کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6019953 1580379 2016 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MicroRNAs associated with the pathogenesis of multiple sclerosis
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
MicroRNAs associated with the pathogenesis of multiple sclerosis
چکیده انگلیسی
Multiple sclerosis (MS) is not only an autoimmune disease in which autoreactive immune cells against myelin damage axons and nerves in the central nervous system, but also a neurodegenerative disease, in which progressive loss of structure and function of neurons occurs. The mechanisms of MS pathogenesis have not been fully understood. It has been reported that miRNAs may play a critical role in MS pathogenesis. In this review, we have extensively discussed the alterations in the expression of miRNAs detected in patients with MS. The dysregulated miRNAs have been shown to be associated with the pathogenesis of MS. We suggest that such dysregulated miRNAs may potentially be used as biomarkers in the diagnosis of MS, to discover new therapeutic targets for MS treatment, and to predict prognostic markers in responses to MS treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volumes 295–296, 15 June–15 July 2016, Pages 148-161
نویسندگان
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