کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3986443 1601416 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Correlation between P53 expression and malignant risk of gastrointestinal stromal tumors: Evidence from 9 studies
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Correlation between P53 expression and malignant risk of gastrointestinal stromal tumors: Evidence from 9 studies
چکیده انگلیسی

PurposeThe published data about p53 expression and its potential value in malignant risk of Gastrointestinal Stromal Tumors patients seemed inconclusive. To derive a more precise estimation of the relationship between p53 and Malignant risk of GIST, a meta-analysis was performed.Materials and methodsStudies have been identified by searching PubMed and Embase. Inclusive criteria were GIST patients, evaluation of p53 expression and malignant risk. The odds ratio (OR) for positive rate of p53 in NIH very low risk group vs. NIH low risk group, the odds ratio (OR) for positive rate of p53 in NIH low risk group vs. NIH Intermediate risk group and the odds ratio (OR) for positive rate of p53 in NIH Intermediate group vs. NIH high risk group were calculated with 95% confidence interval (CI) for each study as an estimation of potential value of p53 in malignant risk of GIST.ResultsA total of 9 studies including 768 patients were involved in this meta-analysis. The meta-analysis of positive rate of p53 in NIH VL group vs. NIH L group did not attain significant difference (OR 0.38 95% CI, 0.11–1.28; P = 0.12 Pheterogeneity = 0.51). However the overall OR for positive rate of p53 in NIH L group vs. NIH I group revealed that significantly elevated risks of positive p53 in NIH I group were achieved (OR 0.44 95% CI, 0.24–0.82; P = 0.009 Pheterogeneity = 0.32). The overall OR for NIH I group vs. NIH H group was 0.62 (95% CI, 0.37–1.02; P = 0.06 Pheterogeneity = 0.25).ConclusionThe results indicate p53 overexpression correlate with the malignant risk increasing of GIST and have a primary and closest relationship within the NIH I risk group of GIST.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Surgical Oncology (EJSO) - Volume 38, Issue 3, March 2012, Pages 189–195
نویسندگان
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