Di-(2-ethylhexyl) phthalate could disrupt the insulin signaling pathway in liver of SD rats and L02 cells via PPARγ
Keywords: DEHP; ROS; Insulin resistance; PPARγ; Liver; GLUT4;
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Effect of dietary fatty acid composition on growth, fatty acids composition and hepatic lipid metabolism in juvenile turbot (Scophthalmus maximus L.) fed diets with required n3 LC-PUFAs
Keywords: LC-PUFA; Long-chain polyunsaturated fatty acid; HDL-c/LDL-c; Ratio of high- to low-density lipoprotein cholesterol; LPL; Lipoprotein lipase; G6PD; Glucose-6-phosphate dehydrogenase; ME; Malic enzyme; ApoB-100; Apolipoprotein B-100; PPARα; Peroxisome prol
Dual signaling evoked by oxidized LDLs in vascular cells
Keywords: AAPH; 2,2'-azobis(2-amidinopropane) dihydrochloride; AIF; apoptotic inducing factor; AMVN; 2,4-dimethylvaleronitrile; AP-1; activator protein 1; ATF6; activating transcription factor 6; CDE; clathrin-dependent endocytosis; CCL2; chemokine ligand 2 (or MCP
Saponins from stems and leaves of Panax ginseng prevent obesity via regulating thermogenesis, lipogenesis and lipolysis in high-fat diet-induced obese C57BL/6 mice
Keywords: Anti-obesity; Saponins; Panax ginseng; C57BL/6 mice; Haematoxylin and eosin; RT-PCR; aP2; adipocyte fatty acid binding protein 2; ATGL; adipose triglyceride lipase; CD36; cluster of differentiation 36; CPT-1; carnitine O-palmitoyltransferase 1; FFA; free
A-type ECG and EGCG dimers inhibit 3T3-L1 differentiation by binding to cholesterol in lipid rafts
Keywords: A-type ECG and EGCG dimers; Cholesterol; Disruption; Lipid rafts; 3T3-L1 preadipocytes differentiation; A-type ECG dimer; epicatechin-3-gallate-(4βâ8, 2βâOâ7)-epicatechin-3-gallate; A-type EGCG dimer; epigallocatechin-3-gallate-(4βâ8, 2βâOâ
Tributyltin and triphenyltin exposure promotes in vitro adipogenic differentiation but alters the adipocyte phenotype in rainbow trout
Keywords: Organotins; TBT; TPT; Obesogens; Adipocyte culture; PPARγ; Fish;
DBZ is a putative PPARγ agonist that prevents high fat diet-induced obesity, insulin resistance and gut dysbiosis
Keywords: ACC; acetyl-CoA carboxylase; ADRB; adrenoreceptor beta; BAT; brown adipose tissue; CPT1β; carnitine palmitoyltransferase 1 beta; DBZ; danshensu bingpian zhi; Epi-WAT; epididymal white adipose tissue; FATP; fatty acid transport protein; FAS; fatty acid sy
Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of novel quinoxaline derivatives as potential PPARγ and SUR agonists
Keywords: Quinoxaline; PPARγ; Sulfonylurea; Sulfonylthiourea; Docking; Pharmacophore; Anti-hyperglycemic;
PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling
Keywords: AhR; aryl hydrocarbon receptor; CAR; constitutive activated receptor; DEHP; di-(2-ethylhexyl)phthalate; ERα; estrogen receptor α; ERE; estrogen response element; GH; growth hormone; LXR; liver X receptor; Nrf2; nuclear factor erythroid-2-related factor
Molecular aspects of lipid metabolism, digestibility and antioxidant status of Atlantic bluefin tuna (T. thynnus L.) larvae during first feeding
Keywords: ABT; Atlantic bluefin tuna; aco; acyl coA oxidase; alp; alkaline phosphatase; amy; amylase; anpep; amino peptidase; ARA; arachidonic acid (20:4n-6); bal1; bile salt activated lipase 1; bal2; bile salt activated lipase 2; C; free cholesterol; cat; catalase
Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25Â years of research in chemistry and biology
Keywords: Isoprostanes; Neuroprostanes; Phytoprostanes; Lipid Peroxidation; Polyunsaturated fatty acids; AA; Arachidonic acid; AD; Alzheimer's disease; AdA; Adrenic acid; ALA; α-Linolenic acid; APCI; Atmospheric pressure chemical ionization; BHT; Butylated hydroxy
Effects of Klotho on fibrosis and cancer: A renal focus on mechanisms and therapeutic strategies
Keywords: ACE; angiotensin converting enzyme; ADAM; a disintegrin and metalloproteinase; AKI; acute kidney injury; ANGII; angiotensin II; AT1; angiotensin II receptor type 1; AMPKα; AMP-activated protein kinase α; α-SMA; α-smooth muscle actin; CKD; chronic kidn
The macrophage and its related cholesterol efflux as a HDL function index in atherosclerosis
Keywords: ABC; ATP-binding cassette; ABCA-1; ATP-binding cassette A-1; ABCG-1; ATP-binding cassette G-1; CKD; chronic kidney disease; CVD; cardiovascular disease; HDL; high-density lipoprotein; IL; interleukin; IQR; interquartile range; LDL; low-density lipoprotein
MiR-1271 upregulated by saturated fatty acid palmitate provokes impaired insulin signaling by repressing INSR and IRS-1 expression in HepG2 cells
Keywords: microRNA; miR-1271; Saturated fatty acid; Palmitate; Insulin resistance; INSR; IRS-1; Akt2; v-akt murine thymoma viral oncogene homolog 2; C/EBPα; CCAAT/enhancer binding protein alpha; ER; endoplasmic reticulum; FOXQ1; forkhead box Q1; GPC3; glypican 3;
PPARγ suppresses the proliferation of cardiac myxoma cells through downregulation of MEF2D in a miR-122-dependent manner
Keywords: PPARγ; miR-122; MEF2D; Proliferation; Cardiac myxoma;
Wnt/β-catenin signaling plays a distinct role in methyl gallate-mediated inhibition of adipogenesis
Keywords: Methyl gallate; Wnt/β-catenin; Adipogenesis; PPARγ;
Distinct functions of PPARγ isoforms in regulating adipocyte plasticity
Keywords: Obesity; PPARγ; Adipocyte; PPARγ isoforms; Browning; Beiging;
PPARγ inhibits HMGB1 expression through upregulation of miR-142-3p in vitro and in vivo
Keywords: PPARγ; miR-142-3p; HMGB1; Inflammation;
Promotion of adipogenesis by 15-(S)-hydroxyeicosatetraenoic acid
Keywords: 3T3-L1; Obesity; Adipogenesis; 15-(S)-hydroxyeicosatetraenoic acid; PPARγ; hBMSC;
Daidzein reduces the proliferation and adiposeness of 3T3-L1 preadipocytes via regulating adipogenic gene expression
Keywords: Daidzein; 3T3-L1 preadipocytes; Proliferation; Adipogenesis; Arachidonic acid (PubChem CID: 444899); Daidzein (PubChem CID: 5281708); Dexamethasone (PubChem CID: 5743); Dimethyl sulfoxide (PubChem CID: 679); Isopropanol (PubChem CID: 3776); Oil Red O (Pub
Rosiglitazone attenuates inflammation and CA3 neuronal loss following traumatic brain injury in rats
Keywords: Traumatic brain injury; PPARγ; Inflammation; Rosiglitazone; Behavioral; Cell survival;
The synthetic ajoene analog SPA3015 induces apoptotic cell death through crosstalk between NF-κB and PPARγ in multidrug-resistant cancer cells
Keywords: SPA3015; Multidrug resistance; Apoptosis; NF-κB; PPARγ;
Targeting ODC1 inhibits tumor growth through reduction of lipid metabolism in human hepatocellular carcinoma
Keywords: HCC; ODC1; Polyamine; KLF2; PPARγ; Lipogenesis;
Peroxisome proliferator-activated receptor γ down-regulation mediates the inhibitory effect of d-δ-tocotrienol on the differentiation of murine 3T3-F442A preadipocytes
Keywords: Tocotrienol; Lovastatin; Adipocyte; Mevalonate; PPARγ; ANOVA; analysis of variance; C/EBPα; CCAAT/enhancer-binding protein α; FAS; fatty acid synthase; GLUT4; glucose transport protein 4; HMG CoA; 3-hydroxy-3-methylglutaryl coenzyme A; PBS; phosphate-b
Pioglitazone prevents tau oligomerization
Keywords: Tau; Pioglitazone; PPARγ; Phosphorylation; GSK3β; Tau oligomer; Caspase;
PPARγ regulates exocrine pancreas lipase
Keywords: Pancreatic lipase; PPARγ; Polyunsaturated fatty acids; Exocrine pancreas;
Ginsenoside Re reduces Aβ production by activating PPARγ to inhibit BACE1 in N2a/APP695 cells
Keywords: Ginsenoside Re; Alzheimer´s disease; Aβ; BACE1; PPARγ;
MiR-146a modulates macrophage polarization by inhibiting Notch1 pathway in RAW264.7 macrophages
Keywords: Arg1; arginase 1; iNOS; inducible NO synthase; IL-10; interleukin-10; miRNA; microRNAs; PPARγ; peroxisome proliferator-activated receptor γ; TNF-α; tumor necrosis factor alpha,; Macrophage;; Polarization;; miR-146a;; Notch1;; PPARγ;
Evaluation of role of telmisartan in combination with 5-fluorouracil in gastric cancer cachexia
Keywords: QoL; quality of life; PPARγ; peroxisome proliferator activated receptor gamma; RAAS; renin angiotensin aldosterone system; VSMC; vascular smooth muscle cell; 5-FU; 5-Flourouracil; MNNG; N-methyl-Nâ²-nitro-N-nitrosoguanidine; VLDL; very low density lipop
Pin1 enhances adipocyte differentiation by positively regulating the transcriptional activity of PPARγ
Keywords: Adipogenesis; Pin1; PPARγ; ERK;
Full length articleHepatic injury associated with Trypanosoma cruzi infection is attenuated by treatment with 15-deoxy-Î12,14 prostaglandin J2
Keywords: Liver; Trypanosoma cruzi; Inflammation; PPARγ; 15-Deoxi-Î12-14 prostaglandine J2;
Upregulation of MKP-7 in response to rosiglitazone treatment ameliorates lipopolysaccharide-induced destabilization of SIRT1 by inactivating JNK
Keywords: SIRT1; silent mating type information regulation 2 homolog 1; PPARγ; peroxisome proliferator-activated receptor γ; LPS; lipopolysaccharide; MKP-7; mitogen-activated protein kinase phosphatase-7; PGC-1α; peroxisome proliferator-activated receptor gamma
Cryptotanshinone, a compound of Salvia miltiorrhiza inhibits pre-adipocytes differentiation by regulation of adipogenesis-related genes expression via STAT3 signaling
Keywords: Cryptotanshinone; Adipogenesis; C/EBPβ; PPARγ; STAT3; CT; cryptotanshinone; RA; retinoic acid; Tro; troglitazone; C/EBP; CCAAT/enhancer-binding protein; PPARγ; peroxisome proliferation-activity receptor γ; GAPDH; glycerol-3-phosphate dehydrogenase; IB
Expression, regulation and functional assessment of the 80 amino acid Small Adipocyte Factor 1 (Smaf1) protein in adipocytes
Keywords: Adipocyte; Adipogenesis; PPARγ; Differentiation; Lipid metabolism; Smaf1; Adipogenin;
Steroid receptor RNA activator: Biologic function and role in disease
Keywords: AF-2; activation function-2; AR; androgen receptor; C/EBPα; ccaat-enhancer-binding protein α; CTCF; CCCTC-binding factor; Ddx5; DEAD box protein 5; ERα; estrogen receptor α; GR; glucocorticoid receptor; Hes1; hairy and enhancer of split-1; HP1γ; hete
PPARγ signaling and emerging opportunities for improved therapeutics
Keywords: PPARγ; peroxisome proliferator-activated receptor gamma; TZD; thiazolidinedione; T2DM; type 2 diabetes mellitus; RGZ; rosiglitazone; 15d-PGJ2; 15-deoxy-D12,14-prostanglandin J2; PGC-1α; PPARγ co-activator-1α; RXR; retinoid X receptor; PPRE; peroxisome
Peroxisome proliferator-activated receptor-γ (PPARγ) agonist is neuroprotective and stimulates PGC-1α expression and CREB phosphorylation in human dopaminergic neurons
Keywords: PPARγ; PGC-1α; SIRT1; CREB; Dopaminergic neurons; Mitochondria; AC6; adenylyl cyclase 6; CRE; cAMP responsive element; CREB; cAMP responsive element-binding protein; FCCP; carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone; GW1929; N-(2-benzoylphenyl)
Dioscin attenuates gastric ischemia/reperfusion injury through the down-regulation of PKC/ERK1/2 signaling via PKCα and PKCβ2 inhibition
Keywords: Anti-oxidative stress; Dioscin; Gastric ischemia-reperfusion; Natural product; PKC/ERK1/2 signaling pathway; H/R; hypoxia-reoxygenation; I/R; ischemia-reperfusion; siRNA; small interfering RNA; ROS; reactive oxygen species; PKC; Protein kinase C; MAPK; mi
PPARγ Regulates Mouse Meibocyte Differentiation and Lipid Synthesis
Keywords: eyelid; lipid; meibocytes; meibomian gland; PPARγ; tear film;
PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease
Keywords: PPARγ; peroxisome proliferation-activated receptor gamma; 15D-PGJ2; 15-deoxy-Î12,14-Prostaglandin J2; TZDs; thiazolidinediones; CNS; central nervous system; WAT; white adipose tissue; BAT; brown adipose tissue; SRC; steroid receptor coactivator; CBP; CR
DNA Topoisomerase IIα contributes to the early steps of adipogenesis in 3T3-L1 cells
Keywords: MCE; mitotic clonal expansion; C/EBP; CCAAT/enhancer-binding protein; PPARγ; peroxisome proliferator-activated receptor γ; IR; insulin receptor; PI3K; phosphoinositide 3-kinase; PKB; protein kinase B; Topo IIα and β; DNA Topoisomerase IIα and β; mTO
Potential antihyperglycaemic effect of myricetin derivatives from Syzygium malaccense
Keywords: 2-NBDG; 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose; AdipoQ; adiponectin, C1Q and collagen domain containing; Akt1; RAC-alpha serine/threonine-protein kinase or thymoma viral proto-oncogene 1; CAT; catalase; DM; diabetes mellitus; DIM; d
AMPK promotes osteogenesis and inhibits adipogenesis through AMPK-Gfi1-OPN axis
Keywords: BMSC; bone marrow stromal cell; AMPK; AMP-activated protein kinase; OPN; osteopontin; Gfi1; growth factor independence-1; Runx2; runt-related transcription factor 2; Osx; Osterix; ALP; alkaline phosphatase; BSP; bone sialoprotein; OC; osteocalcin; PPARγ;
MicroRNAs associated with the pathogenesis of multiple sclerosis
Keywords: BBB; blood-brain barrier; BMI1; B lymphoma Mo-MLV insertion region 1 homolog; CAPS-3; caspase-3; CEBPB; CCAAT/enhancer-binding protein beta; CNS; central nervous system; EAE; experimental autoimmune encephalomyelitis; GA; Glatiramer acetate; HIF-1; hypo
The antiproliferative and proapoptotic effects of cladosporols A and B are related to their different binding mode as PPARγ ligands
Keywords: CAD; caspase-activated deoxyribonuclease; CRC; colorectal cancer; HR-ESI-MS; high resolution electrospray ionization mass; LBD; ligand-binding domain; MDA; malondialdehyde; NCoEx; nuclear corepressor exchange factor; PPARs; peroxisome proliferator-activat
New telmisartan-derived PPARγ agonists: Impact of the 3D-binding mode on the pharmacological profile
Keywords: PPARγ; Transactivation; Cytotoxicity; Binding mode; Molecular modeling; Amax; maximum intrinsic activity; BPO; benzoyl peroxide; DMEM; Dulbecco's modified Eagle medium; LBD; ligand binding domaine; mp; melting point; NBS; N-bromosuccinimide; PPAR; peroxi
Pioglitazone inhibits EGFR/MDM2 signaling-mediated PPARγ degradation
Keywords: Pioglitazone; PPARγ; EGFR; Ubiquitination; Degradation;
Anti-diabetic functional foods as sources of insulin secreting, insulin sensitizing and insulin mimetic agents
Keywords: GLUT-1; Glucose-transporter 1; GLUT-2; Glucose-transporter 2; GLUT-3; Glucose-transporter 3; GLUT-4; Glucose transporter 4; SUR1; Sulphonylurea receptor 1; HOMA-β; Homeostasis model assessment of β-cell function; HOMA-IR; Homeostasis model assessment of
PPARγ is regulated by miR-27b-3p negatively and plays an important role in porcine oocyte maturation
Keywords: Pig; miRNA; Oocyte maturation; PPARγ; Fatty acid metabolism;