Ketogenic diet-induced peroxisome proliferator-activated receptor-γ activation decreases neuroinflammation in the mouse hippocampus after kainic acid-induced seizures

► Ketogenic diet (KD) attenuated neuroinflammation in the kainic acid (KA)-induced seizure mice. ► KD induces activation of PPARγ expression in the mouse hippocampus. ► KD inhibits NF-κB-mediated COX-2 expression in the KA-treated hippocampus.