Heterogeneity of Tumor and Immune Cell PD-L1 Expression and Lymphocyte Counts in Surgical NSCLC Samples
Keywords: CD8; Immunotherapy; Non-small-cell lung cancer; PD-L1; TILs;
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Human regulatory B cells control the TFH cell response
Keywords: Regulatory B cells; follicular T helper cells; IL-12; IL-21; antibody production; humoral immune response; Bcl-6; B-cell lymphoma 6; Breg; Regulatory B; DC; Dendritic cell; Foxp3; Forkhead box P3; GC; Germinal center; ICAM; Intercellular adhesion molecule
Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas
Keywords: Immunotherapy; GPC3; MAGEC2; Galectin 9; APC; antigen-presenting cells; BTLA; BÂ and T lymphocyte attenuator; CFSE; carboxyfluorescein diacetate succinimidyl ester; CTL; cytotoxic T cells; CTLA4; cytotoxic T-lymphocyte associated protein 4; GAL-9; galecti
Development of CAR T cells designed to improve antitumor efficacy and safety
Keywords: 28z; CD28 + CD3ζ; 4-1BBL; 4-1BB ligand; B-ALL; B cell acute lymphatic leukemia; BBz; 4-1BB + CD3ζ; CAR; chimeric antigen receptor; CD40L; CD40 ligand; CRS; cytokine release syndrome; CTLA-4; cytotoxic T-lymphocyte associated protein 4; DCs; dendriti
Viral Load Affects the Immune Response to HBV in Mice With Humanized Immune System and Liver
Keywords: NK Cell; CXCL10; Mouse Model; IL10; HBe; cccDNA; covalently closed circular DNA; CHB; chronically HBV infected; ELISA; enzyme-Linked Immunosorbent Assay; ETV; entecavir; hAlb; human Albumin; HBcAg; hepatitis B core antigen; HBe; hepatitis B envelope; HBs;
PD-1/PD-L1 expression in extra-medullary lesions of multiple myeloma
Keywords: Extramedullary myeloma; PD-L1; PD-1; Immunohistochemistry;
Intracranial response to nivolumab in NSCLC patients with untreated or progressing CNS metastases
Keywords: CNS; central nervous system; K-RAS; Kirsten rat sarcoma; mRECIST; modified Response Evaluation Criteria in Solid Tumors; MRI; magnetic resonance imaging; NSCLC; non-small cell lung cancer; pts; patients; PET-CT; positron emission tomography-computer tomog
The characteristic profiles of PD-1 and PD-L1 expressions and dynamic changes during treatment in active tuberculosis
Keywords: Tuberculosis; PD-1; PD-L1; T cell subsets;
Analysis of expression of PTEN/PI3Â K pathway and programmed cell death ligand 1 (PD-L1) in malignant pleural mesothelioma (MPM)
Keywords: Malignant pleural mesothelioma; PD-L1; PI3Â K; Prognostic factor;
Problems of variable biomarker evaluation in stratified medicine research-A case study of ERCC1 in non-small-cell lung cancer
Keywords: ERCC1; excision repair cross-complementation group 1; FISH; fluorescence in situ hybridization; IHC; immunohistochemistry; NER; nucleotide excision repair; NR; not reported; NSCLC; non-small-cell lung cancer; PD-L1; programmed-death ligand 1; RTqPCR; reve
Clinical and pathologic features of lung cancer expressing programmed cell death ligand 1 (PD-L1)
Keywords: Lung cancer; PD-L1; EMT; Prognostic factor; Adenocarcinoma;
Prognostic significance of PD-L1 and PD-L2 in breast cancer
Keywords: Breast cancer; Prognosis; Biomarker; Survival; PD-L1; PD-L2;
The role of antagonists of the PD-1:PD-L1/PD-L2 axis in head and neck cancer treatment
Keywords: PD-1; PD-L1; PD-L2; B7-H1; Immune checkpoint; Squamous cell carcinoma; Head and neck cancer; Immunotherapy;
Clinicopathological and prognostic significance of programmed cell death ligand-1 expression in lung adenocarcinoma and its relationship with p53 status
Keywords: Lung cancer; Adenocarcinoma; Cancer immunotherapy; PD-L1; p53
Predictive relevance of PD-L1 expression combined with CD8+ TIL density in stage III non-small cell lung cancer patients receiving concurrent chemoradiotherapy
Keywords: PD-L1; immunohistochemistry; non-small cell lung cancer; chemoradiotherapy; CD8+ TIL;
PD-L1 expression is associated with massive lymphocyte infiltration and histology in gastric cancerâ
Keywords: PD-L1; EBV; Gastric cancer; Prognosis; HER2;
Sarcomatoid lung carcinomas show high levels of programmed death ligand-1 (PD-L1) and strong immune-cell infiltration by TCD3 cells and macrophages
Keywords: Lung sarcomatoid carcinoma; PD-L1; Tumor-Infiltrating lymphocytes; Tumor-Infiltratingmacrophages; Non-small-cell lung cancer;
BIP induces mice CD19hi regulatory B cells producing IL-10 and highly expressing PD-L1, FasL
Keywords: BIP; Regulatory B cells; IL-10; PD-L1; FasL
The PD-1:PD-L1 immune inhibitory checkpoint in Helicobacter pylori infection and gastric cancer: a comprehensive review and future perspectives
Keywords: Tumour; Immunology; PD-L1; Gastric Cancer; Helicobacter pylori
Original ArticleImmunology/InfectionEarly Tumor-Infiltrating Dendritic Cells Change their Characteristics Drastically in Association with Murine Melanoma Progression
Keywords: CFSE; carboxyfluorescein succinimidyl ester; DCs; dendritic cells; LNs; lymph nodes; PD-L1; programmed death-ligand 1; rDCs; resident DCs; TIDCs; tumor-infiltrating dendritic cells; VEGFR-2; vascular endothelial growth factor receptor 2;
Original StudyPrognostic Implications of Tumor-Infiltrating Lymphocytes in Association With Programmed Death Ligand 1 Expression in Early-Stage Breast Cancer
Keywords: Hormone receptor; Immunohistochemistry; PD-L1; Prognosis; Tumor infiltrating lymphocytes;
Follicular dendritic cell sarcoma: clinicopathologic study of 15 cases with emphasis on novel expression of MDM2, somatostatin receptor 2A, and PD-L1
Keywords: Follicular dendritic cell sarcoma; FDC tumor; MDM2; Somatostatin receptor; PD-L1; Head and neck; Spleen
A fully human monoclonal antibody targeting PD-L1 with potent anti-tumor activity
Keywords: Monoclonal antibody; PD-L1; B60-55; Tumor; Therapeutic agent;
PD-L1 is upregulated by radiochemotherapy in rectal adenocarcinoma patients and associated with a favourable prognosis
Keywords: PD-L1; PD-1; Nivolumab; Pembrolizumab; Rectal; Cancer; Adenocarcinoma; Radiation; Radiochemotherapy; Radiotherapy;
Ãvaluation de l'expression de PD-L1 en immunohistochimie : un biomarqueur émergent dans les carcinomes pulmonaires non à petites cellules
Keywords: PD-L1; Carcinome pulmonaire non à petites cellules; Biomarqueur prédictif; Immunothérapies anti-tumorales; PD-L1; Non-small cell lung cancer; Predictive biomarker; Cancer immunotherapy;
Predictive biomarkers of response to PD-1/PD-L1 immune checkpoint inhibitors in non-small cell lung cancer
Keywords: Immune checkpoint inhibition; PD-1; PD-L1; Biomarker; NSCLC;
Prognostic Significance of PD-L1 in Patients with Non-Small Cell Lung Cancer: A Large Cohort Study of Surgically Resected Cases
Keywords: Immunomodulation; PD-L1; Laboratory correlates; Molecular diagnosis and prognosis;
Biomarqueurs prédictifs de réponse aux traitements bloquant les voies de costimulation inhibitrices
Keywords: Biomarqueurs; Microenvironnement; tumoral; PD-L1; Lymphocytes T CD8; Mutations et néoépitopes; Marker; Tumoral microenvironment; PD-L1; CD8-T cell;
HESI/FDA workshop on immunomodulators and cancer risk assessment: Building blocks for a weight-of-evidence approach
Keywords: Immunotoxicology; Immunotoxicity; Immunomodulation; Immunosuppression; Carcinogenicity; Cancer; Risk assessment; CTL; cytotoxic T-lymphocytes; EBV; Epstein-Barr virus; FDA; Food and Drug Administration; HESI; Health and Environmental Sciences Institute;
Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel-Lindau Gene Mutation Status
Keywords: ccRCC; VHL mutations; HIF-2α; PD-L1;
PD-L1 expression is associated with tumor-infiltrating T cells and favorable prognosis in high-grade serous ovarian cancer
Keywords: PD-L1; Adaptive resistance; Ovarian cancer;
Prevailing over T cell exhaustion: New developments in the immunotherapy of pancreatic cancer
Keywords: Pancreatic cancer; T cells; Exhaustion; Immunotherapy; ACT; adoptive cell transfer; AP-1; activator protein-1; APC; antigen-presenting cells; CAR; chimeric antigen receptor; CTL; cytotoxic T cells; CTLA-4; cytotoxic T lymphocyte antigen 4; FDA; US Food an
PD-L1 Is Upregulated by Simultaneous Amplification of the PD-L1 and JAK2 Genes in Non–Small Cell Lung Cancer
Keywords: Non–small cell lung cancer; Gene amplification; PD-L1; JAK2; Inhibitor
Immune biomarkers PD-1/PD-L1 and TLR3 in malignant pleural mesotheliomas
Keywords: Pleura; Mesothelioma; Immunohistochemistry; PD-L1; PD-1; TLR3; TILs;
Apigenin inhibits the inducible expression of programmed death ligand 1 by human and mouse mammary carcinoma cells
Keywords: Breast cancer; Flavonoid; Immune evasion; PD-L1; Signal transduction;
Rapid and objective CT scan prognostic scoring identifies metastatic patients with long-term clinical benefit on anti-PD-1/-L1 therapy
Keywords: CT scan; Prognostic score; Immunotherapy; PD-1; PD-L1;
Expression and prognostic roles of PIK3CA, JAK2, PD-L1, and PD-L2 in Epstein-Barr virus–associated gastric carcinoma
Keywords: EBVaGC; PIK3CA; JAK2; PD-L1; PD-L2
Correlation between PD-L1 expression and outcome of NSCLC patients treated with anti-PD-1/PD-L1 agents: A meta-analysis
Keywords: NSCLC; PD-1; PD-L1; Nivolumab; Pembrolizumab;
Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission
Keywords: hepatitis B virus; HBV e antigen; Kupffer cells; PD-1; PD-L1; HBV vertical transmission
PD-L1 Expression in Lung Cancer
Keywords: Lung cancer; Biomarker; PD-L1; Immunotherapy;
Research ArticleEffector T cell function rather than survival determines extent and duration of hepatitis in mice
Keywords: Alb; albumin; B6; C57BL/6; CFSE; carboxyfluorescein succinimidyl ester; CTL; cytotoxic T lymphocyte; LN; lymph node(s); Met; metallothionein; PD-1; programmed cell death 1; PD-L1; programmed cell death-ligand 1; RAG; recombination-activating genes; SOCS-1
Role of regulatory B cells in immune tolerance to allergens and beyond
Keywords: Regulatory B cells; IL-10; IL-35; TGF-β; IgG4; tolerance; allergen; autoimmunity; suppression; BR1; B10; AIT; Allergen immunotherapy; BCR; B-cell receptor; Breg; Regulatory B; DC; Dendritic cell; EAE; Experimental autoimmune encephalomyelitis; MZ; Margin
PD-L1 (B7-H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas
Keywords: PD-L1; Tumor infiltrating lymphocytes; Primary breast cancer; Metastatic breast cancer; Tumor microenvironment
Successful Immunotherapy against a Transplantable Mouse Squamous Lung Carcinoma with Anti-PD-1 and Anti-CD137 Monoclonal Antibodies
Keywords: Immunotherapy; Lung cancer; Squamous; CD-137; PD-1; PD-L1;
Predictive Markers for the Efficacy of Anti-PD-1/PD-L1 Antibodies in Lung Cancer
Keywords: Lung cancer; Immunotherapy; PD-1; PD-L1; Biomarker;
Signaling pathway and dysregulation of PD1 and its ligands in lymphoid malignancies
Keywords: PD-1; PD-L1; PD-L2; Lymphoid malignancies; Pidilizumab; Nivolumab; Pembrolizumab
Review articlePD-1/PD-L and autoimmunity: A growing relationship
Keywords: PD-1; PD-L1; PD-L2; Autoimmunity;
Essential role of HDAC6 in the regulation of PD-L1 in melanoma
Keywords: Histone deacetylases; HDAC6; PD-L1; STAT3; PP2A; Melanoma; Nexturastat; Tubastatin A;
A Harmonization Study for the Use of 22C3 PD-L1 Immunohistochemical Staining on Ventana's Platform
Keywords: PD-L1; IHC; Dako; Ventana; Harmonization;
Programmed Cell Death Ligand 1 Expression in Resected Lung Adenocarcinomas: Association with Immune Microenvironment
Keywords: KRAS mutation; Lung adenocarcinoma; PD-L1; Smoking; Tumor microenvironment;