کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5646768 | 1407071 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of regulatory B cells in immune tolerance to allergens and beyond
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کلمات کلیدی
IL-10regulatory BIL-35AITIgG4TregBR1EAEB10OVATGF-βPLAPD-L1BCRAllergen - آلرژنphospholipase A2 - آنزیم فسفولیپاز A2 experimental autoimmune encephalomyelitis - آنسفالومیلیت خودایمنی تجربیOvalbumin - اوبلبومینAllergen immunotherapy - ایمنوتراپی آلرژنBreg - برگیTolerance - تلرانس autoimmunity - خودایمنیSuppression - سرکوبDendritic cell - سلول دندریتیکregulatory B cells - سلول های تنظیم کننده BProgrammed death ligand 1 - لیگاند مرگ برنامه ریزی شده 1Regulatory T - مقررات Tmarginal zone - منطقه حاشیه ایB-cell receptor - گیرنده سلول B
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Immune tolerance to both self-antigens and innocuous non-self-antigens is essential to protect the host against chronic inflammatory diseases and tissue damage. A wide range of cell types and suppressive molecules are involved in induction and maintenance of tolerance. In addition to their key function in the production of immunoglobulins, B cells can regulate immune responses through their surface molecules and secretion of cytokines. Regulatory B (Breg) cells are characterized by their immunosuppressive capacity, which is often mediated through IL-10 secretion. However, IL-35 and TGF-β have also been associated with B cell-mediated immunosuppression. Several types of murine and human Breg cells have been described, such as mouse CD5+CD1dhi B10 cells, CD21hiCD23hiCD24hi transitional stage 2-like B cells, and CD138+ plasma cells and plasmablasts. Human Breg cell types include CD27+CD24high B10 cells, CD24hiCD38hi immature transitional B cells, and CD73âCD25+CD71+ BR1 cells and a subset of plasma cells. Support for the in vivo existence of allergen-specific human Breg cells comes from direct detection of their increase during the course of allergen-specific immunotherapy, as well as their increased expression in nonallergic but high-dose allergen-exposed beekeepers. Human BR1 cells selectively upregulate IgG4 antibodies on differentiation to plasma cells. This suggests an additional immune regulatory role because of the noninflammatory and blocking antibody function of IgG4. Taken together, Breg cells appear to be involved in mediating allergen tolerance, but many open questions remain to be answered.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 138, Issue 3, September 2016, Pages 654-665
Journal: Journal of Allergy and Clinical Immunology - Volume 138, Issue 3, September 2016, Pages 654-665
نویسندگان
Willem PhD, Barbara PhD, Oliver F. MSc, Kirstin MSc, Anna MSc, Mübeccel PhD,