Keywords: Nonalcoholic steatohepatitis; Children; Liver; Steatosis; PNPLA3; TM6SF2; Obesity; Alanine aminotransferase;
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Keywords: ATP; Adenosine 5c-triphosphate; ALT; Alanine aminotransferase; aa; Amino acid; ASK1; Apoptosis signal- regulating kinase 1; AST; Aspartate aminotransferase; BASH; Both alcoholic and non-alcoholic liver disease; CCR2/CCR5; C-C chemokine receptor types 2 an
Keywords: 2-AG; 2-arachidonoylglycerol; AADAC; arylacetamide deacetylase; ABHD5/CGI-58; alpha-beta-hydrolase domain containing 5/comparative gene identification-58; ATGL/ PNPLA2; adipose triglyceride lipase; CE; cholesteryl esters; CES/Ces; carboxylesterase; DG; di
Keywords: Non-alcoholic fatty liver disease; PNPLA3; Atherosclerosis; Carotid intima-media thickness; Ectopic fat storage;
Keywords: ACC; acetyl-CoA carboxylase; ApoB; apolipoprotein B; ApoCII; apolipoprotein C-II; APPL-1; adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and a leucine zipper motif; CD36; fatty acid translocase; CETP; cholesteryl est
Keywords: SNP; single nucleotide polymorphism; PNPLA3; patatin-like phospholipase domain-containing 3; BMI; body mass index; CRP; C-reactive protein; OR; odds ratios; Longitudinal study; Hepatic steatosis; Risk factors; Population study;
Keywords: Fatty Liver Disease; Latinos; Epidemiology; GWAS; genome-wide association study; HCC; hepatocellular carcinoma; NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; PNPLA3; patatin-like phospholipase domain containing 3; T2DM; type
Keywords: AF; atrial fibrillation; CVD; cardiovascular disease; FHBL; familial hypobetalipoproteinemia; FRS; Framingham risk score; GGT; gamma-glutamyltransferase; GWAS; genome wide association study; HCC; hepatocellular carcinoma; MetS; metabolic syndrome; NAFLD;
Keywords: GLUT; Glucose transporter; T1DM; Type-1 diabetes mellitus; T2DM; Type-2 diabetes mellitus; PKB/Akt; protein kinase B; GSK-3; glycogen synthase kinase-3; PGC-1α; peroxisome proliferator-activated receptor gamma coactivator-1α; FOXO; forkhead box O; VLDL;
Keywords: ALT; alanine aminotransferase; BMI; body mass index; ELISA; enzyme-linked immunosorbent assay; FNDC5; fibronectin type III domain containing 5; GWAS; genome-wide association studies; IR; insulin resistance; NAFLD; nonalcoholic fatty liver disease; NASH; n
Keywords: Genetic Factors; Fatty Liver; NASH; NAFLD; AE; additive genetic and unique environment model; ALT; alanine aminotransferase; CI; confidence interval; DZ; dizygotic; MRE; magnetic resonance elastography; MRI; magnetic resonance imaging; MZ; monozygotic; NA
Keywords: Gene Expression; IL8; Immune Regulation; Inflammatory Response; ALT; alanine aminotransferase; AST; aspartate aminotransferase; AT; adipose tissue; ATM; adipose tissue macrophage; AUROC; area under receiver operating characteristic; BMI; body mass index;
Keywords: PNPLA; patatin-like phospholipase domain-containing protein; ADPN; adiponutrin; LPAAT; lysophosphatidic acid acyltransferaese; VLDL; very low density lipoprotein; ApoB100; Apolipoprotein B100; PPD; Plasma Proteome Database; CBS; Center of Biological Seque
PNPLA3 rs738409 polymorphism is associated with liver fibrosis progression in patients with chronic hepatitis C: A repeated measures study
Keywords: Liver stiffness; Chronic hepatitis C; Cirrhosis; Hepatic fibrosis; PNPLA3; SNPs;
The PNPLA3 SNP rs738409:G allele is associated with increased liver disease-associated mortality but reduced overall mortality in a population-based cohort
Keywords: PNPLA3; Variant; Mortality; Liver-related; Fatty liver disease; Population-based; Study of Health in Pomerania;
Heterogeneous expression of human PNPLA3 triggers algal lipid accumulation and lipid droplet enlargement
Keywords: PNPLA3; Microalga; Lipid accumulation; Biofuel;
Reply to: “The PNPLA3 SNP rs738409:G allele is associated with increased liver disease-associated mortality but reduced overall mortality in a population-based cohort”
Keywords: Alcohol dependence; Alcoholic hepatitis; Alcohol-related cirrhosis; Genetic polymorphism; PNPLA3; Risk allele; Survival; Mortality; Liver-related; Sex-variant interaction;
Genetics and epigenetics of NAFLD and NASH: Clinical impact
Keywords: Non-alcoholic fatty liver disease; Steatohepatitis; Genetic variation; Epigenetics; PNPLA3;
Donor PNPLA3 rs738409 genotype is a risk factor for graft steatosis. A post-transplant biopsy-based study
Keywords: Liver biopsy; Liver transplantation; NAFLD; PNPLA3;
Human-based systems: Mechanistic NASH modelling just around the corner?
Keywords: Elafibranor (PubChem CID: 9864881); Obeticholic acid (PubChem CID: 447715); Pioglitazone (PubChem CID: 4829); Rosiglitazone (PubChem CID: 77999); Fenofibrate (PubChem CID: 3339); Serine (PubChem CID: 5951); ACC1; acetyl-coenzyme A carboxylase 1; AdipoR; a
Non-alcoholic fatty liver disease and its treatment with n-3 polyunsaturated fatty acids
Keywords: NAFLD; Omega-3 fatty acids; Fish oil; Algal oil; Insulin resistance; Metabolic syndrome; ALA; alpha-linolenic acid; ALT; alanine aminotransferase; Apo; apolipoprotein; AST; aspartate aminotransferase; BMI; body mass index; ChREBP; carbohydrate response el
Research paperPatatin-like phospholipase domain-containing protein 3 (PNPLA3): A potential role in the association between liver disease and bipolar disorder
Keywords: Bipolar disorder; Affective disorder; Patatin-like phospholipase domain-containing protein 3; PNPLA3; Non-alcoholic fatty liver disease; NAFLD;
Gene polymorphisms of desaturase enzymes of polyunsaturated fatty acid metabolism and adiponutrin and the increased risk of nonalcoholic fatty liver disease
Keywords: NAFLD; nonalcoholic fatty liver disease; MetS; metabolic syndrome; PUFAs; polyunsaturated fatty acids; CAD; coronary artery disease; CVD; cardiovascular disease; PNPLA3; patatin-like phospholipase domain containing protein-3; GWAS; genome wide association
A case of hypocholesterolemia and steatosis in a carrier of a PCSK9 loss-of-function mutation and polymorphisms predisposing to nonalcoholic fatty liver disease
Keywords: Dyslipidemia; Hypocholesterolemia; Hypobetalipoproteinemia; Liver steatosis; PCSK9; Proprotein convertase subtilisin/kexin type 9; PNPLA3; TM6SF2; Nonalcoholic fatty liver disease;
Binge alcohol alters PNPLA3 levels in liver through epigenetic mechanism involving histone H3 acetylation
Keywords: Binge ethanol; Chronic-binge ethanol; Epigenetics; Histone acetylation; PNPLA3;
The interrelationship between bile acid and vitamin A homeostasis
Keywords: ATGL; Adipose triglyceride lipase; ADH; Alcohol dehydrogenase; ALD; Alcoholic liver disease; atRA; All-trans retinoic acid; ASBT/SLC10A2; Apical sodium-dependent bile salt transporter; ABCA1; ATP-binding cassette transporter member 1; BCMO1; Beta-carotene
Anti-obesity effect of radix Angelica sinensis and candidate causative genes in transcriptome analyses of adipose tissues in high-fat diet-induced mice
Keywords: RAS; Radix Angelica sinensis; HFD; high-fat diet; DEGs; differentially-expressed genes; qPCR; quantitative real-time PCR; TCMs; Chinese herbal medicines; RIN; RNA integrity number; FPKM; fragments per kilobase of transcript per million fragments mapped; F
Factors Associated With Persistent Increase in Level of Alanine Aminotransferase in Patients With Chronic Hepatitis B Receiving Oral Antiviral Therapy
Keywords: Hepatitis B Virus Infection; HBV; Adiponutrin/Patatin-Like Phospholipase-3; Serum Transaminase; ALT; alanine aminotransferase; BMI; body mass index; CHB; chronic hepatitis B; CI; confidene interval; HBeAg; hepatitis B e antigen; HBsAg; hepatitis B surface
Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy
Keywords: NAFLD; non-alcoholic fatty liver disease; GWAS; genome-wide association study; PNPLA3; patatin-like phospholipase domain-containing-3; TM6SF2; transmembrane 6 superfamily member 2; GCKR; glucokinase regulatory protein; IRGM; immunity-related GTPase family
Research ArticleMERTK rs4374383 polymorphism affects the severity of fibrosis in non-alcoholic fatty liver disease
Keywords: MERTK; myeloid-epithelial-reproductive tyrosine kinase; PNPLA3; patatin-like phospholipase-3; IR; insulin resistance; NAFLD; non-alcoholic fatty liver disease; NASH; non-alcoholic steatohepatitis; HOMA; homeostasis model assessment; NASH; MERTK; Fibrosis;
Nonalcoholic Fatty Liver Disease: From Pathogenesis to Emerging TreatmentThe multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)
Keywords: Insulin resistance; Lipotoxicity; Gut microbiome; Metabolic syndrome; PNPLA3;
EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease
Keywords: ALT; alanine transaminase; BMI; body mass index; CAP; controlled attenuation parameter; CCR; chemokine receptor; CK-18; cytokeratin-18 fragments; CKD; chronic kidney disease; CT; computed tomography; CVD; cardiovascular disease; EASD; European Association
Impact of PNPLA3 variants on liver histology of 168 patients with HIV infection and chronic hepatitis C
Keywords: HIV/HCV coinfection; liver biopsy; liver histology; liver steatosis; PNPLA3;
The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent
Keywords: PNPLA3; TM6SF2; NASH; Arachidonic Acid; BMI; body mass index; CI; confidence interval; DHS; Dallas Heart Study; ER; endoplasmic reticulum; HWE; Hardy-Weinberg equilibrium; IFG; impaired fasting glucose; MBOAT7; membrane bound O-acyltransferase domain cont
Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites
Keywords: Liver; Nonalcoholic Fatty Liver Disease; Diagnosis; Prediction; Triglycerides; AST; aspartate aminotransferase; AUROC; area under the receiver operating characteristic curve; CI; confidence interval; fP; fasting plasma; fS; fasting serum; GC; gas chromato
The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study
Keywords: ALT, Alanine aminotransferase; GGT, Gamma-glutamyl transferase; IL-6, interleukin-6; TNF-α, tumor necrosis factor-αIrisin; Children; PNPLA3
Identification of a putative patatin-like phospholipase domain-containing protein 3 (PNPLA3) ortholog involved in lipid metabolism in microalga Phaeodactylum tricornutum
Keywords: PNPLA3; Microalga; Neutral lipid; Lipid accumulation; Biofuel;
PNPLA3 genotype increases susceptibility of nonalcoholic steatohepatitis among obese patients with nonalcoholic fatty liver disease
Keywords: PNPLA3; Nonalcoholic steatohepatitis; Nonalcoholic fatty liver disease; Obesity; Bariatric surgery;
Research ArticleHepatic steatosis in Wilson disease - Role of copper and PNPLA3 mutations
Keywords: NAFLD; non-alcoholic fatty liver disease; NAS; NAFLD-activity score; NASH; non-alcoholic steatohepatitis; PNPLA3; patatin-like phospholipase domain-containing protein 3; SNP; single nucleotide polymorphism; WD; Wilson disease; Wilson disease; PNPLA3; Stea
Research ArticleTargeted-bisulfite sequence analysis of the methylation of CpG islands in genes encoding PNPLA3, SAMM50, and PARVB of patients with non-alcoholic fatty liver disease
Keywords: NAFLD; non-alcoholic fatty liver disease; NASH; non-alcoholic steatohepatitis; GWAS; genome-wide association study; SNP; single-nucleotide polymorphism; PNPLA3; patatin-like phospholipase domain containing 3; LD; linkage disequilibrium; SAMM50; SAMM50 sor
The adiponutrin I148M variant is a risk factor for HCV-associated liver cancer in North-African patients
Keywords: HCV; hepatitis C virus; HCC; hepatocellular carcinoma; CHC; chronic hepatitis C; TG; triglyceride; NAFLD; nonalcoholic fatty liver disease; PNPLA3; adiponutrin/patatin-like phospholipase domain-containing 3; PBMCs; peripheral blood mononuclear cells; qRT-
Research ArticleCarriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma
Keywords: NAFLD; NASH; Steatohepatitis; PNPLA3; Hepatocellular carcinoma; HCC; Gene;
Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function
Keywords: PNPLA3; patatin-like phospholipase domain containing 3; ADPN; adiponutrin; Sf9; Spodoptera frugiperda 9; LPAAT; lysophosphatidic acid acyl transferase; YPDS; Yeast Extract Peptone Dextrose plus Sorbitol; BMGY; buffered glycerol-complex medium; BMMY; buffe
Obestatin and Nt8U influence glycerolipid metabolism and PPAR gamma signaling in mice
Keywords: ADIPOQ; adiponectin,C1Qand collagen domain containing; AKR1B7; aldo-keto reductase family 1,member 7; ANGPTL4; angiopoietin-like 4; ANXA13; annexinA13; APOL2; apolipoprotein L 8; CD36; cluster of differentiation 36 antigen; DGAT2; diacylglycerol O-acylt
Shifts in dietary carbohydrate-lipid exposure regulate expression of the non-alcoholic fatty liver disease-associated gene PNPLA3/adiponutrin in mouse liver and HepG2 human liver cells
Keywords: ACC1; acetyl CoA-carboxylase; ALA; α-linolenic acid; BSA; bovine serum albumin; ChREBP; carbohydrate response element binding protein; DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; HC; high-carbohydrate; HF; high fat; LE; lipid emulsion; LA; lin
Transcriptomics profiling and steroid production in mummichog (Fundulus heteroclitus) testes after treatment with 5α-dihydrotestosterone
Keywords: 11KT; 11-ketotestosterone; ABCC2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; ABCC3; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; ABCG8; ATP-binding cassette, sub-family G (WHITE), member 8; ACY1; aminoacylase 1; ADAR; adenosine d
Research ArticlePNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis
Keywords: HCC; hepatocellular carcinoma; HCV; hepatitis C virus; PNPLA3; patatin-like phospholipase-3; SNP; single nucleotide polymorphism; SVR; sustained virological response; Adiponutrin; Polymorphism; Hepatocarcinoma;
Association Between Variants in or Near PNPLA3, GCKR, and PPP1R3B With Ultrasound-Defined Steatosis Based on Data From the Third National Health and Nutrition Examination Survey
Keywords: Nonalcoholic Fatty Liver Disease; Replication; Candidate Gene Study; Genome-wide Association Study; SNP; ALT; alanine aminotransferase; AST; aspartate aminotransferase; EAF; effect allele frequency; HDL-c; high-density lipoprotein cholesterol; HS; hepatic
Exploration of a symptoms experience in people with obesity-related nonalcoholic fatty liver disease
Keywords: PNPLA3; Nonalcoholic fatty liver disease; Symptoms experience;
Research ArticleIL28B and PNPLA3 polymorphisms affect histological liver damage in patients with non-alcoholic fatty liver disease
Keywords: IL28B; interleukin 28B; PNPLA3; patatin-like phospholipase-3; UA; uric acid; IR; insulin resistance; NAFLD; non-alcoholic fatty liver disease; NASH; non-alcoholic steatohepatitis; HOMA; homeostasis model assessment; IL28B; NASH;