
A signaling-enhanced chimeric receptor to activate the ICOS pathway in T cells
Keywords: ADA; anti-drug antibody; CD3; cluster of differentiation 3; B7RP1; B7 related protein 1; ICOS; inducible costimulator; TCR; T cell receptor; ICOS-CD3; chimeric receptor consisting of full-length ICOS and the cytoplasmic region of CD3 zeta; ITAM; immune