Ï-3 fatty acids attenuate mucosal inflammation in premature rat pups
Keywords: DHA; EPA; NEC; NF-κB; PPARγ;
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(â)-Epigallocatechin-3-gallate blocks 3T3-L1 adipose conversion by inhibition of cell proliferation and suppression of adipose phenotype expression
Keywords: (â)-Epigallocatechin-3-gallate (EGCG); 3T3-L1; Adipogenesis; Obesity; C/EBPα; PPARγ; Catechins;
Induction of ROS, p53, p21 in DEHP- and MEHP-exposed LNCaP cells-protection by selenium compounds
Keywords: CM-H2DCFA; 5-(and 6-) chloromethyl-2â²,7â²-dichlorodihydrofluorescein diacetate; DAB; 3,3â²-diaminobenzidine; DCF; 2â²,7â²-dichlorofluorescein; DEHP; di(2-ethylhexyl)phthalate; DR5; death receptor 5; FBS; fetal bovine serum; FCS; fetal calf serum; GP
Activation of Trim17 by PPARγ is involved in Di(2-ethylhexyl) phthalate (DEHP)-induced apoptosis on Neuro-2a cells
Keywords: DEHP; PPARγ; Trim17; Apoptosis; Developmental neurotoxicity;
PPARγ in coronary atherosclerosis: In vivo expression pattern and correlations with hyperlipidemic status and statin treatment
Keywords: PPARγ; Statins; Tissue factor; Coronary atherosclerosis; Immunohistochemistry;
The environmental obesogen tributyltin chloride acts via peroxisome proliferator activated receptor gamma to induce adipogenesis in murine 3T3-L1 preadipocytes
Keywords: Obesogen; Tributyltin; TBT; PPARγ; Endocrine disrupter; Adipogenesis;
Inhibitory effect of β-asarone, a component of Acorus calamus essential oil, on inhibition of adipogenesis in 3T3-L1 cells
Keywords: Acorus calamus; β-Asarone; Adipogenesis; PPARγ; C/EBPα; C/EBPβ;
Engineering and optimization of an allosteric biosensor protein for peroxisome proliferator-activated receptor γ ligands
Keywords: PPARγ; Biosensor; Fusion protein; Nuclear hormone receptor; Hormone assay; Engineered allostery;
Development of enzyme-linked immunosorbent assay for Î12-prostaglandin J2 and its application to the measurement of the endogenous product generated by cultured adipocytes during the maturation phase
Keywords: PPARγ; peroxisome proliferator-activated receptor γ; PG; prostaglandin; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; COX; cyclooxygenase; L-PGDS; lipocalin-type prostaglandin D synthase; ELISA; enzyme-linked immunosorbent assay; DME-HEPES; Dulbecco's mo
Ketogenic diet-induced peroxisome proliferator-activated receptor-γ activation decreases neuroinflammation in the mouse hippocampus after kainic acid-induced seizures
Keywords: Ketogenic diet; Kainic acid; PPARγ; COX-2; Hippocampus;
Cytotoxicity of troglitazone through PPARγ-independent pathway and p38 MAPK pathway in renal cell carcinoma
Keywords: Troglitazone; PPARγ; Renal cell carcinoma; Apoptosis; p38 MAPK;
Antiatherogenic effect of pioglitazone on uremic apolipoprotein E knockout mice by modulation of the balance of regulatory and effector T cells
Keywords: Uremia; Atherosclerosis; Regulatory T cells; Effector T cells; Pioglitazone; PPARγ;
PEDF inhibits IL8 production in prostate cancer cells through PEDF receptor/phospholipase A2 and regulation of NFκB and PPARγ
Keywords: Ab; antibody; CRPC; Castration-Resistant Prostate Cancer; HRPC; Hormone-Refractory Prostate Cancer; IL8; interleukin-8; NFκB; Nuclear Factor Kappa-B; PPARγ; Peroxisome Proliferation Activated Receptor gamma; PEDF; Pigment Epithelium-Derived Factor; PEDF
Pioglitazone enhances cholesterol efflux from macrophages by increasing ABCA1/ABCG1 expressions via PPARγ/LXRα pathway: Findings from in vitro and ex vivo studies
Keywords: PPARγ; Macrophage; Cholesterol efflux; ABCA1; ABCG1;
Research ArticleOleuropein attenuates hepatic steatosis induced by high-fat diet in mice
Keywords: NAFLD; non-alcoholic fatty liver disease; TG; triglyceride; FFA; free fatty acid; ALT; alanine aminotransferase; AST; aspartate aminostransferase; LXR; liver X receptor; SREBP-1c; sterol regulatory element-binding protein-1c; PPARγ; peroxisome proliferat
PPARγ stabilizes HO-1 mRNA in monocytes/macrophages which affects IFN-β expression
Keywords: 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; CRE; causes recombination; CO; carbon monoxide; CHX; cycloheximide; d/n; dominant negative; DPI; diphenyliodonium; HE; hydroethidine; HO-1; heme oxygenase-1; LPS; lipopolysaccharide; LysM; lysozyme M; mac; macr
Effect of tocopherol supplementation on serum 8-epi-prostaglandin F2 alpha and adiponectin concentrations, and mRNA expression of PPARγ and related genes in ovine placenta and uterus
Keywords: Vitamin E; Adiponectin; Isoprostane; ADIPQ; PPARγ; Sheep;
Modulation of inflammatory response and parasitism by 15-Deoxy-Î12,14 prostaglandin J2 in Trypanosoma cruzi-infected cardiomyocytes
Keywords: Trypanosoma cruzi; Inflammation; Parasitism; Neonatal cardiomyocytes; 15-Deoxy-Î12,14 prostaglandin J2; PPARγ; NF-κB; Erk-MAPK;
15-Deoxy-Î12,14-prostaglandin J2 interferes inducible synthesis of prostaglandins E2 and F2α that suppress subsequent adipogenesis program in cultured preadipocytes
Keywords: PG; prostaglandin; PMA; phorbol 12-myristate 13-acetate; 15d-PGJ2; 15-deoxy-Î12,14-PGJ2; PPARγ; peroxisome proliferator-activated receptor γ; COX; cyclooxygenase; PDTC; pyrrolidinedithiocarbamate; NF-κB; nuclear factor-kappa B; L-PGDS; lipocalin-type
Anti-proliferative effect of a putative endocannabinoid, 2-arachidonylglyceryl ether in prostate carcinoma cells
Keywords: AA; arachidonic acid; AEA; anandamide (arachidonylethanolamide); 2-AG; 2-arachidonoylglycerol; CBR; cannabinoid receptor; DAK; diazomethylarachidonyl ketone; EC; endocannabinoids; FAAH; fatty acid amide hydrolase; MGL; monoacylglycerol lipase; NE; 2-arach
Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice
Keywords: Gut microbiota; prebiotics; adipose tissue; high-fat feeding; GPR43; PPARγ;
Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPARγ) in K562 cancer cells
Keywords: Carotenoids; K562 cancer cells; PPARγ; p21; Cyclin D1; Nrf2;
Research ReportNeuroprotective effects of KR-62980, a new PPARγ agonist, against chemical ischemia-reperfusion in SK-N-SH cells
Keywords: Chemical ischemia; PPARγ; ROS; PTEN; Rosiglitazone;
Stable over-expression of PPARβ/δ and PPARγ to examine receptor signaling in human HaCaT keratinocytes
Keywords: ADRP; adipocyte differentiation-related protein; atRA; all-trans retinoic acid; ANGPTL4; angiopoietin-like protein 4; CRABP-II; cellular retinoic acid binding protein II; CYP26A1; cytochrome P450 26A1; DMEM; Dulbecco's minimal essential medium; DMSO; dime
Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas
Keywords: Cannabinoids; Cannabinoid receptors; Food intake; Obesity; Insulin secretion; Islets of Langerhans; β-cells; AC; adenylate cyclase; ACEA; N-(2-chloroethyl)5,8,11,14-eicosaetraenamide; AEA; N-arachidonoyl ethanolamine; 2-AG; 2-arachidonoyl glycerol; AM251
Research ArticleInhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib
Keywords: HSCs; hepatic stellate cells; α-SMA; α-smooth muscle actin-expressing; PARP; poly (ADP-ribose) polymerase; PPARγ; peroxisome proliferator-activated receptor γ; TRAIL-R; tumor necrosis factor-related apoptosis-inducing ligand receptor; PDGF; platelet-d
Molecular mechanisms of human lipodystrophies: From adipocyte lipid droplet to oxidative stress and lipotoxicity
Keywords: AC; adenyl cyclase; AGPAT2; 1-acylglycerol-3-phosphate-O-acyltransferase 2; AT; adipose tissue; ATGL; adipose triglyceride lipase; BSCL; Berardinelli-Seip congenital lipodystrophy; C/EBP; CCAAT/enhancer binding protein; CGI-58; comparative gene identifica
Kudzu root: Traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases
Keywords: ACE2; angiotensin-converting enzyme 2; ADP; adenosine diphosphate; AGE; advanced glycation end-products; APV; DL-2-amino-5-phosphonovaleric acid; AT1; angiotensin II type I receptor; Aβ25-35; β-amyloid; Bcl-2; B-cell leukemia/lymphoma-2; BKCa; large-con
Flexible ligand recognition of peroxisome proliferator-activated receptor-γ (PPARγ)
Keywords: PPARγ; Peroxisome proliferator-activated receptor-γ; Ligand recognition; Fragment molecular orbital; Hydrophobic residue;
Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds
Keywords: Puerarin; Isoflavone; Diabetes mellitus; PPARγ; Glucose uptake;
Nifedipine inhibits advanced glycation end products (AGEs) and their receptor (RAGE) interaction-mediated proximal tubular cell injury via peroxisome proliferator-activated receptor-gamma activation
Keywords: AGEs; RAGE; Nifedipine; Diabetic nephropathy; PPARγ;
The gene expression of the myocardial lipid droplet protein is highly regulated by PPARγ in adipocytes differentiated from MEFs or SVCs
Keywords: MEF; SVC; MLDP; Adipocyte; SREBP-1; PPARγ;
Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components
Keywords: 15d-PGJ2; 15-deoxy-Î12,14 prostaglandin J2; 5-ASA; 5-aminosalicylic acid; c9, t11; cis-9 trans-11; CLA; conjugated linoleic acid; DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; IgA; immunoglobulin A; IL; interleukin; PPARγ; peroxisome proliferat
Structural requirement for PPARγ binding revealed by a meta analysis of holo-crystal structures
Keywords: PPARγ; Ligand binding; Electrostatic potential; Principal component analysis;
Decrease in uptake of arachidonic acid by indomethacin in LS174T human colon cancer cells; a novel cyclooxygenase-2-inhibition-independent effect
Keywords: NSAID; Indomethacin; Arachidonic acid; FAT/CD36; PPARγ;
Isorhamnetin-induced anti-adipogenesis is mediated by stabilization of β-catenin protein
Keywords: Isorhamnetin; PPARγ; C/EBPα; β-catenin;
Bitter melon (Momordica charantia) triterpenoid extract reduces preadipocyte viability, lipid accumulation and adiponectin expression in 3T3-L1 cells
Keywords: Momordica charantia; Bitter melon; Saponins; Adipogenesis; 3T3-L1; PPARγ;
Mathematical modeling of preadipocyte fate determination
Keywords: Proliferation; Differentiation; PPARγ; NFâκB; Cyclin D1;
Research ArticleRosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin
Keywords: Liver injury; Adiponectin; Rosiglitazone; Mitochondria; Uncoupling protein 2; NAFLD; non-alcoholic fatty liver disease; AKO; adiponectin knockout; MRC; mitochondria respiratory chain; UCP2; uncoupling protein 2; TZDs; thiazolidinediones; PPARγ; peroxisom
Ras signalling regulates differentiation and UCP1 expression in models of brown adipogenesis
Keywords: AEBP1; AE-binding protein 1; C/EBP; CCAAT/enhancer-binding protein; CS; citrate synthase; DMEM; Dulbecco's Modified Eagle's Medium; DMSO; dimethyl sulfoxide; ERK; extracellular signal-regulated kinase; FABP4; fatty acid-binding protein 4; FBS; foetal bovi
Farglitazar Lacks Antifibrotic Activity in Patients With Chronic Hepatitis C Infection
Keywords: Peroxisome Proliferator-Activated Receptor-γ; Fibrosis; Treatment; Smooth Muscle Actin; CHC; chronic hepatitis C; ECM; extracellular matrix; HCV; hepatitis C virus; IFN; interferon; PPARγ; peroxisome proliferator-activated receptor γ; SAE; serious adve
Telmisartan suppresses cerebral injury in a murine model of transient focal ischemia
Keywords: Angiotensin II type1 receptor blocker; Ischemia/reperfusion cerebral injury; Neuroprotection; PPARγ agonist activity; Anti-inflammation; AT1; angiotensin II type1; ARB; AT1 receptor blockers; RAS; rennin-angiotensin system; PPARγ; peroxisome prolifera
The PXR is a drug target for chronic inflammatory liver disease
Keywords: ALT; alanine aminotransferase; CsA; cyclosporin A; GT; gliotoxin; GAPDH; glyceradehyde 3 phosphate dehydrogenase; HYP; hyperforin; IKK2-In; IκB kinase 2 inhibitor; LPS; lipopolysaccharide; METYR; metyrapone; MTS; ([3-(4,5-dimethylthiazol-2-yl)-5-(3-carbo
Extension of the neuroprotective time window for thiazolidinediones in ischemic stroke is dependent on time of reperfusion
Keywords: cerebral ischemia; neuroprotection; pioglitazone; rosiglitazone; PPARγ; ANOVA; analysis of variance; AP-1; activator protein 1; CBF; cerebral blood flow; CT; computed tomography; Ct; cycle threshold; Cu/Zn; copper/zinc; DMSO; dimethyl sulfoxide; FDA; Fed
NO modulates the molecular basis of rat interscapular brown adipose tissue thermogenesis
Keywords: Nitric oxide; UCP1; PPARγ; PGC-1α; Brown adipose tissue; Cold;
Mesalamine Inhibits Epithelial β-Catenin Activation in Chronic Ulcerative Colitis
Keywords: APC; adenomatous polyposis coli gene; CAC; colitis-associated cancer; CRC; colorectal cancer; HD; high dose; LD; low dose; P-β-catenin; Akt-phosphorylated β-catenin; PI3K; phosphoinositide-3 kinase; PPARγ; peroxisome proliferator-activated receptor γ;
MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis
Keywords: BDL; bile duct ligation; CCl4; carbon tetrachloride; ChIP; chromatin immunoprecipitation; CREB; adenosine 3â²,5â²-cyclic monophosphate response element-binding protein; HSC; hepatic stellate cell; MeCP2; methyl-CpG binding protein 2; PPARγ; peroxisome
Cerebroprotective action of telmisartan by inhibition of macrophages/microglia expressing HMGB1 via a peroxisome proliferator-activated receptor γ-dependent mechanism
Keywords: Telmisartan; Cerebral ischemia; Macrophage/microglia; High-mobility group box1; PPARγ;