Keywords: IMCL; Intramyocellular lipid; DAG; diacylglycerol; CPT1; carnitine palmitoyl transferase1; ACAT1; acetyl-CoA acetyltransferase1; FASN; fatty acid synthase; SUCLG1; succinyl-CoA ligase (synthetase); NF-kB; nuclear factor kappaB; TNFa; tumour necrosis facto
مقالات ISI (ترجمه نشده)
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Keywords: 2,4-D; dichlorophenoxyacetic acid; [35S]TBPS; [35S]tertiary-butylbicyclophosphorothionate; 3-NP; 3-nitropropionic acid; 4CL; 4-coumarate: CoA ligase; 4-O-MH; 4-O-methylhonokiol; 6-OHDA; 6-hydroxydopamine; 8-oxo-dG; 8-oxo-2â²-deoxyguanosine; AChE; acetylc
Keywords: α-sma; alpha smooth muscle actin; BSA; bovine serum albumin; cc-3; cleaved caspase-3; Cho; choroid; GFAP; glial fibrillary acidic protein; IB4; isolectin B4; Iba1; ionized calcium binding adapter molecule 1; INL; inner nuclear layer; NG2; neuron-glial an
Knockdown of the thyroid hormone transporter MCT8 in chicken retinal precursor cells hampers early retinal development and results in a shift towards more UV/blue cones at the expense of green/red cones
Keywords: Thyroid hormone; Monocarboxylate transporter 8; Retina; Development; Chicken embryo; RNA interference; AP; alkaline phosphatase; BRN3a; brain-specific homeobox/POU domain protein 3a; CNS; central nervous system; CRX; Cone-Rod homeobox; DAC; displaced amac
Protein kinase C alpha-mediated phosphorylation of PIM-1L promotes the survival and proliferation of acute myeloid leukemia cells
Keywords: PKCα; PIM-1L; p27KIP1; FLT3-ITD; Acute myeloid leukemia;
Galangin's potential as a functional food ingredient
Keywords: Galangin; Propolis; Alpinia officinarum; Functional food ingredient; Polypharmacology; Flavonoid; AChE; acetylcholinesterase; AD; Alzheimer's disease; ADME; Administration, Distribution, Metabolism and Excretion; AHR; airway hyperresponsive; AhR; aryl h
Differential roles of PKC isoforms (PKCs) in GnRH stimulation of MAPK phosphorylation in gonadotrope derived cells
Keywords: GnRH; PKCα; PKCβII; PKCδ; PKCε; MAPK; ERK; JNK; p38; Gonadotropes; LβT2 cells; αT3-1 cells; anti-DP antibodies; anti-diphospho-antibodies; DAG; diacylglycerol; DN; dominant negative; ERK; extracellular signal-regulated kinase; FSH; follicle stimula
Chemokine CC-motif ligand 2 participates in platelet function and arterial thrombosis by regulating PKCα-P38MAPK-HSP27 pathway
Keywords: CCL2; CCR2; Platelet activation; Arterial thrombosis; PKCα; P38MAPK;
Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating
Keywords: TIRFM; Total Internal Reflection Fluorescence Microscopy; tRFP; tag Red Fluorescence Protein; FBS; fetal bovine serum; Noco; nocodazole; Cyt-D; cytochalasin D; TIR-FRAP; Total Internal Reflection - Fluorescence Recovery after Photobleaching; MSD; mean s
Syndecan-4 deficiency accelerates the transition from compensated hypertrophy to heart failure following pressure overload
Keywords: Syndecan-4; Angiogenesis; Cardiac hypertrophy; Heart failure; PKCα;
Biphasic and directed translocation of protein kinase Cα inside cultured endothelial cells before migration
Keywords: EC; endothelial cell; PKCα; protein kinase Cα; Fura-2-AM; Fura-2-acetoxymethyl ester; SA; stretch-activated; Endothelial cell; Protein kinase Cα; Mechanical injury; Mechanical stimulation;
Original articleThe interplay between intracellular progesterone receptor and PKC plays a key role in migration and invasion of human glioblastoma cells
Keywords: Glioblastoma; Progesterone receptor; PKCα; Migration; Invasion; PIBF;
Nelumbo nucifera leaf polyphenol extract inhibits breast cancer cells metastasis in vitro and in vivo through PKCα targeting
Keywords: Breast cancer; Nelumbo nucifera leaf extract; Nelumbo nucifera leaf polyphenol extract; PKCα; Migration; MMP-9; NLE; N. nucifera leaf extract; NLPE; N. nucifera leaf polyphenolic extract;
Biological or pharmacological activation of protein kinase C alpha constrains hepatitis E virus replication
Keywords: PKCα; Hepatitis E virus; PMA; AP-1; ISG;
Differential roles of PKC isoforms (PKCs) and Ca2+ in GnRH and phorbol 12-myristate 13-acetate (PMA) stimulation of p38MAPK phosphorylation in immortalized gonadotrope cells
Keywords: GnRH; PKCα; PKCβII; PKCδ; PKCε; MAPKs; p38; Gonadotropes; αT3-1 and LβT2 cells; CaMK; calmodulin-dependent protein kinase; DAG; diacylglycerol; ERK; extracellular-signal-regulated kinases; GnRH; gonadotropin-releasing hormone; GnRHR; gonadotropin-re
Myocardin: A novel player in atherosclerosis
Keywords: Myocardin; Atherosclerosis; Inflammation; Lipid metabolism; VSMC; Abca1; MYOCD; Myocardin; AS; atherosclerosis; SRF; serum response factor; VSMC; vascular smooth muscle cell; Mrtf-A/B; Myocardin-related transcription factors A/B; Mamstr; Mef2-activating S
The key residue within the second extracellular loop of human EP3 involved in selectively turning down PGE2- and retaining PGE1-mediated signaling in live cells
Keywords: EP selectivity; G protein-coupled receptor (GPCR); Prostaglandin; Prostaglandin E1; Prostaglandin E2; Receptor regulation; AA; arachidonic acid; COX-1 and -2; cyclooxygenase-1 and -2, respectively; cPGES; cytosolic PGES; DGLA; dihomo-γ-linolenic acid; EP
Involvement of PKCα and ERK1/2 signaling pathways in EGCG's protection against stress-induced neural injuries in Wistar rats
Keywords: 5-HT; 5-hydroxytryptamine or serotonin; AD; Alzheimer's disease; ATP; adenosine triphosphate; BBB; blood-brain barrier; CNS; central nervous system; DA; dopamine; EGCG; epigallocatechin-3-gallate; ERK1/2; extracellular signal-regulated kinase 1/2; GC; g
Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease
Keywords: AD; Alzheimer's disease; AGC; protein kinase A/protein kinase G/protein kinase C; Akt; protein kinase B; ATG13; autophagy-related gene 13; Aβ; amyloid-beta; BDNF; brain-derived neurotrophic factor; CaMKII; Ca2+/calmodulin-dependent kinase II; cAMP; cyc
Sub-cellular localization specific SUMOylation in the heart
Keywords: AMPK; adenosine monophosphate-activated protein kinase; CAMKK; calcium-calmodulin-activated protein kinase kinase; CHIP; carboxyl terminus of HSP70-interacting protein; CVD; cardiovascular disease; cTnI; cardiac troponin I; d-flow; disturbed flow; DeSI; d
Diverse roles of HDAC6 in viral infection: Implications for antiviral therapy
Keywords: HDAC6; Viral infection; Viral pathogenesis; Antiviral therapy; CBP; cAMP response element-binding protein (CREB) binding protein; HCV; hepatitis C virus; HDAC6; histone deacetylase 6; HIV; human immunodeficiency virus; IAV; influenza A virus; IFN; interfe
Mosla scabra flavonoids ameliorate the influenza A virus-induced lung injury and water transport abnormality via the inhibition of PRR and AQP signaling pathways in mice
Keywords: MF; total flavonoids extracted from Mosla Scabra; IAV; influenza A virus; LD50; 50% lethal dose; RFQ-PCR; Real-time Fluorescence Quantitative Polymerase Chain Reaction; IC50; 50% influenza virus-inhibitory concentration; HDF-1; 5-hydroxy-6,7-dimethoxyflav
Original ArticleKeratinocytes/EpidermisKeratin Isotypes Control Desmosome Stability and Dynamics through PKCα
Keywords: DP; desmoplakin; Dsg; desmoglein; K; keratin; KIF; keratin intermediate filament; KtyI; keratin type I gene cluster; KtyII; keratin type II gene cluster; PKCα; protein kinase C alpha; PKP; plakophilin; PM; plasma membrane; WB; Western blotting; WT; wild-
Antagonistic Regulation of Intercellular Cohesion by Plakophilins 1 and 3
Keywords: AJ; adherens junctions; DSC; desmocollin; DSG; desmoglein; DSP; desmoplakin; HCM; high calcium medium; KO; knockout; LCM; low calcium medium; PBS; phosphate buffered saline; PKCα; protein kinase C alpha; PKP; plakophilin; WT; wild type;
Trans-10,cis-12 conjugated linoleic acid (CLA) interferes with lipid droplet accumulation during 3T3-L1 preadipocyte differentiation
Keywords: Conjugated linoleic acid (CLA); Adipocytes; Perilipin-1; Hormone-sensitive lipase; PKCα; Lipolysis;
Up-regulation of glutamine synthesis in microglia activated with endotoxin
Keywords: ATP; adenosine 5â²-triphosphate; DMEM; Dulbecco's modified essential medium; GFAP; glial fibrillary acidic protein; GLAST; glutamate-aspartate transporter; Gln; glutamine; GLT-1; glutamate transporter-1; Glu; glutamate; GS; glutamine synthetase; HRP;
PKCα promotes generation of reactive oxygen species via DUOX2 in hepatocellular carcinoma
Keywords: PKCα; DUOX2; Reactive oxygen species; Hepatocellular carcinoma;
VEGF-A promotes cardiac stem cell engraftment and myocardial repair in the infarcted heart
Keywords: VEGF-A; Cardiac stem cells; Myocardial infarction; VCAM-1; PKCα;
Brain-derived neurotrophic factor inhibits osmotic swelling of rat retinal glial (Müller) and bipolar cells by activation of basic fibroblast growth factor signaling
Keywords: BDNF; brain-derived neurotrophic factor; bFGF; basic fibroblast growth factor; GDNF; glial cell line-derived neurotrophic factor; HEPES; (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; K252a; (9S,10R,12R)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-
MicroRNAs as regulatory elements in triple negative breast cancer
Keywords: HER2; human epidermal growth factor receptor 2; RISC; RNA-induced silencing complex; NF-κB; nuclear factor κB; Rb; retinoblastoma; XIAP; X-linked inhibitor of apoptosis; VHL; von Hippel-Lindau; PKCα; protein kinase Cα; TNBC; triple negative breast c
Molecular interplays involved in the cellular uptake of octaarginine on cell surfaces and the importance of syndecan-4 cytoplasmic V domain for the activation of protein kinase Cα
Keywords: CPPs; cell-penetrating peptides; GAGs; glycosaminoglycans; HSPGs; heparan sulfate proteoglycans; Syn-4; syndecan-4; CD; cytoplasmic domain; PKCα; protein kinase C-alpha; PtdIns[4,5]P2; phosphatidylinositol (4,5) bisphosphate; Syn-4ÎV; V domain-lacking s
The role of VLA-4 binding for experimental melanoma metastasis and its inhibition by heparin
Keywords: FCS; fetal calf serum; FAK; focal adhesion kinase; LMWH; low molecular weight heparin; mAb; monoclonal Antibody; PBS; phosphate-buffered saline; PE labeled; Phycoerythrin labeled; PKCα; protein kinase C alpha; UFH; unfractionated heparin; VCAM-1; vascula
Endothelial PKCα-MAPK/ERK-phospholipase A2 pathway activation as a response of glioma in a triple culture model. A new role for pericytes?
Keywords: Microvascular endothelial cells; Microvascular pericytes; C6 cells; TEER; Permeability; Matrigel assay; Cytosolic and calcium independent phospholipase A2; PKCα; ERK1/2; COX-1/-2; PGE2;
The role of anti-apoptotic protein kinase Cα in response to hypericin photodynamic therapy in U-87 MG cells
Keywords: Hypericin; Photodynamic therapy; PKCα; Apoptosis; U87 MG cells;
PKCα and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription
Keywords: AP1; activator protein 1; cpm; counts per minute; EMSA; electrophoretic mobility shift assay; FACS; fluorescence activated cell sorter; ERK; extracellular regulated kinase; IL-2; interleukin-2; IFNγ; interferon gamma; IκB; inhibitor of NFκB; IKK; IκB
ELAV proteins along evolution: Back to the nucleus?
Keywords: RBP; RNA-binding protein; elav; embryonic lethal abnormal vision; miRNA; microRNA; rbp9; RNA-binding protein 9; fne; found in neurons; ARE; AU-rich element; UTR; untranslated region; RRM; RNA recognition motif; PABP; polyA-binding protein; eiF4A; eukaryot
Apelin-13 increases expression of ATP-binding cassette transporter A1 via activating protein kinase C α signaling in THP-1 macrophage-derived foam cells
Keywords: Apelin; ABCA1; PKCα; Calpain; Atherosclerosis; PKC; protein kinase C; ABCA1; ATP-binding cassette transporter A1; apoE; apolipoprotein E; RCT; reverse cholesterol transport; apoA-I; apolipoprotein A-I; TGF-β1; transforming growth factor-β1; IFN-γ; int
Original ReportPKCα Is Required for Inflammation-Induced Trafficking of Extrasynaptic AMPA Receptors in Tonically Firing Lamina II Dorsal Horn Neurons During the Maintenance of Persistent Inflammatory Pain
Keywords: Extrasynaptic AMPA receptors; PKCα; inflammatory pain; substantia gelatinosa neurons;
The membrane binding kinetics of full-length PKCα is determined by membrane lipid composition
Keywords: PKC; Protein kinase C; POPC; 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; POPS; 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoserine; PIP2; Phosphatidylinositol 4,5-bisphosphate; DOG; 1,2-Dioleoyl-sn-glycerol; IP3; Inositol 1,4,5-trisphosphate; PKCα; Rap
Ei24-deficiency attenuates protein kinase Cα signaling and skin carcinogenesis in mice
Keywords: DMBA/TPA skin-carcinogenesis; EGFR; Ei24; PKCα; RINCK1;
PPARδ prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-κB and inhibition of the PKCα/MEK1/2/ERK1/2/AP-1 pathway
Keywords: AP-1; activator protein-1; CNS; central nervous system; Cox-2; cyclooxygenase-2; ERK1/2; extracellular signal-related kinase 1/2; ICAM-1; intracellular cellular adhesion molecule-1; IL-1β; interleukin-1β; MCP-1; monocyte chemoattractant protein-1; MEK1/
PICOT increases cardiac contractility by inhibiting PKCζ activity
Keywords: PICOT; PKCζ; PKCα; PP2A; Contractility;
Different subcellular populations of L-type Ca2+ channels exhibit unique regulation and functional roles in cardiomyocytes
Keywords: LTCC; L-type Ca2+ channel; EC; excitation-contraction; ICa,L; L-type Ca2+ current; SR; sarcoplasmic reticulum; T-tubules; transverse tubules; CICR; Ca2+-induced Ca2+ release; [Ca2+]i; free intracellular Ca2+ concentration; PKA; protein kinase A; Cav; ca
Aging-related alterations in the expression and distribution of GluR2 and PICK1 in the rat hippocampus
Keywords: Aging; GluR2; PICK1; PKCα; Calcineurin;
Spleen tyrosine kinase suppresses osteoblastic differentiation through MAPK and PKCα
Keywords: Spleen tyrosine kinase (Syk); MC3T3-E1 cells; Osteoblastic differentiation; MAPK; PKCα;
Baicalein inhibits the migration and invasive properties of human hepatoma cells
Keywords: MAPK; mitogen-activated protein kinase; MMP; matrix metalloproteinase; PKC; protein kinase C; (IKB)-β; phosphorylated I-kappa-B; Baicalein; Flavonoid; Hepatoma; Invasion; p38; PKCα;
Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through α2β1 integrin and MT1-MMP
Keywords: 3D; three-dimensional; 2D; two-dimensional; ECM; extracellular matrix; MT1-MMP; membrane type-1 matrix metalloproteinase; MLC; myosin light chain; PKCα; protein kinase α; K-ras; Integrin; MT1-MMP; Syndecan; Invasion; Contraction;
Annexin A6-Linking Ca2+ signaling with cholesterol transport
Keywords: AA; arachidonic acid; AnxA; annexin group A; BCC; breast cancer cells; cav-1; caveolin-1; cPLA2; cytoplasmic phospholipase A2; CHO; Chinese Hamster Ovary; DRM; detergent resistant membranes; EGFR; epidermal growth factor receptor; eNOS; endothelial nitric
Rotenone induces degeneration of photoreceptors and impairs the dopaminergic system in the rat retina
Keywords: CB; calbindin; COX; cytochrome c oxidase; ERG; electroretinogram; GCL; ganglion cell layer; INL; inner nuclear layer; IPL; inner plexiform layer; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; ONL; outer nuclear layer; OPL; outer plexiform layer; PD;
Erk1/2-dependent phosphorylation of PKCα at threonine 638 in hippocampal 5-HT1A receptor-mediated signaling
Keywords: Hippocampus; PKCα; Erk; 5-HT1A receptor;