RNAi construct of a cytochrome P450 gene CYP82D109 blocks an early step in the biosynthesis of hemigossypolone and gossypol in transgenic cotton plants

RNAi knock-down of a gossypol pathway cytochrome P450 hydroxylase gene CYP82D109 cloned from cotton resulted in the blockage of gossypol and heliocides biosynthesis. It also enhanced the pathogen induced lacinilene C pathway in cotton.