Keywords: iDOSY; (integrated into) diffusion ordered spectroscopy; 2A6; human cytochrome P450 monooxygenase 2A6; BFP; blue fluorescent protein; Bx1; indole synthase from Zea mays; CaMV; cauliflower mosaic virus; CLIP-COSY; clean in-phase correlation spectroscopy; c
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Keywords: Peroxygenation; Peroxide shunt; P450; Heme-thiolate; Deacylation; Geminal alcohol;
Keywords: AcHz; acetylhydrazine; AcINH; acetylisoniazid; ALP; alkaline phosphatase; ALT; alanine aminotransferase; DiAcHz; diacetylhydrazine; GSH; glutathione; GST; glutathione S-transferase; Hz; hydrazine; INA; isonicotinic acid; INH; isoniazid; MPO; myeloperoxida
Keywords: ANOVA; analysis of variance; CPR; cytochrome P450 reductase; DAMGO; [D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin acetate; GTPγS; guanosine 5â²-O-(3-thiotriphosphate) tetralithium salt; icv; intracerebroventricular; Null; neuronal cytochrome P450 reductase de
Keywords: P450; Arachidonic acid; Epoxygenase; 20-HETE; EET; Hypertension;
Keywords: Pesticides; Toxicokinetics; P450; In vitro metabolism; Risk assessment;
Keywords: Corynebacterium glutamicum; 4-Cresol; Aromatic compound degradation; P450; cre genes;
Keywords: Hydroxy fatty acid; P450; Lipoxygenase; Hydratase; 12-Hydroxylase; Diol synthase; Biotransformation;
Keywords: Nilaparvata lugens; Imidacloprid; Pymetrozine; Cross-resistance; P450
Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants
Keywords: CYP450; CYP2C9 variants; Synthetic cannabinoids; Enzyme kinetics; Toxicity; Î9-THC; (â)-Î9-Tetrahydrocannabinol; P450; cytochrome P450; CYP; specific P450; UGTs; uridine diphosphate (UDP)-glucuronosyltransferases; LC-MS/MS; Liquid chromatography-tande
Donor and recipient P450 gene polymorphisms influence individual pharmacological effects of tacrolimus in Chinese liver transplantation patients
Keywords: Liver transplantation; Tacrolimus; P450; SNP; Pharmacogenomics;
Osh6p, a homologue of the oxysterol-binding protein, is involved in production of functional cytochrome P450 belonging to CYP52 family in n-alkane-assimilating yeast Yarrowia lipolytica
Keywords: Yarrowia lipolytica; n-alkane; P450; Oxysterol-binding protein; OSH6; Phospholipid;
Integrated metabolomic and transcriptomic analyses revealed the distribution of saponins in Panax notoginseng
Keywords: AACT; acetoacetyl-CoA acyltransferase; DS; dammarenediol-II synthase; DXPS; 1-deoxy-d-xylulose 5-phosphate synthase; DXPR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; FPS; farnesyl pyrophosphate synthase; FPP; farnesyl diphosphate; GDPS; gerenyl diph
Cap 'n' collar C regulates genes responsible for imidacloprid resistance in the Colorado potato beetle, Leptinotarsa decemlineata
Keywords: Insecticide resistance; RNA sequencing; RNA interference; Xenobiotic transcription factor; ABC transporter; P450; CPB; Colorado potato beetle; CncC; Cap 'n' collar isoform C; XTFs; Xenobiotic transcription factors; Nrf2; NF-E2-related factor 2; P450;
Description of an orthologous cluster of ochratoxin A biosynthetic genes in Aspergillus and Penicillium species. A comparative analysis
Keywords: Cluster; Halogenase; P450; PKS; NRPS; bZIP;
Serum derived from ulcerative colitis mouse changes the metabolism of the fluorescent substrate by P450 depending on the degree of disease progression
Keywords: Cytochrome P450; Ulcerative colitis; Fluorescent P450 inhibition assay; BOMCC; 7-benzyloxy-methyloxy-3-cyanocoumarin; CYP; cytochrome P450; DAI; disease activity index; DBOMF; dibenzyl-methyl-fluorescein; DSS; 4,4-dimethyl-4-silapentane-1-sulfonic acid; E
In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants
Keywords: AUC; area under the plasma concentration vs. time curve; CL; total body clearance; P450; general term for cytochrome P450 (EC 1.14.14.1); V; volume of distribution; Marmoset; CYP3A4; CYP2C19; Polymorphism; PBPK;
Peroxidase-like activity of cytochrome b5 is triggered upon hemichrome formation in alkaline pH
Keywords: CO; Carbon monoxide; Cytochrome b5; Cb5; Cyt c; Cytochrome c; EDTA; Ethylene diamine tetra acetic acid; EPR; Electron paramagnetic resonance; HS; High spin; H2O2; hydrogen peroxide; LS; Low spin; LSpH7; pHÂ 7 signal; LSpH12; pHÂ 12 signal; LSpH12â²; pH 1
Expression profile changes of cytochrome P450 genes between thiamethoxam susceptible and resistant strains of Aphis gossypii Glover
Keywords: Aphis gossypii; Insecticide resistance; P450;
Roles of LsCYP4DE1 in wheat adaptation and ethiprole tolerance in Laodelphax striatellus
Keywords: Laodelphax striatellus; P450; Xenobiotics detoxification; Wheat adaptation; Ethiprole tolerance;
Characterization of CYP2C Induction in Cryopreserved Human Hepatocytes and Its Application in the Prediction of the Clinical Consequences of the Induction
Keywords: cytochrome P450; mathematical models; hepatocytes; drug-drug interaction; induction; CAR; constitutive androstane receptor; CITIO; 6-(4-clorophenyl) imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime; P450; cytochrome P450; DDI; drug-d
Insights into the functional properties of the marneral oxidase CYP71A16 from Arabidopsis thaliana
Keywords: P450; cytochrome P450 monooxygenase; CPR; cytochrome P450 reductase; LB; lysogeny broth (medium); TB; terrific broth (medium); IPTG; isopropyl-β-d-thiogalactopyranoside; GC/MS; gas chromatography coupled with mass spectrometry; HPLC; high performance liq
Structure of cytochrome P450 2B4 with an acetate ligand and an active site hydrogen bond network similar to oxyferrous P450cam
Keywords: P450; cytochrome P450; P450cam; cytochrome P450 camphor; 4-CPI; 4-(4-chloro-phenyl) imidazole; Cymal-5; 5-cyclohexyl-1-pentyl-β-d-maltoside; WT; wild type; H-bond; hydrogen bond;
In silico analysis of cytochrome P450 monooxygenases in chronic granulomatous infectious fungus Sporothrix schenckii: Special focus on CYP51
Keywords: P450; Cytochrome P450 monooxygenase; PDP; P450 diversity percentage; HAP; Human and animal pathogen; AP; Animal pathogen; PP; Plant pathogen; HP; Human pathogen; HIV; Human Immunodeficiency Virus; P450; Genome data mining; Homology modeling; Docking; Muta
Formation and biological targets of botanical o-quinones
Keywords: Quinones; P450; Bioactivation; Botanicals; Chemoprevention; Carcinogen; ARE; antioxidant response element; BiP; binding immunoglobin protein; COX-2; cyclooxygenase-2; JNK; c-Jun N-terminal kinase; EGCG; (â)-epigallocatechin gallate; GST; glutathione-S-t
High fat diet induced obesity is mitigated in Cyp3a-null female mice
Keywords: P450; Non-alcoholic fatty liver disease (NAFLD); Ketosis; Toxicology;
Transcriptome profiling reveals differential gene expression of detoxification enzymes in Sitophilus zeamais responding to terpinen-4-ol fumigation
Keywords: Terpinen-4-ol; Maize weevil; Transcriptome; Detoxification; P450;
Critical differences in drug metabolic properties of human hepatic cellular models, including primary human hepatocytes, stem cell derived hepatocytes, and hepatoma cell lines
Keywords: ACN; acetonitrile; BCA; bicinchoninic acid; DMSO; dimethyl sulfoxide; ESI; electrospray ionization; HPLC; high pressure liquid chromatography; iPSC; induced pluripotent stem cell; LDA; low density array; MS; mass spectrometry; P450; cytochrome P450; PCA;
CYP2C76 deficiency is embryonic lethal in cynomolgus macaques: The potential role of CYP2C76 in early embryogenesis
Keywords: Cytochrome P450; Embryogenesis; Progesterone; Null allele; Cynomolgus macaque; ART; assisted reproduction technology; P450; cytochrome P450 (EC 1.14.14.1); ICSI; intracytoplasmic sperm injection; PCR; polymerase chain reaction; PGD; preimplantation geneti
CYP260B1 acts as 9α-hydroxylase for 11-deoxycorticosterone
Keywords: AdR; adrenodoxin reductase; Adx4-108; adrenodoxin (truncated form); P450; cytochrome P450; DOC; 11-deoxycorticosterone; HP-β-CD; 2-hydroxypropyl-β-cyclodextrin; T224A mutant; CYP260B1-T224A; Steroids; 11-Deoxycorticosterone; CYP260B1; Sorangium cellul
Structural insights into the binding of lauric acid to CYP107L2 from Streptomyces avermitilis
Keywords: P450; CYP; CYP107L2; Streptomyces avermitilis; Lauric acid; X-ray crystal structure;
Nitric oxide-regulated proteolysis of human CYP2B6 via the ubiquitin-proteasome system
Keywords: AAF; L-alanyl-N-[(1S)â3-chloro-2-oxo-1-(phenylmethyl)propyl]-L-alaninamide, mono trifluoro-acetate; ALLN; N-acetyl-L-leucyl-N-[(1S)â1-formylpentyl]-L-leucinamide; Cal III; N-[(1S)â1-[[(1-formyl-2-phenylethyl)amino]carbonyl]â2-methylpropyl]-carbami
Pyrethroid resistance in Iranian field populations of Rhipicephalus (Boophilus) annulatus
Keywords: LPT; larval packet test; R. (B.); Rhipicephalus (Boophilus); FC; formulation concentration; DF; dilution factor; P450; cytochrome P450 monooxygenase; GST; glutathione S-transferases; TMBZ; tetramethylbenzidine; p-NPA; para-nitrophenyl acetate; CDNB; 1-chl
The liver transcriptome of suckermouth armoured catfish (Pterygoplichthys anisitsi, Loricariidae): Identification of expansions in defensome gene families
Keywords: RNA-Seq; P450; SULT; ABC transporters; Nuclear receptors;
Oxidation reactivity of 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) by Compound I model of cytochrome P450s
Keywords: 1,2-Bis(2,4,6-tribromophenoxy)ethane (BTBPE); Alternative brominated flame retardants; Metabolic reactivity; P450; Compound I;
CYPome of the conifer pathogen Heterobasidion irregulare: Inventory, phylogeny, and transcriptional analysis of the response to biocontrol
Keywords: Gene expression; Genome; Heterobasidion annosum s.l.; Homology modelling; P450;
Apigenin-7-O-glucoside oxidation catalyzed by P450-bioinspired systems
Keywords: Biomimetic catalysis; Metalloporphyrin; Jacobsen catalyst; A7G; P450;
Describing the role of Drosophila melanogaster ABC transporters in insecticide biology using CRISPR-Cas9 knockouts
Keywords: P-glycoprotein; ABCB1; Multi-drug resistance; CRISPR-Cas9; Drosophila melanogaster; Insecticide resistance; BBB; Blood Brain Barrier; HPLC-MS; high pressure liquid chromatography coupled with mass spectrometry; P450; Cytochrome P450; ABC; ABC Transporter;
Comparative transcriptome analysis reveals potential gene targets for ovipositional inhibition by diallyl trisulfide against female Sitotroga cerealella
Keywords: DATS; diallyl trisulfide; DEGs; differentially expressed genes; EG; experimental group; CG; control group; Nr; non-redundant protein database; Nt; non-redundant nucleotide database; Swiss-Prot; Swiss Protein database; KEGG; Kyoto Encyclopedia of Genes and
Cap n collar transcription factor regulates multiple genes coding for proteins involved in insecticide detoxification in the red flour beetle, Tribolium castaneum
Keywords: Red flour beetle; RNA-seq; P450; GST; ABC transporter;
Lipidomics in translational research and the clinical significance of lipid-based biomarkers
Keywords: 5-HETE; 5-hydroxyicosatetraenoic acid; 12-HETE; 12-hydroxyicosatetraenoic acid; 15-HETE; 15-hydroxyicosatetraenoic acid; aa; diacyl; ae; acyl-alkyl; ACs; acylcarnitines; ACOG; The American College of Obstetricians and Gynecologists; AD; Alzheimer's dise
Recombinant expression and characterization of Lucilia cuprina CYP6G3: Activity and binding properties toward multiple pesticides
Keywords: Cytochrome P450; CYP6G3; Lucilia cuprina; Australian sheep blowfly; Insecticide resistance; Diazinon; Imidacloprid; 7EC; 7-ethoxycoumarin; BR; 7-benzyloxyresorufin; CuOOH; cumene hydroperoxide; δ-ALA; delta-aminolevulinic acid; DDT; dichlorodiphenyltrich
Isochlorogenic acid A affects P450 and UGT enzymes in vitro and in vivo
Keywords: Isochlorogenic acid A; P450; UGT; Herb-drug interaction;
Resistance monitoring and cross-resistance patterns of three rice planthoppers, Nilaparvata lugens, Sogatella furcifera and Laodelphax striatellus to dinotefuran in China
Keywords: Resistance monitoring; Cross-resistance; Dinotefuran; P450; Rice planthoppers;
Glutathione S-transferases are involved in thiamethoxam resistance in the field whitefly Bemisia tabaci Q (Hemiptera: Aleyrodidae)
Keywords: Bemisia tabaci; B. tabaci; PCR; polymerase chain reaction; qRT-PCR; quantitative real-time PCR; GST; glutathione S-transferase; CarE; carboxylesterase; P450; cytochrome-P450-dependent monooxygenase; Bemisia tabaci; Thiamethoxam; Glutathione S-transferase;
Biochemical analysis of recombinant CYP4A11 allelic variant enzymes: W126R, K276T and S353G
Keywords: P450; CYP4A11; Allele; Fatty acid hydroxylase; Polymorphism;
Identification of protein-protein interactions of isoflavonoid biosynthetic enzymes with 2-hydroxyisoflavanone synthase in soybean (Glycine max (L.) Merr.)
Keywords: Metabolon; Isoflavone; 2-Hydroxyisoflavanone synthase; Chalcone synthase; Chalcone isomerase; Protein-protein interaction; BiFC; bimolecular fluorescence complementation; GmCHS; chalcone synthase of Glycine max; GmCHR; chalcone reductase of G. max; GmCH
Characterization of CYP71Z18 indicates a role in maize zealexin biosynthesis
Keywords: Maize; Zea mays; Poaceae; Biosynthesis; Terpenoid; Phytoalexin; P450; Zealexin;
Oxidation of R- and S-omeprazole stereoselectively mediated by liver microsomal cytochrome P450 2C19 enzymes from cynomolgus monkeys and common marmosets
Keywords: P450; general term for cytochrome P450 (EC 1.14.14.1); Macaque; Marmoset; CYP2C19; Genotyping; Stereoselectivity;
Comparison of mercury sulfides with mercury chloride and methylmercury on hepatic P450, phase-2 and transporter gene expression in mice
Keywords: P450; cytochrome enzyme genes; Ugt1a1; UDP-glucuronosyltransferase family 1, subfamily A, polypeptide 1; Sult1a1; sulfotransferase family 1, subfamily a, peptide1; Gst-mu; glutathione S-transferase mu; Oatp1a1; organic anion transporting polypeptide 1a1;