HMGA2 promotes adipogenesis by activating C/EBPβ-mediated expression of PPARγ
Keywords: Adipogenesis; HMGA2; C/EBPβ; PPARγ;
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Leucine stimulates PPARβ/δ-dependent mitochondrial biogenesis and oxidative metabolism with enhanced GLUT4 content and glucose uptake in myotubes
Keywords: Mitochondrial biogenesis; PPARα; PPARβ/δ; PPARγ; PGC-1α;
The nuclear cofactor receptor interacting protein-140 (RIP140) regulates the expression of genes involved in Aβ generation
Keywords: PPARγ; Alzheimer's disease; RIP140; BACE1; GSK3; Aβ;
The commonly used nonionic surfactant Span 80 has RXRα transactivation activity, which likely increases the obesogenic potential of oil dispersants and food emulsifiers
Keywords: DWH; Deepwater Horizon; CWAF; Corexit-enhanced Water Accommodated Fraction; DOSS; dioctyl sodium sulfosuccinate; EDCs; endocrine disrupting chemicals; RXRα; retinoid X receptor alpha; PPARγ; peroxisome proliferator-activated receptor gamma; TBT; tributy
Trans10, cis12 conjugated linoleic acid inhibits 3T3-L1 adipocyte adipogenesis by elevating β-catenin levels
Keywords: Conjugated linoleic acid (CLA); Adipocytes; Wnt; β-Catenin; PPARγ; GSK3-β; Adipogenesis;
PPARγ-induced upregulation of CD36 enhances hematoma resolution and attenuates long-term neurological deficits after germinal matrix hemorrhage in neonatal rats
Keywords: PPARγ; CD36; Germinal matrix hemorrhage; Post-hemorrhagic ventricular dilation; Hematoma resolution;
Antiadipogenic and proosteogenic effects of luteolin, a major dietary flavone, are mediated by the induction of DnaJ (Hsp40) Homolog, Subfamily B, Member 1
Keywords: Pparγ; peroxisome proliferator activated receptor γ; aP2; adipocyte protein 2; siRNA; small interfering RNA; MSC; mesenchymal stem cells; DMI; Dexamethasone, IBMX, and Insulin; Dnajb1; DnaJ (Hsp40) Homolog, Subfamily B, Member 1; LCA; licochalcone A; TN
New PPARγ partial agonist improves obesity-induced metabolic alterations and atherosclerosis in LDLrâ/â mice
Keywords: Atherosclerosis; Diabetes; Obesity; PPARγ; Thiazolidinediones;
Iridoid-loganic acid versus anthocyanins from the Cornus mas fruits (cornelian cherry): Common and different effects on diet-induced atherosclerosis, PPARs expression and inflammation
Keywords: Cornelian cherry; Iridoids; Anthocyanins; Loganic acid; Atherosclerosis; Hypercholesterolemia; PPARα; PPARγ; IL-6; TNFα;
PFOS induces adipogenesis and glucose uptake in association with activation of Nrf2 signaling pathway
Keywords: PFOS; Nrf2; Pparγ; Adipogenesis; Glucose uptake; ARE;
Glycogen synthase kinase 3 is part of the molecular machinery regulating the adaptive response to LPS stimulation in microglial cells
Keywords: Brain macrophages; Microglia; Endotoxin tolerance; M1; M2; Inflammation; Wnt3a; PPARγ; Lithium;
Hypoxic inhibition of JMJD3 reduces H3K27me3 demethylation and induction of the STAT6 target gene CCL18
Keywords: C/EBPβ; CCAAT/enhancer binding protein (C/EBP), beta; c-myc; MYC = v-myc avian myelocytomatosis viral oncogene homolog; CBP; CREBBP = CREB binding protein; CCL18; chemokine (CC motif) ligand 18 (pulmonary and activation-regulated); CHX; cycloheximid;
LFG-500, a newly synthesized flavonoid, attenuates lipopolysaccharide-induced acute lung injury and inflammation in mice
Keywords: ALI; acute lung injury; BALF; bronchoalveolar lavage fluid; DMSO; dimethyl sulfoxide; EMSA; electrophoretic mobility shift assay; ELISA; enzyme-linked immunoassay; IL-1β; interleukin-1β; LPS; lipopolysaccharide; MPO; myeloperoxidase; MAPK; mitogen-activ
Cyanidin 3-O-β-glucopyranoside activates peroxisome proliferator-activated receptor-γ and alleviates cognitive impairment in the APPswe/PS1ÎE9 mouse model
Keywords: AD; Alzheimer's disease; Cy3G; cyanidin 3-O-β-glucopyranoside; Aβ25-35; beta-amyloid 25-35; PAP mouse; APPswe/PS1ÎE9 mouse; PPARγ; peroxisome proliferator-activated receptor-γ; SPs; senile plaques; H2O2; hydrogen peroxide; CNS; central nervous sy
Telmisartan attenuates hyperglycemia-exacerbated VCAM-1 expression and monocytes adhesion in TNFα-stimulated endothelial cells by inhibiting IKKβ expression
Keywords: Telmisartan; Vascular inflammation; Hyperglycemia; IKKβ; VCAM-1; Telmisartan (PubChem CID: 65,999); Losartan (PubChem CID: 3961); Fimasartan (PubChem CID: 9,870,652); VCAM-1; vascular cell adhesion molecule-1; ICAM-1; intercellular adhesion molecule-1; E
The elusive endogenous adipogenic PPARγ agonists: Lining up the suspects
Keywords: NO; nitric oxide; NO2; dioxide radical; O2; superoxide; ONO2â; Â peroxynitrite; 15-dPGJ2; 15-deoxy-Î12,14-prostaglandin J2; AA; arachidonic acid; ADH; alcohol dehydrogenase; AF-1; ligand-independent activation function; AF-2; ligand-dependent activatio
PPARγ and MyoD are differentially regulated by myostatin in adipose-derived stem cells and muscle satellite cells
Keywords: Myostatin; Adipose-derived stem cells; Muscle satellite cells; PPARγ; MyoD;
ATF3 inhibits PPARγ-stimulated transactivation in adipocyte cells
Keywords: aP2; adipocyte fatty acid binding protein; ATF3; activation transcription factor 3; ATF/CRE; ATF/CREB responsive element; ChIP; chromatin immunoprecipitation; ER; endoplasmic reticulum; LBD; ligand-binding domain; PPARγ; peroxisome proliferator activated
Regulation of retinoid X receptor gamma expression by fed state in mouse liver
Keywords: RXRγ; Liver; Feeding; Glucose; Lipid metabolism; RXR; retinoid X receptor; PPARγ; peroxisome proliferator-activated receptor gamma; RAR; retinoic acid receptor; FXR; farnesoid X receptor; LXR; liver X receptor; SREBP-1c; sterol regulatory element-bindin
Involvement of PPARγ in emodin-induced HK-2 cell apoptosis
Keywords: PPARγ; Emodin; HK-2 cell; Apoptosis; Caspase 3; Cytochrome c;
Ginsenoside Rb1 promotes browning through regulation of PPARγ in 3T3-L1 adipocytes
Keywords: Ginsenoside Rb1; PPARγ; Browning; Mitochondrial respiration; 3T3-L1 adipocytes;
Expression regulation and targeting of the peroxisome proliferator-activated receptor γ following electrically-induced status epilepticus
Keywords: Epileptogenesis; Learning; Inflammation; Rosiglitazone; PPARγ;
MicroRNA-130a and -130b enhance activation of hepatic stellate cells by suppressing PPARγ expression: A rat fibrosis model study
Keywords: miR-130a; miR-130b; PPARγ; TGF-β1; Hepatic stellate cells; Liver fibrosis;
Dietary obacunone supplementation stimulates muscle hypertrophy, and suppresses hyperglycemia and obesity through the TGR5 and PPARγ pathway
Keywords: Obacunone; TGR5; PPARγ; Hyperglycemia; Obesity; Hypertrophy;
FABP4 inhibition suppresses PPARγ activity and VLDL-induced foam cell formation in IL-4-polarized human macrophages
Keywords: Lipoprotein lipase; Fatty acid binding proteins; PPARγ; Foam cell formation; CCL; chemokine (C-C motif) ligand; FABP; fatty acid binding protein; LDL; low density lipoprotein; LPL; lipoprotein lipase; M-CSF; macrophage colony-stimulating factor; Mo; mono
Curcumin retunes cholesterol transport homeostasis and inflammation response in M1 macrophage to prevent atherosclerosis
Keywords: Curcumin; M1 macrophages; Cholesterol uptake; Cholesterol efflux; Inflammation; PPARγ;
MicroRNA-27b plays a role in pulmonary arterial hypertension by modulating peroxisome proliferator-activated receptor γ dependent Hsp90-eNOS signaling and nitric oxide production
Keywords: miR-27b; PPARγ; Pulmonary artery hypertension; Endothelial nitric oxide synthase; NO;
An active extract of Ulmus pumila inhibits adipogenesis through regulation of cell cycle progression in 3T3-L1 cells
Keywords: PPARγ; peroxisome proliferator-activated receptor-γ; C/EBPα; CCAAT/enhancer-binding protein alpha; DMEM; Dulbecco's Modified Eagle Medium; PBS; phosphate buffer saline; TNF-α; tumor necrosis factor α; NF-κB; nuclear factor kappa-light-chain-enhanc
Flightless-1, a novel transcriptional modulator of PPARγ through competing with RXRα
Keywords: PPARγ; Flightless-I (FLII); RXRα; Adipogenesis; Coregulators; Interaction;
Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity
Keywords: VDR; vitamin D receptor; LBD; ligand-binding domain; 1α,25-(OH)2D3; 1α,25-dihydroxyvitamin D3; SERM; selective estrogen receptor modulator; ERα; estrogen receptor α; PPARγ; peroxisome proliferator-activated receptor γ; Vitamin D; Nuclear receptor; X
Probiotic yogurt improves body mass index and fasting insulin levels without affecting serum leptin and adiponectin levels in non-alcoholic fatty liver disease (NAFLD)
Keywords: NAFLD; non-alcoholic fatty liver disease; BMI; body mass index; WC; waist circumference; IR; insulin resistance; HOMA; homeostasis model assessment; cfu; colony-forming units; SCFA; small chain fatty acid; ANGPTL4; protein like angiopoetin 4 gene; SFA; sa
Cell Cycle Regulation of Smooth Muscle Cells-Searching for Inhibitors of Neointima Formation: Is Combretastatin A4 an Alternative to Sirolimus and Paclitaxel?
Keywords: CA4; combretastatin A4; CDK; cyclin-dependent kinase; CI; confidence interval; mTOR; mammalian target of rapamycin; PPARγ; peroxisome proliferator activated receptor γ; SMC; smooth muscle cell;
Facilitation of adipocyte differentiation of 3T3-L1 cells by debrominated tetrabromobisphenol A compounds detected in Japanese breast milk
Keywords: BFRs; brominated flame retardants; BPA; bisphenol A; C/EBPα; CCAAT-enhancer-binding protein alpha; 2,2â²-DiBBPA; 2,2â²-dibromobisphenol A; 2,6-DiBBPA; 2,6-dibromobisphenol A; GC/MS; gas chromatography/mass spectrometry; LOD; limit of detection; LOQ; li
Inhibition of ASCT2 is essential in all-trans retinoic acid-induced reduction of adipogenesis in 3T3-L1 cells
Keywords: ATRA; all-trans retinoic acid; DIM; dexamethasone, insulin and 3-isobutylmethylxanthine; FXR; farnesoid X Receptor; Gapdh; glyceraldehyde 3-phosphate dehydrogenase; GPNA; l-γ-glutamyl-p-nitroanilide; PPARγ; peroxisome proliferator-activated receptor γ;
Lipids generated during acute pancreatitis increase inflammatory status of macrophages by interfering with their M2 polarization
Keywords: Macrophages; Pancreatitis; Inflammation; Adipose tissue; Phenotype; PPARγ; AP; Acute Pancreatitis; EWAT; Epididymal White adipose tissue; RWAT; Retroperitoneal White adipose tissue; MWAT; Mesenteric adipose tissue; MPO; Myeloperoxidase;
CD1d serves as a surface receptor for oxidized cholesterol induction of peroxisome proliferator-activated receptor-γ
Keywords: Atherosclerosis; Oxysterols; PPARγ; Lipid antigens;
Role of PRDM16 and its PR domain in the epigenetic regulation of myogenic and adipogenic genes during transdifferentiation of C2C12 cells
Keywords: C/EBP; CCAAT/enhancer binding protein; ChIP; chromatin immunoprecipitation; H3K4me3; histone H3 lysine 4 trimethylation; H3K9me1; H3K9 monomethylation; mCK; muscle creatine kinase; MEF; Myocyte-specific enhancer factor; MyHC; myosin heavy chain; NFAT; nuc
Curcumin attenuates cardiomyocyte hypertrophy induced by high glucose and insulin via the PPARγ/Akt/NO signaling pathway
Keywords: Cardiomyocytes hypertrophy; Diabetes; Curcumin; PPARγ; Akt; NO;
Molecular characterization, transcriptional activity and nutritional regulation of peroxisome proliferator activated receptor gamma in Nile tilapia (Oreochromis niloticus)
Keywords: PPARγ; Lipid metabolism; Transcriptional regulation; Transfection; Dual luciferase reporter system;
Activation of peroxisome proliferator-activated receptor-γ (PPARγ) inhibits hepatoma cell growth via downregulation of SEPT2 expression
Keywords: PPARγ; Hepatocellular carcinoma; SEPT2; Rosiglitazone; Proteomics; Spectrometry;
Perinatal nicotine exposure suppresses PPARγ epigenetically in lung alveolar interstitial fibroblasts
Keywords: α-SMA; Alpha smooth muscle actin; ATII; Alveolar epithelial type II; Aza-CdR; 5-Aza-2â²-deoxycytidine; ChIP; Chromatin immunoprecipitation; DMSO; Dimethyl sulfoxide; DNMT1; DNA methyltransferase 1; LIFs; Lipofibroblasts; MSP; Methylation-specific-PCR; M
Telmisartan attenuated LPS-induced neuroinflammation in human IMR-32 neuronal cell line via SARM in AT1R independent mechanism
Keywords: LPS; PPARγ; IMR-32 cell line; SARM; Cytokines; MyD88; p65(NFκB); MAPK; ERK; JNK;
Pseudolaric acid B inhibits T-cell mediated immune response in vivo via p38MAPK signal cascades and PPARγ activation
Keywords: Pseudolaric acid B; Delayed-type hypersensitivity; Microarray; p38MAPK; PPARγ;
PPARγ-Dependent and -Independent Inhibition of the HMGB1/TLR9 Pathway by Eicosapentaenoic Acid Attenuates Ischemic Brain Damage in Ovariectomized Rats
Keywords: Eicosapentaenoic acid; PPARγ; HMGB1; RAGE; toll-like receptors; brain ischemia; ovariectomy;
α-Lipoic acid treatment increases mitochondrial biogenesis and promotes beige adipose features in subcutaneous adipocytes from overweight/obese subjects
Keywords: α-Lip; α-Lipoic acid; LDH; lactate dehydrogenase; mtDNA; mitochondrial DNA; Sirt1; Sirtuin 1; PGC-1α; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; Nrf1; nuclear respiratory factor 1; Tfam; mitochondrial transcription factor; C
Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype
Keywords: Pioglitazone; Losartan; PPARγ; Chronic kidney disease; Atherosclerosis; Macrophage phenotype;
Research ReportRosiglitazone attenuates early brain injury after experimental subarachnoid hemorrhage in rats
Keywords: SAH; subarachnoid hemorrhage; EBI; early brain injury; PPARγ; peroxisome proliferator-activated receptor γ; BBB; blood brain barrier; PI3K; phosphoinositide 3-kinase; Akt; protein kinase B; p-Akt; phosphorylated Akt; MMP-9; matrix metallopeptidase 9; DI
Interactions between dietary protein levels, growth performance, feed utilization, gene expression and metabolic products in juvenile grass carp (Ctenopharyngodon idella)
Keywords: NPY; neuropeptide Y; ACC1; acetyl-CoA carboxylase 1; UCP1; uncoupling protein 1; PPARγ; peroxisome proliferator-activated receptor γ; PWG; percent weight gain; FCR; feed conversion ratio; AST; aspartate aminotransferase; ALT; alanine transaminase; TG; t
n-3 Polyunsaturated fatty acids inhibit Fc ε receptor I-mediated mast cell activation
Keywords: AA; arachidonic acid; ANOVA; analysis of variance; β-hex; β-hexosaminidase; BMMC; bone marrow-derived mast cells; CCL2; chemokine (C-C motif) ligand 2; cys-LT; cysteinyl leukotrienes; DHA; docosahexaenoic acid; DNP; 2,4-dinitrophenol; DPA; docosapentaen
Rhizoma Dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPARγ factor and the NADPH oxidase/ROS-NF-κB signal pathway
Keywords: Rhizoma Dioscoreae Nipponicae polysaccharides (RDNP); Nox4; ROS; PPARγ; NF-κB;