Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs

► Classification of NSAIDs in three classes based on underlying toxicity. ► Ketoprofen and indomethacin show same mitochondrial toxicity as diclofenac. ► Main toxicity ibuprofen and naproxen is not related to mitochondrial respiration. ► Use of yeast as a simple, cellular model system to test toxicity.