Fluoride-induced cyclooxygenase-2 expression and prostaglandin E2 production in A549 human pulmonary epithelial cells
Keywords: Fluoride; COX-2; PGE2; MAPKs; A549
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Protective effects of butanol fraction from Betula Platyphyla var. japonica on cartilage alterations in a rabbit collagenase-induced osteoarthritis
Keywords: Butanol fraction from the bark of Betula platyphylla var. japonica; Cartilage alternations; MMPs; TIMP-1; PGE2; Cyclooxygenase
Valnemulin downregulates nitric oxide, prostaglandin E2, and cytokine production via inhibition of NF-κB and MAPK activity
Keywords: Valnemulin; NO; PGE2; Cytokines; NF-κB; MAPKs
Different populations of prostaglandin EP3 receptor-expressing preoptic neurons project to two fever-mediating sympathoexcitatory brain regions
Keywords: GABA; inflammation; rostral medullary raphe; stress response; sympathetic nervous system; thermoregulation; BAT; brown adipose tissue; CTb; cholera toxin b-subunit; DMH; dorsomedial hypothalamus; DMH-CTb; cholera toxin b-subunit derived from the dorsomedi
A combination of aspirin and γ-tocopherol is superior to that of aspirin and α-tocopherol in anti-inflammatory action and attenuation of aspirin-induced adverse effects
Keywords: Vitamin E; NSAIDs; Cyclooxygenase; PGE2; Inflammation;
Nitric oxide and ERK/MAPK mediation of estrous behavior induced by GnRH, PGE2 and db-cAMP in rats
Keywords: NO; MAPK; Estrous behavior; GnRH; PGE2; cAMP;
Anti-inflammatory effects and gastrointestinal safety of NNU-hdpa, a novel dual COX/5-LOX inhibitor
Keywords: Anti-inflammatory; Edema; COX/5-LOX; PGE2; LTB4
Effects of limonene and essential oil from Citrus aurantium on gastric mucosa: Role of prostaglandins and gastric mucus secretion
Keywords: Citrus aurantium; Essential oil; Limonene; Gastric protection; PGE2
Polyunsaturated fatty acids differentially alter PGF2α and PGE2 release from bovine trophoblast and endometrial tissues during short-term culture
Keywords: Endometrium; Trophoblast; PGF2α; PGE2; Polyunsaturated fatty acids; Bovine
Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology
Keywords: MAPKAPK2; Cartilage; MK2; Metalloproteinases; PGE2
Acute and persistent nociceptive paw sensitisation in mice: The involvement of distinct signalling pathways
Keywords: PGE2; Dopamine; Hyperalgesia; PKA; PKC; ERK;
Cyclooxygenase-2/prostaglandin E2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells
Keywords: Icariside II; Apoptosis; PC-3 cells; COX-2; PGE2
A COX-2 inhibitor nimesulide analog selectively induces apoptosis in Her2 overexpressing breast cancer cells via cytochrome c dependent mechanisms
Keywords: PI3K; phosphatidylinositol 3-kinase; AKT; protein kinase B; PDK; phosphoinositide-dependent kinase; MAPK; mitogen activated protein kinase; COX-2; cyclooxygenase 2; NSAIDs; non-steroidal anti-inflammatory drugs; PGE2; prostaglandin E2; Her2; human epiderm
Contribution of calcium-containing crystals to cartilage degradation and synovial inflammation in osteoarthritis
Keywords: Osteoarthritis; CPPD; CPPT; BCP; DCPD; MMP-13; NO; PGE2; Chondrocyte; Synoviocyte; Pyrophosphate
sPLA2-IIa is an inflammatory mediator when the ocular surface is compromised
Keywords: sPLA2-IIa; PGE2; cytokines; dry eye disease; compromised ocular surface
Constitutive COX-2 activity in cardiomyocytes confers permanent cardioprotection: Constitutive COX-2 expression and cardioprotection
Keywords: Ischemia; Reperfusion; COX-2; Transgenic model; PGE2; PGI2; Arachidonic acid; Cell death; NMR
Heat loss responses and blockade of prostaglandin E2-induced thermogenesis elicited by α1-adrenergic activation in the rostromedial preoptic area
Keywords: noradrenaline; thermoregulation; PGE2; median preoptic nucleus; ratAVPe, anteroventral periventricular nucleus; HDB, nucleus of the horizontal limb of the diagonal band of Broca; LPO, lateral preoptic area; LPS, lipopolysaccharide; MnPO, median preoptic n
PGE2 signal via EP2 receptors evoked by a selective agonist enhances regeneration of injured articular cartilage
Keywords: PGE2; EP2; Agonist; Cartilage; Defect; Repair; Therapeutic drug; Osteoarthritis
Cytosolic phospholipase A2-driven PGE2 synthesis within unsaturated fatty acids-induced lipid bodies of epithelial cells
Keywords: Lipid droplet; Epithelial cell; cPLA2-α; PGE2; Arachidonic acid; Oleic acid; p38 MAP kinase
Oenothera laciniata inhibits lipopolysaccharide induced production of nitric oxide, prostaglandin E2, and proinflammatory cytokines in RAW264.7 macrophages
Keywords: COX-2; iNOS; Inflammation; PGE2; Primary skin irritation; Oenothera laciniata
p38 mitogen-activated kinase (MAPK) is essential for equine neutrophil migration
Keywords: TLR; toll-like receptor; COX-2; cyclooxygenase 2; IL1-β; interleukin 1-β; IL-6; interleukin-6; DRD; differential mRNA display; MAIL; molecule possessing ankyrin-repeats induced by lipopolysaccharide; MMPs; matrix metalloproteinase enzymes; ROS; reactive
Prostaglandin E receptor subtype EP3 in conjunctival epithelium regulates late-phase reaction of experimental allergic conjunctivitis
Keywords: Conjunctival epithelium; prostaglandin E receptor subtype EP3; allergic conjunctivitis; eosinophilic conjunctival inflammation; EP3 agonist; alum; Aluminum hydroxide; cPGES; Cytosolic prostaglandin E synthase; EAC; Experimental allergic conjunctivitis; mP
Adenosine analogs and electromagnetic fields inhibit prostaglandin E2 release in bovine synovial fibroblasts
Keywords: Adenosine receptors; Synovial fibroblasts; Electromagnetic field; PGE2
Cyclic AMP regulates extracellular matrix gene expression and metabolism in cultured primary rat chondrocytes
Keywords: AC; adenylyl cyclase; Act D; actinomycin D; Agc1; aggrecan; ANOVA; analysis of variance; cAMP; cyclic 3â², 5â²-adenosine monophosphate; cGK; cyclic guanine monophosphate-dependent protein kinase; Col2a1; type II collagen; Col10a1; type X collagen; CPT-c
Secreted phospholipases A2: A proinflammatory connection between macrophages and mast cells in the human lung
Keywords: AA; arachidonic acid; Akt; protein kinase B; BA; bronchial asthma; BAL; bronchoalveolar lavage; BBMCs; bone marrow-derived mast cells; COPD; chronic obstructive pulmonary disease; ERK1/2; extracellular-regulated kinase 1/2; HSPG; heparan sulfate proteogly
CCR7-specific migration to CCL19 and CCL21 is induced by PGE2 stimulation in human monocytes: Involvement of EP2/EP4 receptors activation
Keywords: PGE2; CCR7; Migration; Monocytes; cAMP
Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects
Keywords: Human mast cells; vascular endothelial growth factors; vascular endothelial growth factor receptors; angiogenesis; prostaglandin E2; adenosine; chemotaxis; CAM; Chorioallantoic membrane; CBMC; Cord blood-derived mast cell; GAPDH; Glyceraldehyde-3-phosph
Expression of cyclooxygenase-1/-2, microsomal prostaglandin-E synthase-1 and E-prostanoid receptor 2 and regulation of inflammatory mediators by PGE2 in the amoeboid microglia in hypoxic postnatal rats and murine BV-2 cells
Keywords: microglia; hypoxia; COX-1/-2; mPGES-1; EP2 receptor antagonist; PGE2; AA; arachidonic acid; AMC; amoeboid microglial cells; cAMP; cyclic adenosine monophosphate; CNS; central nervous system; COX-1; cyclooxygenase-1; COX-2; cyclooxygenase-2; cPGES; cytosol
Cellular and molecular pathways linking inflammation and cancer
Keywords: COX-2; cycloxygenase-2; TGFβ; transforming growth factor-β; HIF-1; hypoxia inducible factor 1; STAT-3; signal transducers and activator of transcription-3; TAMs; tumour-associated macrophages; TNFalpha; tumour necrosis factor alpha; TEMs; Tie2-expressin
Effects of compounds from Kaempferia parviflora on nitric oxide, prostaglandin E2 and tumor necrosis factor-alpha productions in RAW264.7 macrophage cells
Keywords: NO; PGE2; Kaempferia parviflora; Zingiberaceae; Anti-inflammatory compounds
Inflammation, Epithelial to Mesenchymal Transition, and Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance
Keywords: EGFR TK inhibitor; G-protein coupled receptors; Inflammation; Cyclooxygenase-2; PGE2; Epithelial to mesenchymal transition; Drug resistance; NSCLC
mTORC2 regulates PGE2-mediated endothelial cell survival and migration
Keywords: mTOR; Rapamycin; PGE2; Angiogenesis; Endothelial cell; Migration; Survival; Rac; Akt
Misoprostol, an anti-ulcer agent and PGE2 receptor agonist, protects against cerebral ischemia
Keywords: Stroke; Misoprostol; Prostaglandin; PGE2; Cerebral ischemia;
Prostaglandin E2 inhibits tumor necrosis factor-alpha RNA through PKA type I
Keywords: Raw 264.7 cells; Inflammation; cAMP; Epac; PGE2; Prostacyclin; Macrophage; Tumor necrosis factor-alpha; Lipopolysaccharide;
Human EP3I prostanoid receptor induces VEGF and VEGF receptor-1 mRNA expression
Keywords: EP3I receptor; VEGF; VEGFR-1; PGE2
Gingival crevicular fluid PGE2, IL-1ß, t-PA, PAI-2 levels in type 2 diabetes and relationship with periodontal disease
Keywords: Diabetes; ELISA; Gingival crevicular fluid; IL-1beta Periodontal disease; PGE2; PAI-2; t-PA
The other side of the medal: How chemokines promote analgesia
Keywords: CFA; complete Freund's adjuvant; CCL2, MCP-1; monocyte chemoattractant protein 1; CCL3, MIP-1α; macrophage inflammatory protein-1α; CXCL1, KC; keratinocyte derived chemokine; CXCL2/3, MIP-2; macrophage inflammatory protein-2; CXCL8; interleukin-8; DRG;
Prostaglandin receptor EP2 protects dopaminergic neurons against 6-OHDA-mediated low oxidative stress
Keywords: Parkinson's disease; Inflammation; Neuroprotection; PGE2; 6-OHDA; cAMP; PKA; Butaprost
Local Inflammatory and Metabolic Response in the Knee Synovium After Arthroscopy or Arthroscopic Anterior Cruciate Ligament Reconstruction
Keywords: Anterior cruciate ligament; Inflammation; Knee arthroscopy; Microdialysis; PGE2; Synovial membrane metabolism
Role of IL-18 in overt pain-like behaviour in mice
Keywords: IL-18 (Interleukin-18); Pain; Overt pain; Hyperalgesia; Nociception; Inflammation; Endothelin; IFN-γ; (interferon-γ); PGE2
Cellular mechanisms of estradiol-mediated masculinization of the brain
Keywords: Sexual differentiation; Estradiol; PGE2; Glutamate; GABA
Expression and localization of prostaglandin transporter in Alzheimer disease brains and age-matched controls
Keywords: Central nervous system; Cyclooxygenases; Neuroinflammation; PGE2
Involvement of the cytoskeleton in the effect of PGE2 on ion transport in the rat distal colon
Keywords: PGE2; Microfilaments; Microtubules; Actin; Colchicine; Na+K+-ATPase; Na+K+2Clâ;
Melatonin inhibits prostaglandin E2- and sodium nitroprusside-induced ion secretion in rat distal colon
Keywords: Melatonin; Secretion; Colon; SNP; PGE2;
Human mesenchymal stem cell proliferation is regulated by PGE2 through differential activation of cAMP-dependent protein kinase isoforms
Keywords: PKA; cAMP; Mesenchymal stem cell; Proliferation; Prostanoid; PGE2
Anti-inflammatory effects and changes in prostaglandin patterns induced by 7β-hydroxy-epiandrosterone in rats with colitis
Keywords: Inflammation; Oxidative stress; COX-2; PGE2; PGD2; 15d-PGJ2
7β-hydroxy-epiandrosterone modulation of 15-deoxy-Î12,14-prostaglandin J2, prostaglandin D2 and prostaglandin E2 production from human mononuclear cells
Keywords: Steroids; 7β-Hydroxy-epiandrosterone; 15d-PGJ2; PGE2; PGD2; Human mononuclear cells; Inflammation;
Time-course evaluation and treatment of skin inflammatory immune response after ultraviolet B irradiation
Keywords: UVB; TNF-α; PGE2; Skin inflammation; NSAID treatment
Cyclooxygenase-2/PGE2 pathway facilitates pentylenetetrazol-induced seizures
Keywords: COX-2; Celecoxib; Epilepsy; PGE2; EEG; PTZ