Keywords: Malaria; Plasmodium falciparum; Chloroquine resistance; Pfcrt; Intron; Exon 2; Artemisinin combination therapy; Thailand;
مقالات ISI (ترجمه نشده)
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Keywords: Plasmodium falciparum; Eritrea; Drug resistance; Kelch 13 propeller; Pfmdr1; Pfcrt;
Keywords: Antimalarial policy; Drug resistance; Microsatellites; pfcrt; pfmdr1; pfdhfr
Keywords: Plasmodium falciparum; Chloroquine; pfcrt; Drug resistance; Hodeidah; Treatment-seeking behavior;
Keywords: PfCRT; P. falciparum chloroquine resistance transporter protein; CQ; chloroquine; TMD; transmembrane domain; SDS; sodium dodecyl sulfate; TFE; trifluoroethanol; DLS; dynamic light scattering; CD; circular dichroism; ITC; isothermal titration calorimetry;
Pfcrt genotypes and related microsatellite DNA polymorphisms on Plasmodium falciparum differed among populations in the Greater Mekong Subregion
Keywords: CQ; chloroquine; DNA; deoxyribonucleic acid; GMS; Greater Mekong Subregion; Lao PDR; The Lao People's Democratic Republic; PCR; polymerase chain reaction; pfcrt; Plasmodium falciparum chloroquine resistance transporter; WHO; World Health Organization;
Engineering and purification of a thermostable, high-yield, variant of PfCRT, the Plasmodium falciparum chloroquine resistance transporter
Keywords: PfCRT; Membrane protein; Membrane transport; Recombinant protein expression; Protein purification; Construct screening; Protein stability; Drug resistance; Malaria; Transporter; Plasmodium falciparum; Neospora canium; NcCRT;
Synergism between Pfcrt and Pfmdr1 genes could account for the slow recovery of chloroquine sensitive Plasmodium falciparum strains in Ghana after chloroquine withdrawal
Keywords: Malaria; Drug resistance; Haplotype; Recovery; Synergism; Gene; Plasmodium falciparum; Chloroquine; Amodiaquine; Quinine; Pfcrt; Pfmdr1;
Research paperPolymorphisms in Pfcrt and Pfmdr-1 genes after five years withdrawal of chloroquine for the treatment of Plasmodium falciparum malaria in West Bengal, India
Keywords: Chloroquine sensitivity; Plasmodium falciparum; Pfcrt; Pfmdr-1; India;
Sequence analysis of pfcrt and pfmdr1 genes and its association with chloroquine resistance in Southeast Indian Plasmodium falciparum isolates
Keywords: Drug resistance; Plasmodium falciparum; Chloroquine; pfcrt; pfmdr1CQ, chloroquine; pfcrt, Plasmodium falciparum chloroquine resistance transporter; pfmdr1, Plasmodium falciparum multidrug resistance 1; SNP, single nucleotide polymorphism; K76T, lysine res
Analysis of genetic diversity in the chloroquine-resistant gene Pfcrt in field Plasmodium falciparum isolates from five regions of the southern Cameroon
Keywords: P. falciparum-malaria; Chloroquine-resistance; Pfcrt; Single nucleotide polymorphism; Cameroon;
Identification of chloroquine resistance Pfcrt-K76T and determination of Pfmdr1-N86Y copy number by SYBR Green I qPCR
Keywords: Plasmodium falciparum; DNA copy number variation; Pfmdr1; Pfcrt; Real-time PCR
Single nucleotide polymorphisms in Plasmodium falciparum V type H+ pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms
Keywords: P. falciparum; Malaria; Pfcrt; Pfmdr1; Pfvp2; Chloroquine; Resistance;
A 2-amino quinoline, 5-(3-(2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid, interacts with PfMDR1 and inhibits its drug transport in Plasmodium falciparum
Keywords: Malaria; PfMDR1; PfCRT; MK571; Chloroquine; Antimalarials;
DNA sequence polymorphisms of the pfmdr1 gene and association of mutations with the pfcrt gene in Indian Plasmodium falciparum isolates
Keywords: Plasmodium falciparum; pfmdr1; Pfcrt; Single Nucleotide Polymorphisms (SNPs); India;
Analyses of genetic variations at microsatellite loci present in-and-around the Pfcrt gene in Indian Plasmodium falciparum
Keywords: Malaria; Plasmodium falciparum; India; Microsatellites; Pfcrt; Genetic diversity;
Polymorphic patterns of pfcrt and pfmdr1 in Plasmodium falciparum isolates along the Thai-Myanmar border
Keywords: Plasmodium falciparum; Multidrug resistance; Pfcrt; Pfmdr1; Gene mutation; Gene copy number;
Large differences in prevalence of Pfcrt and Pfmdr1 mutations between Mwanza, Tanzania and Iganga, Uganda-A reflection of differences in policies regarding withdrawal of chloroquine?
Keywords: Chloroquine resistance; Pfcrt; Pfmdr1; Malaria; Mwanza, Tanzania; Iganga, Uganda;
Tricks in Plasmodium's molecular repertoire - Escaping 3â²UTR excision-based conditional silencing of the chloroquine resistance transporter gene
Keywords: Plasmodium berghei; PfCRT; Sporozoite; Conditional knockdown; 3â²UTR; RACE;
PfCRT and its role in antimalarial drug resistance
Keywords: Plasmodium falciparum; malaria; drug resistance; PfCRT; heme detoxification; haplotypes; selective sweep; transmission
Update on genetic markers of quinine resistance in Plasmodium falciparum
Keywords: Malaria; Drug resistance; Quinine; Pfnhe; Pfcrt; Pfmdr1; Microsatellite;
Increased prevalence of the Plasmodium falciparum Pfmdr1 86N genotype among field isolates from Franceville, Gabon after replacement of chloroquine by artemether-lumefantrine and artesunate-mefloquine
Keywords: ACT; artemisinin-based combination therapy; AL; artemether-lumefantrine; AM; artesunate-mefloquine; CHL; centre hospitalier de Libreville; CI95%; confidence interval 95%; CQ; chloroquine; MQ; mefloquine; N86Y; asparagine (N) to tyrosine (Y) substituti
In vitro amodiaquine resistance and its association with mutations in pfcrt and pfmdr1 genes of Plasmodium falciparum isolates from Nigeria
Keywords: Plasmodium falciparum; Amodiaquine; Resistance; Mutation; pfcrt; pfmdr1;
Drug-resistant malaria: Molecular mechanisms and implications for public health
Keywords: Drug resistance; Antimalarial drug; pfcrt; pfmdr1; Plasmodium falciparum; Plasmodium vivax
A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT
Keywords: Malaria; Chloroquine resistance; Resistance-reverser; Chemosensitizer; Dibemethin; PfCRT
Monitoring of in vitro susceptibilities and molecular markers of resistance of Plasmodium falciparum isolates from Thai-Myanmar border to chloroquine, quinine, mefloquine and artesunate
Keywords: Plasmodium falciparum; pfcrt; pfmdr1; Gene copy number; Drug resistance
Transporters as mediators of drug resistance in Plasmodium falciparum
Keywords: Malaria; Drug resistance; PfMDR1; PfCRT; PfMRP; Transport
Association between chloroquine resistance phenotypes and point mutations in pfcrt and pfmdr1 in Plasmodium falciparum isolates from Thailand
Keywords: Plasmodium falciparum; pfcrt; pfmdr1; Quinoline antimalarials; Drug resistance
Association of molecular markers in Plasmodium falciparum crt and mdr1 with in vitro chloroquine resistance: A Philippine study
Keywords: Chloroquine resistance; Philippines; pfcrt; pfmdr1
A unique methodology for detecting the spread of chloroquine-resistant strains of Plasmodium falciparum, in previously unreported areas, by analyzing anophelines of malaria endemic zones of Orissa, India
Keywords: Malaria; Chloroquine resistance (CQR); Anopheles; Plasmodium falciparum; Pfcrt; K76T
Spread and evolution of Plasmodium falciparum drug resistance
Keywords: Malaria; Drug resistance; pfcrt; dhfr; Evolution; Spread
Stage independent chloroquine resistance and chloroquine toxicity revealed via spinning disk confocal microscopy
Keywords: BR; (short) bolus exposure during ring stage; BS; (short) bolus exposure during schizont stage; BT; (short) bolus exposure during trophozoite stage; CE; continuous exposure; CQ; chloroquine; CQR; chloroquine resistance (resistant); CQS; chloroquine sensit
Pfcrt haplotypes and in-vivo chloroquine response in Sundergarh district, Orissa, India
Keywords: Malaria; Plasmodium falciparum; Chloroquine; Pfcrt; Haplotype; India;
Field-based evidence for the linkage of pfcrt and pfdhfr drug-resistant malaria genotypes and clinical profiles of severe malaria in Niger
Keywords: Malaria; pfcrt; pfdhr; Virulence; Cerebral malaria; Severe malarial anaemia; Niger;
Chloroquine resistant P. falciparum prevalence is low and unchanged between 1990 and 2005 in Guinea-Bissau: An effect of high chloroquine dosage?
Keywords: In vitro; Chloroquine resistance; Guinea-Bissau; Pfcrt; Pfmdr1
Selection of pfmdr1 mutations after amodiaquine monotherapy and amodiaquine plus artemisinin combination therapy in East Africa
Keywords: Malaria; Plasmodium falciparum; Resistance; Amodiaquine; Desethylamodiaquine; ACT; pfcrt; pfmdr1; Kenya; Zanzibar
Plasmodium falciparum Na+/H+ exchanger activity and quinine resistance
Keywords: CQ; chloroquine; MQ; mefloquine; AQ; amodiaquine; QN; quinine; QD; quinidine; CQR; chloroquine resistance (or resistant); PfCRT; Plasmodium falciparum chloroquine resistance transporter; MDR; multidrug resistance; QR; quinoline resistance; Pgp; P-glycopro
Quinoline resistance associated polymorphisms in the pfcrt, pfmdr1 and pfmrp genes of Plasmodium falciparum in Iran
Keywords: Plasmodium falciparum; Chloroquine resistance; pfmdr1; pfcrt; pfmrp; Iran
Multiplex PCR–RFLP methods for pfcrt, pfmdr1 and pfdhfr mutations in Plasmodium falciparum
Keywords: Falciparum; pfmdr1; pfcrt; pfdhfr; Multiplex PCR; Malaria
First evidence of pfcrt mutant Plasmodium falciparum in Madagascar
Keywords: Malaria; Plasmodium falciparum; Chloroquine; pfcrt; Resistance; Madagascar;
Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of pfcrt 76T and pfmdr1 86Y
Keywords: Plasmodium falciparum; Malaria; Drug resistance; Amodiaquine; ACT; pfcrt; pfmdr1; pfmrp; Kenya
Drug resistance–virulence relationship in Plasmodium falciparum causing severe malaria in an area of seasonal and unstable transmission
Keywords: Severe malaria; Resistance; Virulence; Mutation; pfcrt; pfmdr1
Wide variation in microsatellite sequences within each Pfcrt mutant haplotype
Keywords: Pfcrt; Plasmodium falciparum chloroquine resistance transporter; U.P.; Uttar Pradesh; M.P.; Madhya Pradesh; A&N; Andaman and Nicobar; Plasmodium falciparum; Nucleotide sequence; Microsatellite alleles; Chloroquine resistance; pfcrt Mutations;
Malaria transmission intensity and the rate of spread of chloroquine resistant Plasmodium falciparum: Why have theoretical models generated conflicting results?
Keywords: Malaria drug resistance; Pfcrt; Pfmdr1
Role of pfmdr1 mutations on chloroquine resistance in Plasmodium falciparum isolates with pfcrt K76T from Papua New Guinea
Keywords: Plasmodium falciparum; Chloroquine resistance; In vitro; pfcrt; pfmdr1
Flashback to the 1960s: Utility of archived sera to explore the origin and evolution of Plasmodium falciparum chloroquine resistance in the Pacific
Keywords: Chloroquine resistance; Pacific; pfcrt; Archival samples
Expression and function of pvcrt-o, a Plasmodium vivax ortholog of pfcrt, in Plasmodium falciparum and Dictyostelium discoideum
Keywords: CQ; chloroquine; CQS; chloroquine sensitivity; CQR; chloroquine resistance; DV; digestive vacuole; h; hour; hdhfr; human dihydrofolate reductase gene; IC50; 50% drug inhibitory concentration value; luc; luciferase gene; min; minutes; PbEF1α; intergenic r
Functional reconstitution of purified chloroquine resistance membrane transporter expressed in yeast
Keywords: PfCRT; Yeast expression system; Proteoliposome; CQ transport activity
In vivo chloroquine resistance and prevalence of the pfcrt codon 76 mutation in Plasmodium falciparum isolates from the Republic of Congo
Keywords: P. falciparum; Chloroquine; Malaria; Congo; Pfcrt;
Malaria in the Nuba Mountains of Sudan: baseline genotypic resistance and efficacy of the artesunate plus sulfadoxine-pyrimethamine and artesunate plus amodiaquine combinations
Keywords: Artesunate; Amodiaquine; Sulfadoxine-pyrimethamine; Pfcrt; Dhfr; Sudan;