Keywords: مدولاتور آلوزیستریک مثبت; cholecystokinin; type 1 cholecystokinin receptor; positive allosteric modulators; biased agonists; satiety
مقالات ISI مدولاتور آلوزیستریک مثبت (ترجمه نشده)
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Keywords: مدولاتور آلوزیستریک مثبت; Alpha 7 nicotinic acetylcholine receptors; Positive allosteric modulators; Schizophrenia; Animal models; Cognition; Ketamine
Keywords: مدولاتور آلوزیستریک مثبت; Calcimimetics; Positive allosteric modulators; 1,2,4-Thiadiazoles; Metabolite ID; Time dependent inhibition;
Keywords: مدولاتور آلوزیستریک مثبت; Metabotropic glutamate receptors; mGluR8; Retina; Positive allosteric modulators;
Keywords: مدولاتور آلوزیستریک مثبت; Nicotinic receptors; Chronic pain; Inflammation; Mice; Allosteric modulators; nAChR; nicotinic acetylcholine receptor(s); s.c.; subcutaneous injection; i.p.; intraperitoneally; CNS; central nervous system; ACh; acetylcholine; PAMs; positive allosteric mod
The GluN2B subunit represents a major functional determinant of NMDA receptors in human induced pluripotent stem cell-derived cortical neurons
Keywords: مدولاتور آلوزیستریک مثبت; Human induced pluripotent stem cell-derived neurons; iCell Neurons; iCell GlutaNeurons; NMDA receptors; GluN2B; Positive allosteric modulators;
In vivo anesthetic effect and mechanism of action of active compounds from Alpinia galanga oil on Cyprinus carpio (koi carp)
Keywords: مدولاتور آلوزیستریک مثبت; 1,8-Cineole; 4-Allylphenyl acetate; Methyl eugenol; Computational docking; GABAA benzodiazepine-binding site; AGO; Alpinia galanga oil; BZD; Benzodiazepine; GABAA; γ-Aminobutyric acid type A; NMDA; N-methyl-d-aspartate; ÎGbind; Binding energy; Ki; Inhib
Research PaperThe interaction between alpha 7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α represents a new antinociceptive signaling pathway in mice
Keywords: مدولاتور آلوزیستریک مثبت; nAChRs; α7 nicotinic acetylcholine receptors; PPAR-α; nuclear peroxisome proliferator-activated receptors type-α; PAMs; positive allosteric modulators; ago-PAMs; ago-allosteric ligands; PEA; palmitoylethanolamide; OEA; oleoylethanolamide; CB1 and CB2;
Reprint of Pharmacological and molecular characterization of the positive allosteric modulators of metabotropic glutamate receptor 2
Keywords: مدولاتور آلوزیستریک مثبت; Metabotropic glutamate receptor; mGlu2; mGlu3; mGluR; Negative allosteric modulators; Positive allosteric modulators; LY354740; LY487379; ECL; extracellular loop; FLIPR; Fluorometric Imaging Plate Reader; GPCR; G-protein coupled receptor; mGluR; metabotro
Short communicationThe combination of memantine and galantamine improves cognition in rats: The synergistic role of the α7 nicotinic acetylcholine and NMDA receptors
Keywords: مدولاتور آلوزیستریک مثبت; α-7 Nicotinic receptor; Galantamine; Memantine; Positive allosteric modulators; Cognition; Animal models;
Positive allosteric modulators of the α7 nicotinic acetylcholine receptor potentiate glutamate release in the prefrontal cortex of freely-moving rats
Keywords: مدولاتور آلوزیستریک مثبت; Positive allosteric modulators; Choline; Microelectrode array; Prefrontal cortex; Glutamate; α7 receptorsα7nAChR, Alpha7 nicotinic acetylcholine receptor; Cholox, choline-sensitive; Gluox, glutamate-sensitive; MEA, microelectrode array; NAcSh, nucleus acc
Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective
Keywords: مدولاتور آلوزیستریک مثبت; Cys-loop receptors; Nicotinic receptors; Patch-clamp; Single-channel recordings; Positive allosteric modulators; nAChR; nicotinic acetylcholine receptor; ACh; acetylcholine; 5-HT3A; serotonin type 3A receptor; PAM; positive allosteric modulator; PAM-2; 3-
Positive allosteric modulation of alpha 7 nicotinic acetylcholine receptors enhances recognition memory and cognitive flexibility in rats
Keywords: مدولاتور آلوزیستریک مثبت; Alpha 7 nicotinic acetylcholine receptor; Positive allosteric modulators; Galantamine; Recognition memory; Set-shifting; Attention;
Synthesis and activity of substituted heteroaromatics as positive allosteric modulators for α4β2α5 nicotinic acetylcholine receptors
Keywords: مدولاتور آلوزیستریک مثبت; Substituted heteroaromatics; α4β2α5; Positive allosteric modulators;
Allosteric modulators of human A2B adenosine receptor
Keywords: مدولاتور آلوزیستریک مثبت; ADA; adenosine deaminase; AR; adenosine receptor; cAMP; 3â²,5â²-cyclic adenosine monophosphate; BAY 60-6583; 2-[6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-ylsulfanyl]acetamide; CHO; Chinese hamster ovary; DMAP; 4-dimethylaminopyridine
Chalcones as positive allosteric modulators of α7 nicotinic acetylcholine receptors: A new target for a privileged structure
Keywords: مدولاتور آلوزیستریک مثبت; α7 Nicotinic receptor; Positive allosteric modulators; Chalcones; Neuroprotection; AnalgesiaACh, acetylcholine; α-Bgt, α-bungarotoxin; CFA, complete Freund's adjuvant; DMEM, Dulbecco's modified eagle's medium; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-dipheny
New potent calcimimetics: II. Discovery of benzothiazole trisubstituted ureas
Keywords: مدولاتور آلوزیستریک مثبت; Calcium sensing receptor; Benzothiazole urea; Positive allosteric modulators;
New potent calcimimetics: I. Discovery of a series of novel trisubstituted ureas
Keywords: مدولاتور آلوزیستریک مثبت; Calcimimetics; Trisubstituted ureas; Positive allosteric modulators; Calcium sensing receptor;
The NMDA receptor as a target for cognitive enhancement
Keywords: مدولاتور آلوزیستریک مثبت; Synaptic plasticity; NMDA receptor; Cognitive enhancement; LTP; Synaptic transmission; Hippocampus; Positive allosteric modulators; AChR; acetylcholine receptor; AKAP79/150; A-kinase anchoring proteins; AMPAR; AMPA receptor; CaMKII; Ca2+/calmodulin-depend
α7 Nicotinic acetylcholine receptors and their role in cognition
Keywords: مدولاتور آلوزیستریک مثبت; Selective alpha7 nicotinic; Cognition; Learning and memory; Positive allosteric modulators
A novel series of positive modulators of the AMPA receptor: Structure-based lead optimization
Keywords: مدولاتور آلوزیستریک مثبت; AMPA receptor; Positive allosteric modulators; Ion channels; SBDD
Role of the GABAB receptor in alcohol-seeking and drinking behavior
Keywords: مدولاتور آلوزیستریک مثبت; GABAB receptor; Direct agonists; Baclofen; Positive allosteric modulators; Alcohol intake; Operant alcohol self-administration; Reinforcing and motivational properties of alcohol; Alcohol-preferring rats
Comparative pharmacology and computational modelling yield insights into allosteric modulation of human α7 nicotinic acetylcholine receptors
Keywords: مدولاتور آلوزیستریک مثبت; Computational modelling; Electrophysiology; Ivermectin; Nicotinic acetylcholine receptor; Positive allosteric modulators; Ion channels
Positive modulation of α7 nAChR responses in rat hippocampal interneurons to full agonists and the α7-selective partial agonists, 4OH-GTS-21 and S 24795
Keywords: مدولاتور آلوزیستریک مثبت; Brain slices; Patch-clamp; nAChRs; Partial agonists; Full agonists; Hippocampus; Positive allosteric modulators;
3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: A novel series of mGluR2 positive allosteric modulators
Keywords: مدولاتور آلوزیستریک مثبت; mGluR2; Positive allosteric modulators; Potentiators; Anxiety; Schizophrenia
A novel class of positive allosteric modulators of AMPA receptors: Design, synthesis, and structure–activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, LY2059346
Keywords: مدولاتور آلوزیستریک مثبت; Positive allosteric modulators; AMPA receptors