p53 at the crossroads between cancer and neurodegeneration
Keywords: p53; Alzheimer disease; Cancer; Conformational alteration; Gain of function; Oxidative stress; Free radicals;
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Correlation between P53 expression and malignant risk of gastrointestinal stromal tumors: Evidence from 9 studies
Keywords: Gastrointestinal stromal tumors; Immunohistochemistry; P53; Malignant risk; Meta-analysis
Fascin is a predictor for invasiveness and recurrence of urothelial carcinoma of bladder
Keywords: Fascin; p53; CK20; Multidrug resistance gene; Bladder urothelial carcinoma
Adenocarcinoma with pyloric gland phenotype of the extrahepatic bile ducts: a previously unrecognized and distinctive morphologic variant of extrahepatic bile duct carcinoma
Keywords: Pyloric gland; Adenocarcinoma; Extrahepatic bile ducts; Gastric mucins; Intestinal mucins; CDX2; p53
Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC δ-independent mechanism
Keywords: Rottlerin; NAG-1; Apoptosis; p53; Colon carcinoma cells;
In vitro malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene
Keywords: Benzo(a)pyrene; 16HBE cells; Malignant transformation; Cell migration; p53; p-Akt (Ser473);
Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats
Keywords: Aging; Senescence; Polyphenols; Vascular aging; Telomeres; p53; p16; Red wine; Resveratrol; CR; calorie restriction; RS; resveratrol; RW; red wine; HRS; high resveratrol; LRS; low resveratrol; HR; heart rate; EDV; end-diastolic volume; ESV; end-sistolic v
Disruption of the p53-p21 pathway inhibits efficiency of the lytic-replication cycle of herpes simplex virus type 2 (HSV-2)
Keywords: HSV-2; Viral replication; p53; p21; siRNAs;
Chromatin remodelling protein SMAR1 inhibits p53 dependent transactivation by regulating acetyl transferase p300
Keywords: SMAR1; p300; Chromatin; p53; Transactivation;
The fungicide mancozeb induces toxic effects on mammalian granulosa cells
Keywords: Mancozeb; Granulosa cells; Mouse; Human; p53;
IGF-I enhances cellular senescence via the reactive oxygen species-p53 pathway
Keywords: IGF-I; Cellular senescence; ROS; p53; Longevity;
Inhibitory role of E2F-1 in the regulation of tumor suppressor p53 during DNA damage response
Keywords: Adriamycin; Apoptosis; DNA damage; E2F-1; p53;
XPD could suppress growth of HepG2.2.15 and down-regulate the expression of hepatitis B virus x protein through P53 pathway
Keywords: Xeroderma pigmentosum D; P53; Hepatoma cells; Apoptosis; Hepatitis B virus X protein;
In vitro binding properties of tumor suppressor p53 with PUMA and NOXA
Keywords: p53; PUMA; NOXA; Interaction; Apoptosis;
TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradation
Keywords: ARF; ADP ribosylation factor; GST; glutathione S-transferase; MDM2; murine double minute; p53; tumor suppressor protein 53; RING; really interesting new gene; TRIAD1; two RING fingers and DRIL 1; p53; MDM2; Ubiquitination; TRIAD1;
Cell density-dependent acetylation of ÎNp63α is associated with p53-dependent cell cycle arrest
Keywords: ÎNp63α; Acetylation; Cell cycle arrest; p53; p21;
Role of CSN5/JAB1 in Wnt/β-catenin activation in colorectal cancer cells
Keywords: CSN5; COP9 signalosome; Protein degradation; Cullin-RING-ubiquitin ligase; MIF; p53; APC; adenomatous polyposis coli; CDK; cyclin-dependent kinase; CHX; cycloheximide; COP; constitutive photomorphogenesis; CSN; COP9 signalosome; CRC; colorectal cancer; CR
Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer
Keywords: Methylation; MicroRNA; MicroRNA-34b/c; Small cell lung cancer; Non-small cell lung cancer; p53;
Activation of p53/ATM-dependent DNA damage signaling pathway by shiga toxin in mammalian cells
Keywords: p53; ATM; Shiga toxin; Signaling; Mammalian cell; ApoptosisATM, Ataxia telangiectasia mutant; ATR, ATM and Rad3-related; STX, Shiga toxin; ShET, Shigella enterotoxin; CAD, Caspase activated DNase; PCR, Polymerase chain reaction; VTEC, Verotoxin producing
Expression of the class II tumor suppressor gene RIG1 is directly regulated by p53 tumor suppressor in cancer cell lines
Keywords: Retinoid-inducible gene 1; Retinoic acid receptor responder 3; Tazarotene-induced gene 3; p53; Class II tumor suppressor
Mdm2 and MdmX partner to regulate p53
Keywords: Mdm2; MdmX; MDM4; p53; E3 ligase; Ubiquitination; Regulation; Degradation; Stress response
Genomic instability and p53 alterations in patients with malignant glioma
Keywords: Anaplastic astrocytoma; Glioblastoma; Genomic instability; p53
RUVBL2 is a novel repressor of ARF transcription
Keywords: RUVBL2; ARF; p53; Transcription repression
Tumoral and angiogenesis factors in hepatocellular carcinoma after locoregional therapy
Keywords: Hepatocellular carcinoma; Interventional radiology ablation; Necrosis; Ki-67; P53; VEGF; Immunohistochemistry
The p53-reactivating small-molecule RITA enhances cisplatin-induced cytotoxicity and apoptosis in head and neck cancer
Keywords: p53; Reactivation; Head and neck cancer; Apoptosis; RITA
The dietary phytochemical 3,3′-diindolylmethane induces G2/M arrest and apoptosis in oral squamous cell carcinoma by modulating Akt-NF-κB, MAPK, and p53 signaling
Keywords: 3,3′-Diindolylmethane; Oral cancer; Apoptosis; NF-κB; p53; Indole-3-carbinol
The different regulatory effects of p53 status on multidrug resistance are determined by autophagy in ovarian cancer cells
Keywords: Multidrug resistance; Autophagy; p53; 175H; Ovarian cancer
Role of EBNA1 in NPC tumourigenesis
Keywords: DNA replication; Segregation; Transcription; PML bodies; p53
P53 mediates estradiol induced activation of apoptosis and DNA repair in non-malignant colonocytes
Keywords: Estradiol; Colon; Cancer; Prevention; p53; Apoptosis;
Effects of sperm DNA damage on the levels of RAD51 and p53 proteins in zygotes and 2-cell embryos sired by golden hamsters without the major accessory sex glands
Keywords: ASG; male accessory sex gland; BN; blastomere nuclei; 53BP1; p53-binding protein 1; BSA; bovine serum albumin; CAT; catalase; dsDNA; double strand DNA; FN; female pronucleus; GPx; glutathione peroxidase; H2O2; hydrogen peroxide; HR; homologous recombinati
Impact of cadmium on hOGG1 and APE1 as a function of the cellular p53 status
Keywords: Cadmium; BER; OGG; APE1; p53
Down-regulation of tumor suppressor MTUS1/ATIP is associated with enhanced proliferation, poor differentiation and poor prognosis in oral tongue squamous cell carcinoma
Keywords: ATIP; MTUS1; OTSCC; Tumor suppressor; p53
Characterization of 17.94, a novel anaplastic Wilms' tumor cell line
Keywords: Wilms' tumor; cell line; anaplastic; p53
The Poly(ADP-ribose) polymerases (PARPs): New roles in intracellular transport
Keywords: PARP; PARG; Transport; Crm1; p53; NF-κB; HMGB1; AIF; KIF4; KLF8;
DUSP6 is a novel transcriptional target of p53 and regulates p53-mediated apoptosis by modulating expression levels of Bcl-2 family proteins
Keywords: p53; DUSP6; ERK; Bcl-2 family protein; Cell death;
p53 is correlated with low BMI negative progesterone receptor status and recurring disease in patients with endometrial cancer
Keywords: p53; Phospho-p53; Endometrial cancer
Cleistanthoside A tetraacetate-induced DNA damage leading to cell cycle arrest and apoptosis with the involvement of p53 in lung cancer cells
Keywords: Apoptosis; Cleistanthoside A tetraacetate; G1 arrest; Lung cancer cell; p53
Research ArticleThe four and a half LIM-only protein 2 regulates liver homeostasis and contributes to carcinogenesis
Keywords: Cyclin D1; p53; Liver regeneration; Cirrhosis; Hepatocarcinogenesis; FHL2; four and a half LIM-only protein 2; LIM; lin-11, Islet-1, and mec-3; Apo; apolipoprotein; PH; partial hepatectomy; BrdU; bromodeoxyuridine; TUNEL; terminal transferase-mediated dUT
Molecular alterations in colitis-associated colorectal neoplasia: Study from a low prevalence area using magnifying chromo colonoscopy
Keywords: Ulcerative colitis; Colorectal neoplasia; Magnifying chromo colonoscopy; Microsatellite instability; p53;
Novel MDM2 splice variants identified from oral squamous cell carcinoma
Keywords: Oral squamous cell carcinoma; MDM2; Splice variants; p53;
Irinotecan induces senescence and apoptosis in colonic cells in vitro
Keywords: Irinotecan; p53; Premature senescence; Colonic cells; Apoptosis; DNA damage
Inhibition of GSK-3β reverses the pro-apoptotic effect of proadifen (SKF-525A) in HT-29 colon adenocarcinoma cells
Keywords: A; AR-A014418, GSK-3β inhibitor; ANOVA; analysis of variance; ATF3; activating transcription factor 3; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; Bcl-XL; B-cell lymphoma-extra large; DMSO; dimethyl sulfoxide; DOC-Na; sodium deoxycholate;
MEHP-induced oxidative DNA damage and apoptosis in HepG2 cells correlates with p53-mediated mitochondria-dependent signaling pathway
Keywords: DEHP; di-(2-ethylhexyl)phthalate; MEHP; mono(2-ethylhexyl)phthalate; ROS; reactive oxygen species; 8-OHdG; 8-hydroxy-2â²-deoxyguanosine; MDA; malondialdehyde; SOD; superoxide dismutase; GPx; glutathione peroxidase; Vit C; vitamin C; Mono (2-ethylhexyl)ph
Paeoniflorin inhibits growth of human colorectal carcinoma HT 29 cells in vitro and in vivo
Keywords: Proliferation; HT29 cells; In vitro and in vivo; p53; Apoptosis;
Docetaxel and 5-fluorouracil induce human p53 tumor suppressor gene transcription via a short sequence at core promoter element
Keywords: Docetaxel; 5-FU; p53; MDR-1; PE21; Promoter
A protein transduction method using oligo-arginine (3R) for the delivery of transcription factors into cell nuclei
Keywords: Protein transduction; eGFP; p53; Arginine; Drug delivery; TAT
Role of JNK and p38 MAPK in Taiwanin A-induced cell death
Keywords: Taiwanin A; Apoptosis; p53; Bcl-2; p38; JNK;
A clinical, pathologic, and molecular study of p53 and murine double minute 2 in penile carcinogenesis and its relation to prognosis
Keywords: Murine double minute 2; p53; Penile cancer; Molecular pathogenesis; Prognosis
Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer
Keywords: p53; SCO2; COX; TIGAR; Breast carcinoma
Aberrant expression of cell cycle regulatory genes predicts overall and disease free survival in malignant pleural mesothelioma patients
Keywords: Malignant pleural mesothelioma; Prognosis; p16; p14; p53; p21WAF; p27; Rb