Activation of Trim17 by PPARγ is involved in Di(2-ethylhexyl) phthalate (DEHP)-induced apoptosis on Neuro-2a cells

► DEHP inhibits cell proliferation, induce Neuro-2a cells apoptosis. ► DEHP activate expression of the PPARγ and Trim17 protein. ► PPARγ agonist (troglitazone) enhanced DEHP-induced Trim17 protein expression and PPARγ antagonist (GW9662) reversed DEHP-induced Trim17 protein expression. ► DEHP activates the Trim17 protein via PPARγ leading to cleavage pro-caspase-3 and apoptosis.