from biology to future pharmacotherapy: Regulation of cytochrome P450s and nuclear receptors
Keywords: MicroRNA; P450; CYP; Transcription factors; Post-transcriptional regulation
Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids
Keywords: P450; CYP1A1; CYP1B1; Cancer; Flavonoids; Chemoprevention; Homology modeling; Molecular docking
Induction of P450 3A1/2 and 2C6 by gemfibrozil in Sprague-Dawley rats
Keywords: induction; rat; P450; gemfibrozil
Identification of novel CYP2A6 inhibitors by virtual screening
Keywords: P450; CYP2A6; CoMFA; 3D-QSAR;
2′-Deoxyguanosine as a surrogate trapping agent for DNA reactive drug metabolites
Keywords: LC–MS/MS, liquid chromatography–tandem mass spectrometry; FAPy, formamidopyrimidine; EIC, extracted ion chromatogram; dG, 2′-deoxyguanosine; tR, retention time; RT, room temperatureReactive metabolites; DNA; Nucleoside; Trapping; LC–MS/MS; P450
Metabolism of bupropion by baboon hepatic and placental microsomes
Keywords: Vmax; maximum reaction velocity; Km; substrate concentration causing 50% of the reaction velocity; P450; cytochrome P450; IC50; concentration of compound causing 50% inhibition of the reaction; OH-BUP; hydroxybupropion; TB; threohydrobupropion; EB; erythr
Mutations of human cytochrome P450 reductase differentially modulate heme oxygenase-1 activity and oligomerization
Keywords: CYPOR; HO-1; P450; Reductase; Heme; Oxygenase; POR deficiency;
Metabolism of the herbicides chlorotoluron, diuron, linuron, simazine, and atrazine by CYP1A9 and CYP1C1 from Japanese eel (Anguilla japonica)
Keywords: Fish; HPLC; CYP; Monooxygenase; Herbicides; P450
The kinetic mechanism for cytochrome P450 metabolism of Type II binding compounds: Evidence supporting direct reduction
Keywords: P450; Type II binding; Kinetics; Drug metabolism
The reaction mechanism of allene oxide synthase: Interplay of theoretical QM/MM calculations and experimental investigations
Keywords: Allene oxide synthase; Hydroperoxide lyase; CYP74; QM/MM; Compound II; P450
In vitro liver metabolism of aclidinium bromide in preclinical animal species and humans: Identification of the human enzymes involved in its oxidative metabolism
Keywords: AB; aclidinium bromide; BChE; butyrylcholinesterase; CID; collision-induced dissociation; P450; cytochrome P450; ESI; electrospray ionization; FMO; flavin-containing monooxigenases; glyc; glycolyl; Kh; hydrolysis rate constant; LC; liquid chromatography;
Species-specific activation of nuclear receptors correlates with the response of liver drug metabolizing enzymes to EMD 392949 in vitro
Keywords: AhR; arylhydrocarbon receptor; bp; base pair; DME; drug metabolizing enzyme; DMEM; Dulbecco's modified Eagle's medium; EMD; EMD 392949; FBS; fetal bovine serum; nt; nucleotide(s); NXR; nuclear xenobiotic receptor; P450; cytochrome P450-dependent monooxyge
Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC–MS/MS—A high throughput approach to evaluate drug–drug interactions
Keywords: Drug–drug interaction; P450; Tolbutamide; Omeprazole; Midazolam; Dextromethorphan; LC–MS/MS; Incurred sample reproducibility (ISR)
Enhanced bioaccumulation of dietary contaminants in catfish with exposure to the waterborne surfactant linear alkylbenzene sulfonate
Keywords: ABC transporters; ATP-binding cassette transporters; BaP; benzo(a)pyrene; BCRP; breast cancer resistance protein; DPH; 1,6-diphenyl - 1, 3, 5 - hexatriene; IVM; ivermectin; LAS; linear alkylbenzene sulfonate, C-12, sodium dodecylbenzene sulfonate; Meq
Plant NADPH-cytochrome P450 oxidoreductases
Keywords: CPR; P450; Evolution; Structural domains; Electron transfer; Physiology; Homologs; Subcellular localization;
Pharmacogenetics and forensic toxicology
Keywords: Pharmacogenetics; Forensic toxicology; Polymorphism; P450; CYP2D6; Tramadol; Codeine; Antidepressants
Metabolism of carbosulfan II. Human interindividual variability in its in vitro hepatic biotransformation and the identification of the cytochrome P450 isoforms involved
Keywords: Pesticides; Xenobiotic; Risk assessment; In vitro metabolism; P450; LC–MS
Complex metabolism of aromatic glucosinolates in Pieris rapae caterpillars involving nitrile formation, hydroxylation, demethylation, sulfation, and host plant dependent carboxylic acid formation
Keywords: Carboxylic acid; Detoxification; Glucosinolate; Nitrilase; Nitrile; Nitrile-specifier protein; O-Demethylase; P450; Sulfate conjugate
The effects of type II binding on metabolic stability and binding affinity in cytochrome P450 CYP3A4
Keywords: P450; Metabolic stability; Type II binding; 3A4
Phytoremediation potential of the novel atrazine tolerant Lolium multiflorum and studies on the mechanisms involved
Keywords: Atrazine; Lolium multiflorum; P450; Phytoremediation; psbA gene
Biochemical basis for differences in metabolism-dependent genotoxicity by two diazinylpiperazine-based 5-HT2C receptor agonists
Keywords: Salmonella; Reactive metabolite; P450; DNA; Covalent binding; Glutathione; Cyanide; Amine