Ordered chimerogenesis applied to CYP2B P450 enzymes
Keywords: P450; CYP2B6; CYP2B11; Chimera; Cyclophosphamide; Channel;
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Preliminary characterization of a murine model for 1-bromopropane neurotoxicity: Role of cytochrome P450
Keywords: 1-Bromopropane; 1-Aminobenzotriazole; Hepatotoxicity; Neurotoxicity; Murine model; P450;
In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries
Keywords: Hepatotoxicity; DILI; Idiosyncratic hepatotoxicity; Individual differences; Risk factors; P450; CYP3A4; Acetaminophen; Cyclophosphamide; Ketoconazole; Tamoxifen; Human hepatocytes
Atypical profiles and modulations of heme-enzymes catalyzed outcomes by low amounts of diverse additives suggest diffusible radicals' obligatory involvement in such redox reactions
Keywords: Heme-enzymes; Redox reaction; Peroxidase; P450; Modulation; ABTS; 2,2â²-azino-bis(3-ethylbenzothiazoline-6-sulphonate); am; amaranth; Amt; amitrol; Asc; ascorbate; Azd; azide; CAT; catalase; CN; cyanide; CPO; chloroperoxidase; CV; crystal violet; cyt. c;
Gossypol toxicity and detoxification in Helicoverpa armigera and Heliothis virescens
Keywords: Insect plant interaction; Helicoverpa armigera; Heliothis virescens; Gossypol detoxification; Cytochrome P450; CYP6AE14; DMSO; dimethyl sulfoxide; P450; cytochrome P450 monooxygenase; SB-gossypol; Schiff base gossypol;
Pyriproxyfen is metabolized by P450s associated with pyrethroid resistance in An. gambiae
Keywords: Pyriproxyfen; Insecticide resistance; P450; Olyset Duo; PPF; pyriproxyfen; ALA; 5-Aminolevulinic acid; DEF; diethoxyfluorescein; CPR; cytochrome P450 reductase;
Oxylipin biosynthesis in spikemoss Selaginella moellendorffii: Molecular cloning and identification of divinyl ether synthases CYP74M1 and CYP74M3
Keywords: DES; divinyl ether synthase; HPL; hydroperoxide lyase; AOS; allene oxide synthase; EAS; epoxyalcohol synthase; 13(S)-HPOT; (9Z,11E,13S,15Z)-13-hydroperoxyoctadecatrienoic acid; 13(S)-HPOD; (9Z,11E,13S)-13-hydroperoxyoctadecadienoic acid; 9(S)-HPOD; (9S,10
Functional analysis and crystallographic structure of clotrimazole bound OleP, a cytochrome P450 epoxidase from Streptomyces antibioticus involved in oleandomycin biosynthesis
Keywords: OleP; 8.8a-deoxyoleandolide epoxigenase; P450; cytochrome P450; EpoK; Epothilone C-D monooxygenase; PimD; Pimaricin monooxygenase; MycG; Mycinamicin monooxygenase; CLT; clotrimazole; KC; ketoconazole; DMSO; dimethyl sulfoxide; DEO; 8.8a-deoxyoleandolide
Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo
Keywords: AUC; area under the plasma concentration vs. time curve; CL; total body clearance; P450; general term for cytochrome P450 (EC 1.14.14.1); t1/2; elimination half-life; V; volume of distribution; Cynomolgus monkey; CYP2C19; Genotyping; Stereoselectivity; S-
Heterologous expression and characterization of CYP61A1 from dandruff-causing Malassezia globosa
Keywords: CYP (or P450); cytochrome P450; PCR; polymerase chain reaction; TB; terrific broth; DTT; dithiothreitol; CYP; P450; CYP61A1; C22-desaturase; Sterol; Azole; Malassezia globosa;
P450-catalyzed regio- and stereoselective oxidative hydroxylation of disubstituted cyclohexanes: creation of three centers of chirality in a single CH-activation event
Keywords: Regioselectivity; CH-activation; P450; Monooxygenase; Diastereoselectivity;
A P450 fusion library of heme domains from Rhodococcus jostii RHA1 and its evaluation for the biotransformation of drug molecules
Keywords: P450; Biotransformation; P450Rhf; Imipramine; N-demethylation; Drug metabolism; Diltiazem;
Variation in P450-mediated fenvalerate resistance levels is not correlated with CYP337B3 genotype in Chinese populations of Helicoverpa armigera
Keywords: Helicoverpa armigera; P450; CYP337B3; Fenvalerate; Resistance;
Distribution and excretion of 2,2â²,3,4â²,5,5â²,6-heptachlorobiphenyl (CB187) and its metabolites in rats and guinea pigs
Keywords: PCB; polychlorinated biphenyls; OH; hydroxy; GC; gas chromatography; ECD; electron capture detector; MS; mass spectrometry; PB; phenobarbital; MC; 3-methylcholanthrene; IP; intraperitoneally; heptaCB; heptachlorobiphenyl; hexaCB; hexachlorobiphenyl; penta
Functional characterization of CYP107W1 from Streptomyces avermitilis and biosynthesis of macrolide oligomycin A
Keywords: P450; CYP; CYP107W1; Streptomyces avermitilis; Oligomycin; X-ray crystal structure
Functional characterization of CYP1A9 and CYP1C1 from Anguillus japonica
Keywords: Fish; HPLC; CYP; Monooxygenase; progesterone; P450; Site-directed mutagenesisCYP, Cytochrome P450; IPTG, isopropyl-thio-β-D-thiogalactopyranoside; ANF, α-naphthoflavone
Subacute nicotine co-exposure has no effect on 2,2â²,3,5â²,6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat
Keywords: Ct; fractional amplification (cycle number at which fluorescence exceeds a user-defined threshold); d; day; b.w.; body weight; DE; diatomaceous earth; EF; enantiomeric fraction; qPCR; quantitative (real-time) polymerase chain reaction; PCBs; polychlorinat
Transcription factors, CncC and Maf, regulate expression of CYP6BQ genes responsible for deltamethrin resistance in Tribolium castaneum
Keywords: Insecticide resistance; Tribolium; P450; Xenobiotic transcription factors
RNAi construct of a cytochrome P450 gene CYP82D109 blocks an early step in the biosynthesis of hemigossypolone and gossypol in transgenic cotton plants
Keywords: Gossypium hirsutum; Malvaceae; Cotton; Sesquiterpenes; Gossypol; Lacinilene C; Heliocide; P450; δ-Cadinen-2-one; CYP82D;
Benzo[a]pyrene-induced nitric oxide production acts as a survival signal targeting mitochondrial membrane potential
Keywords: AhR; aryl hydrocarbon receptor; B[a]P; benzo[a]pyrene; ÎΨm; mitochondrial membrane potential; iNOS; inducible nitric oxide synthase; P450; cytochrome P450; PAH; polycyclic aromatic hydrocarbon; Benzo[a]pyrene; Nitric oxide; Mitochondrial membrane hyperp
Access channels to the buried active site control substrate specificity in CYP1A P450 enzymes
Keywords: 9MAN; 9-methyl-anthracene; ANT; anthracene; BaP; benzo[a]pyrene; BCA; bicinchoninic acid; DMF; dimethylformamide; DPHE; 9,10-dihydrophenanthrene; EFEE; 7-ethoxy-fluorescein ethyl ester; EOR; 7-ethoxy-resorufin; LC; liquid chromatography; MDS; multidimensi
The plastic response of Manduca sexta to host and non-host plants
Keywords: Manduca sexta; Herbivore; Transcriptome; Detoxification; Olfactory receptor; Immunity; AM; antennae and maxillae; G; gut with Malpighian tubules; SG; silk gland (labial gland); W; whole insect; P450; cytochrome P450 monooxygenase; GST; glutathione S-trans
Photo-initiated crosslinking extends mapping of the protein-protein interface to membrane-embedded portions of cytochromes P450 2B4 and b5
Keywords: a.i.; absolute intensity; Da; Dalton; DLPC; dilauroylphosphatidylcholine; E. coli; Escherichia coli; EDC; 1-ethyl-3-(3-dimethyl (aminopropyl)) carbodiimide hydrochloride; FTICR; Fourier Transform Ion Cyclotron Resonance; HPLC; High-Performance Liquid Chro
RNAi validation of resistance genes and their interactions in the highly DDT-resistant 91-R strain of Drosophila melanogaster
Keywords: ABC transporters; ATP-binding cassette transporter; DDD; dichlorodiphenyldichloroethane; ddH2O; distilled, deionized water; DDT; dichlorodiphenyltrichoroethane; dsRNA; double stranded RNA; GC/MS; gas chromatography/mass spectrometry; GLC; gas-liquid chr
Genome-wide analysis reveals the expansion of Cytochrome P450 genes associated with xenobiotic metabolism in rice striped stem borer, Chilo suppressalis
Keywords: P450; cytochrome P450 protein; CYP; cytochrome P450 gene; SSB; striped stem borer (SSB); Chilo suppressalis; Cytochrome P450 gene; Genome; Expansion; Phylogenetic analysis; Xenobiotic metabolism;
P450 enzyme-inducing and non-enzyme-inducing antiepileptic drugs for seizure prophylaxis after glioma resection surgery: A meta-analysis
Keywords: Glioma; Treatment; P450; AEDs
Detection and molecular cloning of CYP74Q1 gene: Identification of Ranunculus acris leaf divinyl ether synthase
Keywords: DES; divinyl ether synthase; RaDES; Ranunculus acris divinyl ether synthase; HPL; hydroperoxide lyase; AOS; allene oxide synthase; 13(S)-HPOT; (9Z,11E,13S,15Z)-13-hydroperoxyoctadecatrienoic acid; 13(S)-HPOD; (9Z,11E,13S)-13-hydroperoxyoctadecadienoic aci
Altered substrate specificity of the Pterygoplichthys sp. (Loricariidae) CYP1A enzyme
Keywords: P450; Catfish; Adaptation; Evolution; Kinetics parameters; Coumarins
Mediated electron transfer with monooxygenases-Insight in interactions between reduced mediators and the co-substrate oxygen
Keywords: P450; Cofactor substitution; Redox mediators; Electro-enzymatic process; Oxygen dilemma;
Research ReportSignificance of neuronal cytochrome P450 activity in opioid-mediated stress-induced analgesia
Keywords: AA; arachidonic acid; PAG; periaqueductal gray; P450; cytochrome P450 monooxygenase; Stress; Analgesia; Cytochrome P450; Brain; Opioid; μ Opioid receptor;
exo-Brevicomin biosynthetic pathway enzymes from the Mountain Pine Beetle, Dendroctonus ponderosae
Keywords: exo-Brevicomin; Bark beetle; Pheromone; Metabolic pathway; Functional assay; P450; Dehydrogenase;
Dimethocaine, a synthetic cocaine derivative: Studies on its in vitro metabolism catalyzed by P450s and NAT2
Keywords: Designer drug; DMC; Cocaine; Metabolism; P450; NAT;
Abiraterone inhibits 1α,25-dihydroxyvitamin D3 metabolism by CYP3A4 in human liver and intestine in vitro
Keywords: 1α,25(OH)2D3; 1α,25-dihydroxyvitamin D3; P450; cytochrome P450; VDR; vitamin D receptor; LC-MS/MS; liquid chromatography-tandem mass spectrometry; HLM; human liver microsomes; HIM; human intestinal microsomes; CRPC; castration-resistant prostate can
Research PaperReversing effects of lignans on CCl4-induced hepatic CYP450 down regulation by attenuating oxidative stress
Keywords: SLE; schisandra lignans extract; DDB; dimethyl diphenyl bicarboxylate; CCl4; carbon tetrachloride; DMEs; drug metabolizing enzymes(DMEs); P450; cytochrom P450; NADP+; β-nicotinamide adenine dinucleotide phosphate; LC-MS; liquid chromatography mass spectr
Detection of superoxide production in stimulated and unstimulated living cells using new cyclic nitrone spin traps
Keywords: BMPO; 5-tert-butoxycarbonyl-5-methyl-1-pyrroline N-oxide; CAT; catalase; CD-DIPPMPO; 6-monodeoxy-6-mono-4-[(5-diisopropoxyphosphoryl-5-methyl-1-pyrroline-N-oxide)-ethylenecarbamoyl-(2,3-di-O-methyl)hexakis-(2,3,6-tri-O-methyl)]-β-cyclodextrin; DEPMPO; 5-
The evolution of insecticide resistance in the peach potato aphid, Myzus persicae
Keywords: Myzus persicae; Esterase; P450; Acetylcholinesterase; Nicotinic acetylcholine receptor; Voltage-gated sodium channel;
An independent occurrence of the chimeric P450 enzyme CYP337B3 of Helicoverpa armigera confers cypermethrin resistance in Pakistan
Keywords: Pest management; Helicoverpa armigera; Cytochrome P450 monooxygenase CYP337B3; Unequal crossing-over; Pyrethroid resistance; Cypermethrin; AFLP; amplified fragment length polymorphism; BC; backcross; EPIC; exon-primed intron-crossing primer; FSD; Helicove
Genomic analysis of the interaction between pesticide exposure and nutrition in honey bees (Apis mellifera)
Keywords: JH; juvenile hormone III; MF; methyl farnesoate; P450; cytochrome P450 monooxygenase; FDR; false discovery rate; CCE; carboxyl/cholinesterase; GST; glutathione-S-transferase; GO; gene ontogeny; qRT-PCR; quantitative real-time polymerase chain reaction; SD
An in vitro tool to assess cytochrome P450 drug biotransformation-dependent cytotoxicity in engineered HepG2 cells generated by using adenoviral vectors
Keywords: Adv; adenovirus; BSO; l-buthionine S,R-sulphoximine; P450; cytochrome P450; DMSO; dimetyl sulfoxide; FCS; fetal calf serum; GSH; glutathione; EDTA; ethylenediaminetetraacetic acid; MOI; multiplicity of infection; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diph
Stereo- and regioselectivity in the P450-catalyzed oxidative tandem difunctionalization of 1-methylcyclohexene
Keywords: Enantioselectivity; CH-activation; P450; Monooxygenase; Diastereoselectivity;
T-2 toxin is hydroxylated by chicken CYP3A37
Keywords: ACN; acetonitrile; CID; collision induced dissociation; CPR; cytochrome P450 reductase; DMSO; dimethyl sulfoxide; ERND; erythromycin N-demethylase; ESI; electrospray ionization; HPLC-Q-TOF/MS; high performance liquid chromatography-quadrupole time-of-flig
Isolation and characterization of a cDNA encoding (S)-cis-N-methylstylopine 14-hydroxylase from opium poppy, a key enzyme in sanguinarine biosynthesis
Keywords: BIA; benzylisoquinoline alkaloid; BBE; berberine bridge enzyme; CFS; cheilanthifoline synthase; CID; collision-induced dissociation; DBOX; dihydrobenzophenanthridine oxidase; ESI; electrospray ionization; MSH; (S)-cis-N-methylstylopine 14-hydroxylase; NMC
Human cytochrome P450-dependent differential metabolism among three 2α-substituted-1α,25-dihydroxyvitamin D3 analogs
Keywords: 25(OH)D3; 25-hydroxyvitamin D3; 1α,25(OH)2D3; 1α,25-dihydroxyvitamin D3; 1α,2α,25(OH)3D3; 1α,2α,25-trihydroxyvitamin D3; P450; cytochrome P450; UGT; UDP-glucuronosyltransferase; Glc-UA; glucuronic acid; HPLC; high-performance liquid chromatography;
Molecular cloning and characterization of a cytochrome P450 in sanguinarine biosynthesis from Eschscholzia californica cells
Keywords: CjSMT; Coptis japonica (S)-scoulerine-9-O-methyltransferase; CYP719A2/A3; stylopine synthase; CYP719A5; cheilanthifoline synthase; EST; expressed sequence tag; LC-MS; liquid chromatography-mass spectrometry; P6H; protopine 6-hydroxylase; P450; cytochr
A novel P450-initiated biphasic process for sustainable biodegradation of benzo[a]pyrene in soil under nutrient-sufficient conditions by the white rot fungus Phanerochaete chrysosporium
Keywords: P450; Response surface methodology; Genetic algorithm; PAH biodegradation; Transcript analysis in soil; Non-ligninolytic;
Bioactivation of bisphenol A and its analogs (BPF, BPAF, BPZ and DMBPA) in human liver microsomes
Keywords: BP; bisphenol; BPA; bisphenol A; BPF; bisphenol F; BPAF; bisphenol AF; BPZ; bisphenol Z; DMBPA; 3,3â²-dimethyl BPA; ER; estrogen receptor; ESI; electrospray ionization; GSH; reduced glutathione; HCA; hydroxycumyl alcohol; LC-MS/MS; liquid chromatograph
Phosphatidic acid and phosphoinositides facilitate liposome association of Yas3p and potentiate derepression of ARE1 (alkane-responsive element one)-mediated transcription control
Keywords: AID; auxin-inducible degron; ARE1; alkane-responsive element 1; bHLH; basic helix-loop-helix; DAG; diacylglycerol; DAGPP; diacylglycerol pyrophosphate; DTT; dithiothreitol; 2D-TLC; two-dimensional thin layer chromatography; EGFP; enhanced green fluorescen
High-level heterologous expression of fungal cytochrome P450s in Escherichia coli
Keywords: Eukaryotic cytochrome P450; High-level expression; Escherichia coli; Large-scale screening; Heterologous expression; Wood-rotting basidiomycetes; EDTA; ethylenediaminetetraacetic acid; HEPES; 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid; IPTG;
11β-Hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione
Keywords: 11KA4; 11-ketoandrostenedione; 11KT; 11-ketotestosterone; 11OH-5α-dione; 11β-hydroxy 5α-androstanedione; 11OH-AST; 11β-hydroxyandrosterone; 11OHA4; 11β-hydroxyandrostenedione; 11OHT; 11β-hydroxytestosterone; 11βHSD; 11β-hydroxysteroid dehydrogenas
A computational protocol to predict suitable redox mediators for substitution of NAD(P)H in P450 monooxygenases
Keywords: P450; Cofactor substitution; Redox mediators; Protein docking; Electro enzymatic process