کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8259136 | 1534630 | 2016 | 54 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cyanidin 3-O-β-glucopyranoside activates peroxisome proliferator-activated receptor-γ and alleviates cognitive impairment in the APPswe/PS1ÎE9 mouse model
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کلمات کلیدی
MWMCy3GPBSRGZROI18F-FDGDMEMFITCPPARγSPSDCFH-DA2′,7′-dichlorofluorescin diacetate - 2 '، 7'-dichlorofluorescin diacetate2-deoxy-2-[18F]fluoro-D-glucose - 2-deoxy-2- [18F] fluoro-D-glycose3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide - 3- (4،5-dimethyl-2-thiazolyl) -2،5-difenyl-2-H-tetrazolium bromideAβ25–35 - A25-35DMSO - DMSODulbecco's modified Eagle's medium - Medal of Eagle اصلاح شده DulbeccoMTT - MTTPET/CT - PET / CTROS - ROSTZDs - TZD هاHydrogen peroxide - آب اکسیژنهTem - این استAlzheimer's disease - بیماری آلزایمرpositron emission tomography-computed tomography - توموگرافی کامپیوتری انتشارات پوزیترونthiazolidinediones - تیازولیدیدونهاCNS - دستگاه عصبی مرکزیDimethyl sulfoxide - دیمتیل سولفواکسیدrosiglitazone - روزیگلیتازونCongo red - سرخ کنگوSH-SY5Y cells - سلول های SH-SY5YHepG2 cells - سلولهای HepG2central nervous system - سیستم عصبی مرکزیdiscrimination index - شاخص تبعیضsenile plaques - صفحات سالخوردهPhosphate buffered saline - فسفات بافر شورfluorescein isothiocyanate - فلوئورسین ایسوتیوسیاناتMorris water maze - ماز آب آب موریسSUV - ماشین شاسی بلندNeuroprotection - محافظت نورونی یا محافظت از عصبSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیInsulin resistance - مقاومت به انسولینscanning electron microscope - میکروسکوپ الکترونی اسکنTransmission electron microscope - میکروسکوپ الکترونی انتقالH2O2 - هیدروژن پراکسیدPropidium iodide - پروتئین یدیدReactive oxygen species - گونههای فعال اکسیژنPeroxisome proliferator-activated receptor-γ - گیرنده پروتئینی فعال پروکسیوم - γ
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Alzheimer's disease (AD) is currently one of the most common neurodegenerative disorders worldwide. To date, no cure has been developed for AD, and some disease-modifying treatments show side effects and low efficacy. Increasing evidence shows that cyanidin 3-O-β-glucopyranoside (Cy3G), which is naturally derived from many plants, may provide protection against neurodegenerative diseases including AD; however, its exact role is still unclear. Therefore, we investigated the mechanisms of the effects of Cy3G on beta-amyloid 25-35 (Aβ25-35)-induced SH-SY5Y cell injury and cognitive impairment in the APPswe/PS1ÎE9 (PAP) mouse model of AD. Furthermore, we aimed to determine the molecular target initiated by Cy3G. The data indicated that Cy3G-mediated neuroprotection involved the inhibition of Aβ25-35 binding to the cell surface and spontaneous aggregation of Aβ25-35 fibrils at the molecular level. Furthermore, in an in vitro study, Aβ25-35-mediated cytotoxicity, which was caused by inducing apoptotic cell death and ROS formation, was also ameliorated by Cy3G intervention. In addition, upregulation of peroxisome proliferator-activated receptor-γ (PPARγ) protein involved in glucose/lipid metabolism by Cy3G treatment verified that the initiated molecule was Cy3G. In an in vivo study, Cy3G was shown to alleviate cognitive impairment, improve cerebral glucose uptake and decrease fasting blood glucose levels. In conclusion, Cy3G ameliorates amyloid β peptide-induced injury both in vitro and in vivo through the PPARγ pathway. Thus, Cy3G has a good safety profile as a potential natural PPARγ agonist and may be used as an ideal alternative to traditional disease-modifying treatments against AD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1862, Issue 9, September 2016, Pages 1786-1800
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1862, Issue 9, September 2016, Pages 1786-1800
نویسندگان
Nan Song, Ling Zhang, Wei Chen, Hua Zhu, Wei Deng, Yunlin Han, Jianguo Guo, Chuan Qin,