Modulation of inflammatory response and parasitism by 15-Deoxy-Δ12,14 prostaglandin J2 in Trypanosoma cruzi-infected cardiomyocytes

► 15-Deoxy-Δ12,14 (15d) prostaglandin J2 down-regulates nitric oxide synthase-2, matrix metalloproteases-2 (MMP-2) and MMP-9 expression and activity. ► Parasitism in cardiac cells increases after 15d-Prostaglandin J2 treatment. ► Extracellular-signal regulated kinase-mitogen-activated protein kinase (Erk-MAPK) and nuclear factor-κB (NF-κB) participate in 15d-Prostaglandin J2 peroxisome proliferator-activated receptor γ-independent effects.